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Book ; Online: (Table DR1) Trace element contents in basalts from ODP Hole 33-317A, supplementary data to: Ingle, Stephanie; Mahoney, John J; Sato, Hiroshi; Coffin, Millard F; Kimura, Jun-Ichi; Hirano, Naoto; Nakanishi, Masao (2007): Depleted mantle wedge and sediment fingerprint in unusual basalts from the Manihiki Plateau, central Pacific Ocean. Geology 2007 35(7), 35(7), 595-598

Ingle, Stephanie / Coffin, Millard F / Hirano, Naoto / Kimura, Jun-Ichi / Mahoney, John J / Nakanishi, Masao / Sato, Hiroshi

2007

Abstract: Numerous large igneous provinces formed in the Pacific Ocean during Early Cretaceous time, but their origins and relations are poorly understood. We present new geochronological and geochemical data on rocks from the Manihiki Plateau and compare these ... ...

Abstract	Numerous large igneous provinces formed in the Pacific Ocean during Early Cretaceous time, but their origins and relations are poorly understood. We present new geochronological and geochemical data on rocks from the Manihiki Plateau and compare these results to those for other Cretaceous Pacific plateaus. A dredged Manihiki basalt gives an 40Ar-39Ar age of 117.9+/-3.5 Ma (2 sigma), essentially contemporaneous with the Ontong Java Plateau ~2500 km to the west, and the possibly related Hikurangi Plateau ~3000 km to the south. Drilled Manihiki lavas are tholeiitic with incompatible trace element abundances similar to those of Ontong Java basalts. These lavas may result from high degrees of partial melting during the main eruptive phase of plateau formation. There are two categories of dredged lavas from the Danger Islands Troughs, which bisect the plateau. The first is alkalic lavas having strong enrichments in light rare earth and large-ion lithophile elements; these lavas may represent late-stage activity, as one sample yields an 40Ar-39Ar age of 99.5+/-0.7 Ma. The second category consists of tholeiitic basalts with U-shaped incompatible element patterns and unusually low abundances of several elements; these basalts record a mantle component not previously observed in Manihiki, Ontong Java, or Hikurangi lavas. Their trace element characteristics may result from extensive melting of depleted mantle wedge material mixed with small amounts of volcaniclastic sediment. We are unaware of comparable basalts elsewhere.
Language	English
Dates of publication	2007-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1130/G23741A.1
DOI	10.1594/PANGAEA.721831
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Water-Soluble Chiral Ag

Nakanishi, Tatsuya / Yao, Hiroshi

The journal of physical chemistry letters

2023 Volume 14, Issue 45, Page(s) 10285–10292

Abstract: Despite significant advances in atomically precise Au clusters with chirality, Ag clusters with the relevant features are still less explored. In this study, we report successful synthesis of chiral ... ...

Abstract	Despite significant advances in atomically precise Au clusters with chirality, Ag clusters with the relevant features are still less explored. In this study, we report successful synthesis of chiral Ag
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.3c02780
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Article ; Online: Cathepsin regulation on microglial function.

Nakanishi, Hiroshi

Biochimica et biophysica acta. Proteins and proteomics

2020 Volume 1868, Issue 9, Page(s) 140465

Abstract: Microglia, the resident mononuclear phagocyte population in the brain, have long been implicated in the pathology of neurodegenerative age-associated disorders. However, activated microglia have now been identified as homeostatic keepers in the brain, ... ...

