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Article: Intraoperative thromboelastography-guided transfusion in a patient with factor XI deficiency: A case report.

Guo, Wen-Juan / Chen, Wei-Yun / Yu, Xue-Rong / Shen, Le / Huang, Yu-Guang

World journal of clinical cases

2022 Volume 10, Issue 1, Page(s) 242–248

Abstract: Background: Factor XI (FXI) deficiency, also known as hemophilia C, is a rare bleeding disorder ...

Abstract	Background: Factor XI (FXI) deficiency, also known as hemophilia C, is a rare bleeding disorder of unpredictable severity that correlates poorly with FXI coagulation activity. This often poses great challenges in perioperative hemostatic management. Thromboelastography (TEG) is a method for testing blood coagulation using a viscoelastic hemostatic assay of whole blood to assess the overall coagulation status. Here, we present the successful application of intraoperative TEG monitoring in an FXI-deficient patient as an individualized blood transfusion strategy. Case summary: A 21-year-old male patient with FXI deficiency was scheduled to undergo reconstructive surgery for macrodactyly of the left foot under general anesthesia. To minimize his bleeding risk, he was scheduled to receive fresh frozen plasma (FFP) as an empirical prophylactic FXI replacement at a dose of 15-20 mL/kg body weight (900-1200 mL) before surgery. Subsequent FFP transfusion was to be adjusted according to surgical need. Instead, TEG assessment was used at the beginning and toward the end of his surgery. According to intraoperative TEG results, the normalization of coagulation function was achieved with an infusion of only 800 mL FFP, and blood loss was minimal. The patient showed an uneventful postoperative course and was discharged on postoperative day 8. Conclusion: TEG can be readily applied in the intraoperative period to individualize transfusion needs in patients with rare inherited coagulopathy.
Language	English
Publishing date	2022-01-05
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v10.i1.242
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Tests of $CP$ symmetry in the entangled $\Xi^0-\bar{\Xi}^0$ Pairs

BESIII Collaboration / Ablikim, M. / Achasov, M. N. / Adlarson, P. / Ai, X. C. / Aliberti, R. / Amoroso, A. / An, M. R. / An, Q. / Bai, Y. / Bakina, O. / Balossino, I. / Ban, Y. / Batozskaya, V. / Begzsuren, K. / Berger, N. / Berlowski, M. / Bertani, M. / Bettoni, D. /

