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  1. Article: Corrigendum: Single-Cell RNA Analysis of Type I Spiral Ganglion Neurons Reveals a

    Grandi, Fiorella Carla / De Tomasi, Lara / Mustapha, Mirna

    Frontiers in molecular neuroscience

    2021  Volume 14, Page(s) 686790

    Abstract: This corrects the article DOI: 10.3389/fnmol.2020.00083.]. ...

    Abstract [This corrects the article DOI: 10.3389/fnmol.2020.00083.].
    Language English
    Publishing date 2021-05-05
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2021.686790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Single-Cell RNA Analysis of Type I Spiral Ganglion Neurons Reveals a

    Grandi, Fiorella Carla / De Tomasi, Lara / Mustapha, Mirna

    Frontiers in molecular neuroscience

    2020  Volume 13, Page(s) 83

    Abstract: In the mature cochlea, each inner hair cell (IHC) is innervated by multiple spiral ganglion neurons of type I (SGNI). SGNIs are morphologically and electro-physiologically diverse. Also, they differ in their susceptibility to noise insult. However, the ... ...

    Abstract In the mature cochlea, each inner hair cell (IHC) is innervated by multiple spiral ganglion neurons of type I (SGNI). SGNIs are morphologically and electro-physiologically diverse. Also, they differ in their susceptibility to noise insult. However, the molecular underpinnings of their identity and physiological differences remain poorly understood. In this study, we developed a novel triple transgenic mouse, which enabled the isolation of pure populations of SGNIs and the analysis of a 96-gene panel
    Language English
    Publishing date 2020-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2020.00083
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  3. Article ; Online: A critical period of prehearing spontaneous Ca

    Carlton, Adam J / Jeng, Jing-Yi / Grandi, Fiorella C / De Faveri, Francesca / Ceriani, Federico / De Tomasi, Lara / Underhill, Anna / Johnson, Stuart L / Legan, Kevin P / Kros, Corné J / Richardson, Guy P / Mustapha, Mirna / Marcotti, Walter

    The EMBO journal

    2023  Volume 42, Issue 4, Page(s) e112118

    Abstract: Sensory-independent ... ...

    Abstract Sensory-independent Ca
    MeSH term(s) Animals ; Hair Cells, Auditory, Inner/physiology ; Action Potentials/physiology ; Signal Transduction ; Cochlea/physiology ; Mammals
    Language English
    Publishing date 2023-01-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2022112118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1808: Show issues Location:
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  4. Article ; Online: BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing.

    Carlton, Adam J / Jeng, Jing-Yi / Grandi, Fiorella C / De Faveri, Francesca / Amariutei, Ana E / De Tomasi, Lara / O'Connor, Andrew / Johnson, Stuart L / Furness, David N / Brown, Steve D M / Ceriani, Federico / Bowl, Michael R / Mustapha, Mirna / Marcotti, Walter

    Cell reports

    2024  Volume 43, Issue 4, Page(s) 114025

    Abstract: Type I spiral ganglion neurons (SGNs) convey sound information to the central auditory pathway by forming synapses with inner hair cells (IHCs) in the mammalian cochlea. The molecular mechanisms regulating the formation of the post-synaptic density (PSD) ...

    Abstract Type I spiral ganglion neurons (SGNs) convey sound information to the central auditory pathway by forming synapses with inner hair cells (IHCs) in the mammalian cochlea. The molecular mechanisms regulating the formation of the post-synaptic density (PSD) in the SGN afferent terminals are still unclear. Here, we demonstrate that brain-specific angiogenesis inhibitor 1 (BAI1) is required for the clustering of AMPA receptors GluR2-4 (glutamate receptors 2-4) at the PSD. Adult Bai1-deficient mice have functional IHCs but fail to transmit information to the SGNs, leading to highly raised hearing thresholds. Despite the almost complete absence of AMPA receptor subunits, the SGN fibers innervating the IHCs do not degenerate. Furthermore, we show that AMPA receptors are still expressed in the cochlea of Bai1-deficient mice, highlighting a role for BAI1 in trafficking or anchoring GluR2-4 to the PSDs. These findings identify molecular and functional mechanisms required for sound encoding at cochlear ribbon synapses.
    MeSH term(s) Animals ; Receptors, AMPA/metabolism ; Mice ; Spiral Ganglion/metabolism ; Hearing/physiology ; Cochlea/metabolism ; Post-Synaptic Density/metabolism ; Mice, Knockout ; Hair Cells, Auditory, Inner/metabolism ; Mice, Inbred C57BL ; Synapses/metabolism ; Receptors, G-Protein-Coupled
    Chemical Substances Receptors, AMPA ; Adgrv1 protein, mouse ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.114025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells.

    Jeng, Jing-Yi / Johnson, Stuart L / Carlton, Adam J / De Tomasi, Lara / Goodyear, Richard J / De Faveri, Francesca / Furness, David N / Wells, Sara / Brown, Steve D M / Holley, Matthew C / Richardson, Guy P / Mustapha, Mirna / Bowl, Michael R / Marcotti, Walter

    The Journal of physiology

    2020  Volume 598, Issue 18, Page(s) 3891–3910

    Abstract: Key points: Age-related hearing loss (ARHL) is a very heterogeneous disease, resulting from cellular senescence, genetic predisposition and environmental factors (e.g. noise exposure). Currently, we know very little about age-related changes occurring ... ...

