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  1. Article: Human Saposin B Ligand Binding and Presentation to α-Galactosidase A.

    Sawyer, Thomas K / Aral, Efecan / Staros, James V / Bobst, Cedric E / Garman, Scott C

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Sphingolipid activator protein B (saposin B; SapB) is an essential activator ...

    Abstract Sphingolipid activator protein B (saposin B; SapB) is an essential activator of globotriaosylceramide (Gb3) catabolism by α-galactosidase A. However, the manner by which SapB stimulates α-galactosidase A activity remains unknown. To uncover the molecular mechanism of SapB presenting Gb3 to α-galactosidase A, we subjected the fluorescent substrate globotriaosylceramide-nitrobenzoxidazole (Gb3-NBD) to a series of biochemical and structural assays involving SapB. First, we showed that SapB stably binds Gb3-NBD using a fluorescence equilibrium binding assay, isolates Gb3-NBD from micelles, and facilitates α-galactosidase A cleavage of Gb3-NBD
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.04.584535
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  2. Article ; Online: ATP11C promotes the differentiation of pre-B cells into immature B cells but does not affect their IL-7-dependent proliferation.

    Yabas, Mehmet / Bostanci, Ayten / Aral, Seda

    Immunologic research

    2023  Volume 71, Issue 4, Page(s) 609–616

    Abstract: ... fully understood. So far, ATP11C was shown to be important for B cells, and mice deficient for ATP11C ... had a developmental arrest at the pro-B to pre-B cell transition stage of B cell development. Using ... an ATP11C-deficient pre-B cell line generated through CRISPR/Cas9 engineering, we here tested the role ...

    Abstract The P4-type ATPases are believed to function as flippases that contribute to the organization of the asymmetric aminophospholipid distribution on the plasma membranes of eukaryotes by their ability to internalize specific phospholipids from the outer leaflet to the inner leaflet. Despite the existence of 14 members of the P4-type ATPases in humans and 15 in mice, their roles in the immune system have not been fully understood. So far, ATP11C was shown to be important for B cells, and mice deficient for ATP11C had a developmental arrest at the pro-B to pre-B cell transition stage of B cell development. Using an ATP11C-deficient pre-B cell line generated through CRISPR/Cas9 engineering, we here tested the role of ATP11C in pre-B cells in vitro and showed that ablation of ATP11C in pre-B cells causes a defect in the flippase activity. We further demonstrated that loss of ATP11C does not impede the proliferation of pre-B cells in response to IL-7. However, pre-B cells lacking ATP11C failed to differentiate into immature B cells upon removal of IL-7. These results suggest that disruption of lipid asymmetry by loss of ATP11C in pre-B cells may control the switch from proliferation to differentiation in pre-B cells.
    MeSH term(s) Humans ; Mice ; Animals ; Precursor Cells, B-Lymphoid/metabolism ; Interleukin-7/metabolism ; Adenosine Triphosphatases/metabolism ; Cell Differentiation ; Cell Proliferation ; Membrane Transport Proteins/metabolism
    Chemical Substances Interleukin-7 ; Adenosine Triphosphatases (EC 3.6.1.-) ; ATP11C protein, human (EC 3.6.1.-) ; Membrane Transport Proteins ; ATP11C protein, mouse (EC 3.6.1.-)
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1007/s12026-023-09364-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1755: Show issues Location:
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  3. Article ; Online: Thyroid hormone resistance with succinate dehydrogenase-B gene mutation.

    Erel, Cansu / Cakmak, Ramazan / Hacisahinogullari, Hulya / Artan, Selay / Kubat Uzum, Ayse / Aral, Ferihan / Tanakol, Refik / Yazici, Hulya

    Minerva endocrinology

    2021  Volume 47, Issue 2, Page(s) 137–139

    MeSH term(s) Humans ; Mutation ; Paraganglioma/genetics ; Succinate Dehydrogenase/genetics ; Thyroid Hormone Resistance Syndrome/genetics
    Chemical Substances Succinate Dehydrogenase (EC 1.3.99.1)
    Language English
    Publishing date 2021-11-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062786-2
    ISSN 2724-6116
    ISSN (online) 2724-6116
    DOI 10.23736/S2724-6507.21.03602-2
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    Zs.A 2105: Show issues Location:
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  4. Article: Potential added value of a RT-qPCR method of SOX 11 expression, in the context of a multidisciplinary diagnostic assessment of B cell malignancies.

