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Article ; Online: Daily Vitamin D Supplementation Improves Vitamin D Deficiency in Patients With Chronic Liver Disease.

Mariano da Rocha, Carolina Roos / Guaragna-Filho, Guilherme / Kieling, Carlos Oscar / Adami, Marina Rossato / Guedes, Renata Rostirola / Gonçalves Vieira, Sandra Maria

Journal of pediatric gastroenterology and nutrition

2023 Volume 76, Issue 6, Page(s) 723–730

Abstract: ... cholecalciferol (OC) treatment in children with chronic liver disease (CLD) and 25(OH)D deficiency.: Methods ... for serum 25(OH)D, liver function, bone metabolism, Child-Pugh classification, and anthropometry. Patients ... with 25(OH)D deficiency (defined as 25(OH)D < 20 ng/mL) who received 6000 IU/day of OC were analyzed pre ...

Abstract	Objective: The objective of this article is to evaluate the response to 6000 IU oral cholecalciferol (OC) treatment in children with chronic liver disease (CLD) and 25(OH)D deficiency. Methods: This historical cohort included non-transplanted CLD patients younger than 18 years old, which were analyzed for serum 25(OH)D, liver function, bone metabolism, Child-Pugh classification, and anthropometry. Patients with 25(OH)D deficiency (defined as 25(OH)D < 20 ng/mL) who received 6000 IU/day of OC were analyzed pre- and post-intervention, and considered responders if 25(OH)D > 20 ng/mL after at least 60 days. We compared clinical and laboratory data from patients with and without 25(OH)D deficiency, responders and nonresponders. Results: We studied 96 patients, of which 57.2% had biliary atresia. The prevalence of 25(OH)D deficiency was 67.7% (65/96). These patients were younger ( P < 0.001), had higher Child-Pugh scores ( P < 0.001), higher levels of total bilirubin (TB) ( P < 0.001), gamma-glutamyl transferase ( P < 0.001), and alkaline phosphatase ( P = 0.002), as well as lower levels of phosphorus ( P = 0.009) compared with patients without 25(OH)D deficiency. The median treatment length was 126 days (70-307 days). At the end of treatment, we observed a higher median of 25(OH)D ( P < 0.001), and lower median of parathyroid hormone (PTH) ( P = 0.023). Nine patients (29%) restored 25(OH)D to normal range; they had lower Child-Pugh score ( P = 0.001), lower TB levels ( P = 0.001), and higher level of phosphorus ( P = 0.003) after treatment. Conclusion: Despite an increase in 25(OH)D and decrease in PTH levels, 6000 IU/day of OC was not sufficient to restore 25(OH)D deficiency in most of the patients in this study.
MeSH term(s)	Humans ; Adolescent ; Vitamin D ; Vitamins ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/drug therapy ; Cholecalciferol/therapeutic use ; Liver Diseases/complications ; Liver Diseases/drug therapy ; Parathyroid Hormone/therapeutic use ; Dietary Supplements ; Phosphorus
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins ; Cholecalciferol (1C6V77QF41) ; Parathyroid Hormone ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000003769
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Article ; Online: GLA:D

Kjaer, Per / Kongsted, Alice / Ris, Inge / Abbott, Allan / Rasmussen, Charlotte Diana Nørregaard / Roos, Ewa M / Skou, Søren T / Andersen, Tonny Elmose / Hartvigsen, Jan

BMC musculoskeletal disorders

2018 Volume 19, Issue 1, Page(s) 418

Abstract: ... is to present the development, theories, and underlying evidence for 'GLA:D Back' - a group education ... for the promotion of self-management in people with persistent/recurrent back pain.: Methods: GLA:D Back ... a ready-to-use structured program - GLA:D® Back - to support self-management for people with persistent ...