    Abstract Key points: Age-related hearing loss (ARHL) is a very heterogeneous disease, resulting from cellular senescence, genetic predisposition and environmental factors (e.g. noise exposure). Currently, we know very little about age-related changes occurring in the auditory sensory cells, including those associated with the outer hair cells (OHCs). Using different mouse strains, we show that OHCs undergo several morphological and biophysical changes in the ageing cochlea. Ageing OHCs also exhibited the progressive loss of afferent and efferent synapses. We also provide evidence that the size of the mechanoelectrical transducer current is reduced in ageing OHCs, highlighting its possible contribution in cochlear ageing.
    Abstract: Outer hair cells (OHCs) are electromotile sensory receptors that provide sound amplification within the mammalian cochlea. Although OHCs appear susceptible to ageing, the progression of the pathophysiological changes in these cells is still poorly understood. By using mouse strains with a different progression of hearing loss (C57BL/6J, C57BL/6NTac, C57BL/6NTac
    MeSH term(s) Animals ; Cadherins ; Cochlea ; Hair Cells, Auditory, Outer ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Otoacoustic Emissions, Spontaneous
    Chemical Substances Cadherins ; Cdh23 protein, mouse
    Language English
    Publishing date 2020-07-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP279795
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Targeted Exome Sequencing Identifies

    Heidet, Laurence / Morinière, Vincent / Henry, Charline / De Tomasi, Lara / Reilly, Madeline Louise / Humbert, Camille / Alibeu, Olivier / Fourrage, Cécile / Bole-Feysot, Christine / Nitschké, Patrick / Tores, Frédéric / Bras, Marc / Jeanpierre, Marc / Pietrement, Christine / Gaillard, Dominique / Gonzales, Marie / Novo, Robert / Schaefer, Elise / Roume, Joëlle /
    Martinovic, Jelena / Malan, Valérie / Salomon, Rémi / Saunier, Sophie / Antignac, Corinne / Jeanpierre, Cécile

    Journal of the American Society of Nephrology : JASN

    2017  Volume 28, Issue 10, Page(s) 2901–2914

    Abstract: Congenital anomalies of the kidney and urinary tract (CAKUT) occur in three to six of 1000 live births, represent about 20% of the prenatally detected anomalies, and constitute the main cause of CKD in children. These disorders are phenotypically and ... ...

    Abstract Congenital anomalies of the kidney and urinary tract (CAKUT) occur in three to six of 1000 live births, represent about 20% of the prenatally detected anomalies, and constitute the main cause of CKD in children. These disorders are phenotypically and genetically heterogeneous. Monogenic causes of CAKUT in humans and mice have been identified. However, despite high-throughput sequencing studies, the cause of the disease remains unknown in most patients, and several studies support more complex inheritance and the role of environmental factors and/or epigenetics in the pathophysiology of CAKUT. Here, we report the targeted exome sequencing of 330 genes, including genes known to be involved in CAKUT and candidate genes, in a cohort of 204 unrelated patients with CAKUT; 45% of the patients were severe fetal cases. We identified pathogenic mutations in 36 of 204 (17.6%) patients. These mutations included five
    MeSH term(s) Cohort Studies ; DNA Mutational Analysis ; DNA-Binding Proteins/genetics ; Exome ; Female ; Humans ; Male ; Pre-B-Cell Leukemia Transcription Factor 1 ; Proto-Oncogene Proteins/genetics ; Urogenital Abnormalities/genetics
    Chemical Substances DNA-Binding Proteins ; Pre-B-Cell Leukemia Transcription Factor 1 ; Proto-Oncogene Proteins ; PBX1 protein, human
    Language English
    Publishing date 2017-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2017010043
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    Zs.A 3344: Show issues Location:
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  7. Article ; Online: Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice.

    De Tomasi, Lara / David, Pierre / Humbert, Camille / Silbermann, Flora / Arrondel, Christelle / Tores, Frédéric / Fouquet, Stéphane / Desgrange, Audrey / Niel, Olivier / Bole-Feysot, Christine / Nitschké, Patrick / Roume, Joëlle / Cordier, Marie-Pierre / Pietrement, Christine / Isidor, Bertrand / Khau Van Kien, Philippe / Gonzales, Marie / Saint-Frison, Marie-Hélène / Martinovic, Jelena /
    Novo, Robert / Piard, Juliette / Cabrol, Christelle / Verma, Ishwar C / Puri, Ratna / Journel, Hubert / Aziza, Jacqueline / Gavard, Laurent / Said-Menthon, Marie-Hélène / Heidet, Laurence / Saunier, Sophie / Jeanpierre, Cécile

    American journal of human genetics

    2017  Volume 101, Issue 5, Page(s) 803–814

    Abstract: Congenital anomalies of the kidney and urinary tract (CAKUT) constitute a major cause of chronic kidney disease in children and 20% of prenatally detected anomalies. CAKUT encompass a spectrum of developmental kidney defects, including renal agenesis, ... ...