Abstract	Microglia, the resident mononuclear phagocyte population in the brain, have long been implicated in the pathology of neurodegenerative age-associated disorders. However, activated microglia have now been identified as homeostatic keepers in the brain, because they are involved in the initiation and resolution of neuropathology. The complex roles of activated microglia appear to be linked to change from inflammatory and neurotoxic to anti-inflammatory and neuroprotective phenotypes. Increased expression and secretion of various cathepsins support roles of activated microglia in chronic neuroinflammation, the neurotoxic M1-like polarization and neuronal death. Moreover, changes in expression and localization of microglial cathepsin B play a critical role in the acceleration of the brain aging. Beyond the role as brain-resident macrophages, many lines of evidence have shown that microglia have essential roles in the maturation and maintenance of neuronal circuits in the developing and adult brain. Cathepsin S secreted from microglia induces the diurnal variation of spine density of cortical neurons though proteolytic modification of peri-synaptic extracellular matrix molecules. In this review, I highlight the emerging roles of cathepsins that support the roles of microglia in both normal healthy and pathological brains. In addition, I discuss cathepsin inhibitors as potential therapeutic targets for brain disorders.
MeSH term(s)	Animals ; Brain/metabolism ; Cathepsin B/metabolism ; Cathepsin H/metabolism ; Cathepsins/metabolism ; Chronic Pain/metabolism ; Humans ; Inflammation ; Microglia/metabolism ; Microglia/pathology ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Neurodegenerative Diseases/metabolism ; Neurons/metabolism ; Neurons/pathology ; Phenotype
Chemical Substances	NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human ; Cathepsins (EC 3.4.-) ; Cathepsin B (EC 3.4.22.1) ; Cathepsin H (EC 3.4.22.16) ; cathepsin S (EC 3.4.22.27)
Language	English
Publishing date	2020-06-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2918798-9
ISSN	1878-1454 ; 1570-9639
ISSN (online)	1878-1454
ISSN	1570-9639
DOI	10.1016/j.bbapap.2020.140465
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Article ; Online: The expression system affects the binding affinity between p75NTR and proNGF.

Hino, Mami / Nakanishi, Masayuki / Nomoto, Hiroshi

Biochemistry and biophysics reports

2024 Volume 38, Page(s) 101702

Abstract: ProNGF (nerve growth factor) is a precursor of NGF and a signaling peptide exerting opposite effects on neuronal cells, i.e., apoptotic or neuritogenic. The conflicting biological activity of proNGF depends on the relative levels of two membrane ... ...

Abstract	ProNGF (nerve growth factor) is a precursor of NGF and a signaling peptide exerting opposite effects on neuronal cells, i.e., apoptotic or neuritogenic. The conflicting biological activity of proNGF depends on the relative levels of two membrane receptors, TrkA and p75NTR. The effect of proNGF depends on the expression levels of these receptor proteins and their affinity to proNGF. Since the affinity of proteins has been studied with various recombinant proteins, it is worth comparing the affinity of these proteins within one experiment with the same method. This study examined the affinity between a recombinant proNGF and p75NTR expressed in common systems: bacterial, insect, and mammalian cells. The extracellular domain of p75NTR expressed in the insect or mammalian systems bound to native mature NGF, with a higher affinity for the insect receptor. The uncleavable proNGF was expressed in the three systems and they showed neuritogenic activity in PC12 cells. These recombinant proteins were used to compare their binding affinity to p75NTR. The insect p75NTR showed a higher binding affinity to proNGF than the mammalian p75NTR. The insect p75NTR bound proNGF from the insect system with the highest affinity, then from the mammalian system, and the lowest from the bacterial system. Conversely, the mammalian p75NTR showed no such preference for proNGF. Because the recombinant proNGF and p75NTR from different expression systems are supposed to have the same amino acid sequences, these differences in the affinity depend likely on their post-translational modifications, most probably on their glycans. Each recombinant proNGF and p75NTR in various expression systems exhibited different mobilities on SDS-PAGE and reactivities with glycosidases and lectins.
Language	English
Publishing date	2024-04-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2831046-9
ISSN	2405-5808 ; 2405-5808
ISSN (online)	2405-5808
ISSN	2405-5808
DOI	10.1016/j.bbrep.2024.101702
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Article: Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging.

Nakanishi, Hiroshi

Neural regeneration research

2019 Volume 15, Issue 1, Page(s) 25–29

Abstract: Interleukin-1β is a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer's disease, Parkinson's disease, stroke and persistent pain. Activated ... ...

