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  1. Article ; Online: Must an inventor "possess" an invention to patent it?

    Woessner, Warren D / Chadwick, Robin A

    Cold Spring Harbor perspectives in medicine

    2014  Volume 4, Issue 11, Page(s) a020867

    Abstract: The requirements for patenting inventions relating to biotechnology have become increasingly strict and complicated in recent years. Despite early patent rulings that there is no need for an inventor to "reduce to practice" an invention, the courts are ... ...

    Abstract The requirements for patenting inventions relating to biotechnology have become increasingly strict and complicated in recent years. Despite early patent rulings that there is no need for an inventor to "reduce to practice" an invention, the courts are now ruling that an inventor must "possess" his or her invention before filing for patent. This review discusses what such "possession" may mean and describes decisions in which courts have found that an inventor has met or failed the possession test before filing for patent protection.
    MeSH term(s) Biotechnology/legislation & jurisprudence ; Drug Industry/legislation & jurisprudence ; Humans ; Inventions/legislation & jurisprudence ; Patents as Topic/legislation & jurisprudence ; United States
    Language English
    Publishing date 2014-09-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a020867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Diagnostic claims post-Mayo and Myriad: the pile-up begins.

    Woessner, Warren D / Chadwick, Robin A

    Pharmaceutical patent analyst

    2013  Volume 2, Issue 2, Page(s) 165–167

    MeSH term(s) Biomarkers ; Down Syndrome/diagnosis ; Female ; Humans ; Patents as Topic ; Pregnancy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2013-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2046-8962
    ISSN (online) 2046-8962
    DOI 10.4155/ppa.13.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Let's get physical.

    Woessner, Warren D

    The American journal of bioethics : AJOB

    2002  Volume 2, Issue 3, Page(s) 21–22

    MeSH term(s) Base Sequence ; Genes ; Humans ; Patents as Topic/legislation & jurisprudence ; United States
    Language English
    Publishing date 2002
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2060433-6
    ISSN 1526-5161
    ISSN 1526-5161
    DOI 10.1162/152651602760250039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6814: Show issues Location:
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  4. Article ; Online: Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma.

    Gyurdieva, Alexandra / Zajic, Stefan / Chang, Ya-Fang / Houseman, E Andres / Zhong, Shan / Kim, Jaegil / Nathenson, Michael / Faitg, Thomas / Woessner, Mary / Turner, David C / Hasan, Aisha N / Glod, John / Kaplan, Rosandra N / D'Angelo, Sandra P / Araujo, Dejka M / Chow, Warren A / Druta, Mihaela / Demetri, George D / Van Tine, Brian A /
    Grupp, Stephan A / Fine, Gregg D / Eleftheriadou, Ioanna

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 5296

    Abstract: Autologous T cells transduced to express a high affinity T-cell receptor specific to NY-ESO-1 (letetresgene autoleucel, lete-cel) show promise in the treatment of metastatic synovial sarcoma, with 50% overall response rate. The efficacy of lete-cel ... ...

    Abstract Autologous T cells transduced to express a high affinity T-cell receptor specific to NY-ESO-1 (letetresgene autoleucel, lete-cel) show promise in the treatment of metastatic synovial sarcoma, with 50% overall response rate. The efficacy of lete-cel treatment in 45 synovial sarcoma patients (NCT01343043) has been previously reported, however, biomarkers predictive of response and resistance remain to be better defined. This post-hoc analysis identifies associations of response to lete-cel with lymphodepleting chemotherapy regimen (LDR), product attributes, cell expansion, cytokines, and tumor gene expression. Responders have higher IL-15 levels pre-infusion (p = 0.011) and receive a higher number of transduced effector memory (CD45RA- CCR7-) CD8 + cells per kg (p = 0.039). Post-infusion, responders have increased IFNγ, IL-6, and peak cell expansion (p < 0.01, p < 0.01, and p = 0.016, respectively). Analysis of tumor samples post-treatment illustrates lete-cel infiltration and a decrease in expression of macrophage genes, suggesting remodeling of the tumor microenvironment. Here we report potential predictive and pharmacodynamic markers of lete-cel response that may inform LDR, cell dose, and strategies to enhance anticancer efficacy.
    MeSH term(s) Antigens, Neoplasm/metabolism ; Biomarkers/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Sarcoma, Synovial/genetics ; Sarcoma, Synovial/pathology ; Sarcoma, Synovial/therapy ; Tumor Microenvironment
    Chemical Substances Antigens, Neoplasm ; Biomarkers ; Membrane Proteins ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2022-09-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-32491-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The DNA sequence of human chromosome 7.