Abstract	Background: Clinical guidelines recommend that people with back pain be given information and education about their back pain, advice to remain active and at work, and exercises to improve mobility and physical activity. Guidelines, however, rarely describe how this is best delivered. The aim of this paper is to present the development, theories, and underlying evidence for 'GLA:D Back' - a group education and exercise program that translates guideline recommendations into a clinician-delivered program for the promotion of self-management in people with persistent/recurrent back pain. Methods: GLA:D Back, which included a rationale and objectives for the program, theory and evidence for the interventions, and program materials, was developed using an iterative process. The content of patient education and exercise programs tested in randomised trials was extracted and a multidisciplinary team of expert researchers and clinicians prioritised common elements hypothesised to improve back pain beliefs and management skills. The program was tested on eight people with persistent back pain in a university clinic and 152 patients from nine primary care physiotherapy and chiropractic clinics. Following feedback from the clinicians and patients involved, the working version of the program was created. Results: Educational components included pain mechanisms, pain modulation, active coping strategies, imaging, physical activity, and exercise that emphasised a balance between the sum of demands and the individual's capacity. These were operationalised in PowerPoint presentations with supporting text to aid clinicians in delivering two one-hour patient education lectures. The exercise program included 16 supervised one-hour sessions over 8 weeks, each comprising a warm-up section and eight types of exercises for general flexibility and strengthening of six different muscle groups at four levels of difficulty. The aims of the exercises were to improve overall back fitness and, at the same time, encourage patients to explore variations in movement by incorporating education content into the exercise sessions. Conclusion: From current best evidence about prognostic factors in back pain and effective treatments for back pain, research and clinical experts developed a ready-to-use structured program - GLA:D® Back - to support self-management for people with persistent/recurrent back pain.
MeSH term(s)	Back Pain/rehabilitation ; Denmark ; Exercise Therapy/methods ; Exercise Therapy/standards ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Patient Education as Topic ; Physical Therapy Specialty/methods ; Physical Therapy Specialty/standards ; Pilot Projects ; Practice Guidelines as Topic ; Program Evaluation ; Quality of Life ; Research Design ; Self-Management/methods ; Treatment Outcome
Language	English
Publishing date	2018-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-018-2334-x
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Article ; Online: Comments on Letter to the Editor by Ph.D. Jussi Sipilä regarding our paper "Geochemistry of multiple sclerosis in Finland".

Åström, Mats E / Roos, Per M

The Science of the total environment

2022 Volume 859, Issue Pt 2, Page(s) 160367

Language	English
Publishing date	2022-11-18
Publishing country	Netherlands
Document type	Letter
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.160367
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Article ; Online: Developing a capacity-building intervention for healthcare workers to improve communication skills and awareness of hard of hearing and D/deaf patients: results from a participatory action research study.

Grazioli, Véronique S / Graells, Madison / Schmutz, Elodie / Cantero, Odile / Sebaï, Tanya / Favre, Vanessa / Richème-Roos, Jessica / Morisod, Kevin / Jeanneret, Michel / Singy, Pascal / Bodenmann, Patrick

BMC health services research

2024 Volume 24, Issue 1, Page(s) 301

Abstract: Background: Healthcare workers (HCWs) are commonly not prepared to properly communicate with D ... aimed to develop and evaluate a capacity-building intervention for HCWs to raise their awareness of D ... in communicating with D/deaf and HoH patients and organizational payoffs (use frequency of basic rules and tools ...

Abstract	Background: Healthcare workers (HCWs) are commonly not prepared to properly communicate with D/deaf and hard of hearing (HoH) patients. The resulting communication challenges reinforce the existing barriers to accessing and benefiting from quality of care in these populations. In response, this study aimed to develop and evaluate a capacity-building intervention for HCWs to raise their awareness of D/deaf and HoH individuals' experiences in healthcare and improve their capacity to communicate with these populations. Methods: This study featured a participatory action research design using qualitative and quantitative methods. The intervention was developed and tested through 4 iterative phases. Reactions (i.e., satisfaction and perception of the intervention content, quality, appropriateness and usefulness) were assessed quantitatively and qualitatively after the intervention, whereas perceived knowledge and self-efficacy in communicating with D/deaf and HoH patients and organizational payoffs (use frequency of basic rules and tools improving communication) were quantitatively assessed before, after and 6-month post-intervention. Results: Main qualitative and quantitative findings showed that the final version of the intervention reached high levels of satisfaction among participants. Next, perceived knowledge and self-efficacy scores obtained after receiving the intervention and 6 months later were significantly higher than those yielded in the initial assessment, although both scores significantly decreased at 6 months (compared to the scores obtained just after the intervention). Finally, findings showed no significant changes in organizational payoffs after receiving the intervention. Echoing these results, main qualitative findings documented that after receiving the intervention, participants felt more confident yet not more equipped to communicate with D/deaf and HoH patients. Conclusions: Findings suggest that the capacity-building intervention is a promising means to sustainably increase HCWs' perceived knowledge and self-efficacy on how communicating with D/deaf and HoH patients, although complementary approaches and follow-up intervention reminders may be necessary to enable practice changes in the working environment.
MeSH term(s)	Humans ; Hearing Loss ; Communication ; Health Personnel ; Health Services Research ; Hearing
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-024-10574-3
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Article: D. CARLETON GAJDUSEK.

Roos, Raymond P

Proceedings of the American Philosophical Society

2015 Volume 159, Issue 1, Page(s) 97–106

MeSH term(s)	Anthropology/history ; History, 20th Century ; History, 21st Century ; Kuru/history ; Neuropathology/history
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article ; Portraits
ZDB-ID	2173401-X
ISSN	0003-049X
ISSN	0003-049X
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Article ; Online: Changes in physical activity and the association between pain and physical activity - a longitudinal analysis of 17,454 patients with knee or hip osteoarthritis from the GLA:D® registry.

