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  1. Article ; Online: My Future in Medicine: How COVID-19 Is Inspiring the Next Generation of Infectious Disease Specialists.

    Allen, Jawara

    The Journal of infectious diseases

    2020  Volume 221, Issue 12, Page(s) 1938–1939

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Internet ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Specialization
    Keywords covid19
    Language English
    Publishing date 2020-04-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiaa178
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  3. Article ; Online: My Future in Medicine

    Allen, Jawara

    The Journal of Infectious Diseases

    How COVID-19 Is Inspiring the Next Generation of Infectious Disease Specialists

    2020  Volume 221, Issue 12, Page(s) 1938–1939

    Keywords Immunology and Allergy ; Infectious Diseases ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiaa178
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Impact of the gut microbiome on the genome and epigenome of colon epithelial cells

    Jawara Allen / Cynthia L. Sears

    Genome Medicine, Vol 11, Iss 1, Pp 1-

    contributions to colorectal cancer development

    2019  Volume 18

    Abstract: Abstract In recent years, the number of studies investigating the impact of the gut microbiome in colorectal cancer (CRC) has risen sharply. As a result, we now know that various microbes (and microbial communities) are found more frequently in the stool ...

    Abstract Abstract In recent years, the number of studies investigating the impact of the gut microbiome in colorectal cancer (CRC) has risen sharply. As a result, we now know that various microbes (and microbial communities) are found more frequently in the stool and mucosa of individuals with CRC than healthy controls, including in the primary tumors themselves, and even in distant metastases. We also know that these microbes induce tumors in various mouse models, but we know little about how they impact colon epithelial cells (CECs) directly, or about how these interactions might lead to modifications at the genetic and epigenetic levels that trigger and propagate tumor growth. Rates of CRC are increasing in younger individuals, and CRC remains the second most frequent cause of cancer-related deaths globally. Hence, a more in-depth understanding of the role that gut microbes play in CRC is needed. Here, we review recent advances in understanding the impact of gut microbes on the genome and epigenome of CECs, as it relates to CRC. Overall, numerous studies in the past few years have definitively shown that gut microbes exert distinct impacts on DNA damage, DNA methylation, chromatin structure and non-coding RNA expression in CECs. Some of the genes and pathways that are altered by gut microbes relate to CRC development, particularly those involved in cell proliferation and WNT signaling. We need to implement more standardized analysis strategies, collate data from multiple studies, and utilize CRC mouse models to better assess these effects, understand their functional relevance, and leverage this information to improve patient care.
    Keywords Medicine ; R ; Genetics ; QH426-470
    Subject code 306
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development.

    Allen, Jawara / Sears, Cynthia L

    Genome medicine

    2019  Volume 11, Issue 1, Page(s) 11

    Abstract: In recent years, the number of studies investigating the impact of the gut microbiome in colorectal cancer (CRC) has risen sharply. As a result, we now know that various microbes (and microbial communities) are found more frequently in the stool and ... ...

    Abstract In recent years, the number of studies investigating the impact of the gut microbiome in colorectal cancer (CRC) has risen sharply. As a result, we now know that various microbes (and microbial communities) are found more frequently in the stool and mucosa of individuals with CRC than healthy controls, including in the primary tumors themselves, and even in distant metastases. We also know that these microbes induce tumors in various mouse models, but we know little about how they impact colon epithelial cells (CECs) directly, or about how these interactions might lead to modifications at the genetic and epigenetic levels that trigger and propagate tumor growth. Rates of CRC are increasing in younger individuals, and CRC remains the second most frequent cause of cancer-related deaths globally. Hence, a more in-depth understanding of the role that gut microbes play in CRC is needed. Here, we review recent advances in understanding the impact of gut microbes on the genome and epigenome of CECs, as it relates to CRC. Overall, numerous studies in the past few years have definitively shown that gut microbes exert distinct impacts on DNA damage, DNA methylation, chromatin structure and non-coding RNA expression in CECs. Some of the genes and pathways that are altered by gut microbes relate to CRC development, particularly those involved in cell proliferation and WNT signaling. We need to implement more standardized analysis strategies, collate data from multiple studies, and utilize CRC mouse models to better assess these effects, understand their functional relevance, and leverage this information to improve patient care.
    MeSH term(s) Animals ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/microbiology ; Epigenesis, Genetic ; Gastrointestinal Microbiome ; Humans ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/microbiology
    Language English
    Publishing date 2019-02-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2484394-5
    ISSN 1756-994X ; 1756-994X
    ISSN (online) 1756-994X
    ISSN 1756-994X
    DOI 10.1186/s13073-019-0621-2
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  6. Article ; Online: Reimagining Undergraduate Medical Education in a Post-COVID-19 Landscape.

    Guo, Matthew Z / Allen, Jawara / Sakumoto, Matthew / Pahwa, Amit / Santhosh, Lekshmi

    Journal of general internal medicine

    2022  Volume 37, Issue 9, Page(s) 2297–2301

    Abstract: Online education due to the COVID-19 pandemic caused many medical schools to increasingly employ asynchronous and virtual learning that favored student independence and flexibility. At the same time, the COVID-19 pandemic highlighted existing ... ...