Bianchi, F. / Bianco, E. / Bortone, A. / Boyko, I. / Briere, R. A. / Brueggemann, A. / Cai, H. / Cai, X. / Calcaterra, A. / Cao, G. F. / Cao, N. / Cetin, S. A. / Chang, J. F. / Chang, T. T. / Chang, W. L. / Che, G. R. / Chelkov, G. / Chen, C. / Chen, Chao / Chen, G. / Chen, H. S. / Chen, M. L. / Chen, S. J. / Chen, S. M. / Chen, T. / Chen, X. R. / Chen, X. T. / Chen, Y. B. / Chen, Y. Q. / Chen, Z. J. / Cheng, W. S. / Choi, S. K. / Chu, X. / Cibinetto, G. / Coen, S. C. / Cossio, F. / Cui, J. J. / Dai, H. L. / Dai, J. P. / Dbeyssi, A. / de Boer, R. E. / Dedovich, D. / Deng, Z. Y. / Denig, A. / Denysenko, I. / Destefanis, M. / De Mori, F. / Ding, B. / Ding, X. X. / Ding, Y. / Dong, J. / Dong, L. Y. / Dong, M. Y. / Dong, X. / Du, M. C. / Du, S. X. / Duan, Z. H. / Egorov, P. / Fan, Y. L. / Fang, J. / Fang, S. S. / Fang, W. X. / Fang, Y. / Farinelli, R. / Fava, L. / Feldbauer, F. / Felici, G. / Feng, C. Q. / Feng, J. H. / Fischer, K / Fritsch, M. / Fritzsch, C. / Fu, C. D. / Fu, J. L. / Fu, Y. W. / Gao, H. / Gao, Y. N. / Gao, Yang / Garbolino, S. / Garzia, I. / Ge, P. T. / Ge, Z. W. / Geng, C. / Gersabeck, E. M. / Gilman, A / Goetzen, K. / Gong, L. / Gong, W. X. / Gradl, W. / Gramigna, S. / Greco, M. / Gu, M. H. / Gu, Y. T. / Guan, C. Y / Guan, Z. L. / Guo, A. Q. / Guo, L. B. / Guo, M. J. / Guo, R. P. / Guo, Y. P. / Guskov, A. / Han, T. T. / Han, W. Y. / Hao, X. Q. / Harris, F. A. / He, K. K. / He, K. L. / Heinsius, F. H. H. / Heinz, C. H. / Heng, Y. K. / Herold, C. / Holtmann, T. / Hong, P. C. / Hou, G. Y. / Hou, X. T. / Hou, Y. R. / Hou, Z. L. / Hu, H. M. / Hu, J. F. / Hu, T. / Hu, Y. / Huang, G. S. / Huang, K. X. / Huang, L. Q. / Huang, X. T. / Huang, Y. P. / Hussain, T. / Hüsken, N / Imoehl, W. / Irshad, M. / Jackson, J. / Jaeger, S. / Janchiv, S. / Jeong, J. H. / Ji, Q. / Ji, Q. P. / Ji, X. B. / Ji, X. L. / Ji, Y. Y. / Jia, X. Q. / Jia, Z. K. / Jiang, P. C. / Jiang, S. S. / Jiang, T. J. / Jiang, X. S. / Jiang, Y. / Jiao, J. B. / Jiao, Z. / Jin, S. / Jin, Y. / Jing, M. Q. / Johansson, T. / K., X. / Kabana, S. / Kalantar-Nayestanaki, N. / Kang, X. L. / Kang, X. S. / Kappert, R. / Kavatsyuk, M. / Ke, B. C. / Khoukaz, A. / Kiuchi, R. / Kliemt, R. / Kolcu, O. B. / Kopf, B. / Kuessner, M. K. / Kupsc, A. / Kühn, W. / Lane, J. J. / Larin, P. / Lavania, A. / Lavezzi, L. / Lei, T. T. / Lei, Z. H. / Leithoff, H. / Lellmann, M. / Lenz, T. / Li, C. / Li, C. H. / Li, Cheng / Li, D. M. / Li, F. / Li, G. / Li, H. / Li, H. B. / Li, H. J. / Li, H. N. / Li, Hui / Li, J. R. / Li, J. S. / Li, J. W. / Li, K. L. / Li, Ke / Li, L. J / Li, L. K. / Li, Lei / Li, M. H. / Li, P. R. / Li, Q. X. / Li, S. X. / Li, T. / Li, W. D. / Li, W. G. / Li, X. H. / Li, X. L. / Li, Xiaoyu / Li, Y. G. / Li, Z. J. / Li, Z. X. / Liang, C. / Liang, H. / Liang, Y. F. / Liang, Y. T. / Liao, G. R. / Liao, L. Z. / Libby, J. / Limphirat, A. / Lin, D. X. / Lin, T. / Liu, B. J. / Liu, B. X. / Liu, C. / Liu, C. X. / Liu, F. 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L. / Ouyang, Q. / Pacetti, S. / Pan, X. / Pan, Y. / Pathak, A. / Patteri, P. / Pei, Y. P. / Pelizaeus, M. / Peng, H. P. / Peters, K. / Ping, J. L. / Ping, R. G. / Plura, S. / Pogodin, S. / Prasad, V. / Qi, F. Z. / Qi, H. / Qi, H. R. / Qi, M. / Qi, T. Y. / Qian, S. / Qian, W. B. / Qiao, C. F. / Qin, J. J. / Qin, L. Q. / Qin, X. P. / Qin, X. S. / Qin, Z. H. / Qiu, J. F. / Qu, S. Q. / Redmer, C. F. / Ren, K. J. / Rivetti, A. / Rodin, V. / Rolo, M. / Rong, G. / Rosner, Ch. / Ruan, S. N. / Salone, N. / Sarantsev, A. / Schelhaas, Y. / Schoenning, K. / Scodeggio, M. / Shan, K. Y. / Shan, W. / Shan, X. Y. / Shangguan, J. F. / Shao, L. G. / Shao, M. / Shen, C. P. / Shen, H. F. / Shen, W. H. / Shen, X. Y. / Shi, B. A. / Shi, H. C. / Shi, J. L. / Shi, J. Y. / Shi, Q. Q. / Shi, R. S. / Shi, X. / Song, J. J. / Song, T. Z. / Song, W. M. / Song, Y. J. / Song, Y. X. / Sosio, S. / Spataro, S. / Stieler, F. / Su, Y. J. / Sun, G. B. / Sun, G. X. / Sun, H. / Sun, H. K. / Sun, J. F. / Sun, K. / Sun, L. / Sun, S. S. / Sun, T. / Sun, W. Y. / Sun, Y. / Sun, Y. J. / Sun, Y. Z. / Sun, Z. T. / Tan, Y. X. / Tang, C. J. / Tang, G. Y. / Tang, J. / Tang, Y. A. / Tao, L. Y / Tao, Q. T. / Tat, M. / Teng, J. X. / Thoren, V. / Tian, W. H. / Tian, Y. / Tian, Z. F. / Uman, I. / Wang, S. J. / Wang, B. / Wang, B. L. / Wang, Bo / Wang, C. W. / Wang, D. Y. / Wang, F. / Wang, H. J. / Wang, H. P. / Wang, J. P. / Wang, K. / Wang, L. L. / Wang, M. / Wang, Meng / Wang, S. / Wang, T. / Wang, T. J. / Wang, W. / Wang, W. P. / Wang, X. / Wang, X. F. / Wang, X. J. / Wang, X. L. / Wang, Y. / Wang, Y. D. / Wang, Y. F. / Wang, Y. H. / Wang, Y. N. / Wang, Y. Q. / Wang, Yaqian / Wang, Yi / Wang, Z. / Wang, Z. L. / Wang, Z. Y. / Wang, Ziyi / Wei, D. / Wei, D. H. / Weidner, F. / Wen, S. P. / Wenzel, C. W. / Wiedner, U. W. / Wilkinson, G. / Wolke, M. / Wollenberg, L. / Wu, C. / Wu, J. F. / Wu, L. H. / Wu, L. J. / Wu, X. / Wu, X. H. / Wu, Y. / Wu, Y. J. / Wu, Z. / Xia, L. / Xian, X. 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2023

Abstract: The $J/\psi \to \Xi^0 \bar{\Xi}^{0}$ process and subsequent decays are investigated using $(10087 ... of $\Xi^0$ and $\bar{\Xi}^0$ are measured with greatly improved precision over previous measurements to be ... alpha_{\Xi} = -0.3750 \pm 0.0034 \pm 0.0016$, $\bar{\alpha}_{\Xi} = 0.3790 \pm 0.0034 \pm 0.0021$, $\phi ...