    Abstract Congenital anomalies of the kidney and urinary tract (CAKUT) constitute a major cause of chronic kidney disease in children and 20% of prenatally detected anomalies. CAKUT encompass a spectrum of developmental kidney defects, including renal agenesis, hypoplasia, and cystic and non-cystic dysplasia. More than 50 genes have been reported as mutated in CAKUT-affected case subjects. However, the pathophysiological mechanisms leading to bilateral kidney agenesis (BKA) remain largely elusive. Whole-exome or targeted exome sequencing of 183 unrelated familial and/or severe CAKUT-affected case subjects, including 54 fetuses with BKA, led to the identification of 16 heterozygous variants in GREB1L (growth regulation by estrogen in breast cancer 1-like), a gene reported as a target of retinoic acid signaling. Four loss-of-function and 12 damaging missense variants, 14 being absent from GnomAD, were identified. Twelve of them were present in familial or simplex BKA-affected case subjects. Female BKA-affected fetuses also displayed uterus agenesis. We demonstrated a significant association between GREB1L variants and BKA. By in situ hybridization, we showed expression of Greb1l in the nephrogenic zone in developing mouse kidney. We generated a Greb1l knock-out mouse model by CRISPR-Cas9. Analysis at E13.5 revealed lack of kidneys and genital tract anomalies in male and female Greb1l
    MeSH term(s) Animals ; Child ; Congenital Abnormalities/genetics ; Exome/genetics ; Female ; Fetus/abnormalities ; Heterozygote ; Humans ; Kidney/abnormalities ; Kidney Diseases/congenital ; Kidney Diseases/genetics ; Male ; Membrane Proteins ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation/genetics ; Neoplasm Proteins/genetics ; Phenotype ; Proteins/genetics ; Urinary Tract/abnormalities ; Urogenital Abnormalities/genetics
    Chemical Substances GREB1 protein, human ; KIAA0575 protein, mouse ; Membrane Proteins ; Neoplasm Proteins ; Proteins
    Language English
    Publishing date 2017-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219384-x
    ISSN 1537-6605 ; 0002-9297
    ISSN (online) 1537-6605
    ISSN 0002-9297
    DOI 10.1016/j.ajhg.2017.09.026
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  8. Article ; Online: NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics.

