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  1. Article ; Online: A surgeon's view of excising the "surgeon ego" to accelerate progress in the culture of surgery.

    Newman, Kevin J H

    BMJ (Clinical research ed.)

    2019  Volume 364, Page(s) l58

    MeSH term(s) Surgeons
    Language English
    Publishing date 2019-01-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.l58
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  2. Article: Misinformation and the Sins of Memory: False-Belief Formation and Limits on Belief Revision.

    Newman, Eryn J / Swire-Thompson, Briony / Ecker, Ullrich K H

    Journal of applied research in memory and cognition

    2023  Volume 11, Issue 4, Page(s) 471–477

    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2653816-7
    ISSN 2211-3681
    ISSN 2211-3681
    DOI 10.1037/mac0000090
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  3. Article ; Online: Prophylactic administration of HPA-1a-specific antibodies prevents fetal/neonatal alloimmune thrombocytopenia in mice.

    Zhi, Huiying / Sheridan, Douglas / Newman, Debra K / Newman, Peter J

    Blood

    2022  Volume 140, Issue 20, Page(s) 2146–2153

    Abstract: Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening bleeding disorder caused by maternal alloantibodies directed against paternally inherited human platelet alloantigens (HPAs) present on the surface of fetal and neonatal platelets. ... ...

    Abstract Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening bleeding disorder caused by maternal alloantibodies directed against paternally inherited human platelet alloantigens (HPAs) present on the surface of fetal and neonatal platelets. There are currently no approved therapies for the prevention of FNAIT. We report herein the ability of 2 human HPA-1a-specific therapeutic candidates, one a polyclonal, and the other a monoclonal antibody, to prevent alloimmunization in a novel preclinical mouse model of FNAIT. Both antibody preparations effected the rapid and complete elimination of HPA-1a+ platelets from circulation and prevented the development of HPA-1a alloantibodies. HPA-1a- female mice treated prophylactically with anti-HPA-1a antibody prior to exposure to HPA-1a+ platelets gave birth to HPA-1a+/- pups with significantly improved platelet counts and no bleeding symptoms. These preclinical data establish both the potential and threshold exposure targets for prophylactic treatment with HPA-1a-specific antibodies for the prevention of FNAIT in humans.
    MeSH term(s) Pregnancy ; Humans ; Female ; Mice ; Animals ; Thrombocytopenia, Neonatal Alloimmune/prevention & control ; Isoantibodies ; Antigens, Human Platelet ; Integrin beta3 ; Prenatal Care ; Fetus
    Chemical Substances Isoantibodies ; Antigens, Human Platelet ; Integrin beta3
    Language English
    Publishing date 2022-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022015666
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  4. Article ; Online: MT-RNR1 Genotype Should Not Affect Childhood Vaccination-Unintended Consequences of Guidelines.

    McDermott, John H / Wolf, Joshua / Newman, William G

    JAMA pediatrics

    2023  Volume 177, Issue 11, Page(s) 1119–1120

    MeSH term(s) Humans ; Genetic Testing ; Genotype ; Vaccination ; Mutation
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2023.3263
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  5. Article ; Online: Coordinated head direction representations in mouse anterodorsal thalamic nucleus and retrosplenial cortex.

    van der Goes, Marie-Sophie H / Voigts, Jakob / Newman, Jonathan P / Toloza, Enrique H S / Brown, Norma J / Murugan, Pranav / Harnett, Mark T

    eLife

    2024  Volume 13

    Abstract: The sense of direction is critical for survival in changing environments and relies on flexibly integrating self-motion signals with external sensory cues. While the anatomical substrates involved in head direction (HD) coding are well known, the ... ...

