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  1. Article ; Online: Bordetella

    Nash, Zachary M / Inatsuka, Carol S / Cotter, Peggy A / Johnson, Richard M

    mBio

    2024  , Page(s) e0063224

    Abstract: ... ...

    Abstract Bordetella
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00632-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: My Experience with SARS-CoV-2, with a Focus on Testing.

    Cotter, Peggy A

    Journal of clinical microbiology

    2020  Volume 58, Issue 8

    Abstract: Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) got off to a slow start in the United States. In this commentary, I describe my experience with CoV disease 2019 (COVID-19), with a focus on being tested at the University of North ... ...

    Abstract Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) got off to a slow start in the United States. In this commentary, I describe my experience with CoV disease 2019 (COVID-19), with a focus on being tested at the University of North Carolina-Chapel Hill Respiratory Diagnostic Center on its inaugural day.
    MeSH term(s) Academic Medical Centers ; Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Diagnostic Services/organization & administration ; Hospitals, University ; Humans ; North Carolina ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.01228-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: My Experience with SARS-CoV-2, with a Focus on Testing

    Cotter, Peggy A

    J. clin. microbiol

    Abstract: Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) got off to a slow start in the United States. In this commentary, I describe my experience with CoV disease 2019 (COVID-19), with a focus on being tested at the University of North ... ...

    Abstract Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) got off to a slow start in the United States. In this commentary, I describe my experience with CoV disease 2019 (COVID-19), with a focus on being tested at the University of North Carolina-Chapel Hill Respiratory Diagnostic Center on its inaugural day.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #676018
    Database COVID19

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  4. Article ; Online: My Experience with SARS-CoV-2, with a Focus on Testing

    Cotter, Peggy A.

    Journal of Clinical Microbiology

    2020  Volume 58, Issue 8

    Abstract: ABSTRACT Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) got off to a slow start in the United States. In this commentary, I describe my experience with CoV disease 2019 (COVID-19), with a focus on being tested at the University ... ...

    Abstract ABSTRACT Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) got off to a slow start in the United States. In this commentary, I describe my experience with CoV disease 2019 (COVID-19), with a focus on being tested at the University of North Carolina—Chapel Hill Respiratory Diagnostic Center on its inaugural day.
    Keywords Microbiology (medical) ; covid19
    Language English
    Publisher American Society for Microbiology
    Publishing country us
    Document type Article ; Online
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.01228-20
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: An IS-mediated, RecA-dependent, bet-hedging strategy in

    Lowrey, Lillian C / Kent, Leslie A / Rios, Bridgett M / Ocasio, Angelica B / Cotter, Peggy A

    eLife

    2023  Volume 12

    Abstract: Adaptation to fluctuating environmental conditions is difficult to achieve. Phase variation mechanisms can overcome this difficulty by altering genomic architecture in a subset of individuals, creating a phenotypically heterogeneous population with ... ...

    Abstract Adaptation to fluctuating environmental conditions is difficult to achieve. Phase variation mechanisms can overcome this difficulty by altering genomic architecture in a subset of individuals, creating a phenotypically heterogeneous population with subpopulations optimized to persist when conditions change, or are encountered, suddenly. We have identified a phase variation system in
    MeSH term(s) Humans ; DNA Transposable Elements ; Burkholderia/physiology ; Genomics ; Biofilms
    Chemical Substances DNA Transposable Elements
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.84327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: An account of American Academy of Microbiology reforms and pandemic operations.

    Casadevall, Arturo / Cotter, Peggy A / Enquist, Lynn / Donohue, Timothy J / Bertuzzi, Stefano / Nguyen, Nguyen K

    mBio

    2023  , Page(s) e0233423

    Abstract: Change is an inevitable part of any organization if it wants to adapt and strive in a changing environment. That was what the American Academy of Microbiology (Academy) did from 2019-2023 when it transformed itself into a scientific think tank at ASM ... ...

    Abstract Change is an inevitable part of any organization if it wants to adapt and strive in a changing environment. That was what the American Academy of Microbiology (Academy) did from 2019-2023 when it transformed itself into a scientific think tank at ASM while maintaining the high standard of an honorific community of scholars. Here, we report on the recent history of the Academy and the changes that have taken place during this period. With the contribution of many thougtful leaders, the Academy refreshed its commitment to promote excellence and uphold its high values.
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02334-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The BvgS PAS Domain, an Independent Sensory Perception Module in the

    Sobran, M Ashley / Cotter, Peggy A

    Journal of bacteriology

    2019  Volume 201, Issue 17

    Abstract: To detect and respond to the diverse environments they encounter, bacteria often use two-component regulatory systems (TCS) to coordinate essential cellular processes required for survival. In ... ...