Abstract	Interleukin-1β is a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer's disease, Parkinson's disease, stroke and persistent pain. Activated microglia are the main cellular source of interleukin-1β in the brain. Cathepsin B is associated with the production and secretion of interleukin-1β through pyrin domain-containing protein 3 inflammasome-independent processing of procaspase-3 in the phagolysosomes. The leakage of cathepsin B from the endosomal-lysosomal system during aging is associated with the proteolytic degradation of mitochondrial transcription factor A, which can stabilize mitochondrial DNA. Therefore, microglial cathepsin B could function as a major driver for inflammatory brain diseases and brain aging. Orally active and blood-brain barrier-permeable specific inhibitors for cathepsin B can be potentially effective new pharmaceutical interventions against inflammatory brain diseases and brain aging.
Language	English
Publishing date	2019-09-19
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.264444
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Article ; Online: Drainage of Retropharyngeal Abscess Through the External Auditory Canal.

Nakanishi, Ryo / Iio, Kazuki / Nakamura, Toshiki / Yoshitomi, Ai / Enokizono, Mikako / Hataya, Hiroshi

The Pediatric infectious disease journal

2024

Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000004313
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Article ; Online: Gingipain-carrying outer membrane vesicles from Porphyromonas gingivalis cause barrier dysfunction of Caco-2 cells by releasing gingipain into the cytosol.

Nonaka, Saori / Okamoto, Rin / Katsuta, Yui / Kanetsuki, Shiori / Nakanishi, Hiroshi

Biochemical and biophysical research communications

2024 Volume 707, Page(s) 149783

Abstract: Ingestion of Porphyromonas gingivalis, a periodontal pathogen, disrupts the intestinal barrier in mice. However, the involvement of outer membrane vesicles (OMVs) secreted from P. gingivalis in the destruction of the intestinal barrier remains unclear. ... ...

Abstract	Ingestion of Porphyromonas gingivalis, a periodontal pathogen, disrupts the intestinal barrier in mice. However, the involvement of outer membrane vesicles (OMVs) secreted from P. gingivalis in the destruction of the intestinal barrier remains unclear. In this study, we tested the hypothesis that OMVs carrying gingipains, the major cysteine proteases produced by P. gingivalis, affects the intestinal barrier function. OMVs increased the permeability of the Caco-2 cell monolayer, a human intestinal epithelial cell line, accompanied by degradation of the tight junction protein occludin. In contrast, OMVs prepared from mutant strains devoid of gingipains failed to induce intestinal barrier dysfunction or occludin degradation in Caco-2 cells. A close histological examination revealed the intracellular localization of gingipain-carrying OMVs. Gingipain activity was detected in the cytosolic fraction of Caco-2 cells after incubation with OMVs. These results suggest that gingipains were internalized into intestinal cells through OMVs and transported into the cytosol, where they then directly degraded occludin from the cytosolic side. Thus, P. gingivalis OMVs might destroy the intestinal barrier and induce systemic inflammation via OMV itself or intestinal substances leaked into blood vessels, causing various diseases.
MeSH term(s)	Animals ; Mice ; Humans ; Gingipain Cysteine Endopeptidases/metabolism ; Caco-2 Cells ; Porphyromonas gingivalis/physiology ; Cytosol/metabolism ; Occludin/metabolism ; Adhesins, Bacterial/metabolism
Chemical Substances	Gingipain Cysteine Endopeptidases ; Occludin ; Adhesins, Bacterial
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2024.149783
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Article ; Online: Loss of complex-type N-linked glycans attenuates maximum cell density and susceptibility to human serum of Trypanosoma brucei brucei.

Nakanishi, Masayuki / Takeguchi, Masaki / Takezaki, Reo / Hino, Mami / Nomoto, Hiroshi

Parasitology international

2024 Volume 101, Page(s) 102874

Abstract: Trypanosoma brucei brucei is a parasitic protist that expresses cell surface proteins modified with complex-type N-linked glycan (NLG), like multicellular organisms. However, little is known about the role of complex-type NLG. In T. b. brucei, it has ... ...