    Nagy-Reis, Mariana / Oshima, Júlia Emi de Faria / Kanda, Claudia Zukeran / Palmeira, Francesca Belem Lopes / de Melo, Fabiano Rodrigues / Morato, Ronaldo Gonçalves / Bonjorne, Lilian / Magioli, Marcelo / Leuchtenberger, Caroline / Rohe, Fabio / Lemos, Frederico Gemesio / Martello, Felipe / Alves-Eigenheer, Milene / da Silva, Rafaela Aparecida / Silveira Dos Santos, Juliana / Priante, Camila Fátima / Bernardo, Rodrigo / Rogeri, Patricia / Assis, Julia Camara /
    Gaspar, Lucas Pacciullio / Tonetti, Vinicius Rodrigues / Trinca, Cristiano Trapé / Ribeiro, Adauto de Souza / Bocchiglieri, Adriana / Hass, Adriani / Canteri, Adriano / Chiarello, Adriano Garcia / Paglia, Adriano Pereira / Pereira, Adriele Aparecida / de Souza, Agnis Cristiane / Gatica, Ailin / Medeiro, Akyllam Zoppi / Eriksson, Alan / Costa, Alan Nilo / González-Gallina, Alberto / Yanosky, Alberto A / Jesus de la Cruz, Alejandro / Bertassoni, Alessandra / Bager, Alex / Bovo, Alex Augusto Abreu / Cravino Mol, Alexandra / Bezerra, Alexandra Maria Ramos / Percequillo, Alexandre / Vogliotti, Alexandre / Costa Lopes, Alexandre Martins / Keuroghlian, Alexine / Zúñiga Hartley, Alfonso Christopher / Devlin, Allison L / de Paula, Almir / García-Olaechea, Alvaro / Sánchez, Amadeo / Aquino, Ana Carla Medeiros Morato / Srbek-Araujo, Ana Carolina / Ochoa, Ana Cecilia / Tomazzoni, Ana Cristina / Lacerda, Ana Cristyna Reis / Bacellar, Ana Elisa de Faria / Campelo, Ana Kellen Nogueira / Herrera Victoria, Ana María / Paschoal, Ana Maria de Oliveira / Potrich, Ana Paula / Gomes, Ana Paula Nascimento / Olímpio, Ana Priscila Medeiros / Cunha Costa, Ana Raissa / Jácomo, Anah Tereza de Almeida / Calaça, Analice Maria / Jesus, Anamélia Souza / de Barros Barban, Ananda / Feijó, Anderson / Pagoto, Anderson / Rolim, Anderson Claudino / Hermann, Andiara Paula / Souza, Andiara Silos Moraes de Castro E / Chein Alonso, André / Monteiro, André / Mendonça, André Faria / Luza, André Luís / Moura, André Luis Botelho / da Silva, André Luiz Ferreira / Lanna, Andre Monnerat / Antunes, Andre Pinassi / Nunes, André Valle / Dechner, Andrea / Carvalho, Andrea Siqueira / Novaro, Andres Jose / Scabin, Andressa Barbara / Gatti, Andressa / Nobre, Andrezza Bellotto / Montanarin, Anelise / Deffaci, Ângela Camila / de Albuquerque, Anna Carolina Figueiredo / Mangione, Antonio Marcelo / Pinto, Antonio Millas Silva / Mendes Pontes, Antonio Rossano / Bertoldi, Ariane Teixeira / Calouro, Armando Muniz / Fernandes, Arthur / Ferreira, Arystene Nicodemo / Ferreguetti, Atilla Colombo / Rosa, Augusto Lisboa Martins / Banhos, Aureo / Francisco, Beatriz da Silva de Souza / Cezila, Beatriz Azevedo / Beisiegel, Beatriz de Mello / de Thoisy, Benoit / Ingberman, Bianca / Neves, Bianca Dos Santos / Pereira-Silva, Brenda / Bertagni de Camargo, Bruna / Andrade, Bruna da Silva / Santos, Bruna Silva / Leles, Bruno / Torres Parahyba Campos, Bruno Augusto / Kubiak, Bruno Busnello / França, Bruno Rodrigo de Albuquerque / Saranholi, Bruno Henrique / Pereira Mendes, Calebe / Cantagallo Devids, Camila / Pianca, Camila / Rodrigues, Camila / Islas, Camila Alvez / de Lima, Camilla Angélica / de Lima, Camilo Ribeiro / Gestich, Carla Cristina / Tedesco, Carla Denise / De Angelo, Carlos / Fonseca, Carlos / Hass, Carlos / Peres, Carlos A / Kasper, Carlos Benhur / Durigan, Carlos Cesar / Fragoso, Carlos Eduardo / Verona, Carlos Eduardo / Rocha, Carlos Frederico Duarte / Salvador, Carlos Henrique / Vieira, Carlos Leonardo / Ruiz, Carmen Elena Barragán / Cheida, Carolina Carvalho / Sartor, Caroline Charão / Espinosa, Caroline da Costa / Fieker, Carolline Zatta / Braga, Caryne / Sánchez-Lalinde, Catalina / Machado, Cauanne Iglesias Campos / Cronemberger, Cecilia / Luna, Cecília Licarião / Del Vechio, Christine / Bernardo, Christine Steiner S / Hurtado, Cindy Meliza / Lopes, Cíntia M / da Rosa, Clarissa Alves / Cinta, Claudia Cristina / Costa, Claudia Guimaraes / Zárate-Castañeda, Claudia Paola / Novaes, Claudio Leite / Jenkins, Clinton N / Seixas, Cristiana Simão / Martin, Cristiane / Zaniratto, Cristiane Patrícia / López-Fuerte, Cristina Fabiola / da Cunha, Cristina Jaques / De-Carvalho, Crizanto Brito / Chávez, Cuauhtémoc / Santos, Cyntia Cavalcante / Polli, Daiana Jeronimo / Buscariol, Daiane / Carreira, Daiane Cristina / Galiano, Daniel / Thornton, Daniel / Ferraz, Daniel da Silva / Lamattina, Daniela / Moreno, Daniele Janina / Moreira, Danielle Oliveira / Farias, Danilo Augusto / Barros-Battesti, Darci Moraes / Tavares, Davi Castro / Costa Braga, David / Gaspar, Denise Alemar / Friedeberg, Diana / Astúa, Diego / Silva, Diego Afonso / Viana, Diego Carvalho / Lizcano, Diego J / Varela, Diego M / Loretto, Diogo / Gräbin, Diogo Maia / Eaton, Donald P / Machado da Silva, Douglas / Dias, Douglas de Matos / Camara, Edeltrudes Maria Valadares Calaça / Barbier, Eder / Chávez-González, Edgar / Rocha, Ednaldo Cândido / Lima, Edson de Souza / Carrano, Eduardo / Eizirik, Eduardo / Nakano-Oliveira, Eduardo / Rigacci, Eduardo Delgado / Santos, Eduardo Marques / Venticinque, Eduardo Martins / Alexandrino, Eduardo Roberto / Abreu Ribeiro, Edvandro / Setz, Eleonore / Rocha, Eliana César Laranjeira Duarte / Carvalho, Elildo Alves Ribeiro / Rechenberg, Elisabete / Fraga, Elmary da Costa / Mendonça, Eloisa Neves / D'Bastiani, Elvira / Isasi-Catalá, Emiliana / Guijosa-Guadarrama, Emiliano / Ramalho, Emiliano Esterci / González, Enrique / Hasui, Érica / Saito, Erica Naomi / Fischer, Erich / Aguiar, Erick Francisco / Rocha, Erick Sekiama / Martínez Nambo, Erik Daniel / de la Peña-Cuéllar, Erika / Castro, Érika Paula / de Freitas, Evellyn Borges / Pedó, Ezequiel / Rocha, Fabiana Lopes / Girardi, Fabiane / Pereira, Fabiane de Aguiar / Soares, Fábio Angelo Melo / Roque, Fabio de Oliveira / Díaz-Santos, Fabio Gabriel / Patiu, Fabio Mello / do Nascimento, Fabio Oliveira / Keesen Ferreira, Fabíola / Diaz-Santos, Fabricio / Moreli Fantacini, Felipe / Pedrosa, Felipe / Pessoa da Silva, Felipe / Velez-Garcia, Felipe / Gomes, Felipe Bittioli R / Guedes da Silva, Fernanda / Michalski, Fernanda / de Azevedo, Fernanda Cavalcanti / de Barros, Fernanda Cristina / Santos, Fernanda da Silva / Abra, Fernanda Delborgo / Ramalho, Fernanda do Passo / Hatano, Fernanda Martins / Anaguano-Yancha, Fernando / Gonçalves, Fernando / Pedroni, Fernando / Passos, Fernando C / Jacinavicius, Fernando de Castro / Bonfim, Fernando César Gonçalves / Puertas, Fernando Henrique / Contreras-Moreno, Fernando M / Tortato, Fernando Rodrigo / Santos, Filipe Martins / Chaves, Flávia Guimarães / Tirelli, Flavia Pereira / Vilas Boas, Flávio Eduardo / Rodrigues, Flavio Henrique Guimarães / Ubaid, Flávio Kulaif / Grotta-Neto, Francisco / Palomares, Francisco / Souza, Franco Leandro / Costa, Francys Emanuelle / França, Frederico G R / Ramírez Pinto, Fredy / Aguiar, Gabriel Lima / Hofmann, Gabriel Selbach / Heliodoro, Gabriela / Duarte, Gabriela Teixeira / Ribeiro de Andrade, Gabrielle / Beca, Gabrielle / Zapata-Ríos, Galo / Giné, Gastón Andrés Fernandez / Powell, George V N / Wilson Fernandes, Geraldo / Forero-Medina, German / Melo, Geruza L / Santana, Gindomar Gomes / Ciocheti, Giordano / Alves, Giselle Bastos / Souto, Glauber Henrique Borges de Oliveira / Villarroel, Glenda Jéssica / Porfirio, Grasiela Edith de Oliveira / Batista, Graziele Oliveira / Behling, Greici Maia / Ayala Crespo, Guido Marcos / Mourão, Guilherme de Miranda / Rezende, Guilherme Zamarian / Toledo, Gustavo Alves da Costa / Herrera, Heitor Miraglia / Alves Prado, Helena / Bergallo, Helena de Godoy / Secco, Helio / Rajão, Henrique / Roig, Henrique Llacer / Concone, Henrique Villas Boas / Duarte, Herbert / Ermenegildo, Hiago / Ferreira Paulino Neto, Hipólito / Quigley, Howard / Lemos, Hudson Macedo / Cabral, Hugo / Fernandes-Ferreira, Hugo / Del Castillo, Hugo Fernando / Ribeiro, Igor Kintopp / Coelho, Igor Pfeifer / Franceschi, Ingridi Camboim / Melo, Isabel / Oliveira-Bevan, Isabella / Mourthe, Italo / Bernardi, Itiberê / de la Torre, J Antonio / Marinho-Filho, Jader / Martinez, Jaime / Palacios Perez, Jaime Xavier / Pérez-Torres, Jairo / Bubadué, Jamile / Silveira, Jana Rangel / Seibert, Jardel Brandão / Oliveira, Jasmim Felipe / Assis, Jasmine Resende / De la Maza, Javier / Hinojosa, Javier / Metzger, Jean Paul / Thompson, Jeffrey James / Svenning, Jens-Christian / Gouvea, Jéssica Abonizio / Souza, Jesus Rodrigues Domingos / Pincheira-Ulbrich, Jimmy / Nodari, Joana Zorzal / Miranda, João / Zecchini Gebin, João Carlos / Giovanelli, João Gabriel Ribeiro / Rossi Junior, João Luiz / Pandini Favoretti, João Paulo / Villani, João Paulo / Just, João Paulo Gava / Souza-Alves, João Pedro / Costa, Jociel Ferreira / Rocha, Joedison / Polisar, John / Sponchiado, Jonas / Cherem, Jorge José / Marinho, Jorge Reppold / Ziegler, Jörn / Cordeiro, José / de Sousa