Abstract	The $J/\psi \to \Xi^0 \bar{\Xi}^{0}$ process and subsequent decays are investigated using $(10087 \pm 44)\times 10^6$ $J/\psi$ events collected at the BESIII experiment. The decay parameters of $\Xi^0$ and $\bar{\Xi}^0$ are measured with greatly improved precision over previous measurements to be $\alpha_{\Xi} = -0.3750 \pm 0.0034 \pm 0.0016$, $\bar{\alpha}_{\Xi} = 0.3790 \pm 0.0034 \pm 0.0021$, $\phi_{\Xi} = 0.0051 \pm 0.0096 \pm 0.0018$~rad, $\bar{\phi}_{\Xi} = -0.0053 \pm 0.0097 \pm 0.0019$~rad, where the first and the second uncertainties are statistical and systematic, respectively. From these measurements, precise $CP$ symmetry tests in $\Xi^0$ decay are performed, and $A^{\Xi}_{CP} = (-5.4 \pm 6.5 \pm 3.1) \times 10^{-3}$ and $\Delta\phi^{\Xi}_{CP} = (-0.1 \pm 6.9 \pm 0.9) \times 10^{-3}$~rad are consistent with $CP$ conservation. The sequential decay also enables a separation of weak and strong phase differences, which are found for the first time to be $\xi_{P}-\xi_{S} = (0.0 \pm 1.7 \pm 0.2) \times 10^{-2}$~rad and $\delta_{P}-\delta_{S} = (-1.3 \pm 1.7 \pm 0.4)\times 10^{-2}$~rad, respectively. In addition, we measure the $\Lambda$ decay parameters and test $CP$ symmetry in $\Lambda$ decays.
Keywords	High Energy Physics - Experiment
Subject code	612
Publishing date	2023-05-16
Publishing country	us
Document type	Book ; Online
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Article ; Online: Structures of factor XI and prekallikrein bound to domain 6 of high-molecular weight kininogen reveal alternate domain 6 conformations and exosites.

Li, Chan / Barroeta, Awital Bar / Wong, Szu Shen / Kim, Hyo Jung / Pathak, Monika / Dreveny, Ingrid / Meijers, Joost C M / Emsley, Jonas

Journal of thrombosis and haemostasis : JTH

2023 Volume 21, Issue 9, Page(s) 2378–2389

Abstract: ... and compare this with the coagulation factor XI (FXI)-HK complex.: Methods: We produced recombinant ...

Abstract	Background: High-molecular weight kininogen (HK) circulates in plasma as a complex with zymogen prekallikrein (PK). HK is both a substrate and a cofactor for activated plasma kallikrein, and the principal exosite interactions occur between PK N-terminal apple domains and the C-terminal D6 domain of HK. Objectives: To determine the structure of the complex formed between PK apple domains and an HKD6 fragment and compare this with the coagulation factor XI (FXI)-HK complex. Methods: We produced recombinant FXI and PK heavy chains (HCs) spanning all 4 apple domains. We cocrystallized PKHC (and subsequently FXIHC) with a 31-amino acid synthetic peptide spanning HK residues Ser565-Lys595 and determined the crystal structure. We also analyzed the full-length FXI-HK complex in solution using hydrogen deuterium exchange mass spectrometry. Results: The 2.3Å PKHC-HK peptide crystal structure revealed that the HKD6 sequence WIPDIQ (Trp569-Gln574) binds to the apple 1 domain and HK FNPISDFPDT (Phe582-Thr591) binds to the apple 2 domain with a flexible intervening sequence resulting in a bent double conformation. A second 3.2Å FXIHC-HK peptide crystal structure revealed a similar interaction with the apple 2 domain but an alternate, straightened conformation of the HK peptide where residues LSFN (Leu579-Asn583) interacts with a unique pocket formed between the apple 2 and 3 domains. HDX-MS of full length FXI-HK complex in solution confirmed interactions with both apple 2 and apple 3. Conclusions: The alternate conformations and exosite binding of the HKD6 peptide likely reflects the diverging relationship of HK to the functions of PK and FXI.
MeSH term(s)	Humans ; Kininogen, High-Molecular-Weight/metabolism ; Factor XI/metabolism ; Prekallikrein/metabolism ; Molecular Weight ; Binding Sites ; Kininogens/chemistry ; Peptides/chemistry
Chemical Substances	Kininogen, High-Molecular-Weight ; Factor XI (9013-55-2) ; Prekallikrein (9055-02-1) ; Kininogens ; Peptides
Language	English
Publishing date	2023-04-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1016/j.jtha.2023.03.042
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Book ; Online: First simultaneous measurement of $\Xi^0$ and $\bar{\Xi}^0$ asymmetry parameters in $\psi(3686)$ decay

BESIII Collaboration / Ablikim, M. / Achasov, M. N. / Adlarson, P. / Aliberti, R. / Amoroso, A. / An, M. R. / An, Q. / Bai, Y. / Bakina, O. / Balossino, I. / Ban, Y. / Batozskaya, V. / Begzsuren, K. / Berger, N. / Bertani, M. / Bettoni, D. / Bianchi, F. / Bianco, E. /

