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  1. Article ; Online: Dangerous Needle Stick.

    Krantz, Mori J / Flagg, Thomas P / Haigney, Mark C P

    Circulation

    2020  Volume 141, Issue 17, Page(s) 1424–1426

    MeSH term(s) Adult ; Echocardiography ; Electrocardiography ; Humans ; Male ; Needlestick Injuries/complications ; Needlestick Injuries/diagnostic imaging ; Needlestick Injuries/physiopathology ; Needlestick Injuries/therapy ; Pericardial Effusion/diagnostic imaging ; Pericardial Effusion/etiology ; Pericardial Effusion/physiopathology ; Pericardial Effusion/therapy ; Potassium Citrate/administration & dosage ; Potassium Citrate/adverse effects ; Suicide, Attempted ; Tomography, X-Ray Computed
    Chemical Substances Potassium Citrate (EE90ONI6FF)
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.120.045929
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Considerations for Optimizing Warfighter Psychological Health with a Research-Based Flavonoid Approach: A Review.

    Currie, Tanisha L / Engler, Marguerite M / Krauthamer, Victor / Scott, Jonathan M / Deuster, Patricia A / Flagg, Thomas P

    Nutrients

    2023  Volume 15, Issue 5

    Abstract: Optimal nutrition is imperative for psychological health. Oxidative stress and inflammation are underlying etiologies for alterations in psychological health. Warfighters are at risk of health concerns such as depression due to increased stress in ... ...

    Abstract Optimal nutrition is imperative for psychological health. Oxidative stress and inflammation are underlying etiologies for alterations in psychological health. Warfighters are at risk of health concerns such as depression due to increased stress in austere environments and family separation while deployed. Over the last decade, research has demonstrated the health benefits of flavonoids found in fruits and berries. Berry flavonoids have potent antioxidant and anti-inflammatory properties by inhibiting oxidative stress and inflammation. In this review, the promising effects of various berries rich in bioactive flavonoids are examined. By inhibiting oxidative stress, berry flavonoids have the potential to modulate brain, cardiovascular, and intestinal health. There is a critical need for targeted interventions to address psychological health concerns within the warfighter population, and a berry flavonoid-rich diet and/or berry flavonoid dietary supplement intervention may prove beneficial as an adjunctive therapy. Structured searches of the literature were performed in the PubMed, CINAHL, and EMBASE databases using predetermined keywords. This review focuses on berry flavonoids' critical and fundamental bioactive properties and their potential effects on psychological health in investigations utilizing cell, animal, and human model systems.
    MeSH term(s) Animals ; Humans ; Flavonoids/pharmacology ; Diet ; Fruit ; Antioxidants/pharmacology ; Inflammation
    Chemical Substances Flavonoids ; Antioxidants
    Language English
    Publishing date 2023-02-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15051204
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  3. Article ; Online: The Effects of Berry Extracts on Oxidative Stress in Cultured Cardiomyocytes and Microglial Cells: A Potential Cardioprotective and Neuroprotective Mechanism.

    Currie, Tanisha L / Engler, Marguerite M / Olsen, Cara H / Krauthamer, Victor / Scott, Jonathan M / Deuster, Patricia A / Flagg, Thomas P

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 9

    Abstract: Oxidative stress is a key underlying factor in cognitive decline and atherosclerosis. Oxidative stress occurs at the cellular level with an imbalance between reactive oxygen species and reactive nitrogen species and a deficiency in antioxidants. Mounting ...

    Abstract Oxidative stress is a key underlying factor in cognitive decline and atherosclerosis. Oxidative stress occurs at the cellular level with an imbalance between reactive oxygen species and reactive nitrogen species and a deficiency in antioxidants. Mounting evidence suggests that berry flavonoids may promote cellular health by exerting antioxidant properties. Black currant and various berry extracts were tested in microglia (BV-2) and cardiomyocyte (HL-1) cell lines to study their biological effects. The principal ingredients in black currant and cranberry extract-delphinidin 3-rutinoside (D3R) and cyanidin 3-glucoside (C3G), were also assessed. A menadione-induced oxidative stressor was used, and its output was quantified to detect oxidative stress (CellROX
    MeSH term(s) Anthocyanins/pharmacology ; Antioxidants/pharmacology ; Fruit ; Microglia ; Myocytes, Cardiac ; Oxidative Stress ; Plant Extracts/pharmacology ; Ribes ; Vaccinium macrocarpon
    Chemical Substances Anthocyanins ; Antioxidants ; Plant Extracts
    Language English
    Publishing date 2022-04-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27092789
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  4. Article ; Online: Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation.