    Abstract To detect and respond to the diverse environments they encounter, bacteria often use two-component regulatory systems (TCS) to coordinate essential cellular processes required for survival. In pathogenic
    MeSH term(s) Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Bordetella Infections/microbiology ; Bordetella bronchiseptica/metabolism ; Female ; Gene Expression Regulation, Bacterial/physiology ; Mice ; Mice, Inbred BALB C ; Mutation ; Protein Conformation ; Protein Domains ; Respiratory Tract Infections/microbiology ; Transcription Factors/metabolism ; Transcription, Genetic
    Chemical Substances Bacterial Proteins ; Transcription Factors
    Language English
    Publishing date 2019-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00286-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.50: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article ; Online: Bordetella

    Nash, Zachary M / Cotter, Peggy A

    Microbiology spectrum

    2019  Volume 7, Issue 2

    Abstract: Bacteria use a variety of mechanisms to translocate proteins from the cytoplasm, where they are synthesized, to the cell surface or extracellular environment or directly into other cells, where they perform their ultimate functions. Type V secretion ... ...

    Abstract Bacteria use a variety of mechanisms to translocate proteins from the cytoplasm, where they are synthesized, to the cell surface or extracellular environment or directly into other cells, where they perform their ultimate functions. Type V secretion systems (T5SS) use β-barrel transporter domains to export passenger domains across the outer membranes of Gram-negative bacteria. Distinct among T5SS are type Vb or two-partner secretion (TPS) systems in which the transporter and passenger are separate proteins, necessitating a mechanism for passenger-translocator recognition in the periplasm and providing the potential for reuse of the translocator. This review describes current knowledge of the TPS translocation mechanism, using
    MeSH term(s) Adhesins, Bacterial/metabolism ; Bacterial Outer Membrane Proteins/metabolism ; Bordetella/metabolism ; Bordetella/pathogenicity ; Bordetella pertussis/metabolism ; Bordetella pertussis/pathogenicity ; Gram-Negative Bacteria ; Hemagglutinins/metabolism ; Membrane Transport Proteins ; Models, Molecular ; Secretory Pathway/physiology ; Type V Secretion Systems/metabolism ; Virulence ; Virulence Factors, Bordetella/metabolism ; Whooping Cough/microbiology
    Chemical Substances Adhesins, Bacterial ; Bacterial Outer Membrane Proteins ; Hemagglutinins ; Membrane Transport Proteins ; Type V Secretion Systems ; Virulence Factors, Bordetella ; fhaC protein, Bordetella pertussis ; filamentous hemagglutinin adhesin, Bordetella pertussis
    Language English
    Publishing date 2019-03-29
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2165-0497
    ISSN (online) 2165-0497
    DOI 10.1128/microbiolspec.PSIB-0024-2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Regulated, sequential processing by multiple proteases is required for proper maturation and release of Bordetella filamentous hemagglutinin.

    Nash, Zachary M / Cotter, Peggy A

    Molecular microbiology

    2019  Volume 112, Issue 3, Page(s) 820–836

    Abstract: Filamentous hemagglutinin (FHA) is a critically important virulence factor produced by Bordetella species that cause respiratory infections in humans and other animals. It is also a prototypical member of the widespread two partner secretion (TPS) ... ...