Bloms, J. / Bortone, A. / Boyko, I. / Briere, R. A. / Brueggemann, A. / Cai, H. / Cai, X. / Calcaterra, A. / Cao, G. F. / Cao, N. / Cetin, S. A. / Chang, J. F. / Chang, T. T. / Chang, W. L. / Che, G. R. / Chelkov, G. / Chen, C. / Chen, Chao / Chen, G. / Chen, H. S. / Chen, M. L. / Chen, S. J. / Chen, S. M. / Chen, T. / Chen, X. R. / Chen, X. T. / Chen, Y. B. / Chen, Y. Q. / Chen, Z. J. / Cheng, W. S. / Choi, S. K. / Chu, X. / Cibinetto, G. / Coen, S. C. / Cossio, F. / Cui, J. J. / Dai, H. L. / Dai, J. P. / Dbeyssi, A. / de Boer, R. E. / Dedovich, D. / Deng, Z. Y. / Denig, A. / Denysenko, I. / Destefanis, M. / De Mori, F. / Ding, B. / Ding, X. X. / Ding, Y. / Dong, J. / Dong, L. Y. / Dong, M. Y. / Dong, X. / Du, S. X. / Duan, Z. H. / Egorov, P. / Fan, Y. L. / Fang, J. / Fang, S. S. / Fang, W. X. / Fang, Y. / Farinelli, R. / Fava, L. / Feldbauer, F. / Felici, G. / Feng, C. Q. / Feng, J. H. / Fischer, K / Fritsch, M. / Fritzsch, C. / Fu, C. D. / Fu, Y. W. / Gao, H. / Gao, Y. N. / Gao, Yang / Garbolino, S. / Garzia, I. / Ge, P. T. / Ge, Z. W. / Geng, C. / Gersabeck, E. M. / Gilman, A / Goetzen, K. / Gong, L. / Gong, W. X. / Gradl, W. / Gramigna, S. / Greco, M. / Gu, M. H. / Gu, Y. T. / Guan, C. Y / Guan, Z. L. / Guo, A. Q. / Guo, L. B. / Guo, R. P. / Guo, Y. P. / Guskov, A. / H., X. T. / Han, W. Y. / Hao, X. Q. / Harris, F. A. / He, K. K. / He, K. L. / Heinsius, F. H. / Heinz, C. H. / Heng, Y. K. / Herold, C. / Holtmann, T. / Hong, P. C. / Hou, G. Y. / Hou, Y. R. / Hou, Z. L. / Hu, H. M. / Hu, J. F. / Hu, T. / Hu, Y. / Huang, G. S. / Huang, K. X. / Huang, L. Q. / Huang, X. T. / Huang, Y. P. / Hussain, T. / Hüsken, N / Imoehl, W. / Irshad, M. / Jackson, J. / Jaeger, S. / Janchiv, S. / Jeong, J. H. / Ji, Q. / Ji, Q. P. / Ji, X. B. / Ji, X. L. / Ji, Y. Y. / Jia, Z. K. / Jiang, P. C. / Jiang, S. S. / Jiang, T. J. / Jiang, X. S. / Jiang, Y. / Jiao, J. B. / Jiao, Z. / Jin, S. / Jin, Y. / Jing, M. Q. / Johansson, T. / K., X. / Kabana, S. / Kalantar-Nayestanaki, N. / Kang, X. L. / Kang, X. S. / Kappert, R. / Kavatsyuk, M. / Ke, B. C. / Khoukaz, A. / Kiuchi, R. / Kliemt, R. / Koch, L. / Kolcu, O. B. / Kopf, B. / Kuessner, M. / Kupsc, A. / Kühn, W. / Lane, J. J. / Lange, J. S. / Larin, P. / Lavania, A. / Lavezzi, L. / Lei, T. T. / Lei, Z. H. / Leithoff, H. / Lellmann, M. / Lenz, T. / Li, C. / Li, C. H. / Li, Cheng / Li, D. M. / Li, F. / Li, G. / Li, H. / Li, H. B. / Li, H. J. / Li, H. N. / Li, Hui / Li, J. R. / Li, J. S. / Li, J. W. / Li, Ke / Li, L. J / Li, L. K. / Li, Lei / Li, M. H. / Li, P. R. / Li, S. X. / Li, T. / Li, W. D. / Li, W. G. / Li, X. H. / Li, X. L. / Li, Xiaoyu / Li, Y. G. / Li, Z. J. / Li, Z. X. / Li, Z. Y. / Liang, C. / Liang, H. / Liang, Y. F. / Liang, Y. T. / Liao, G. R. / Liao, L. Z. / Libby, J. / Limphirat, A. / Lin, D. X. / Lin, T. / Liu, B. J. / Liu, B. X. / Liu, C. / Liu, C. X. / Liu, D. / Liu, F. H. / Liu, Fang / Liu, Feng / Liu, G. M. / Liu, H. / Liu, H. B. / Liu, H. M. / Liu, Huanhuan / Liu, Huihui / Liu, J. B. / Liu, J. L. / Liu, J. Y. / Liu, K. / Liu, K. Y. / Liu, Ke / Liu, L. / Liu, L. C. / Liu, Lu / Liu, M. H. / Liu, P. L. / Liu, Q. / Liu, S. B. / Liu, T. / Liu, W. K. / Liu, W. M. / Liu, X. / Liu, Y. / Liu, Y. B. / Liu, Z. A. / Liu, Z. Q. / Lou, X. C. / Lu, F. X. / Lu, H. J. / Lu, J. G. / Lu, X. L. / Lu, Y. / Lu, Y. P. / Lu, Z. H. / Luo, C. L. / Luo, M. X. / Luo, T. / Luo, X. L. / Lyu, X. R. / Lyu, Y. F. / Ma, F. C. / Ma, H. L. / Ma, J. L. / Ma, L. L. / Ma, M. M. / Ma, Q. M. / Ma, R. Q. / Ma, R. T. / Ma, X. Y. / Ma, Y. / Maas, F. E. / Maggiora, M. / Maldaner, S. / Malde, S. / Mangoni, A. / Mao, Y. J. / Mao, Z. P. / Marcello, S. / Meng, Z. X. / Messchendorp, J. G. / Mezzadri, G. / Miao, H. / Min, T. J. / Mitchell, R. E. / Mo, X. H. / Muchnoi, N. Yu. / Nefedov, Y. / Nerling, F. / Nikolaev, I. B. / Ning, Z. / Nisar, S. / Niu, Y. / Olsen, S. L. / Ouyang, Q. / Pacetti, S. / Pan, X. / Pan, Y. / Pathak, A. / Pei, Y. P. / Pelizaeus, M. / Peng, H. P. / Peters, K. / Ping, J. L. / Ping, R. G. / Plura, S. / Pogodin, S. / Prasad, V. / Qi, F. Z. / Qi, H. / Qi, H. R. / Qi, M. / Qi, T. Y. / Qian, S. / Qian, W. B. / Qiao, C. F. / Qin, J. J. / Qin, L. Q. / Qin, X. P. / Qin, X. S. / Qin, Z. H. / Qiu, J. F. / Qu, S. Q. / Redmer, C. F. / Ren, K. J. / Rivetti, A. / Rodin, V. / Rolo, M. / Rong, G. / Rosner, Ch. / Ruan, S. N. / Salone, N. / Sarantsev, A. / Schelhaas, Y. / Schoenning, K. / Scodeggio, M. / Shan, K. Y. / Shan, W. / Shan, X. Y. / Shangguan, J. F. / Shao, L. G. / Shao, M. / Shen, C. P. / Shen, H. F. / Shen, W. H. / Shen, X. Y. / Shi, B. A. / Shi, H. C. / Shi, J. L. / Shi, J. Y. / Shi, Q. Q. / Shi, R. S. / Shi, X. / Song, J. J. / Song, T. Z. / Song, W. M. / Song, Y. J. / Song, Y. X. / Sosio, S. / Spataro, S. / Stieler, F. / Su, Y. J. / Sun, G. B. / Sun, G. X. / Sun, H. / Sun, H. K. / Sun, J. F. / Sun, K. / Sun, L. / Sun, S. S. / Sun, T. / Sun, W. Y. / Sun, Y. / Sun, Y. J. / Sun, Y. Z. / Sun, Z. T. / Tan, Y. X. / Tang, C. J. / Tang, G. Y. / Tang, J. / Tang, Y. A. / Tao, L. Y / Tao, Q. T. / Tat, M. / Teng, J. X. / Thoren, V. / Tian, W. H. / Tian, Y. / Tian, Z. F. / Uman, I. / Wang, B. / Wang, B. L. / Wang, Bo / Wang, C. W. / Wang, D. Y. / Wang, F. / Wang, H. J. / Wang, H. P. / Wang, K. / Wang, L. L. / Wang, M. / Wang, Meng / Wang, S. / Wang, T. / Wang, T. J. / Wang, W. / Wang, W. H. / Wang, W. P. / Wang, X. / Wang, X. F. / Wang, X. J. / Wang, X. L. / Wang, Y. / Wang, Y. D. / Wang, Y. F. / Wang, Y. H. / Wang, Y. N. / Wang, Y. Q. / Wang, Yaqian / Wang, Yi / Wang, Z. / Wang, Z. L. / Wang, Z. Y. / Wang, Ziyi / Wei, D. / Wei, D. H. / Weidner, F. / Wen, S. P. / Wenzel, C. W. / Wiedner, U. / Wilkinson, G. / Wolke, M. / Wollenberg, L. / Wu, C. / Wu, J. F. / Wu, L. H. / Wu, L. J. / Wu, X. / Wu, X. H. / Wu, Y. / Wu, Y. J / Wu, Z. / Xia, L. / Xian, X. M. / Xiang, T. / Xiao, D. / Xiao, G. Y. / Xiao, H. / Xiao, S. Y. / Xiao, Y. L. / Xiao, Z. J. / Xie, C. / Xie, X. H. / Xie, Y. / Xie, Y. G. / Xie, Y. H. / Xie, Z. P. / Xing, T. Y. / Xu, C. F. / Xu, C. J. / Xu, G. F. / Xu, H. Y. / Xu, Q. J. / Xu, W. L. / Xu, X. P. / Xu, Y. C. / Xu, Z. P. / Yan, F. / Yan, L. / Yan, W. B. / Yan, W. C. / Yan, X. Q / Yang, H. J. / Yang, H. L. / Yang, H. X. / Yang, Tao / Yang, Y. / Yang, Y. F. / Yang, Y. X. / Yang, Yifan / Yang, Z. W. / Ye, M. / Ye, M. H. / Yin, J. H. / You, Z. Y. / Yu, B. X. / Yu, C. X. / Yu, G. / Yu, T. / Yu, X. D. / Yuan, C. Z. / Yuan, L. / Yuan, S. C. / Yuan, X. Q. / Yuan, Y. / Yuan, Z. Y. / Yue, C. X. / Zafar, A. A. / Zeng, F. R. / Zeng, X. / Zeng, Y. / Zeng, Y. J. / Zhai, X. Y. / Zhan, Y. H. / Zhang, A. Q. / Zhang, B. L. / Zhang, B. X. / Zhang, D. H. / Zhang, G. Y. / Zhang, H. / Zhang, H. H. / Zhang, H. Q. / Zhang, H. Y. / Zhang, J. J. / Zhang, J. L. / Zhang, J. Q. / Zhang, J. W. / Zhang, J. X. / Zhang, J. Y. / Zhang, J. Z. / Zhang, Jiawei / Zhang, L. M. / Zhang, L. Q. / Zhang, Lei / Zhang, P. / Zhang, Q. Y. / Zhang, Shuihan / Zhang, Shulei / Zhang, X. D. / Zhang, X. M. / Zhang, X. Y. / Zhang, Y. / Zhang, Y. T. / Zhang, Y. H. / Zhang, Yan / Zhang, Yao / Zhang, Z. H. / Zhang, Z. L. / Zhang, Z. Y. / Zhao, G. / Zhao, J. / Zhao, J. Y. / Zhao, J. Z. / Zhao, Lei / Zhao, Ling / Zhao, M. G. / Zhao, S. J. / Zhao, Y. B. / Zhao, Y. X. / Zhao, Z. G. / Zhemchugov, A. / Zheng, B. / Zheng, J. P. / Zheng, W. J. / Zheng, Y. H. / Zhong, B. / Zhong, X. / Zhou, H. / Zhou, L. P. / Zhou, X. / Zhou, X. K. / Zhou, X. R. / Zhou, X. Y. / Zhou, Y. Z. / Zhu, J. / Zhu, K. / Zhu, K. J. / Zhu, L. / Zhu, L. X. / Zhu, S. H. / Zhu, S. Q. / Zhu, T. J. / Zhu, W. J. / Zhu, Y. C. / Zhu, Z. A. / Zou, J. H. / Zu, J.

