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  1. Article ; Online: High survivorship rate and good clinical outcomes after high tibial osteotomy in patients with radiological advanced medial knee osteoarthritis: a systematic review.

    Dal Fabbro, Giacomo / Grassi, Alberto / Agostinone, Piero / Lucidi, Gian Andrea / Fajury, Raschid / Ravindra, Abhijit / Zaffagnini, Stefano

    Archives of orthopaedic and trauma surgery

    2024  

    Abstract: Introduction: The role of valgus producing high tibial osteotomy (HTO) for the treatment of advanced knee osteoarthritis (OA) is still controversial. The aim of the current systematic review was to assess survivorship and patient-reported outcomes ( ... ...

    Abstract Introduction: The role of valgus producing high tibial osteotomy (HTO) for the treatment of advanced knee osteoarthritis (OA) is still controversial. The aim of the current systematic review was to assess survivorship and patient-reported outcomes (PROMs) of high tibial osteotomy in patients with radiological advanced medial knee OA.
    Methods: A systematic search of PubMed, Cochrane and EMBASE database was performed in July 2023 in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines. Inclusion and exclusion criteria were applied to identify studies investigating the survivorship rate and PROMs of valgus-producing high tibial osteotomy in patients with advanced knee OA at x-ray assessment in the medial compartment at minimum-two-years follow up. Advanced radiological OA was defined as Kellgren Lawrence (K-L) ≥ 3 or Ahlbäch ≥ 2. Survivorship was defined as percentage of patients free of total knee arthroplasty (TKA) at follow-up. Clinical interpretation of provided PROMs were performed according to minimal clinically important difference (MCID) and patient acceptable symptom state (PASS) target values reported in literature. Survivorship data and PROMs scores were extracted, and studies were stratified based on selected study features. The quality of included studies was assessed with modified Coleman score.
    Results: A total of 18 studies, totalling 1296 knees with a mean age between 46.9 and 67 years old, were included. Average survivorship was of 74.6% (range 60 - 98.1%) at 10-years follow up. The subjective scoring systems showed good results according to MCID and PASS, and postoperative improvements were partially maintained until final follow-up.
    Conclusion: HTO is worth considering as treatment choice even in patients affected by radiological advanced medial knee osteoarthritis. Long term survivorship and good patient reported clinical outcomes could be expected in this population.
    Level of evidence: IV; systematic review of level III-IV studies.
    Language English
    Publishing date 2024-03-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 80407-1
    ISSN 1434-3916 ; 0003-9330 ; 0344-8444
    ISSN (online) 1434-3916
    ISSN 0003-9330 ; 0344-8444
    DOI 10.1007/s00402-024-05254-0
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  2. Article: Musculoskeletal risk stratification tool to inform a discussion about face-to-face assessment during the COVID-19 pandemic.

    Ravindra, Andrea / Cuff, Andrew / Bernstein, Ian A / Al-Dawoud, Marwan

    BMJ open sport & exercise medicine

    2020  Volume 6, Issue 1, Page(s) e000916

    Abstract: The COVID-19 pandemic and lockdown caused clinicians in the UK to switch to delivering musculoskeletal care using telephone or video consultations. NHS England (an executive non-departmental public body of the Department of Health and Social Care, ... ...

    Abstract The COVID-19 pandemic and lockdown caused clinicians in the UK to switch to delivering musculoskeletal care using telephone or video consultations. NHS England (an executive non-departmental public body of the Department of Health and Social Care, England) recommended prioritisation of more urgent conditions, including those people whose condition has deteriorated and those waiting the longest as part of a phased return to pre-COVID-19 service provision. Clinicians will need to assess an individual's risk factors for complications from COVID-19 alongside their clinical priority to inform a shared decision-making discussion about appropriate face-to-face care delivery. This paper outlines a risk stratification tool that informs that discussion and aims to reduce the subjectivity in the risk assessment between clinicians.
    Keywords covid19
    Language English
    Publishing date 2020-09-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2817580-3
    ISSN 2055-7647
    ISSN 2055-7647
    DOI 10.1136/bmjsem-2020-000916
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  3. Article: The use of a medical application improves the diagnosis of acute kidney injury: A pre-post study.