    Abstract The sense of direction is critical for survival in changing environments and relies on flexibly integrating self-motion signals with external sensory cues. While the anatomical substrates involved in head direction (HD) coding are well known, the mechanisms by which visual information updates HD representations remain poorly understood. Retrosplenial cortex (RSC) plays a key role in forming coherent representations of space in mammals and it encodes a variety of navigational variables, including HD. Here, we use simultaneous two-area tetrode recording to show that RSC HD representation is nearly synchronous with that of the anterodorsal nucleus of thalamus (ADn), the obligatory thalamic relay of HD to cortex, during rotation of a prominent visual cue. Moreover, coordination of HD representations in the two regions is maintained during darkness. We further show that anatomical and functional connectivity are consistent with a strong feedforward drive of HD information from ADn to RSC, with anatomically restricted corticothalamic feedback. Together, our results indicate a concerted global HD reference update across cortex and thalamus.
    MeSH term(s) Animals ; Mice ; Anterior Thalamic Nuclei ; Gyrus Cinguli ; Cerebral Cortex ; Cues ; Rotation ; Mammals
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.82952
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  6. Article ; Online: Reply to "the spectrum of neuro-ophthalmologic involvement in mitochondrial disorders is broad".

    Lock, Jane H / Irani, Neha K / Newman, Nancy J

    Taiwan journal of ophthalmology

    2021  Volume 11, Issue 4, Page(s) 427–428

    Language English
    Publishing date 2021-07-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 2652841-1
    ISSN 2211-5072 ; 2211-5072
    ISSN (online) 2211-5072
    ISSN 2211-5072
    DOI 10.4103/tjo.tjo_19_21
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  7. Article ; Online: Enhancing the palatability of cultivated meat.

    Lambert, Ella G / O'Keeffe, Christopher J / Ward, Alexander O / Anderson, Tim A / Yip, Queenie / Newman, Peter L H

    Trends in biotechnology

    2024  

    Abstract: Cultivated meat (CM) has transitioned from a futuristic concept to a present reality, with select products approved for consumption and sale in Singapore, Israel, and the USA. This evolution has emphasized scalable, cost-effective, and sustainable ... ...

    Abstract Cultivated meat (CM) has transitioned from a futuristic concept to a present reality, with select products approved for consumption and sale in Singapore, Israel, and the USA. This evolution has emphasized scalable, cost-effective, and sustainable production, as well as navigation of regulatory pathways. As CM develops, a crucial challenge lies in delivering products that are highly appealing to consumers. Central to this will be refining CM palatability, a term encompassing food's taste, aroma, texture, tenderness, juiciness, and color. We explore the scientific and engineering approaches to producing palatable CM, including cell-line selection, cell differentiation, and post-processing techniques. This includes a discussion of the structural and compositional properties of meat that are intrinsically coupled to palatability.
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 47474-5
    ISSN 1879-3096 ; 0167-7799
    ISSN (online) 1879-3096
    ISSN 0167-7799
    DOI 10.1016/j.tibtech.2024.02.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2750: Show issues Location:
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  8. Article ; Online: Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice.

    Newman, Mackenzie / Lynch, Cayla / Connery, Heather / Goldsmith, William / Nurkiewicz, Timothy / Raylman, Raymond / Boyd, Jonathan

    Basic & clinical pharmacology & toxicology

    2024  Volume 134, Issue 4, Page(s) 460–471

    Abstract: Fentanyl exposure and overdose are growing concerns in public health and occupational safety. This study aimed to establish parameters of fentanyl lethality in SKH1 mice for future overdose research. Lethality was determined using the up-down procedure, ... ...

    Abstract Fentanyl exposure and overdose are growing concerns in public health and occupational safety. This study aimed to establish parameters of fentanyl lethality in SKH1 mice for future overdose research. Lethality was determined using the up-down procedure, with subjects monitored post-administration using pulse oximetry (5 min) and then whole-body plethysmography (40 min). Following the determination of subcutaneous dose-response, [18F]Fluorodeoxyglucose positron emission tomography (
    MeSH term(s) Humans ; Animals ; Mice ; Fluorodeoxyglucose F18/therapeutic use ; Prognosis ; Fentanyl/toxicity ; Positron-Emission Tomography ; Drug Overdose/drug therapy ; Analgesics, Opioid/therapeutic use
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Fentanyl (UF599785JZ) ; Analgesics, Opioid
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2134679-3
    ISSN 1742-7843 ; 1742-7835
    ISSN (online) 1742-7843
    ISSN 1742-7835
    DOI 10.1111/bcpt.13984
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    Uf I Zs.144: Show issues Location:
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  9. Article ; Online: Novel Monitoring and Dose Adjustment of Argatroban, a Direct Thrombin Inhibitor, to Maintain Therapeutic Anticoagulation in a Patient With Antiphospholipid Antibody Syndrome, Heparin-Induced Thrombocytopenia, and COVID-19 Pneumonia.

