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  1. Article ; Online: Epileptic Encephalopathy

    Hernandez, Ciria C / Hu, Ningning / Shen, Wangzhen / Macdonald, Robert L

    Biomolecules

    2023  Volume 13, Issue 12

    Abstract: Variants in ... ...

    Abstract Variants in the
    MeSH term(s) Humans ; Receptors, GABA-A/metabolism ; Mutation, Missense ; Mutation ; Seizures ; Brain Diseases
    Chemical Substances Receptors, GABA-A
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13121790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Conference proceedings: Status epilepticus in adults and children

    Macdonald, Robert L.

    new developments in pathogenesis and treatment

    (Epilepsia ; 40, Suppl. 1)

    1999  

    Event/congress Merritt Putnam Symposium (17, 1997, BostonMass.)
    Author's details Seventeenth Annual Merritt-Putnam Symposium, December 6, 1997, Boston, Massachusetts. Guest ed. Robert L. Macdonald
    Series title Epilepsia ; 40, Suppl. 1
    Collection
    Language English
    Size S66 S. : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Hagerstown, Md
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT010744451
    Database Catalogue ZB MED Medicine, Health

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    Zs A 517 -40,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: A structural look at GABA

    Hernandez, Ciria C / Macdonald, Robert L

    Brain research

    2019  Volume 1714, Page(s) 234–247

    Abstract: Understanding the genetic variation in ... ...

    Abstract Understanding the genetic variation in GABA
    MeSH term(s) Epilepsy/genetics ; Epilepsy/physiopathology ; Epileptic Syndromes/genetics ; Epileptic Syndromes/metabolism ; Epileptic Syndromes/physiopathology ; Humans ; Mutation/genetics ; Receptors, GABA-A/genetics ; Receptors, GABA-A/metabolism ; Receptors, GABA-A/physiology ; Structure-Activity Relationship
    Chemical Substances Receptors, GABA-A
    Language English
    Publishing date 2019-03-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2019.03.004
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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Quality Indicators for Major Depressive Disorder in Adults: A Review of Performance Measures by the American College of Physicians.

    Qaseem, Amir / Andrews, Rebecca A / Campos, Karen / Goldzweig, Caroline L / MacDonald, Scott / McLean, Robert M / Powell, Rhea E / Fitterman, Nick

    Annals of internal medicine

    2024  Volume 177, Issue 4, Page(s) 507–513

    Abstract: Major depressive disorder (MDD) is a severe mood disorder that affects at least 8.4% of the adult population in the United States. Characteristics of MDD include persistent sadness, diminished interest in daily activities, and a state of hopelessness. ... ...

    Abstract Major depressive disorder (MDD) is a severe mood disorder that affects at least 8.4% of the adult population in the United States. Characteristics of MDD include persistent sadness, diminished interest in daily activities, and a state of hopelessness. The illness may progress quickly and have devastating consequences if left untreated. Eight performance measures are available to evaluate screening, diagnosis, and successful management of MDD. However, many performance measures do not meet the criteria for validity, reliability, evidence, and meaningfulness.
    The American College of Physicians (ACP) embraces performance measurement as a means to externally validate the quality of care of practices, medical groups, and health plans and to drive reimbursement processes. However, a plethora of performance measures that provide low or no value to patient care have inundated physicians, practices, and systems and burdened them with collecting and reporting of data. The ACP's Performance Measurement Committee (PMC) reviews performance measures using a validated process to inform regulatory and accreditation bodies in an effort to recognize high-quality performance measures, address gaps and areas for improvement in performance measures, and help reduce reporting burden. Out of 8 performance measures, the PMC found only 1 measure (suicide risk assessment) that was valid at all levels of attribution. This paper presents a review of MDD performance measures and highlights opportunities to improve performance measures addressing MDD management.
    MeSH term(s) Adult ; Humans ; United States ; Depressive Disorder, Major/diagnosis ; Quality Indicators, Health Care ; Reproducibility of Results
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M23-3077
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  5. Article ; Online: GABRG2

    Hernandez, Ciria C / Shen, Yanwen / Hu, Ningning / Shen, Wangzhen / Narayanan, Vinodh / Ramsey, Keri / He, Wen / Zou, Liping / Macdonald, Robert L

    Biomolecules

    2023  Volume 13, Issue 3

    Abstract: Febrile seizures (FS) are the most common form of epilepsy in children between six months and five years of age. FS is a self-limited type of fever-related seizure. However, complicated prolonged FS can lead to complex partial epilepsy. We found that ... ...