    Abstract Online education due to the COVID-19 pandemic caused many medical schools to increasingly employ asynchronous and virtual learning that favored student independence and flexibility. At the same time, the COVID-19 pandemic highlighted existing shortcomings of the healthcare field in providing for marginalized and underserved communities. This perspective piece details the authors' opinions as medical students and medical educators on how to leverage the aspects of pandemic medical education to train physicians who can better address these needs.
    MeSH term(s) COVID-19 ; Education, Distance ; Education, Medical ; Education, Medical, Undergraduate ; Humans ; Pandemics ; Students, Medical
    Language English
    Publishing date 2022-06-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-022-07503-7
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  7. Article ; Online: Epigenetic Changes Induced by

    Allen, Jawara / Hao, Stephanie / Sears, Cynthia L / Timp, Winston

    Infection and immunity

    2019  Volume 87, Issue 6

    Abstract: ... ...

    Abstract Enterotoxigenic
    MeSH term(s) Animals ; Bacterial Toxins/metabolism ; Bacterial Toxins/toxicity ; Bacteroides Infections/genetics ; Bacteroides Infections/metabolism ; Bacteroides Infections/microbiology ; Bacteroides fragilis/genetics ; Bacteroides fragilis/metabolism ; Cell Line, Tumor ; Colon/microbiology ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/microbiology ; Epigenesis, Genetic ; Humans ; Metalloendopeptidases/metabolism ; Metalloendopeptidases/toxicity ; Methylation ; Mice
    Chemical Substances Bacterial Toxins ; Bacteroides fragilis toxin (EC 3.4.24.-) ; Metalloendopeptidases (EC 3.4.24.-)
    Language English
    Publishing date 2019-05-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00447-18
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  8. Article ; Online: Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene.

    Allen, Jawara / Rosendahl Huber, Axel / Pleguezuelos-Manzano, Cayetano / Puschhof, Jens / Wu, Shaoguang / Wu, Xinqun / Boot, Charelle / Saftien, Aurelia / O'Hagan, Heather M / Wang, Hao / van Boxtel, Ruben / Clevers, Hans / Sears, Cynthia L

    Microbiology spectrum

    2022  Volume 10, Issue 3, Page(s) e0105522

    Abstract: Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and induces tumorigenesis in several mouse models of CRC. However, whether specific mutations ... ...

    Abstract Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and induces tumorigenesis in several mouse models of CRC. However, whether specific mutations induced by ETBF lead to colon tumor formation has not been investigated. To determine if ETBF-induced mutations impact the
    MeSH term(s) Adenomatous Polyposis Coli/genetics ; Adenomatous Polyposis Coli/pathology ; Animals ; Bacterial Infections/pathology ; Bacteroides fragilis/genetics ; Bacteroides fragilis/metabolism ; Colon/microbiology ; Colonic Neoplasms/genetics ; Colonic Neoplasms/microbiology ; Colonic Neoplasms/pathology ; Colorectal Neoplasms/microbiology ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; Disease Models, Animal ; Escherichia coli/genetics ; Genes, APC ; Mice ; Mutation
    Language English
    Publishing date 2022-05-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01055-22
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  9. Article ; Online: Correction: Integrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC-sensitive cell lines.

    Kagohara, Luciane T / Zamuner, Fernando / Davis-Marcisak, Emily F / Sharma, Gaurav / Considine, Michael / Allen, Jawara / Yegnasubramanian, Srinivasan / Gaykalova, Daria A / Fertig, Elana J

    British journal of cancer

    2020  Volume 123, Issue 10, Page(s) 1582–1583

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2020-07-17
    Publishing country England
    Document type Published Erratum
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-020-0998-0
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  10. Article ; Online: Pathophysiology of Medication-Related Osteonecrosis of the Jaw-A Minireview.

    Tetradis, Sotirios / Allen, Matthew R / Ruggiero, Salvatore L

    JBMR plus

    2023  Volume 7, Issue 8, Page(s) e10785

    Abstract: Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse effect ...

    Abstract Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse effect of antiresorptive medications administered for control of osseous malignancy, osteoporosis, or other bone metabolic diseases. Despite being reported in the literature two decades ago, MRONJ etiology, pathophysiology, and progression remain largely unknown, and current nonoperative or operative treatment strategies are mostly empirical. Several hypotheses that attempt to explain the mechanisms of MRONJ pathogenesis have been proposed. However, none of these hypotheses alone is able to capture the complex mechanistic underpinnings of the disease. In this minireview, we aim to highlight key findings from clinical and translational studies and propose a unifying model for the pathogenesis and progression of MRONJ. We also identify aspects of the disease process that require further investigation and suggest areas for future research efforts toward calibrating methodologic approaches and validating experimental findings. © 2023 The Authors.
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2473-4039
    ISSN (online) 2473-4039
    DOI 10.1002/jbm4.10785
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