    Magne, Julien / Jenvrin, Alizée / Chauchet, Adrien / Casasnovas, Olivier / Donzel, Anne / Jego, Laurence / Aral, Bernard / Guy, Julien / Nadal, Nathalie / Vernerey, Dewi / Callier, Patrick / Garnache-Ottou, Francine / Ferrand, Christophe

    Experimental hematology & oncology

    2018  Volume 7, Page(s) 5

    Abstract: ... in mantle cell lymphoma and other B cell malignancies with the proper reference gene; secondly, to define the best ...

    Abstract Background: Expression of SRY [sex-determining region Y]-box11 (SOX11) is specific to mantle cell lymphoma (MCL) and contributes, in conjunction with immunoglobulin variable heavy chain gene mutation status, to the identification of two forms of this disease.
    Methods: The aim of this report was firstly, to design an easy and suitable RT-qPCR method to quantify SOX11 mRNA expression in mantle cell lymphoma and other B cell malignancies with the proper reference gene; secondly, to define the best threshold of relative quantity of SOX11 mRNA in order to reach the best compromise between sensitivity and specificity.
    Results: For best discrimination of MCL and non-MCL groups we determined an area under the curve (AUC) of 0.9750 and a threshold of 1.76 with 100% sensitivity and 88% specificity. AUC and threshold values of respectively 0.91/1.346 [87% sensitivity, 80% specificity] and 0.9525/1.7120 [100% sensitivity, 88% specificity] for GAPDH and RPLP0 respectively denote that the RPLP0 reference gene alone is sufficient for PCR housekeeping gene.
    Conclusion: This work describes an RT-qPCR assay for SOX11 expression in order to better characterize MCL at diagnosis. Further studies on larger cohorts are needed to evaluate this molecular tool, especially for the follow-up of minimal residual disease.
    Language English
    Publishing date 2018-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2669066-4
    ISSN 2162-3619
    ISSN 2162-3619
    DOI 10.1186/s40164-018-0097-6
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  5. Article ; Online: Characteristics of Women with Postpartum Hemorrhage who do not Respond to B-Lynch Suture and Require Hysterectomy

    Fazilet Kübra Boynukalın / Ayşe İlknur ARAL

    Gorm, Vol 20, Iss

    2016  Volume 1

    Abstract: ... requirement of B-Lynch suture for intractable postpartum hemorrhage (PPH) due to uterine atony after vaginal ... cases that B-Lynch suture was performed for intractable PPH due to uterine atony after vaginal delivery ... In group 1 there were 12 cases that B-Lynch suture was failed and lead to hysterectomy and in group 2 there ...

    Abstract OBJECTIVE: Aim of this study is to criticize the women with postpartum hemorrhage due to uterine atony after vaginal delivery. STUDY DESIGN: This was a retrospective analysis performed in Şanlıurfa Maternity Hospital, from September 2008 to August 2010. Criteria for inclusion of the patients in the study were requirement of B-Lynch suture for intractable postpartum hemorrhage (PPH) due to uterine atony after vaginal delivery. The cases were identified by searching operating room records and patient files. There were 51 cases that B-Lynch suture was performed for intractable PPH due to uterine atony after vaginal delivery. In group 1 there were 12 cases that B-Lynch suture was failed and lead to hysterectomy and in group 2 there were 39 patients that B-Lynch suture achieved to cease the hemorrhage. RESULTS: In group 1; the mean age, gravidity and parity of women were 31±4.8, 5.2±2 and 3.8±2.2 respectively. Several high-risk antenatal obstetric to conditions were observed in 8 of 12 (66.7%) women. Induction or augmentation of labor was performed all of the patients who required hysterectomy. In group 2; the mean age, gravidity and parity of women were 26.5±5.5, 3.6±1.9 and 2.3±1.9 respectively. Induction or augmentation of labor was performed 8 of 39 women (20.1%) in group 2. CONCLUSION: Multiparity and induction or augmentation of labor seems to be the major characteristics of women who required hysterectomy after failed B-Lynch suture.
    Keywords Postpartum hemorrhage ; B-Lynch suture ; Postpartum hysterectomy ; Medicine ; R ; Gynecology and obstetrics ; RG1-991
    Subject code 610
    Language English
    Publishing date 2016-04-01T00:00:00Z
    Publisher Medical Network
    Document type Article ; Online
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  6. Article: Optimal reconstruction of historical water supply to a distribution system: B. Applications.