    Vasudevan, Narayanan Puthillathu / Soni, Dharmendra K / Moffett, John R / Krishnan, Jishnu K S / Appu, Abhilash P / Ghoshal, Sarani / Arun, Peethambaran / Denu, John M / Flagg, Thomas P / Biswas, Roopa / Namboodiri, Aryan M

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: The coordination of cellular biological processes is regulated in part via metabolic enzymes acting to match cellular metabolism to current conditions. The acetate activating enzyme, acyl-coenzyme A synthetase short-chain family member 2 (Acss2), has ... ...

    Abstract The coordination of cellular biological processes is regulated in part via metabolic enzymes acting to match cellular metabolism to current conditions. The acetate activating enzyme, acyl-coenzyme A synthetase short-chain family member 2 (Acss2), has long been considered to have a predominantly lipogenic function. More recent evidence suggests that this enzyme has regulatory functions in addition to its role in providing acetyl-CoA for lipid synthesis. We used Acss2 knockout mice (
    MeSH term(s) Animals ; Mice ; Acetate-CoA Ligase/genetics ; Acetate-CoA Ligase/metabolism ; Acetates/metabolism ; Fatty Acids/metabolism ; Gene Expression Regulation ; Lipogenesis ; Liver/metabolism
    Chemical Substances Acetate-CoA Ligase (EC 6.2.1.1) ; Acetates ; ACSS2 protein, mouse (EC 6.2.1.1) ; Fatty Acids
    Language English
    Publishing date 2023-02-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043673
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  5. Article ; Online: Novel cholesterol-dependent regulation of cardiac K

    Geiger, Robert / Fatima, Naheed / Schooley, James F / Smyth, Jeremy T / Haigney, Mark C / Flagg, Thomas P

    Physiological reports

    2020  Volume 8, Issue 24, Page(s) e14675

    Abstract: We recently discovered that the histone deacetylase inhibitor, trichostatin A (TSA), increases expression of the sulfonylurea receptor 2 (SUR2; Abcc9) subunit of the ATP-sensitive ... ...

    Abstract We recently discovered that the histone deacetylase inhibitor, trichostatin A (TSA), increases expression of the sulfonylurea receptor 2 (SUR2; Abcc9) subunit of the ATP-sensitive K
    MeSH term(s) Animals ; COS Cells ; Chlorocebus aethiops ; Cholesterol/metabolism ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Hydroxamic Acids/pharmacology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Sterol Regulatory Element Binding Protein 1/metabolism ; Sulfonylurea Receptors/genetics ; Sulfonylurea Receptors/metabolism
    Chemical Substances ABCC9 protein, human ; Histone Deacetylase Inhibitors ; Hydroxamic Acids ; Sterol Regulatory Element Binding Protein 1 ; Sulfonylurea Receptors ; trichostatin A (3X2S926L3Z) ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2020-12-23
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.14675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Avoiding the chopping block in curricular reform: reimagining physiology laboratories in the era of integrated medical curricula.

    Flagg, Thomas P / Rothwell, Stephen / Neubauer, Brian

    Advances in physiology education

    2017  Volume 41, Issue 2, Page(s) 279–285

    MeSH term(s) Curriculum/trends ; Education, Medical/methods ; Education, Medical/trends ; Humans ; Medical Laboratory Science/education ; Medical Laboratory Science/trends ; Physiology/education ; Physiology/trends ; Schools, Medical/trends
    Language English
    Publishing date 2017-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024917-5
    ISSN 1522-1229 ; 1043-4046
    ISSN (online) 1522-1229
    ISSN 1043-4046
    DOI 10.1152/advan.00194.2016
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5611: Show issues Location:
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  7. Article ; Online: The Effects of Berry Extracts on Oxidative Stress in Cultured Cardiomyocytes and Microglial Cells

    Tanisha L. Currie / Marguerite M. Engler / Cara H. Olsen / Victor Krauthamer / Jonathan M. Scott / Patricia A. Deuster / Thomas P. Flagg

    Molecules, Vol 27, Iss 2789, p

    A Potential Cardioprotective and Neuroprotective Mechanism

    2022  Volume 2789

    Abstract: Oxidative stress is a key underlying factor in cognitive decline and atherosclerosis. Oxidative stress occurs at the cellular level with an imbalance between reactive oxygen species and reactive nitrogen species and a deficiency in antioxidants. Mounting ...