    Gaspar, Andrea / Iturricha-Cáceres, Maria F / Macedo, Etienne / Mehta, Ravindra L / Claure-Del Granado, Rolando

    Frontiers in medicine

    2022  Volume 9, Page(s) 817387

    Abstract: The use of mobile devices by healthcare providers has transformed many aspects of clinical practice. Mobile devices and medical applications provide many benefits, perhaps most significantly increased access to point-of-care (POC) tools, which has been ... ...

    Abstract The use of mobile devices by healthcare providers has transformed many aspects of clinical practice. Mobile devices and medical applications provide many benefits, perhaps most significantly increased access to point-of-care (POC) tools, which has been shown to support better clinical decision making and improved patient outcomes. In LMICs, where computer-based technology is limited, the use of mobile technology has the potential to immensely increase access to point of care tools. In this study, we conducted an interventional, pre-post study to determine whether the use of a medical application could help healthcare providers accurately recognize and diagnose AKI. After preparing 20 clinical vignettes based on AKI cases from our center Global Snapshot study report, we asked 50 last year medical students to identify the presence and stage of AKI first without and then with the use of the IRA SLANH App (IRA SLANH app, Island of the Moon
    Language English
    Publishing date 2022-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.817387
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  4. Article ; Online: Musculoskeletal risk stratification tool to inform a discussion about face-to-face assessment during the COVID-19 pandemic

    Andrea Ravindra / Andrew Cuff / Ian A Bernstein / Marwan Al-Dawoud

    BMJ Open Sport & Exercise Medicine, Vol 6, Iss

    2020  Volume 1

    Abstract: The COVID-19 pandemic and lockdown caused clinicians in the UK to switch to delivering musculoskeletal care using telephone or video consultations. NHS England (an executive non-departmental public body of the Department of Health and Social Care, ... ...

    Abstract The COVID-19 pandemic and lockdown caused clinicians in the UK to switch to delivering musculoskeletal care using telephone or video consultations. NHS England (an executive non-departmental public body of the Department of Health and Social Care, England) recommended prioritisation of more urgent conditions, including those people whose condition has deteriorated and those waiting the longest as part of a phased return to pre-COVID-19 service provision. Clinicians will need to assess an individual’s risk factors for complications from COVID-19 alongside their clinical priority to inform a shared decision-making discussion about appropriate face-to-face care delivery. This paper outlines a risk stratification tool that informs that discussion and aims to reduce the subjectivity in the risk assessment between clinicians.
    Keywords Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration

    Mohi Ahmed / Ruth Moon / Ravindra Singh Prajapati / Elysia James / M. Albert Basson / Andrea Streit

    Communications Biology, Vol 4, Iss 1, Pp 1-

    2021  Volume 10

    Abstract: To improve our understanding of the mechanisms that protect hair cells in the ear from stress-induced death, Ahmed et al delete the chromodomain helicase DNA-binding protein 7 (CHD7) in auditory neurons and hair cells in mice. They observe sensorineural ... ...

    Abstract To improve our understanding of the mechanisms that protect hair cells in the ear from stress-induced death, Ahmed et al delete the chromodomain helicase DNA-binding protein 7 (CHD7) in auditory neurons and hair cells in mice. They observe sensorineural hearing loss and demonstrate that CHD7 controls the expression of stress pathway components, which could help to explain how CHD7 haploinsufficiency causes changes in the ear associated with CHARGE syndrome.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: PRDM1 controls the sequential activation of neural, neural crest and sensory progenitor determinants.

    Prajapati, Ravindra S / Hintze, Mark / Streit, Andrea

    Development (Cambridge, England)

    2019  Volume 146, Issue 24

    Abstract: During early embryogenesis, the ectoderm is rapidly subdivided into neural, neural crest and sensory progenitors. How the onset of lineage determinants and the loss of pluripotency markers are temporally and spatially ... ...

    Abstract During early embryogenesis, the ectoderm is rapidly subdivided into neural, neural crest and sensory progenitors. How the onset of lineage determinants and the loss of pluripotency markers are temporally and spatially coordinated
    MeSH term(s) Animals ; Animals, Genetically Modified ; Cell Differentiation/genetics ; Chick Embryo ; Embryonic Development/genetics ; Gene Expression Regulation, Developmental ; Nervous System/cytology ; Nervous System/embryology ; Neural Crest/cytology ; Neural Crest/embryology ; Neural Stem Cells/physiology ; Neurogenesis/genetics ; Positive Regulatory Domain I-Binding Factor 1/physiology ; Sensory Receptor Cells/cytology ; Sensory Receptor Cells/physiology
    Chemical Substances Positive Regulatory Domain I-Binding Factor 1 (EC 2.1.1.-)
    Language English
    Publishing date 2019-12-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.181107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.183: Show issues Location:
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  7. Article ; Online: The use of a medical application improves the diagnosis of acute kidney injury

    Andrea Gaspar / Maria F. Iturricha-Cáceres / Etienne Macedo / Ravindra L. Mehta / Rolando Claure-Del Granado

    Frontiers in Medicine, Vol

    A pre-post study

    2022  Volume 9

    Abstract: The use of mobile devices by healthcare providers has transformed many aspects of clinical practice. Mobile devices and medical applications provide many benefits, perhaps most significantly increased access to point-of-care (POC) tools, which has been ... ...

    Abstract The use of mobile devices by healthcare providers has transformed many aspects of clinical practice. Mobile devices and medical applications provide many benefits, perhaps most significantly increased access to point-of-care (POC) tools, which has been shown to support better clinical decision making and improved patient outcomes. In LMICs, where computer-based technology is limited, the use of mobile technology has the potential to immensely increase access to point of care tools. In this study, we conducted an interventional, pre-post study to determine whether the use of a medical application could help healthcare providers accurately recognize and diagnose AKI. After preparing 20 clinical vignettes based on AKI cases from our center Global Snapshot study report, we asked 50 last year medical students to identify the presence and stage of AKI first without and then with the use of the IRA SLANH App (IRA SLANH app, Island of the Moon® V.1, 2014; Cochabamba-Bolivia), which was designed specifically for this study. Before the IRA SLANH app was introduced, the mean number of correctly identified cases of AKI was 14.7 ± 4.7 with a minimum of 3 and a maximum of 20. The stage of AKI was correctly identified in only 6.7 ± 4.4 of the cases. After the app was introduced, the number of correctly identified and staged cases of AKI was 20. Medical applications are useful point-of-care tools in the practice of evidence-based medicine. Their use has the potential to play a very important role in early identification and classification of AKI, particularly in LMICs potentially allowing for earlier intervention with preventive and treatment strategies to reverse kidney injury and improve recovery.
    Keywords acute kidney injury ; medical application ; serum creatinine ; mobile health ; smart-phones ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration.

    Ahmed, Mohi / Moon, Ruth / Prajapati, Ravindra Singh / James, Elysia / Basson, M Albert / Streit, Andrea

    Communications biology

    2021  Volume 4, Issue 1, Page(s) 1260

    Abstract: Neurons and sensory cells are particularly vulnerable to oxidative stress due to their high oxygen demand during stimulus perception and transmission. The mechanisms that protect them from stress-induced death and degeneration remain elusive. Here we ... ...