2023

Abstract: The $\Xi^0$ asymmetry parameters are measured using entangled quantum $\Xi^0$-$\bar{\Xi}^0$ pairs ... The relative phase between the transition amplitudes of the $\Xi^0 \bar{\Xi}^0$ helicity states is measured ... alpha_{\bar{\Xi}^0}, \phi_{\Xi^0}, \phi_{\bar{\Xi}^0})$ and the angular distribution parameter $(\alpha ...

Abstract	The $\Xi^0$ asymmetry parameters are measured using entangled quantum $\Xi^0$-$\bar{\Xi}^0$ pairs from a sample of $(448.1 \pm 2.9) \times 10^6$ $\psi(3686)$ events collected with the BESIII detector at BEPCII. The relative phase between the transition amplitudes of the $\Xi^0 \bar{\Xi}^0$ helicity states is measured to be $\Delta \Phi = -0.050 \pm 0.150 \pm 0.020$~rad, which implies that there is no obvious polarization at the current level of statistics. The decay parameters of the $\Xi^0$ hyperon $(\alpha_{\Xi^0}, \alpha_{\bar{\Xi}^0}, \phi_{\Xi^0}, \phi_{\bar{\Xi}^0})$ and the angular distribution parameter $(\alpha_{\psi(3686)})$ and $\Delta \Phi$ are measured simultaneously for the first time. In addition, the $CP$ asymmetry observables are determined to be $A^{\Xi^0}_{CP} = (\alpha_{\Xi^0} + \alpha_{\bar{\Xi}^0})/(\alpha_{\Xi^0} - \alpha_{\bar{\Xi}^0})$ $= -0.007$ $\pm$ 0.082 $\pm$ 0.025 and $\Delta \phi^{\Xi^0}_{CP} = (\phi_{\Xi^0} + \phi_{\bar{\Xi}^0})/2$ $= -0.079$ $\pm$ 0.082 $\pm$ 0.010 rad, which are consistent with $CP$ conservation. Comment: 8 pages, 3 figures, 2 tables, consistent with paper published in Phys. Rev. D (Letter) 108, L011101(2023)
Keywords	High Energy Physics - Experiment
Subject code	612
Publishing date	2023-02-20
Publishing country	us
Document type	Book ; Online
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Article ; Online: Associations of coagulation factor X and XI with incident acute coronary syndrome and stroke: A nested case-control study.

Chen, Huiting / Shen, Miaoyan / Niu, Rundong / Mu, Xuanwen / Jiang, Qin / Peng, Rong / Yuan, Yu / Wang, Hao / Wang, Qiuhong / Yang, Handong / Guo, Huan / He, Meian / Zhang, Xiaomin / Wu, Tangchun

Journal of thrombosis and haemostasis : JTH

2021 Volume 19, Issue 11, Page(s) 2781–2790

Abstract: ... unclear whether coagulation factors X (FX) and XI (FXI) levels are associated with cardiovascular diseases ...