E Silva Júnior, José / Rodriguez-Pulido, Jose Ariel / Chaves Dos Santos, José Carlos / Dos Reis Júnior, José Clemensou / Mantovani, Jose Eduardo / Moreira Ramírez, José Fernando / Sarasola, José Hernán / Cartes, Jose Luis / Duarte, José Maurício Barbanti / Longo, Jose Milton / Dantas, José Oliveira / Venancio, José Otávio / de Matos, Jose Roberto / Pires, José Salatiel Rodrigues / Hawes, Joseph E / Santos, Joyce Gonçalves / Ruiz-Esparza, Juan / Martínez Lanfranco, Juan Andrés / Rudolf, Juan Carlos / Charre-Medellin, Juan Felipe / Zanón-Martínez, Juan Ignacio / Peña-Mondragón, Juan L / Campos Krauer, Juan Manuel / Arrabal, Juan Pablo / Beduschi, Julia / Ilha, Júlia / Mata, Julia Carolina / Bonanomi, Juliana / Jordao, Juliana / de Almeida-Rocha, Juliana Monteiro / Pereira-Ribeiro, Juliane / Zanoni, Juliani Bruna / Bogoni, Juliano André / Chacón Pacheco, Julio Javier / Contreras Palma, Kamila Marianne / Strier, Karen B / Rodriguez Castro, Karen Giselle / Didier, Karl / Schuchmann, Karl L / Chávez-Congrains, Karla / Burs, Kathrin / Ferraz, Katia M P M B / Juarez, Keila Macfadem / Flesher, Kevin / Morais, Kimberly Danielle Rodrigues / Lautenschlager, Laís / Grossel, Laís Aline / Dahmer, Lais Camila / de Almeida, Lana Resende / Fornitano, Larissa / Barbosa, Larissa de Nazaré Barros / Bailey, Larissa L / Barreto, Larissa Nascimento / Villalba, Laura Magnolia / Magalhães, Laura Martins / Cullen, Laury / Marques, Leandro / Marques Costa, Leonardo / Silveira, Leandro / Moreira, Leandro Santana / Sartorello, Leonardo / Oliveira, Leonardo de Carvalho / Gomes, Leonardo de Paula / Aguiar, Leonardo Dos Santos / da Silva, Leonardo Henrique / Mendonça, Leonardo Siqueira / Valenzuela, Leonor Adriana / Benavalli, Letícia / Dias, Leticia Coutinho Sangy / Munhoes, Leticia Prado / Catenacci, Lilian / Rampim, Lilian Elaine / de Paula, Lívia Maria / Nascimento, Lorena Anne / Gonçalves da Silva, Lucas / Quintilham, Lucas / Ramis Segura, Lucas / Perillo, Lucas Neves / Rezende, Lucas Rodrigo / Martínez Retta, Lucía / Rojas, Lucia Nathaly Stefany / Guimarães, Luiza Neves / Araújo, Luciana / Zago da Silva, Luciana / Querido, Luciano Carramaschi de Alagão / Verdade, Luciano Martins / Perera-Romero, Lucy E / Carvalho-Leite, Ludimila Juliele / Hufnagel, Ludmila / Rezende Bernardo, Luis Renato / Oliveira, Luiz Flamarion / Oliveira Santos, Luiz Gustavo Rodrigues / Lyra, Luiz Henrique / Borges, Luiz Henrique Medeiros / Severo, Magnus Machado / Benchimol, Maíra / Quatrocchi, Maira Giuliana / Martins, Maísa Ziviani Alves / Rodrigues, Manoel / Penteado, Marcel José Franco / Figuerêdo Duarte Moraes, Marcela / Oliveira, Marcela Alvares / Lima, Marcela Guimarães Moreira / Pônzio, Marcella do Carmo / Cervini, Marcelo / da Silva, Marcelo / Passamani, Marcelo / Villegas, Marcelo Alejandro / Dos Santos Junior, Marcelo Augusto / Yamane, Marcelo Hideki / Jardim, Marcia Maria de Assis / Leite de Oliveira, Márcio / Silveira, Marcos / Tortato, Marcos Adriano / Figueiredo, Marcos de Souza Lima / Vieira, Marcus Vinícius / Sekiama, Margareth L / Andrade da Silva, Maria Augusta / Nuñez, María Beatriz / Siviero, Maria Brunini / Carrizo, María Celina / Barros, Maria Claudene / Barros, Marília A S / do Rosário, Maria Cristina Ferreira / Peñuela Mora, María Cristina / Fleytas Jover, Maria Del Carmen / Morandi, Maria Elisa de Freitas / Huerta, Maria Emilia / Fernandes, Maria Emília Avelar / Viscarra Siñani, Maria Estela / Iezzi, María Eugenia / Ramos Pereira, Maria João / Gomez Vinassa, Maria Laura / Lorini, Maria Lucia / Jorge, Maria Luisa S P / Morini, Maria Santina / Guenther, Mariana / Landis, Mariana Bueno / Vale, Mariana M / Xavier, Mariana Sampaio / Tavares, Mariana Silva / Kaizer, Mariane / Velilla, Marianela / Bergel, Mariano Maudet / Hartmann, Marilia Teresinha / Lima da Silva, Marina / Rivero, Marina / Salles Munerato, Marina / Xavier da Silva, Marina / Zanin, Marina / Marques, Marinêz Isaac / Haberfeld, Mario / Di Bitetti, Mario S / Bowler, Mark / Galliez, Maron / Ortiz-Moreno, Martha Lucia / Buschiazzo, Martin / Montes, Martin Alejandro / Alvarez, Martín R / Melo-Dias, Mateus / Reis, Matheus Gonçalves / Corrêa, Matheus Rocha Jorge / Tobler, Mathias W / Gompper, Matthew E / Nunez-Regueiro, Mauricio / Brandão Vecchi, Maurício / Graipel, Maurício Eduardo / Godoi, Mauricio Neves / Moura, Mauricio O / Konzen, Maurício Quoos / Pardo, Maximiliano Víctor / Beltrão, Mayara