    Aral, M M / Guan, J / Maslia, M L / Sautner, J B / Gillig, R E / Reyes, J J / Williams, R C

    Journal of water and health

    2004  Volume 2, Issue 3, Page(s) 137–156

    Abstract: In a recently completed case-control epidemiological study, the New Jersey Department of Health and Senior Services (NJDHSS) with support from the Agency for Toxic Substances and Disease Registry (ATSDR) documented an association between prenatal ... ...

    Abstract In a recently completed case-control epidemiological study, the New Jersey Department of Health and Senior Services (NJDHSS) with support from the Agency for Toxic Substances and Disease Registry (ATSDR) documented an association between prenatal exposure to a specific contaminated community water source and leukaemia in female children. An important and necessary step in the epidemiological study was the reconstruction of the historical water supply strategy of the water distribution system serving the Dover Township area, New Jersey. The sensitivity of solutions to: (1) pressure and pattern factor constraints, (2) allowable operational extremes of water levels in the storage tanks, and (3) the non-uniqueness of the water supply solution are analysed in detail. The computational results show that the proposed approach yields satisfactory results for the complete set of monthly simulations and sensitivity analyses, providing a consistent approach for identifying the historical water supply strategy of the water distribution system. Sensitivity analyses indicated that the alternative strategy obtained from the revised objective function and the variation of constraints did not yield significantly different water supply characteristics. The overall analysis demonstrates that the progressive optimality genetic algorithm (POGA) developed to solve the optimization problem is an effective and efficient algorithm for the reconstruction of water supply strategies in water distribution systems.
    MeSH term(s) Algorithms ; Child ; Female ; Humans ; Leukemia/chemically induced ; Leukemia/epidemiology ; Maternal Exposure/adverse effects ; Models, Genetic ; New Jersey/epidemiology ; Risk Assessment/methods ; Sanitary Engineering ; Sensitivity and Specificity ; Time Factors ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/toxicity ; Water Supply/analysis ; Water Supply/statistics & numerical data
    Chemical Substances Water Pollutants, Chemical
    Language English
    Publishing date 2004-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2123845-5
    ISSN 1996-7829 ; 1477-8920
    ISSN (online) 1996-7829
    ISSN 1477-8920
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    Z 7513: Show issues

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  7. Article ; Online: Oxidative Stress in Patients with Chronic Hepatitis B and C

    Pınar Çıragil / Ergül Belge Kurutaş / Ömer Faruk Kökoğlu / Murat Aral

    Balkan Medical Journal, Vol 28, Iss 03, Pp 300-

    2011  Volume 303

    Abstract: Objective: Hepatitis B and hepatitis C virus infections are extensively seen throughout the world ... with chronic hepatitis B (CHB) and C (CHC).Material and Methods: Twenty patients with CHB, 20 with CHC and 30 ...

    Abstract Objective: Hepatitis B and hepatitis C virus infections are extensively seen throughout the world. Disturbances in the antioxidant system and oxidative stress may play a role in the pathogenesis of chronic liver diseases. The aim of this study was to evaluate the oxidant/antioxidant status in the serum of patients with chronic hepatitis B (CHB) and C (CHC).Material and Methods: Twenty patients with CHB, 20 with CHC and 30 healthy volunteers were included in this study. Catalase (CAT), superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels were measured in all patients and control group specthrophotometrically.Results: While CAT and SOD activities were significantly lower in patients with CHC, these enzymes were significantly higher in patients with CHB compared to controls. However, MDA levels were increased in each patient group as compared to the control group. Also, antioxidant enzyme activities were found to be significantly lower and MDA levels were higher in patients with CHC, compared to patients with CHB.Conclusion: We considered that insufficiency of antioxidant barrier may cause oxidative stress in patients with CHB and CHC, so antioxidant treatment should be useful for these patients.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2011-09-01T00:00:00Z
    Publisher Galenos Publishing House
    Document type Article ; Online
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  8. Article: A weak association of HLA-B*2702 with Behçet's disease.