    Ryan, Christine E / Newman, Kelly A / Roberts, Russel J / Frydman, Galit H / Rosovsky, Rachel P

    Critical care explorations

    2023  Volume 5, Issue 4, Page(s) 903

    Abstract: In patients who require systemic anticoagulation, a reliable monitoring method is required to ensure anticoagulation is maintained within the correct therapeutic window and patients are treated appropriately. When titrating direct thrombin inhibitors ( ... ...

    Abstract In patients who require systemic anticoagulation, a reliable monitoring method is required to ensure anticoagulation is maintained within the correct therapeutic window and patients are treated appropriately. When titrating direct thrombin inhibitors (DTIs), dilute thrombin time (dTT) measurements have been demonstrated to be more reliable and accurate than activated partial thromboplastin time (aPTT) measurements and thus often the preferred DTI assessment. However, a clinical need arises when both dTT measurements are not readily available and aPTT measurements are unreliable.
    Case summary: A 57-year-old woman with a history of antiphospholipid antibody syndrome, heparin-induced thrombocytopenia, and multiple prior deep venous thromboses and pulmonary emboli was admitted with COVID-19 pneumonia and intubated due to hypoxic respiratory failure. Argatroban was initiated in place of her home medication warfarin. However, the patient had a prolonged aPTT value at baseline and overnight dTT assay measurements were limited at our institution. A multidisciplinary team of hematology and pharmacy clinicians created a modified patient-specific aPTT target range and argatroban dosing was titrated accordingly. Subsequent aPTT values in the modified target range corresponded to therapeutic dTT values, indicating therapeutic anticoagulation was successfully achieved and maintained. Patient blood samples were additionally evaluated retrospectively using an investigational novel point-of-care test that detected and quantified the argatroban anticoagulant effect.
    Conclusions: Therapeutic anticoagulation with a DTI in a patient with unreliable aPTT measurements can be achieved with use of a modified patient-specific aPTT target range. Early validation of an investigational rapid testing alternative for DTI monitoring is promising.
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Case Reports
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000903
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  10. Article: Opioids and Vitamin C: Known Interactions and Potential for Redox-Signaling Crosstalk.

    Newman, Mackenzie / Connery, Heather / Boyd, Jonathan

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 7

    Abstract: Opioids are among the most widely used classes of pharmacologically active compounds both clinically and recreationally. Beyond their analgesic efficacy via μ opioid receptor (MOR) agonism, a prominent side effect is central respiratory depression, ... ...

    Abstract Opioids are among the most widely used classes of pharmacologically active compounds both clinically and recreationally. Beyond their analgesic efficacy via μ opioid receptor (MOR) agonism, a prominent side effect is central respiratory depression, leading to systemic hypoxia and free radical generation. Vitamin C (ascorbic acid; AA) is an essential antioxidant vitamin and is involved in the recycling of redox cofactors associated with inflammation. While AA has been shown to reduce some of the negative side effects of opioids, the underlying mechanisms have not been explored. The present review seeks to provide a signaling framework under which MOR activation and AA may interact. AA can directly quench reactive oxygen and nitrogen species induced by opioids, yet this activity alone does not sufficiently describe observations. Downstream of MOR activation, confounding effects from AA with STAT3, HIF1α, and NF-κB have the potential to block production of antioxidant proteins such as nitric oxide synthase and superoxide dismutase. Further mechanistic research is necessary to understand the underlying signaling crosstalk of MOR activation and AA in the amelioration of the negative, potentially fatal side effects of opioids.
    Language English
    Publishing date 2022-06-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11071267
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