Guimarães / Mongelli, Melissa / Almeida, Meyline Oliveira / Gilmore, Michael P / Schutte, Michel / Faria, Michel Barros / Luiz, Micheli Ribeiro / de Paula, Milton / Hidalgo-Mihart, Mircea G / Perilli, Miriam Lucia Lages / Freitas-Junior, Mozart Caetano / da Silva, Murillo Prado / Denkiewicz, Natalia Mariana / Torres, Natalia Mundim / Olifiers, Natalie / De Lima, Natani Da Silva / de Albuquerque, Natasha Moraes / Canassa, Nathália Fernandes / de Almeida Curi, Nelson Henrique / Prestes, Nêmora Pauletti / Falconi, Nereyda / Gurgel-Filho, Newton Mota / Pasqualotto, Nielson / Cáceres, Nilton C / Peroni, Nivaldo / de la Sancha, Noé U / Zanella, Noeli / Monroy-Vilchis, Octavio / Pays, Olivier / Arimoro, Omolabake Alhambra / Ribeiro, Otávio Santi / Villalva, Pablo / Gonçalves, Pablo Rodrigues / Santos, Paloma Marques / Brennand, Pamella / Rocha, Patrício / Akkawi, Paula / Cruz, Paula / Ferreira, Paula Modenesi / Prist, Paula Ribeiro / Martin, Paula Sanches / Arroyo-Gerala, Paulina / Auricchio, Paulo / Hartmann, Paulo Afonso / Antas, Paulo de Tarso Zuquim / Camargo, Paulo H S A / Marinho, Paulo Henrique / Ruffino, Paulo Henrique Peira / Prado, Paulo Inácio / Martins, Paulo Wesley / Cordeiro-Estrela, Pedro / Luna, Pedro / Sarmento, Pedro / Faria Peres, Pedro Henrique / Galetti, Pedro Manoel / de Castilho, Pedro Volkmer / Renaud, Pierre-Cyril / Scarascia, Pietro Oliveira / Cobra, Priscilla De Paula Andrade / Lombardi, Pryscilla Moura / Bessa, Rafael / Reyna-Hurtado, Rafael / de Souza, Rafael Cerqueira Castro / Hoogesteijn, Rafael Jan / Alves, Rafael Souza Cruz / Romagna, Rafael Spilere / Silva, Ramon Lima / de Oliveira, Ramonna / Beltrão-Mendes, Raone / Alencar, Raony de Macêdo / Coutinho, Raphaella / da Silva, Raquel Costa / Caribé Grando, Raquel L S C / Matos, Rayanne Gama / Araujo, Raylenne da Silva / Pedroso, Rayssa Faria / Durães, Rayssa Mainette Nantes / Ribeiro, Renan Lieto Alves / Chagas, Renata / Miotto, Renata / Twardowsky Ramalho Bonikowski, Renata / Muylaert, Renata Lara / Pagotto, Renata Valls / Hilário, Renato Richard / Faria, Rhayssa Terra / Bassini-Silva, Ricardo / Sampaio, Ricardo / Sartorello, Ricardo / Pires, Ricardo Araújo / Hatakeyama, Richard / Bianchi, Rita de Cassia / Buitenwerf, Robert / Wallace, Robert / Paolino, Roberta Montanheiro / Fusco-Costa, Roberto / Trovati, Roberto Guilherme / Tomasi, Roberto Junior / Espíndola Hack, Robson Odeli / Magalhães, Rodolfo Assis / Nobrega, Rodrigo Affonso de Albuquerque / Nobre, Rodrigo de Almeida / Massara, Rodrigo Lima / Fróes, Rodrigo Medina / Araújo, Rodrigo Paulo da Cunha / León Pérez, Rodrigo Raúl / Jorge, Rodrigo Silva Pinto / de Paula, Rogério Cunha / Martins, Rogério / da Cunha, Rogério Grassetto Teixeira / Costa, Rômulo / Alves, Romulo Romeu Nobrega / Garcia-Anleu, Rony / Santos Almeida, Rony Peterson / Cueva Loachamín, Rubén Darío / Andrade, Rúbia Santana / Juárez, Rugieri / Bordallo, Samanta Uchôa / Guaragni, Samara Arsego / Carrillo-Percastegui, Samia E / Seber, Samile / Astete, Samuel / Hartz, Sandra Maria / Espinosa, Santiago / Álvarez Solas, Sara / Ramos Lima, Saulo / Silvestre, Saulo Meneses / Machado, Sávio Augusto de Souza / Keuroghlian-Eaton, Sean / Albanesi, Sebastian / Costa, Sebastián Andrés / Bazilio, Sergio / Mendes, Sergio Lucena / Althoff, Sérgio Luiz / Pinheiro, Shery Duque / Napiwoski, Silvio Junior / Fernández Ramirez, Sixto / Talamoni, Sonia Aparecida / Age, Stefani Gabrieli / Pereira, Taiguã Corrêa / Moreira, Tainah Cruz / Trigo, Tatiane Campos / Gondim, Tayana Mendonça da Silva / Karlovic, Thamíris Christina / Cavalcante, Thiago / Maccarini, Thiago / Rodrigues, Thiago Ferreira / de Camargo E Timo, Thiago Philipe / Monterrubio, Tiberio Cesar / Piovezan, Ubiratan / Cavarzere, Vagner / Towns, Valeria / Onofrio, Valeria Castilho / Oliveira, Valeska Buchemi / Araújo, Valquíria Cabral / Melo, Vanessa Lazaro / Kanaan, Vanessa Tavares / Iwakami, Victor / Vale, Victor / Picinatto Filho, Vilmar / Alberici, Vinicius / Bastazini, Vinicius A G / Orsini, Vinícius Santana / Braz, Vivian da Silva / Rojas Bonzi, Viviana B / Guedes Layme, Viviane Maria / Gaboardi, Viviane Telles Rodrigues / Rocha, Vlamir José / Martins, Waldney Pereira / Tomas, Walfrido Moraes / Hannibal, Wellington / Dáttilo, Wesley / Silva, Wesley R / Endo, Whaldener / Bercê, William / Bravata de la Cruz, Yaribeth / Ribeiro, Yuri Geraldo Gomes / Galetti, Mauro / Ribeiro, Milton C