    Gül, A / Uyar, F A / Inanç, M / Ocal, L / Barrett, J H / Aral, O / Koniçe, M / Saruhan-Direskeneli, G

    Genes and immunity

    2002  Volume 3, Issue 6, Page(s) 368–372

    Abstract: This study aimed to analyse the association of HLA-B alleles other than -B51 with Behçet's disease ... BD). We also investigated the frequency of HLA-B alleles sharing the same natural killer cell ... immunoglobulin-like receptor (KIR) binding sequence with HLA-B51. Broad-genotyping of HLA-B locus by PCR-SSOP ...

    Abstract This study aimed to analyse the association of HLA-B alleles other than -B51 with Behçet's disease (BD). We also investigated the frequency of HLA-B alleles sharing the same natural killer cell immunoglobulin-like receptor (KIR) binding sequence with HLA-B51. Broad-genotyping of HLA-B locus by PCR-SSOP in 174 Turkish BD patients and 191 healthy controls confirmed the strong association of B*51 with BD (60.9% in BD patients, 24.6% in healthy controls, OR = 4.78). No other HLA-B allele was identified showing an association with BD after adjusting for multiple testing or by using relative predispositional effects (RPE) analysis after the deletion of B*51. HLA-B alleles reacting with the sequence specific oligonucleotide probe 23, which corresponds to the KIR binding site of B*51, were found to be positive in 127 BD patients (73%) and 90 controls (47%) (OR = 3.03, 95% CI 2-4.7). The repeated RPE analysis after separating HLA-B alleles carrying B51-KIR binding sequence as distinct alleles within a broad-type allele group revealed B*2702 allele as the only allele showing an association with BD after the deletion of B*51. Selective increase of B*2702, the only B*27 allele carrying the same KIR binding sequence with B*51, warrants investigation of the possibility of interaction of HLA molecules with KIRs on NK or other T cells in the pathogenesis of BD.
    MeSH term(s) Behcet Syndrome/genetics ; Behcet Syndrome/immunology ; Female ; Genetic Predisposition to Disease ; HLA-B Antigens/genetics ; HLA-B Antigens/immunology ; Humans ; Male ; Turkey
    Chemical Substances HLA-B Antigens
    Language English
    Publishing date 2002-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2060566-3
    ISSN 1466-4879
    ISSN 1466-4879
    DOI 10.1038/sj.gene.6363863
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5592: Show issues Location:
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  9. Book ; Thesis: Tumorhypoxie und maligne Progression bei primären und rezidivierenden Karzinomen der Cervix uteri

    Aral, Billur

    2000  

    Author's details vorgelegt von Billur Aral
    Language German
    Size 105 Bl., Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Mainz, Univ., Diss., 2000
    HBZ-ID HT013308035
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 MB 2529 order for loan Magazin

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  10. Article: A Prospective Evaluation of Tubarial Gland Doses With Acute Dysphagia and Treatment Tolerance in Head and Neck Cancer Patients.

    Aral, İpek Pınar / Altinisik Inan, Gonca / Dadak, Binnur / Görtan, Fatma Arzu / Tezcan, Yılmaz

    Cureus

    2024  Volume 16, Issue 3, Page(s) e56566

    Abstract: Background This study prospectively analyzed the clinical significance of tubarial glands (TGs) doses in head and neck cancer (HNC) patients. Methods Patients diagnosed with HNC in Ankara Bilkent City Hospital, Turkey were analyzed. TGs volumes and doses ...

    Abstract Background This study prospectively analyzed the clinical significance of tubarial glands (TGs) doses in head and neck cancer (HNC) patients. Methods Patients diagnosed with HNC in Ankara Bilkent City Hospital, Turkey were analyzed. TGs volumes and doses were noted. The patients were evaluated in terms of acute dysphagia (AD) and radiation therapy (RT)-associated xerostomia. Results The median volume of the TGs was 3.5(2.1-5.9)cc. No increased standardized uptake values (SUV) were observed in the TGs. There was no significant relationship between TGs values and the third or sixth months of xerostomia after RT. There was a significant relationship between grade ≥2 AD and TGs-D
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56566
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