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  1. Book: The Myc gene

    Soucek, Laura / Whitfield, Jonathan

    methods and protocols

    (Methods in molecular biology ; 2318 ; Springer protocols)

    2021  

    Author's details edited by Laura Soucek, Jonathan Whitfield
    Series title Methods in molecular biology ; 2318
    Springer protocols
    Collection
    Language English
    Size xiv, 349 Seiten, Illustrationen
    Edition Second edition
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020940462
    ISBN 978-1-0716-1475-4 ; 9781071614761 ; 1-0716-1475-4 ; 1071614762
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -2318- verfügbar in Königswinter Königswinter

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  2. Book: The Myc gene

    Soucek, Laura / Sodir, Nicole M.

    methods and protocols

    (Methods in molecular biology ; 1012 ; Springer protocols)

    2013  

    Author's details ed. by Laura Soucek ; Nicole M. Sodir
    Series title Methods in molecular biology ; 1012
    Springer protocols
    Collection
    Keywords Myc oncogenes ; Cancer genes
    Subject code 616.994042
    Language English
    Size XI, 282 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017784126
    ISBN 978-1-62703-428-9 ; 9781627034296 ; 1-62703-428-5 ; 1627034293
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 2708 available for loan (reading room) Lesesaal EG

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  3. Article: MYC: there is more to it than cancer.

    Zacarías-Fluck, Mariano F / Soucek, Laura / Whitfield, Jonathan R

    Frontiers in cell and developmental biology

    2024  Volume 12, Page(s) 1342872

    Abstract: MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its mechanism of action and targets are not completely elucidated, it has a fundamental role in cellular proliferation, differentiation, metabolism, ribogenesis, and ...

    Abstract MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its mechanism of action and targets are not completely elucidated, it has a fundamental role in cellular proliferation, differentiation, metabolism, ribogenesis, and bone and vascular development. Over 4 decades of research and some 10,000 publications linking it to tumorigenesis (by searching PubMed for "MYC oncogene") have led to MYC becoming a most-wanted target for the treatment of cancer, where many of MYC's physiological functions become co-opted for tumour initiation and maintenance. In this context, an abundance of reviews describes strategies for potentially targeting MYC in the oncology field. However, its multiple roles in different aspects of cellular biology suggest that it may also play a role in many additional diseases, and other publications are indeed linking MYC to pathologies beyond cancer. Here, we review these physiological functions and the current literature linking MYC to non-oncological diseases. The intense efforts towards developing MYC inhibitors as a cancer therapy will potentially have huge implications for the treatment of other diseases. In addition, with a complementary approach, we discuss some diseases and conditions where MYC appears to play a protective role and hence its increased expression or activation could be therapeutic.
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2024.1342872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: eIF4A dependency: the hidden key to unlock KRAS mutant non-small cell lung cancer's vulnerability.

    Casacuberta-Serra, Silvia / Gonzalez-Larreategui, Iñigo / Soucek, Laura

    Translational lung cancer research

    2023  Volume 12, Issue 12, Page(s) 2570–2575

    Language English
    Publishing date 2023-12-22
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeting MYC-driven lymphoma: lessons learned and future directions.

    Martínez-Martín, Sandra / Beaulieu, Marie-Eve / Soucek, Laura

    Cancer drug resistance (Alhambra, Calif.)

    2023  Volume 6, Issue 2, Page(s) 205–222

    Abstract: MYC plays a central role in tumorigenesis by orchestrating cell proliferation, growth and survival, among other transformation mechanisms. In particular, MYC has often been associated with lymphomagenesis. In fact, MYC overexpressing lymphomas such as ... ...