    Ecology

    2020  Volume 101, Issue 11, Page(s) e03128

    Abstract: Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide ... ...

    Abstract Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data.
    MeSH term(s) Animals ; Canidae ; Carnivora ; Ecosystem ; Humans ; Mustelidae ; Ursidae
    Language English
    Publishing date 2020-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2010140-5
    ISSN 1939-9170 ; 0012-9658
    ISSN (online) 1939-9170
    ISSN 0012-9658
    DOI 10.1002/ecy.3128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Rationale and design of an independent randomised controlled trial evaluating the effectiveness of aripiprazole or haloperidol in combination with clozapine for treatment-resistant schizophrenia.

    Nosè, Michela / Accordini, Simone / Artioli, Paola / Barale, Francesco / Barbui, Corrado / Beneduce, Rossella / Berardi, Domenico / Bertolazzi, Gerardo / Biancosino, Bruno / Bisogno, Alfredo / Bivi, Raffaella / Bogetto, Filippo / Boso, Marianna / Bozzani, Alberto / Bucolo, Piera / Casale, Marcello / Cascone, Liliana / Ciammella, Luisa / Cicolini, Alessia /
    Cipresso, Gabriele / Cipriani, Andrea / Colombo, Paola / Dal Santo, Barbara / De Francesco, Michele / Di Lorenzo, Giorgio / Di Munzio, Walter / Ducci, Giuseppe / Erlicher, Arcadio / Esposito, Eleonora / Ferrannini, Luigi / Ferrato, Farida / Ferro, Antonio / Fragomeno, Nicoletta / Parise, Vincenzo Fricchione / Frova, Maria / Gardellin, Francesco / Garzotto, Nicola / Giambartolomei, Andrea / Giupponi, Giancarlo / Grassi, Luigi / Grazian, Natalia / Grecu, Lorella / Guerrini, Gualtiero / Laddomada, Francesco / Lazzarin, Ermanna / Lintas, Camilla / Malchiodi, Francesca / Malvini, Lara / Marchiaro, Livio / Marsilio, Alessandra / Mauri, Massimo Carlo / Mautone, Antonio / Menchetti, Marco / Migliorini, Giuseppe / Mollica, Marco / Moretti, Daniele / Mulè, Serena / Nicholau, Stylianos / Nosè, Flavio / Occhionero, Guglielmo / Pacilli, Anna Maria / Pecchioli, Stefania / Percudani, Mauro / Piantato, Ennio / Piazza, Carlo / Pontarollo, Francesco / Pycha, Roger / Quartesan, Roberto / Rillosi, Luciana / Risso, Francesco / Rizzo, Raffella / Rocca, Paola / Roma, Stefania / Rossattini, Matteo / Rossi, Giuseppe / Rossi, Giovanni / Sala, Alessandra / Santilli, Claudio / Saraò, Giuseppe / Sarnicola, Antonio / Sartore, Francesca / Scarone, Silvio / Sciarma, Tiziana / Siracusano, Alberto / Strizzolo, Stefania / Tansella, Michele / Targa, Gino / Tasser, Annamarie / Tomasi, Rodolfo / Travaglini, Rossana / Veronese, Antonio / Ziero, Simona

    Trials

    2009  Volume 10, Page(s) 31

    Abstract: Background: One third to two thirds of people with schizophrenia have persistent psychotic symptoms despite clozapine treatment. Under real-world circumstances, the need to provide effective therapeutic interventions to patients who do not have an ... ...

    Abstract Background: One third to two thirds of people with schizophrenia have persistent psychotic symptoms despite clozapine treatment. Under real-world circumstances, the need to provide effective therapeutic interventions to patients who do not have an optimal response to clozapine has been cited as the most common reason for simultaneously prescribing a second antipsychotic drug in combination treatment strategies. In a clinical area where the pressing need of providing therapeutic answers has progressively increased the occurrence of antipsychotic polypharmacy, despite the lack of robust evidence of its efficacy, we sought to implement a pre-planned protocol where two alternative therapeutic answers are systematically provided and evaluated within the context of a pragmatic, multicentre, independent randomised study.
    Methods/design: The principal clinical question to be answered by the present project is the relative efficacy and tolerability of combination treatment with clozapine plus aripiprazole compared with combination treatment with clozapine plus haloperidol in patients with an incomplete response to treatment with clozapine over an appropriate period of time. This project is a prospective, multicentre, randomized, parallel-group, superiority trial that follow patients over a period of 12 months. Withdrawal from allocated treatment within 3 months is the primary outcome.
    Discussion: The implementation of the protocol presented here shows that it is possible to create a network of community psychiatric services that accept the idea of using their everyday clinical practice to produce randomised knowledge. The employed pragmatic attitude allowed to randomly allocate more than 100 individuals, which means that this study is the largest antipsychotic combination trial conducted so far in Western countries. We expect that the current project, by generating evidence on whether it is clinically useful to combine clozapine with aripiprazole rather than with haloperidol, provides physicians with a solid evidence base to be directly applied in the routine care of patients with schizophrenia.
    MeSH term(s) Antipsychotic Agents/therapeutic use ; Aripiprazole ; Clinical Protocols ; Clozapine/therapeutic use ; Drug Resistance ; Drug Therapy, Combination ; Government Regulation ; Haloperidol/therapeutic use ; Humans ; Italy ; Piperazines/therapeutic use ; Prospective Studies ; Quinolones/therapeutic use ; Research Design/legislation & jurisprudence ; Schizophrenia/drug therapy ; Schizophrenic Psychology ; Treatment Outcome
    Chemical Substances Antipsychotic Agents ; Piperazines ; Quinolones ; Aripiprazole (82VFR53I78) ; Clozapine (J60AR2IKIC) ; Haloperidol (J6292F8L3D)
    Language English
    Publishing date 2009-05-15
    Publishing country England
    Document type Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/1745-6215-10-31
    Database MEDical Literature Analysis and Retrieval System OnLINE

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