    Abstract Febrile seizures (FS) are the most common form of epilepsy in children between six months and five years of age. FS is a self-limited type of fever-related seizure. However, complicated prolonged FS can lead to complex partial epilepsy. We found that among the GABA
    MeSH term(s) Humans ; Seizures, Febrile/genetics ; Receptors, GABA-A/genetics ; Epilepsies, Myoclonic/genetics ; Epilepsy/genetics ; Mutation, Missense ; Mutation
    Chemical Substances Receptors, GABA-A ; GABRG2 protein, human
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13030414
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  6. Article ; Online: PC-PEP, a Comprehensive Daily Six-Month Home-Based Patient Empowerment Program Leads to Weight Loss in Men with Prostate Cancer: A Secondary Analysis of a Clinical Trial.

    MacNevin, Wyatt / Ilie, Gabriela / Rendon, Ricardo / Mason, Ross / Spooner, Jesse / Chedrawe, Emily / Patil, Nikhilesh / Bowes, David / Bailly, Greg / Bell, David / Wilke, Derek / Zahavich, Jeffery B L / MacDonald, Cody / Rutledge, Robert David Harold

    Current oncology (Toronto, Ont.)

    2024  Volume 31, Issue 3, Page(s) 1667–1688

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Male ; Humans ; Patient Participation ; Prostatic Neoplasms/therapy ; Exercise ; Weight Loss ; Exercise Therapy
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol31030127
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    Zs.A 4305: Show issues Location:
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  7. Article ; Online: Fingolimod mitigates synaptic deficits and psychosis-like behavior in APP/PSEN1 mice.

    Krivinko, Josh M / Erickson, Susan L / MacDonald, Matthew L / Garver, Megan E / Sweet, Robert A

    Alzheimer's & dementia (New York, N. Y.)

    2022  Volume 8, Issue 1, Page(s) e12324

    Abstract: Introduction: Current treatments for psychosis in Alzheimer's disease (AD), a syndrome characterized by more rapid deterioration and reduced synaptic protein abundance relative to non-psychotic AD, are inadequate. Fingolimod, a currently US Food and ... ...

    Abstract Introduction: Current treatments for psychosis in Alzheimer's disease (AD), a syndrome characterized by more rapid deterioration and reduced synaptic protein abundance relative to non-psychotic AD, are inadequate. Fingolimod, a currently US Food and Drug Administration (FDA)-approved pharmacotherapy for multiple sclerosis, alters synaptic protein expression and warrants preclinical appraisal as a candidate pharmacotherapy for psychosis in AD.
    Methods: Presenilin and amyloid precursor protein transgenic mice (APPswe/PSEN1dE9) and wild-type mice were randomized to fingolimod or saline for 7 days. Psychosis-associated behaviors were quantified by open field testing, pre-pulse inhibition of the acoustic startle response testing, and habituation of the acoustic startle response testing. Synaptic proteins were quantified by liquid chromatography/mass spectrometry in homogenate and postsynaptic density fractions.
    Results: Fingolimod treatment increased the synaptic protein abundance in cortical homogenates and normalized psychosis-associated behaviors in APPswe/PSEN1dE9 mice relative to saline. Mitochondrial-related proteins were preferentially altered by fingolimod treatment and correlated with improvements in psychosis-associated behaviors.
    Discussion: Preclinical studies employing complementary psychosis-associated behavioral assessments and proteomic evaluations across multiple AD-related models are warranted to replicate the current study and further investigate fingolimod as a candidate treatment for psychosis in AD.
    Language English
    Publishing date 2022-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2832891-7
    ISSN 2352-8737 ; 2352-8737
    ISSN (online) 2352-8737
    ISSN 2352-8737
    DOI 10.1002/trc2.12324
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  8. Article: Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research.

    Grubisha, Melanie J / Sweet, Robert A / MacDonald, Matthew L

    Frontiers in molecular neuroscience

    2021  Volume 14, Page(s) 689495

    Abstract: Gene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic ... ...