Abstract	Trypanosoma brucei brucei is a parasitic protist that expresses cell surface proteins modified with complex-type N-linked glycan (NLG), like multicellular organisms. However, little is known about the role of complex-type NLG. In T. b. brucei, it has been shown that either one of the glycosyltransferases, TbGT11 or TbGT15, is sufficient to initiate the synthesis of complex-type NLG. To clarify the role of complex-type NLG, it is necessary to generate cells lacking both enzymes. Therefore, we deleted TbGT11 and TbGT15 from the genome of T. b. brucei for the phenotypic examination. The mutant strain grew in culture, with reduced maximum cell density; showed decreased susceptibility to normal human serum, which contains trypanolytic factors; and lacked uptake of the haptoglobin-hemoglobin complex. These data indicate that protein modification by complex-type NLG is not essential but is required for receptor function.
Language	English
Publishing date	2024-02-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1363151-2
ISSN	1873-0329 ; 1383-5769
ISSN (online)	1873-0329
ISSN	1383-5769
DOI	10.1016/j.parint.2024.102874
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Article ; Online: Eosinopenia is associated with adverse outcomes after COVID-19 infection: A perspective from Japan.

Ito, Akihiro / Ishida, Tadashi / Nakanishi, Yosuke / Kobe, Hiroshi / Tokioka, Fumiaki

Respirology (Carlton, Vic.)

2023 Volume 28, Issue 7, Page(s) 677–680

MeSH term(s)	Humans ; COVID-19/epidemiology ; Japan/epidemiology ; Leukocyte Count ; Eosinophils
Language	English
Publishing date	2023-04-27
Publishing country	Australia
Document type	Letter
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.14509
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Article ; Online: The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer.

Stoka, Veronika / Vasiljeva, Olga / Nakanishi, Hiroshi / Turk, Vito

International journal of molecular sciences

2023 Volume 24, Issue 21

Abstract: Papain-like cysteine proteases are composed of 11 human cysteine cathepsins, originally located in the lysosomes. They exhibit broad specificity and act as endopeptidases and/or exopeptidases. Among them, only cathepsins B, H, C, and X/Z exhibit ... ...

Abstract	Papain-like cysteine proteases are composed of 11 human cysteine cathepsins, originally located in the lysosomes. They exhibit broad specificity and act as endopeptidases and/or exopeptidases. Among them, only cathepsins B, H, C, and X/Z exhibit exopeptidase activity. Recently, cysteine cathepsins have been found to be present outside the lysosomes and often participate in various pathological processes. Hence, they have been considered key signalling molecules. Their potentially hazardous proteolytic activities are tightly regulated. This review aims to discuss recent advances in understanding the structural aspects of these four cathepsins, mechanisms of their zymogen activation, regulation of their activities, and functional aspects of these enzymes in neurodegeneration and cancer. Neurodegenerative effects have been evaluated, particularly in Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, and neuropsychiatric disorders. Cysteine cathepsins also participate in tumour progression and metastasis through the overexpression and secretion of proteases, which trigger extracellular matrix degradation. To our knowledge, this is the first review to provide an in-depth analysis regarding the roles of cysteine cathepsins B, H, C, and X in neurodegenerative diseases and cancer. Further advances in understanding the functions of cysteine cathepsins in these conditions will result in the development of novel, targeted therapeutic strategies.
MeSH term(s)	Humans ; Cysteine Proteases ; Neurodegenerative Diseases ; Cysteine/metabolism ; Cathepsin B ; Neoplasms ; Lysosomes/metabolism
Chemical Substances	Cysteine Proteases (EC 3.4.-) ; Cysteine (K848JZ4886) ; Cathepsin B (EC 3.4.22.1)
Language	English
Publishing date	2023-10-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242115613
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