    Abstract MYC plays a central role in tumorigenesis by orchestrating cell proliferation, growth and survival, among other transformation mechanisms. In particular, MYC has often been associated with lymphomagenesis. In fact, MYC overexpressing lymphomas such as high-grade B-cell lymphoma (HGBL) and double expressor diffuse large B-cell lymphomas (DLBCL), are considered addicted to MYC. In such a context, MYC targeting therapies are of special interest, as MYC withdrawal is expected to result in tumor regression. However, whether high MYC levels are always predictive of increased sensitivity to these approaches is not clear yet. Even though no MYC inhibitor has received regulatory approval to date, substantial efforts have been made to investigate avenues to render MYC a druggable target. Here, we summarize the different classes of molecules currently under development, which mostly target MYC indirectly in aggressive B-cell lymphomas, paying special attention to subtypes with MYC/BCL2 or BCL6 translocations or overexpression.
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2578-532X
    ISSN (online) 2578-532X
    DOI 10.20517/cdr.2022.127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: MYC inhibitors in multiple myeloma.

    Martínez-Martín, Sandra / Soucek, Laura

    Cancer drug resistance (Alhambra, Calif.)

    2021  Volume 4, Issue 4, Page(s) 842–865

    Abstract: The importance of MYC function in cancer was discovered in the late 1970s when the sequence of the avian retrovirus that causes myelocytic leukemia was identified. Since then, over 40 years of unceasing research have highlighted the significance of this ... ...

    Abstract The importance of MYC function in cancer was discovered in the late 1970s when the sequence of the avian retrovirus that causes myelocytic leukemia was identified. Since then, over 40 years of unceasing research have highlighted the significance of this protein in malignant transformation, especially in hematologic diseases. Indeed, some of the earliest connections among the higher expression of proto-oncogenes (such as
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2578-532X
    ISSN (online) 2578-532X
    DOI 10.20517/cdr.2021.55
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  7. Article ; Online: An "-omycs" Toolbox to Work with MYC.

    Whitfield, Jonathan / Soucek, Laura

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2318, Page(s) 1–11

    Abstract: The MYC transcription factor coordinates a wide range of intra- and extracellular processes associated with tissue proliferation and regeneration. While these processes are typically tightly regulated in physiological conditions, they become deregulated ... ...

    Abstract The MYC transcription factor coordinates a wide range of intra- and extracellular processes associated with tissue proliferation and regeneration. While these processes are typically tightly regulated in physiological conditions, they become deregulated in cancer, where MYC is oncogenically activated.The last decade has seen MYC progress from a renowned undruggable target to a hot topic in the cancer therapy field, as proof emerged from mouse models that its inhibition constitutes an effective and broadly applicable approach to fight cancer. However, there are several aspects of MYC biology that still appear to be elusive and maintain the interest in further studying this intriguing protein. Since MYC's discovery, more than four decades ago, multiple strategies have been developed to study it, related to the many and varied facets of its biology. This new version of The Myc gene: Methods and Protocols provides valuable tips from key "inhabitants of the MYC world," which significantly increase the reach of our investigative tools to shed light on the mysteries still surrounding MYC.
    MeSH term(s) Animals ; Genes, myc ; Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/physiopathology ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Proto-Oncogene Proteins c-myc/physiology
    Chemical Substances Proto-Oncogene Proteins c-myc
    Language English
    Publishing date 2021-05-21
    Publishing country United States
    Document type Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1476-1_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  8. Article ; Online: The long journey to bring a Myc inhibitor to the clinic.

    Whitfield, Jonathan R / Soucek, Laura

    The Journal of cell biology

    2021  Volume 220, Issue 8

    Abstract: The oncogene Myc is deregulated in the majority of human tumors and drives numerous hallmarks of cancer. Despite its indisputable role in cancer development and maintenance, Myc is still undrugged. Developing a clinical inhibitor for Myc has been ... ...

