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  1. Book: Molecular life sciences / 1

    Wells, Robert D. / Bond, Judith S. / Klinman, Judith P. / Masters, Bettie Sue Siler

    an encyclopedic reference

    2018  

    Author's details editors-in-chief: Robert D. Wells, Judith S. Bond, Judith Klinman, Bettie Sue Siler Masters
    Collection Molecular life sciences
    Language English
    Size xv, 626 Seiten, Illustrationen
    Publishing country United States
    Document type Book
    HBZ-ID HT019765387
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 1198 available for loan (reading room) Lesesaal EG

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  2. Book: Molecular life sciences / 2

    Wells, Robert D. / Bond, Judith S. / Klinman, Judith P. / Masters, Bettie Sue Siler

    an encyclopedic reference

    2018  

    Author's details editors-in-chief: Robert D. Wells, Judith S. Bond, Judith Klinman, Bettie Sue Siler Masters
    Collection Molecular life sciences
    Language English
    Size xv Seiten, Seite 628 - 1245
    Publishing country United States
    Document type Book
    HBZ-ID HT019765389
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 1199 available for loan (reading room) Lesesaal EG

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  3. Book ; Collection: Molecular life sciences

    Wells, Robert D. / Bond, Judith S. / Klinman, Judith P. / Masters, Bettie Sue Siler

    an encyclopedic reference

    (Springer reference)

    2018  

    Author's details editors-in-chief: Robert D. Wells, Judith S. Bond, Judith Klinman, Bettie Sue Siler Masters
    Series title Springer reference
    Keywords Biochemie ; Molekularbiologie
    Subject Molekulare Biologie ; Biologische Chemie
    Language English
    Dates of publication 2018-2018
    Size 2 Bände
    Publisher Springer
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Collection (display volumes)
    HBZ-ID HT019765381
    ISBN 978-1-4614-1529-9 ; 9781461415312 ; 1-4614-1529-2 ; 1461415314
    Database Catalogue ZB MED Medicine, Health

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  4. Book: Genetic instabilities and neurological diseases

    Wells, Robert D.

    2006  

    Title variant Genetic instabilities & neurological diseases
    Author's details ed. Robert D. Wells
    Language English
    Size 734 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT014628982
    ISBN 978-0-12-369462-1 ; 0-12-369462-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 4725 order for loan Magazin

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  5. Book ; Online ; E-Book: Principles of hormone/behavior relations

    Pfaff, Donald W. / Rubin, Robert T. / Head, Geoffrey A.

    2018  

    Author's details Donald W. Pfaff, Robert T. Rubin, Jill E. Schneider, Geoffrey A. Head
    Keywords Human behavior/Endocrine aspects
    Subject code 612.405
    Language English
    Size 1 Online-Ressource (xlvi, 526 Seiten), Illustrationen
    Edition Second edition
    Publisher Elsevier, Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019616476
    ISBN 978-0-12-802667-0 ; 9780128113714 ; 0-12-802667-7 ; 0128113715
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  6. Book: Genetic instabilities and hereditary neurological diseases

    Wells, Robert D.

    1998  

    Author's details ed. Robert D. Wells
    Keywords Nervous System Diseases / genetics ; Chromosome Aberrations ; Nervensystem ; Krankheit ; Erbkrankheit ; Genetik
    Subject Genetische Krankheit ; Heredopathie ; Genetisch bedingte Krankheit ; Genetisches Syndrom ; Erbkrankheiten ; Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Systema nervosum ; NS ; Allgemeine Genetik ; Erbbiologie ; Erbforschung ; Erblehre ; Vererbungslehre ; Vererbungswissenschaft ; Erblichkeitslehre
    Language English
    Size XXIII, 829 S. : Ill., graph. Darst.
    Publisher Academic Press
    Publishing place San Diego u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT009228062
    ISBN 0-12-742935-2 ; 978-0-12-742935-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 7640 order for loan Magazin

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  7. Article ; Online: Improved precision of SPECT myocardial blood flow using a net tracer retention model.

    Cuddy-Walsh, Sarah G / deKemp, Robert A / Ruddy, Terrence D / Wells, R Glenn

    Medical physics

    2023  Volume 50, Issue 4, Page(s) 2009–2021

    Abstract: Background: Noninvasive quantification of absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR) provides incremental benefit to relative myocardial perfusion imaging (MPI) to diagnose and manage heart disease. MBF can be measured with ... ...