    Abstract Neurons and sensory cells are particularly vulnerable to oxidative stress due to their high oxygen demand during stimulus perception and transmission. The mechanisms that protect them from stress-induced death and degeneration remain elusive. Here we show that embryonic deletion of the chromodomain helicase DNA-binding protein 7 (CHD7) in auditory neurons or hair cells leads to sensorineural hearing loss due to postnatal degeneration of both cell types. Mechanistically, we demonstrate that CHD7 controls the expression of major stress pathway components. In its absence, hair cells are hypersensitive, dying rapidly after brief exposure to stress inducers, suggesting that sound at the onset of hearing triggers their degeneration. In humans, CHD7 haploinsufficiency causes CHARGE syndrome, a disorder affecting multiple organs including the ear. Our findings suggest that CHD7 mutations cause developmentally silent phenotypes that predispose cells to postnatal degeneration due to a failure of protective mechanisms.
    MeSH term(s) Animals ; Cochlear Nerve/physiopathology ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Hair Cells, Auditory/physiology ; Humans ; Male ; Mice ; Mutation ; Phenotype ; Stress, Physiological
    Chemical Substances Chd7 protein, mouse ; DNA-Binding Proteins
    Language English
    Publishing date 2021-11-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-021-02788-6
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  9. Article ; Online: FGF21/FGFR1-β-KL cascade in cardiomyocytes modulates angiogenesis and inflammation under metabolic stress

    Namrita Kaur / Sanskruti Ravindra Gare / Andrea Ruiz-Velasco / Jessica M. Miller / Riham R.E. Abouleisa / Qinghui Ou / Jiahan Shen / Handrean Soran / Tamer M.A. Mohamed / Wei Liu

    Heliyon, Vol 9, Iss 4, Pp e14952- (2023)

    2023  

    Abstract: Diabetes is a metabolic disorder with an increased risk of developing heart failure. Inflammation and damaged vasculature are the cardinal features of diabetes-induced cardiac damage. Moreover, systemic metabolic stress triggers discordant intercellular ... ...

    Abstract Diabetes is a metabolic disorder with an increased risk of developing heart failure. Inflammation and damaged vasculature are the cardinal features of diabetes-induced cardiac damage. Moreover, systemic metabolic stress triggers discordant intercellular communication, thus culminating in cardiac dysfunction. Fibroblast growth factor 21 (FGF21) is a pleiotropic hormone transducing cellular signals via fibroblast growth factor receptor 1 (FGFR1) and its co-receptor beta-klotho (β-KL). This study first demonstrated a decreased expression or activity of FGFR1 and β-KL in both human and mouse diabetic hearts. Reinforcing cardiac FGFR1 and β-KL expression can alleviate pro-inflammatory response and endothelial dysfunction upon diabetic stress. Using proteomics, novel cardiomyocyte-derived anti-inflammatory and proangiogenic factors regulated by FGFR1-β-KL signaling were identified. Although not exhaustive, this study provides a unique insight into the protective topology of the cardiac FGFR1-β-KL signaling-mediated intercellular reactions in the heart in response to metabolic stress.
    Keywords Metabolic stress ; Intercellular communication ; Diabetic cardiomyopathy ; Inflammation ; Angiogenesis ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 570
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Musculoskeletal risk stratification tool to inform a discussion about face-to-face assessment during the COVID-19 pandemic

    Ravindra, Andrea / Cuff, Andrew / Bernstein, Ian A / Al-Dawoud, Marwan

    BMJ Open Sport & Exercise Medicine

    2020  Volume 6, Issue 1, Page(s) e000916

    Abstract: The COVID-19 pandemic and lockdown caused clinicians in the UK to switch to delivering musculoskeletal care using telephone or video consultations. NHS England (an executive non-departmental public body of the Department of Health and Social Care, ... ...

    Abstract The COVID-19 pandemic and lockdown caused clinicians in the UK to switch to delivering musculoskeletal care using telephone or video consultations. NHS England (an executive non-departmental public body of the Department of Health and Social Care, England) recommended prioritisation of more urgent conditions, including those people whose condition has deteriorated and those waiting the longest as part of a phased return to pre-COVID-19 service provision. Clinicians will need to assess an individual’s risk factors for complications from COVID-19 alongside their clinical priority to inform a shared decision-making discussion about appropriate face-to-face care delivery. This paper outlines a risk stratification tool that informs that discussion and aims to reduce the subjectivity in the risk assessment between clinicians.
    Keywords covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2817580-3
    ISSN 2055-7647
    ISSN 2055-7647
    DOI 10.1136/bmjsem-2020-000916
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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