Abstract	Background: Coagulation cascade contributes to thrombotic and hemorrhagic diseases, but it remains unclear whether coagulation factors X (FX) and XI (FXI) levels are associated with cardiovascular diseases. Objective: To evaluate prospective associations of FX and FXI levels with incident acute coronary syndrome (ACS), stroke, and their subtypes (acute myocardial infarction, unstable angina, ischemic stroke, and hemorrhagic stroke). Methods: We performed a nested case-control study (n = 1846) within the Dongfeng-Tongji cohort from 2013 to 2016 matched on age (within 1 year), sex, and sampling date (within 1 month) by incidence density sampling, and measured plasma FX and FXI levels by enzyme-linked immunosorbent assay. FX and FXI levels were categorized into three groups (low, <25th; middle, 25th to <75th; and high ≥75th percentiles) according to distributions, and conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: After adjustment for traditional cardiovascular risk factors, compared with middle groups, the OR (95% CI) in high levels of FX and FXI were 1.11 (0.79-1.56) and 0.96 (0.68-1.36) for incident ACS, and 1.01 (0.63-1.62) and 1.72 (1.14-2.60) for incident stroke, respectively. As for subtypes of ACS and stroke, only high FXI levels were significantly associated with incident ischemic stroke (OR 1.66, 95% CI 1.05-2.65). Moreover, all associations remained steady after additional adjustment for platelet and leukocyte. Conclusion: FXI levels were associated with a greater risk of incident ischemic stroke but not hemorrhagic stroke or ACS. FX levels were not associated with incident ACS or stroke.
MeSH term(s)	Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/epidemiology ; Case-Control Studies ; Factor X ; Factor XI ; Humans ; Stroke/diagnosis ; Stroke/epidemiology
Chemical Substances	Factor X (9001-29-0) ; Factor XI (9013-55-2)
Language	English
Publishing date	2021-08-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1111/jth.15486
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Article: SHAO-YANG-XI-BI-FANG INHIBITS CHONDROCYTE INJURY AND INFLAMMATION IN A RAT MODEL OF OSTEOARTHRITIS

Shen, Pengfei / Wang, Bin / Zheng, Chong / Xie, Zikang

Current topics in nutraceutical research

2022 Volume 20, Issue 2, Page(s) 239

Language	English
Document type	Article
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ISSN	1540-7535
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Article ; Online: Characterization of hereditary factor XI deficiency in Taiwanese patients: identification of three novel and two common mutations.

Lin, Hsuan-Yu / Lin, Ching-Yeh / Hung, Mei-Hua / Kuo, Su-Feng / Lin, Jen-Shiou / Shen, Ming-Ching

International journal of hematology

2020 Volume 112, Issue 2, Page(s) 169–175

Abstract: Hereditary coagulation factor XI (FXI) deficiency is a rare bleeding disorder, but information ...

Abstract	Hereditary coagulation factor XI (FXI) deficiency is a rare bleeding disorder, but information on FXI deficiency in Taiwanese patients remains scarce. We evaluated clinical and genetic features of severe FXI deficiency patients in Taiwan. We collected clinical information and performed coagulation laboratory tests and genetic studies in ten unrelated Taiwanese families with severe FXI deficiency. FXI coagulation activity was assayed using a one-stage method. FXI antigen was determined using enzyme-linked immunosorbent assay. Underlying genetic mutations were evaluated using direct sequencing methods. Ten unrelated Taiwanese patients with hereditary FXI deficiency and variable bleeding tendencies were analyzed. Half of the patients were male. The most common bleeding manifestations were easy bruising (40%), bleeding after dental procedures (40%), and postoperative bleeding (33%). Two patients (20%) were asymptomatic. No correlation was found between bleeding manifestations and baseline FXI levels. Three novel mutations were identified: c.1322delT p.Lys442Cysfs8, c.599G > C p.Cys200Ser, and IVS4 c.325 + 2del124. Two common mutations, c.1107C > T p.Tyr369 (40%) and c.841C > T p.Gln281* (30%), were also found. No correlation existed between bleeding and FXI activity, highlighting the difficulty in predicting FXI deficiency-related bleeding. Three novel FXI genetic mutations and two common mutations were identified, contributing to the known spectrum of FXI deficiency-related mutations.
MeSH term(s)	Adolescent ; Adult ; Aged ; Asian Continental Ancestry Group ; Factor XI/genetics ; Factor XI Deficiency/complications ; Factor XI Deficiency/genetics ; Female ; Genetic Predisposition to Disease ; Hemorrhage/etiology ; Hemorrhage/genetics ; Humans ; Male ; Middle Aged ; Mutation ; Taiwan ; Young Adult
Chemical Substances	Factor XI (9013-55-2)
Language	English
Publishing date	2020-04-24
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-020-02883-0
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Article ; Online: Newly discovered native orchids of Taiwan (XI)

Fang-Mei Hsieh / Po-Neng Shen / Ching-Hwang Liu / Tsan-Piao Lin

Taiwania, Vol 63, Iss 3, Pp 241-

2018 Volume 247

Abstract: This report presents three new orchids of Taiwan, i.e., Epipogium meridianus T.P. Lin, Liparis monoceros T.P. Lin, and Nervilia septemtrionarius T.P. Lin. Epipogium meridianus could be a hybrid between E. roseum and E. kentingensis. ...