    Abstract Background: Noninvasive quantification of absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR) provides incremental benefit to relative myocardial perfusion imaging (MPI) to diagnose and manage heart disease. MBF can be measured with single-photon emission computed tomography (SPECT) but the uncertainty in the measured values is high. Standardization and optimization of protocols for SPECT MBF measurements will improve the consistency of this technique. One element of the processing protocol is the choice of kinetic model used to analyze the dynamic image series.
    Purpose: This study evaluates if a net tracer retention model (RET) will provide a better fit to the acquired data and greater test-retest precision than a one-compartment model (1CM) for SPECT MBF, with (+MC) and without (-MC) manual motion correction.
    Methods: Data from previously acquired rest-stress MBF studies (31 SPECT-PET and 30 SPECT-SPECT) were reprocessed ± MC. Rate constants (K1) were extracted using 1CM and RET, +/-MC, and compared pairwise with standard PET MBF measurements using cross-validation to obtain calibration parameters for converting SPECT rate constants to MBF and to assess the goodness-of-fit of the calibration curves. Precision (coefficient of variation of test re-test relative differences, COV) of flow measurements was computed for 1CM and RET ± MC using data from the repeated SPECT MBF studies.
    Results: Both the RET model and MC improved the goodness-of-fit of the SPECT MBF calibration curves to PET. All models produced minimal bias compared with PET (mean bias < 0.6%). The SPECT-SPECT MBF COV significantly improved from 34% (1CM+MC) to 28% (RET+MC, P = 0.008).
    Conclusion: The RET+MC model provides a better calibration of SPECT to PET and blood flow measurements with better precision than the 1CM, without loss of accuracy.
    MeSH term(s) Humans ; Coronary Circulation/physiology ; Tomography, Emission-Computed, Single-Photon/methods ; Radiopharmaceuticals ; Myocardium ; Single Photon Emission Computed Tomography Computed Tomography ; Myocardial Perfusion Imaging/methods ; Positron-Emission Tomography/methods ; Coronary Artery Disease
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2023-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1002/mp.16186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1210: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Subsampling Methods for Fast Electron Backscattered Diffraction Analysis for SEM.

    Broad, Zoë / Nicholls, Daniel / Wells, Jack / Moshtaghpour, Amirafshar / Robinson, Alex W / Masters, Robert / Hughes, Louise / Browning, Nigel D

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue Supplement_1, Page(s) 467–469

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Better translation via collaboration: The MRC National Mouse Genetics Network.

    Sansom, Owen / Wells, Sara / Kent, David / Wood, Andrew / Pitceathly, Robert D S / Isles, Anthony / Liu, Karen / Twigg, Stephen / Blyth, Karen / Chesler, Louis

    Cell genomics

    2024  Volume 4, Issue 2, Page(s) 100483

    Abstract: The MRC National Mouse Genetics Network (NMGN) has been established in the UK to bring together researchers from academia and industry across the country from a wide range of disease areas and research backgrounds to rapidly facilitate clinical ... ...

    Abstract The MRC National Mouse Genetics Network (NMGN) has been established in the UK to bring together researchers from academia and industry across the country from a wide range of disease areas and research backgrounds to rapidly facilitate clinical translation of mouse research findings and foster an environment of interdisciplinary learning.
    MeSH term(s) Animals ; Mice ; Industry
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ISSN 2666-979X
    ISSN (online) 2666-979X
    DOI 10.1016/j.xgen.2023.100483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways.

    Yang, Jiuling / Wang, Li / Byrnes, James R / Kirkemo, Lisa L / Driks, Hannah / Belair, Cassandra D / Aguilar, Oscar A / Lanier, Lewis L / Wells, James A / Fong, Lawrence / Blelloch, Robert

    Cancer immunology research

    2024  Volume 12, Issue 5, Page(s) 575–591

    Abstract: Poliovirus receptor-related 2 (PVRL2, also known as nectin-2 or CD112) is believed to act as an immune checkpoint protein in cancer; however, most insight into its role is inferred from studies on its known receptor, poliovirus receptor (PVR)-related ... ...

    Abstract Poliovirus receptor-related 2 (PVRL2, also known as nectin-2 or CD112) is believed to act as an immune checkpoint protein in cancer; however, most insight into its role is inferred from studies on its known receptor, poliovirus receptor (PVR)-related immunoglobulin domain protein (PVRIG, also known as CD112R). Here, we study PVRL2 itself. PVRL2 levels were found to be high in tumor cells and tumor-derived exosomes. Deletion of PVRL2 in multiple syngeneic mouse models of cancer showed a dramatic reduction in tumor growth that was immune dependent. This effect was even greater than that seen with deletion of PD-L1. PVRL2 was shown to function by suppressing CD8+ T and natural killer cells in the tumor microenvironment. The loss of PVRL2 suppressed tumor growth even in the absence of PVRIG. In contrast, PVRIG loss showed no additive effect in the absence of PVRL2. T-cell immunoreceptor with Ig and ITIM domains (TIGIT) blockade combined with PVRL2 deletion resulted in a near complete block in tumor growth. This effect was not recapitulated by the combined deletion of PVRL2 with its paralog, PVR, which is the ligand for TIGIT. These data uncover PVRL2 as a distinct inhibitor of the antitumor immune response with functions beyond that of its known receptor PVRIG. Moreover, the data provide a strong rationale for combinatorial targeting of PVRL2 and TIGIT for cancer immunotherapy.
    MeSH term(s) Animals ; Receptors, Immunologic/metabolism ; Receptors, Immunologic/genetics ; Nectins/metabolism ; Mice ; Humans ; Tumor Microenvironment/immunology ; Cell Line, Tumor ; Signal Transduction ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; CD8-Positive T-Lymphocytes/immunology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Receptors, Cell Surface
    Chemical Substances Receptors, Immunologic ; Nectins ; NECTIN2 protein, human ; TIGIT protein, human ; PVRIG protein, human ; T cell Ig and ITIM domain protein, mouse ; Receptors, Cell Surface
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2732489-8
    ISSN 2326-6074 ; 2326-6066
    ISSN (online) 2326-6074
    ISSN 2326-6066
    DOI 10.1158/2326-6066.CIR-23-0722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7022: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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