    Hillier, Ladeana W / Fulton, Robert S / Fulton, Lucinda A / Graves, Tina A / Pepin, Kymberlie H / Wagner-McPherson, Caryn / Layman, Dan / Maas, Jason / Jaeger, Sara / Walker, Rebecca / Wylie, Kristine / Sekhon, Mandeep / Becker, Michael C / O'Laughlin, Michelle D / Schaller, Mark E / Fewell, Ginger A / Delehaunty, Kimberly D / Miner, Tracie L / Nash, William E /
    Cordes, Matt / Du, Hui / Sun, Hui / Edwards, Jennifer / Bradshaw-Cordum, Holland / Ali, Johar / Andrews, Stephanie / Isak, Amber / Vanbrunt, Andrew / Nguyen, Christine / Du, Feiyu / Lamar, Betty / Courtney, Laura / Kalicki, Joelle / Ozersky, Philip / Bielicki, Lauren / Scott, Kelsi / Holmes, Andrea / Harkins, Richard / Harris, Anthony / Strong, Cynthia Madsen / Hou, Shunfang / Tomlinson, Chad / Dauphin-Kohlberg, Sara / Kozlowicz-Reilly, Amy / Leonard, Shawn / Rohlfing, Theresa / Rock, Susan M / Tin-Wollam, Aye-Mon / Abbott, Amanda / Minx, Patrick / Maupin, Rachel / Strowmatt, Catrina / Latreille, Phil / Miller, Nancy / Johnson, Doug / Murray, Jennifer / Woessner, Jeffrey P / Wendl, Michael C / Yang, Shiaw-Pyng / Schultz, Brian R / Wallis, John W / Spieth, John / Bieri, Tamberlyn A / Nelson, Joanne O / Berkowicz, Nicolas / Wohldmann, Patricia E / Cook, Lisa L / Hickenbotham, Matthew T / Eldred, James / Williams, Donald / Bedell, Joseph A / Mardis, Elaine R / Clifton, Sandra W / Chissoe, Stephanie L / Marra, Marco A / Raymond, Christopher / Haugen, Eric / Gillett, Will / Zhou, Yang / James, Rose / Phelps, Karen / Iadanoto, Shawn / Bubb, Kerry / Simms, Elizabeth / Levy, Ruth / Clendenning, James / Kaul, Rajinder / Kent, W James / Furey, Terrence S / Baertsch, Robert A / Brent, Michael R / Keibler, Evan / Flicek, Paul / Bork, Peer / Suyama, Mikita / Bailey, Jeffrey A / Portnoy, Matthew E / Torrents, David / Chinwalla, Asif T / Gish, Warren R / Eddy, Sean R / McPherson, John D / Olson, Maynard V / Eichler, Evan E / Green, Eric D / Waterston, Robert H / Wilson, Richard K

    Nature

    2003  Volume 424, Issue 6945, Page(s) 157–164

    Abstract: Human chromosome 7 has historically received prominent attention in the human genetics community, primarily related to the search for the cystic fibrosis gene and the frequent cytogenetic changes associated with various forms of cancer. Here we present ... ...

    Abstract Human chromosome 7 has historically received prominent attention in the human genetics community, primarily related to the search for the cystic fibrosis gene and the frequent cytogenetic changes associated with various forms of cancer. Here we present more than 153 million base pairs representing 99.4% of the euchromatic sequence of chromosome 7, the first metacentric chromosome completed so far. The sequence has excellent concordance with previously established physical and genetic maps, and it exhibits an unusual amount of segmentally duplicated sequence (8.2%), with marked differences between the two arms. Our initial analyses have identified 1,150 protein-coding genes, 605 of which have been confirmed by complementary DNA sequences, and an additional 941 pseudogenes. Of genes confirmed by transcript sequences, some are polymorphic for mutations that disrupt the reading frame.
    MeSH term(s) Animals ; Base Sequence ; Chromosomes, Human, Pair 7 ; Gene Duplication ; Humans ; Mice ; Molecular Sequence Data ; Physical Chromosome Mapping ; Proteins/genetics ; Pseudogenes ; RNA, Untranslated ; Sequence Analysis, DNA ; Species Specificity ; Williams Syndrome/genetics
    Chemical Substances Proteins ; RNA, Untranslated
    Language English
    Publishing date 2003-07-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature01782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
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