Baumbach, L / Grønne, D T / Møller, N C / Skou, S T / Roos, E M

Osteoarthritis and cartilage

2022 Volume 31, Issue 2, Page(s) 258–266

Abstract: ... Method: Data from the Good Life with osteoArthritis in Denmark (GLA:D®) registry, at baseline ...

Abstract	Objective: Investigate change in physical activity following an 8-week education and exercise therapy program for patients with knee/hip osteoarthritis, focusing on those with low physical activity level. Furthermore, to evaluate associations between changes in pain intensity and physical activity. Method: Data from the Good Life with osteoArthritis in Denmark (GLA:D®) registry, at baseline, immediately after completion, and 12 months after entering the program was used. Measures of interest were UCLA activity scale (1-10) and Visual Analog Scale for pain intensity (0-100 mm). Changes in physical activity levels (low 1-4, moderate 5-6, and high 7-10) over three time points were investigated. Asymmetric fixed effects regression models were used to evaluate the association between clinically relevant change in pain (≥15 mm) and change in physical activity level from baseline to 12 months. Results: 37% with low activity level at baseline (n = 4,836) and 69% of all patients (n = 17,454) reached or maintained at least a moderate physical activity level at follow-ups. Surprisingly, both an improvement (β = 1.44, P < 0.001) and a worsening (β = 1.18, P < 0.001) in pain intensity was associated with increased physical activity in low activity patients. For all patients a similar trend was observed (β = 0.51, P < 0.001 and β = 0.11, P = 0.215, respectively). Conclusion: In low active knee or hip OA patients, a third of patients participating in an education and exercise therapy program reached and maintained at least a moderate physical activity level for 1 year. The improvement in physical activity was not dependent on pain reduction.
MeSH term(s)	Humans ; Osteoarthritis, Hip/therapy ; Pain/complications ; Knee Joint ; Osteoarthritis, Knee/complications ; Osteoarthritis, Knee/therapy ; Exercise Therapy ; Registries ; Quality of Life
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1167809-4
ISSN	1522-9653 ; 1063-4584
ISSN (online)	1522-9653
ISSN	1063-4584
DOI	10.1016/j.joca.2022.09.012
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Zs.A 3828: Show issues

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Article ; Online: Level of Digitalization in Germany: Results of the Diabetes Digitalization and Technology (D.U.T) Report 2020.

Roos, Timm / Hochstadt, Sabine / Keuthage, Winfried / Kröger, Jens / Lueg, Andreas / Mühlen, Hansjörg / Schütte, Lisa / Scheper, Nikolaus / Ehrmann, Dominic / Hermanns, Norbert / Heinemann, Lutz / Kulzer, Bernhard

Journal of diabetes science and technology

2020 Volume 16, Issue 1, Page(s) 144–151

Abstract: Background: New diagnostic and therapeutic technologies are increasingly changing the treatment of people with diabetes (PWD), along with increased usage of digital tools. To date, however, there is little data to which level and how diabetologists and ... ...

Abstract	Background: New diagnostic and therapeutic technologies are increasingly changing the treatment of people with diabetes (PWD), along with increased usage of digital tools. To date, however, there is little data to which level and how diabetologists and PWD implement digitalization. Also, not much is known about the view of diabetologists on the current status and future developments in this respect. Method: In an online survey, diabetologists working in clinics and practices across Germany provided responses regarding their view on digitalization and the adoption of new technologies in diabetology to 56 questions. These comments reflect the opinion of several experts about the current importance and use of specific digital/technological topics. Results: Overall, 326 diabetologists took part in the survey. They reported a positive attitude (75.8%) toward new technologies and digitalization, and they see more advantages rather than disadvantages. Younger age of the diabetologists was significantly associated with a more positive attitude ( Conclusions: This survey, which is going to be repeated annually, showed that the diabetologists who participated predominantly have a positive attitude toward new technologies and digital applications and were aware of the associated advantages. However, perceived disadvantages need to be addressed to enable wider adoption of new technologies and digital solutions.
MeSH term(s)	Blood Glucose ; Blood Glucose Self-Monitoring ; Diabetes Mellitus/therapy ; Germany ; Humans ; Technology
Chemical Substances	Blood Glucose
Language	English
Publishing date	2020-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-2968
ISSN (online)	1932-2968
DOI	10.1177/1932296820965553
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Article ; Online: Cathepsin D as biomarker in cerebrospinal fluid of nusinersen-treated patients with spinal muscular atrophy.