    Abstract Gene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic studies and importance in regulating neuronal and circuit function. Here we review the rationale for studying PTMs in psychiatric disease, recent findings in human post-mortem tissue, the required controls for these types of studies, and highlight the emerging mass spectrometry approaches transforming this research direction.
    Language English
    Publishing date 2021-07-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2021.689495
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  9. Article ; Online: National Trends and Prescription Patterns in Opiate Analgesia for Urolithiasis Presenting to Emergency Departments: Analysis of the National Hospital Ambulatory Medical Care Survey, 2006-2018.

    Zhu, Denzel / Macdonald, Eric J / Lesko, Robert P / Watts, Kara L

    Urology

    2021  Volume 164, Page(s) 80–87

    Abstract: Objective: To analyze the National Hospital Ambulatory Medical Care Survey (NHAMCS) database to determine geographic and temporal trends, as well as variables associated with the likelihood of receiving an opioid prescription for urolithiasis in United ... ...

    Abstract Objective: To analyze the National Hospital Ambulatory Medical Care Survey (NHAMCS) database to determine geographic and temporal trends, as well as variables associated with the likelihood of receiving an opioid prescription for urolithiasis in United States (US) emergency departments (EDs).
    Materials and methods: All ED visits for urolithiasis between 2006 and 2018 in the NHAMCS database were analyzed. Age, race/ethnicity, insurance status, ED provider credentials, geographic region, and urban vs rural hospital status were extracted. Linear regression was used to examine overall/regional trends in opioid prescriptions over time. Logistic regression was used to estimate factors associated with higher odds of receiving opioids.
    Results: Fourteen million visits were analyzed, of which, 79.1% (11.0 million) received an opioid prescription. From 2014 to 2018 there was a decline of 3.65%/year of the proportion of visits receiving an opioid prescription (R
    Conclusion: Opioid prescriptions for patients presenting with urolithiasis to the ED have steadily declined from 2014 to 2018, except in the Midwest. NHW race, Midwest region, and urban EDs increase the likelihood of receiving opioids. Continued efforts encouraging non-opioid alternatives for urolithiasis are essential, specifically in Midwestern EDs, to mitigate the ongoing opioid epidemic in the US.
    MeSH term(s) Analgesia ; Analgesics, Opioid/therapeutic use ; Emergency Service, Hospital ; Health Care Surveys ; Hospitals ; Humans ; Opiate Alkaloids ; Pain ; Practice Patterns, Physicians' ; Prescriptions ; United States ; Urolithiasis/drug therapy
    Chemical Substances Analgesics, Opioid ; Opiate Alkaloids
    Language English
    Publishing date 2021-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2021.09.047
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    Zs.A 1142: Show issues Location:
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    Zs.MO 275: Show issues

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  10. Article ; Online: Risk Factors for Delayed Cerebral Ischemia in Good-Grade Patients With Aneurysmal Subarachnoid Hemorrhage.

    Rautalin, Ilari / Juvela, Seppo / Martini, Michael L / Macdonald, Robert Loch / Korja, Miikka

    Journal of the American Heart Association

    2022  Volume 11, Issue 23, Page(s) e027453

    Abstract: Background A subset of good-grade patients with aneurysmal subarachnoid hemorrhage (aSAH) develop delayed cerebral ischemia (DCI) that may cause permanent disabilities after aSAH. However, little is known about the risk factors of DCI among this specific ...

    Abstract Background A subset of good-grade patients with aneurysmal subarachnoid hemorrhage (aSAH) develop delayed cerebral ischemia (DCI) that may cause permanent disabilities after aSAH. However, little is known about the risk factors of DCI among this specific patient group. Methods and Results We obtained a multinational cohort of good-grade (Glasgow Coma Scale 13-15 on admission) patients with aSAH by pooling patient data from 4 clinical trials and 2 prospective cohort studies. We collected baseline data on lifestyle-related factors and the clinical characteristics of aSAHs. By calculating fully adjusted risk estimates for DCI and DCI-related poor outcome, we identified the most high-risk patient groups. The pooled study cohort included 1918 good-grade patients with aSAH (median age, 51 years; 64% women), of whom 21% and 7% experienced DCI and DCI-related poor outcome, respectively. Among men, patients with obesity and (body mass index ≥30 kg/m
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/epidemiology ; Prospective Studies ; Brain Ischemia/epidemiology ; Brain Ischemia/etiology ; Risk Factors ; Obesity ; Hypertension/complications ; Hypertension/epidemiology
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.122.027453
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