    Abstract The oncogene Myc is deregulated in the majority of human tumors and drives numerous hallmarks of cancer. Despite its indisputable role in cancer development and maintenance, Myc is still undrugged. Developing a clinical inhibitor for Myc has been particularly challenging owing to its intrinsically disordered nature and lack of a binding pocket, coupled with concerns regarding potentially deleterious side effects in normal proliferating tissues. However, major breakthroughs in the development of Myc inhibitors have arisen in the last couple of years. Notably, the direct Myc inhibitor that we developed has just entered clinical trials. Celebrating this milestone, with this Perspective, we pay homage to the different strategies developed so far against Myc and all of the researchers focused on developing treatments for a target long deemed undruggable.
    MeSH term(s) Animals ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Cell Proliferation/drug effects ; Diffusion of Innovation ; Drug Design ; Gene Expression Regulation, Neoplastic ; Humans ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Proto-Oncogene Proteins c-myc/antagonists & inhibitors ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Signal Transduction
    Chemical Substances Antineoplastic Agents ; MYC protein, human ; Proto-Oncogene Proteins c-myc
    Language English
    Publishing date 2021-06-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202103090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.190: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Resveratrol derivatives: Synthesis and their biological activities.

    Grau, Laura / Soucek, Richard / Pujol, M Dolors

    European journal of medicinal chemistry

    2022  Volume 246, Page(s) 114962

    Abstract: Resveratrol, a natural compound known especially for its antioxidant properties and protective action, opens the door for both it and its structural derivatives to be considered not only as chemopreventive but also as cancer chemotherapeutic agents. Due ... ...

    Abstract Resveratrol, a natural compound known especially for its antioxidant properties and protective action, opens the door for both it and its structural derivatives to be considered not only as chemopreventive but also as cancer chemotherapeutic agents. Due to the pharmacokinetic problems of resveratrol that demonstrate its poor bioavailability, the study of new derivatives is of interest. Thus, in this work (E)-stilbenes derived directly from resveratrol and other cyclic analogues containing the benzofuran or indole nucleus have been synthesized. The synthesized compounds have been evaluated for their ability to affect tumor growth in vitro. Compounds 2, 3, 4 and 5 have shown cytotoxicity in human colon cancer (HT-29) and human pancreatic adenocarcinoma cells (MIA PaCa-2) higher than those of (E)-resveratrol. The indolic derivative 13, a cyclic analog of resveratrol, has shown in vitro cytotoxic activity 8 times higher than resveratrol against HT-29 cancer cells. The cyclic derivatives 8, 9 and 12 showed a high inhibition of cell growth in HCT-116 (KRas mutant) at 20 μM, while 13 shows moderate antiangiogenesis activity at 10 μM.
    Language English
    Publishing date 2022-11-26
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2022.114962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc.

    Massó-Vallés, Daniel / Soucek, Laura

    Cells

    2020  Volume 9, Issue 4

    Abstract: First designed and published in 1998 as a laboratory tool to study Myc perturbation, Omomyc has come a long way in the past 22 years. This dominant negative has contributed to our understanding of Myc biology when expressed, first, in normal and cancer ... ...

    Abstract First designed and published in 1998 as a laboratory tool to study Myc perturbation, Omomyc has come a long way in the past 22 years. This dominant negative has contributed to our understanding of Myc biology when expressed, first, in normal and cancer cells, and later in genetically-engineered mice, and has shown remarkable anti-cancer properties in a wide range of tumor types. The recently described therapeutic effect of purified Omomyc mini-protein-following the surprising discovery of its cell-penetrating capacity-constitutes a paradigm shift. Now, much more than a proof of concept, the most characterized Myc inhibitor to date is advancing in its drug development pipeline, pushing Myc inhibition into the clinic.
    MeSH term(s) Amino Acid Sequence ; Animals ; Biomedical Research ; Epigenesis, Genetic ; Humans ; Neoplasms/genetics ; Neoplasms/therapy ; Peptide Fragments/administration & dosage ; Peptide Fragments/chemistry ; Peptide Fragments/metabolism ; Proto-Oncogene Proteins c-myc/administration & dosage ; Proto-Oncogene Proteins c-myc/chemistry ; Proto-Oncogene Proteins c-myc/metabolism ; Transcriptional Activation/genetics
    Chemical Substances Peptide Fragments ; Proto-Oncogene Proteins c-myc ; omomyc protein
    Language English
    Publishing date 2020-04-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9040883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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