    Abstract Oxidative stress is a key underlying factor in cognitive decline and atherosclerosis. Oxidative stress occurs at the cellular level with an imbalance between reactive oxygen species and reactive nitrogen species and a deficiency in antioxidants. Mounting evidence suggests that berry flavonoids may promote cellular health by exerting antioxidant properties. Black currant and various berry extracts were tested in microglia (BV-2) and cardiomyocyte (HL-1) cell lines to study their biological effects. The principal ingredients in black currant and cranberry extract–delphinidin 3-rutinoside (D3R) and cyanidin 3-glucoside (C3G), were also assessed. A menadione-induced oxidative stressor was used, and its output was quantified to detect oxidative stress (CellROX TM ). Black currant extract had similar antioxidant effects as N-acetylcysteine (NAC) in HL-1 cells with regard to cellular protection, whereas cranberry extract was ineffective. In contrast, cranberry extract was comparable in effectiveness to black currant extract in BV-2 cells. D3R and C3G also reduced oxidative stress similarly to whole berry extracts, which indicates that these ingredients may confer the antioxidant effects of berries. Black currant and cranberry extracts inhibit oxidative stress in microglial and cardiomyocyte cell lines. Black currant extract was more effective in reducing oxidative stress in the HL-1 cells, whereas cranberry extract was comparable in reducing oxidative stress in the BV-2 cells. The results suggest that berry flavonoids exert neuro- and cardioprotective effects.
    Keywords antioxidants ; anthocyanin ; cyanidin-3-glucoside ; delphinidin-3-rutinoside ; black currant ; cranberry ; Organic chemistry ; QD241-441
    Subject code 500
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Methadone Blockade of Cardiac Inward Rectifier K

    Klein, Michael G / Krantz, Mori J / Fatima, Naheed / Watters, Ashlie / Colon-Sanchez, Dayan / Geiger, Robert M / Goldstein, Robert E / Solhjoo, Soroosh / Mehler, Philip S / Flagg, Thomas P / Haigney, Mark C

    Journal of the American Heart Association

    2022  Volume 11, Issue 11, Page(s) e023482

    Abstract: Background Methadone is associated with a disproportionate risk of sudden death and ventricular tachyarrhythmia despite only modest inhibition of delayed rectifier ... ...

    Abstract Background Methadone is associated with a disproportionate risk of sudden death and ventricular tachyarrhythmia despite only modest inhibition of delayed rectifier K
    MeSH term(s) Action Potentials ; Arrhythmias, Cardiac ; Electrocardiography ; Humans ; Methadone/pharmacology ; Myocytes, Cardiac ; Potassium
    Chemical Substances Potassium (RWP5GA015D) ; Methadone (UC6VBE7V1Z)
    Language English
    Publishing date 2022-06-06
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.121.023482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Rapid Assessment of Proarrhythmic Potential Using Human iPSC-Derived Cardiomyocytes.

    Geiger, Robert M / Klein, Michael G / Fatima, Naheed / Goldstein, Robert E / Krantz, Mori J / Haigney, Mark C / Flagg, Thomas P

    JACC. Clinical electrophysiology

    2020  Volume 6, Issue 14, Page(s) 1860–1862

    MeSH term(s) Humans ; Induced Pluripotent Stem Cells ; Myocytes, Cardiac
    Language English
    Publishing date 2020-12-22
    Publishing country United States
    Document type Letter
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2020.08.034
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  10. Article ; Online: "Cardiac KATP": a family of ion channels.

    Flagg, Thomas P / Nichols, Colin G

    Circulation. Arrhythmia and electrophysiology

    2011  Volume 4, Issue 6, Page(s) 796–798

    MeSH term(s) Animals ; Arrhythmias, Cardiac/metabolism ; Heart Ventricles/metabolism ; KATP Channels/metabolism ; Myocardial Ischemia/metabolism ; Myocytes, Cardiac/metabolism ; Purkinje Fibers/metabolism
    Chemical Substances KATP Channels
    Language English
    Publishing date 2011-12-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2426129-4
    ISSN 1941-3084 ; 1941-3149
    ISSN (online) 1941-3084
    ISSN 1941-3149
    DOI 10.1161/CIRCEP.111.968081
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6667: Show issues Location:
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