Schorling, David C / Kölbel, Heike / Hentschel, Andreas / Pechmann, Astrid / Meyer, Nancy / Wirth, Brunhilde / Rombo, Roman / Sickmann, Albert / Kirschner, Janbernd / Schara-Schmidt, Ulrike / Lochmüller, Hanns / Roos, Andreas

European journal of neurology

2022 Volume 29, Issue 7, Page(s) 2084–2096

Abstract: ... of CSF samples of three SMA type 1 patients revealed the lysosomal protease cathepsin D as a candidate ... a significant decline of cathepsin D levels in SMA patients aged ≥2 months at the start of treatment ... a positive motor response. Moreover, downregulation of cathepsin D was evident in muscle biopsies of SMA ...

Abstract	Background and purpose: The therapeutic landscape of spinal muscular atrophy (SMA) has changed dramatically during the past 4 years, but treatment responses differ remarkably between individuals, and therapeutic decision-making remains challenging, underlining the persistent need for validated biomarkers. Methods: We applied untargeted proteomic analyses to determine biomarkers in cerebrospinal fluid (CSF) samples of SMA patients under treatment with nusinersen. Identified candidate proteins were validated in CSF samples of SMA patients by Western blot and enzyme-linked immunosorbent assay. Furthermore, levels of peripheral neurofilament heavy and light chain were determined. Results: Untargeted proteomic analysis of CSF samples of three SMA type 1 patients revealed the lysosomal protease cathepsin D as a candidate biomarker. Subsequent validation analysis in a larger cohort of 31 pediatric SMA patients (type 1, n = 12; type 2, n = 9; type 3, n = 6; presymptomatically treated, n = 4; age = 0-16 years) revealed a significant decline of cathepsin D levels in SMA patients aged ≥2 months at the start of treatment. Although evident in all older age categories, this decline was only significant in the group of patients who showed a positive motor response. Moreover, downregulation of cathepsin D was evident in muscle biopsies of SMA patients. Conclusions: We identified a decline of cathepsin D levels in CSF samples of SMA patients under nusinersen treatment that was more pronounced in the group of "treatment responders" than in "nonresponders." We believe that our results indicate a suitability of cathepsin D levels as a possible biomarker in SMA also in older patients, in combination with analysis of peripheral neurofilament light chain in adolescents or alone in adult patients.
MeSH term(s)	Adolescent ; Adult ; Aged ; Biomarkers/cerebrospinal fluid ; Cathepsin D/therapeutic use ; Child ; Humans ; Muscular Atrophy, Spinal ; Oligonucleotides ; Proteomics/methods
Chemical Substances	Biomarkers ; Oligonucleotides ; nusinersen (5Z9SP3X666) ; Cathepsin D (EC 3.4.23.5)
Language	English
Publishing date	2022-05-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.15331
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Zs.A 4738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Serum 25-hydroxyvitamin D in amyotrophic lateral sclerosis: mendelian randomization study.

Larsson, Susanna C / Roos, Per M

Neurobiology of aging

2019 Volume 87, Page(s) 140.e1–140.e3

Abstract: ... hydroxyvitamin D (S-25OHD) concentrations and amyotrophic lateral sclerosis (ALS). Summary-level data for genetic ...

Abstract	We conducted a mendelian randomization study to investigate the association between serum 25-hydroxyvitamin D (S-25OHD) concentrations and amyotrophic lateral sclerosis (ALS). Summary-level data for genetic predictors of S-25OHD concentrations were acquired from 2 genome-wide association studies, comprising up to 79,366 individuals. The corresponding data for ALS were collected from 12,577 ALS cases and 23,475 controls. None of 7 single-nucleotide polymorphisms predicting S-25OHD concentrations was associated with ALS, and there was no overall association of genetic predisposition to higher S-25OHD concentrations with ALS. The odds ratio of ALS per genetically predicted one standard deviation increase of S-25OHD concentrations was 0.96 (95% confidence interval: 0.86-1.08; p = 0.52). We conclude that increasing S-25OHD concentrations will unlikely reduce ALS incidence.
MeSH term(s)	Amyotrophic Lateral Sclerosis/genetics ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Humans ; Mendelian Randomization Analysis ; Polymorphism, Single Nucleotide ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/genetics
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2019-11-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2019.10.024
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Zs.A 1685: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Terry D. Fife, MD.

Roos, Karen L

Seminars in neurology

2013 Volume 33, Issue 3, Page(s) 169–170

MeSH term(s)	History, 20th Century ; History, 21st Century ; Neurology/trends ; United States ; Vertigo/therapy ; Vestibular Diseases/therapy
Language	English
Publishing date	2013-07
Publishing country	United States
Document type	Biography ; Editorial ; Historical Article
ZDB-ID	603165-1
ISSN	1098-9021 ; 0271-8235
ISSN (online)	1098-9021
ISSN	0271-8235
DOI	10.1055/s-0033-1355244
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