Abstract	This report presents three new orchids of Taiwan, i.e., Epipogium meridianus T.P. Lin, Liparis monoceros T.P. Lin, and Nervilia septemtrionarius T.P. Lin. Epipogium meridianus could be a hybrid between E. roseum and E. kentingensis.
Keywords	Epipogium meridianus ; hybrid ; Liparis monoceros ; Nervilia septemtrionarius ; Orchidaceae ; Taiwan ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2018-08-01T00:00:00Z
Publisher	National Taiwan University
Document type	Article ; Online
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Article ; Online: Simultaneous Determination of Fangchinoline and Tetrandrine in Qi-Fang-Xi-Bi-Granules by RP-HPLC.

Lu, XinGang / Zhang, RuoXi / Fu, Feng / Shen, Jie / Nian, Hua / Wu, Tao

Journal of chromatographic science

2015 Volume 53, Issue 8, Page(s) 1328–1332

Abstract: Knee Osteoarthritis is one of the most common diseases of elder worldwide. Qi-Fang-Xi-Bi-Granules ...

Abstract	Knee Osteoarthritis is one of the most common diseases of elder worldwide. Qi-Fang-Xi-Bi-Granules (QFXBG) is a new Chinese medicine granules employed for the treatment of Knee Osteoarthritis. Fangchinoline (FAN) and tetrandrine (TET) are used as targets of quality control of QFXBG. A simple, practical high-performance liquid chromatographic method was developed for the simultaneous quantitation of FAN and TET in Stephaniae tetrandrae radix and QFXBG. The analysis was performed on a Athena C18 column (250 × 4.6 mm, 5 µm) with mobile phase of methanol-water (65 : 35, v/v, pH 3.0, adjusted by glacial acetic acid) containing 1.0 g/L sodium 1-octanesulfonate. This method was validated in terms of linearity, precision, accuracy and recovery. Results showed that this method had good linearity with R(2) at >0.999. The limit of detection and limit of quantification for FAN were 0.13 and 0.35 mg/L, while for TET were 0.28 and 0.76 mg/L, respectively. The relative standard deviations of precision were 0.1-1.3% for intraday and 0.5-2.4% for interday. The recovery was 94.56-98.81% of FAN and 94.07-99.12% of TET, respectively. The chromatographic analytical time was 14 min. This method was successfully applied for the quantitative analysis of FAN and TET in Stephaniae tetrandrae radix and QFXBG, so that it could be extended to quality control of QFXGB in commercial.
MeSH term(s)	Benzylisoquinolines/analysis ; Chromatography, High Pressure Liquid/methods ; Chromatography, Reverse-Phase ; Drugs, Chinese Herbal/chemistry ; Linear Models ; Reproducibility of Results ; Sensitivity and Specificity
Chemical Substances	Benzylisoquinolines ; Drugs, Chinese Herbal ; tetrandrine (29EX23D5AJ) ; fangchinoline (953592C3ZB)
Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80141-0
ISSN	1945-239X ; 0021-9665
ISSN (online)	1945-239X
ISSN	0021-9665
DOI	10.1093/chromsci/bmv016
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Article: Bioavailability of heavy metals bounded to PM2.5 in Xi’an, China: seasonal variation and health risk assessment

Wu, Tiantian / Liu, Pingping / He, Xintian / Xu, Hongmei / Shen, Zhenxing

Environmental science and pollution research. 2021 July, v. 28, no. 27

2021

Abstract: ... PM₂.₅ samples were collected in winter and summer 2016 in Xi’an, China. The pollution levels ...

Abstract	Studying the characteristics and health risks of heavy metals in atmospheric fine particulate matter (PM₂.₅) is a crucial component of understanding atmospheric pollution in China. Integrated 24 h PM₂.₅ samples were collected in winter and summer 2016 in Xi’an, China. The pollution levels, speciation, and health risks of seven PM₂.₅-bound metal elements (Al, As, Cd, Cr, Ni, Pb, and Zn) were investigated in this study. The average concentration of PM₂.₅ was 50.1 ± 30.4 μg m⁻³ and was higher in winter than in summer. Significant seasonal variations in the elements were also observed. The average concentration ratios of Al, As, Cd, Cr, and Pb decreased in summer by 17.5%, 6.4%, 42.5%, 34.1%, and 61.4% compared with their concentrations in winter, respectively, whereas Ni and Zn increased by 37.7% and 7.6% in summer. The soluble and exchangeable fraction (F1) accounted for large proportions of Cd and Pb concentrations, indicating their greater hazard to the environment and human health. Al, As, and Cr mainly existed in the residual state (F4), which had relatively high stability in particulate matter. Ni was consistently distributed in different forms (F1–F4). The bioavailability evaluation indicated that Pb, Cd, Ni, and Zn were potential bioavailable element which exhibited strong biological toxicity. Although the concentration of Pb was very low, its BI value was the highest. The carcinogenic and non-carcinogenic risks of Cr and As were relatively high, and thus require attention from the government and environmental management departments.
Keywords	air pollution ; bioavailability ; carcinogenicity ; environmental management ; health effects assessments ; human health ; particulates ; research ; seasonal variation ; summer ; winter ; China
Language	English
Dates of publication	2021-07
Size	p. 35844-35853.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-13198-w
Database	NAL-Catalogue (AGRICOLA)

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