    Abstract Filamentous hemagglutinin (FHA) is a critically important virulence factor produced by Bordetella species that cause respiratory infections in humans and other animals. It is also a prototypical member of the widespread two partner secretion (TPS) pathway family of proteins. First synthesized as a ~370 kDa protein called FhaB, its C-terminal ~1,200 amino acid 'prodomain' is removed during translocation to the cell surface via the outer membrane channel FhaC. Here, we identify CtpA as a periplasmic protease that is responsible for the regulated degradation of the prodomain and for creation of an intermediate polypeptide that is cleaved by the autotransporter protease SphB1 to generate FHA. We show that the central prodomain region is required to initiate degradation of the prodomain and that CtpA degrades the prodomain after a third, unidentified protease (P3) first removes the extreme C-terminus of the prodomain. Stepwise proteolysis by P3, CtpA and SphB1 is required for maturation of FhaB, release of FHA into the extracellular milieu, and full function in vivo. These data support a substantially updated model for the mechanism of secretion, maturation and function of this model TPS protein.
    MeSH term(s) Adhesins, Bacterial/chemistry ; Adhesins, Bacterial/genetics ; Adhesins, Bacterial/metabolism ; Algal Proteins/genetics ; Algal Proteins/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Bordetella bronchiseptica/chemistry ; Bordetella bronchiseptica/genetics ; Bordetella bronchiseptica/metabolism ; Bordetella pertussis/enzymology ; Bordetella pertussis/genetics ; Bordetella pertussis/metabolism ; Carboxypeptidases/genetics ; Carboxypeptidases/metabolism ; Hemagglutinins/chemistry ; Hemagglutinins/genetics ; Hemagglutinins/metabolism ; Proprotein Convertases/genetics ; Proprotein Convertases/metabolism ; Protein Domains ; Protein Processing, Post-Translational ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism
    Chemical Substances Adhesins, Bacterial ; Algal Proteins ; Bacterial Proteins ; Hemagglutinins ; Carboxypeptidases (EC 3.4.-) ; Proprotein Convertases (EC 3.4.21.-) ; Serine Endopeptidases (EC 3.4.21.-) ; photosystem II, D1 polypeptide carboxy-terminal processing protease (EC 3.4.21.102)
    Language English
    Publishing date 2019-06-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.14318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2502: Show issues Location:
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  10. Article ; Online: CDI/CDS system-encoding genes of Burkholderia thailandensis are located in a mobile genetic element that defines a new class of transposon.

    Ocasio, Angelica B / Cotter, Peggy A

    PLoS genetics

    2019  Volume 15, Issue 1, Page(s) e1007883

    Abstract: Intercellular communication and self-recognition are critical for coordinating cooperative and competitive behaviors during sociomicrobiological community development. Contact-dependent growth inhibition (CDI) proteins are polymorphic toxin delivery ... ...

    Abstract Intercellular communication and self-recognition are critical for coordinating cooperative and competitive behaviors during sociomicrobiological community development. Contact-dependent growth inhibition (CDI) proteins are polymorphic toxin delivery systems that inhibit the growth of non-self neighboring bacteria that lack the appropriate immunity protein. In Burkholderia thailandensis, CDI system proteins (encoded by bcpAIOB genes) also induce cooperative behaviors among sibling (self) cells, a phenomenon called contact-dependent signaling (CDS). Here we describe a mobile genetic element (MGE) that carries the bcpAIOB genes in B. thailandensis E264. It is a ~210 kb composite transposon with insertion sequence (IS) elements at each end. Although the ISs are most similar to IS2 of Escherichia coli, the transposase-dependent intermediate molecule displays characteristics more similar to those of the IS26 translocatable unit (TU). A reaction requiring only the "left" IS-encoded transposase results in formation of an extrachromosomal circular dsDNA intermediate ("the megacircle") composed of the left IS and the sequences intervening between the ISs. Insertion of the megacircle into the chromosome occurs next to a pre-existing copy of an IS2-like element, recreating a functional composite transposon. We found that BcpA activity is required for megacircle formation, and in turn, megacircle formation is required for CDS phenotypes. Our data support a model in which the bcpAIOB genes function as both helping and harming greenbeard genes, simultaneously enhancing the fitness of self bacteria that possess the same allele plus tightly linked genes that mediate cooperative behaviors, and killing non-self bacteria that do not possess the same bcpAIOB allele. Mobility of the megacircle between cells could allow bacteria invading a community to be converted to self, and would facilitate propagation of the bcpAIOB genes in the event that the invading strain is capable of overtaking the resident community.
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Toxins/genetics ; Biofilms/growth & development ; Burkholderia/genetics ; Contact Inhibition/genetics ; DNA Transposable Elements/genetics ; DNA, Circular/genetics ; Interspersed Repetitive Sequences/genetics ; Plasmids/genetics ; Sequence Alignment ; Sequence Analysis, DNA ; Signal Transduction ; Transposases/genetics
    Chemical Substances Bacterial Proteins ; Bacterial Toxins ; DNA Transposable Elements ; DNA, Circular ; Transposases (EC 2.7.7.-)
    Language English
    Publishing date 2019-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1007883
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