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  1. Article ; Online: Identity-Based Proxy Re-Encryption Scheme Using Fog Computing and Anonymous Key Generation.

    Lin, Han-Yu / Tsai, Tung-Tso / Ting, Pei-Yih / Fan, Yan-Rong

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 5

    Abstract: In the fog computing architecture, a fog is a node closer to clients and responsible for responding to users' requests as well as forwarding messages to clouds. In some medical applications such as the remote healthcare, a sensor of patients will first ... ...

    Abstract In the fog computing architecture, a fog is a node closer to clients and responsible for responding to users' requests as well as forwarding messages to clouds. In some medical applications such as the remote healthcare, a sensor of patients will first send encrypted data of sensed information to a nearby fog such that the fog acting as a re-encryption proxy could generate a re-encrypted ciphertext designated for requested data users in the cloud. Specifically, a data user can request access to cloud ciphertexts by sending a query to the fog node that will forward this query to the corresponding data owner who preserves the right to grant or deny the permission to access his/her data. When the access request is granted, the fog node will obtain a unique re-encryption key for carrying out the re-encryption process. Although some previous concepts have been proposed to fulfill these application requirements, they either have known security flaws or incur higher computational complexity. In this work, we present an identity-based proxy re-encryption scheme on the basis of the fog computing architecture. Our identity-based mechanism uses public channels for key distribution and avoids the troublesome problem of key escrow. We also formally prove that the proposed protocol is secure in the IND-PrID-CPA notion. Furthermore, we show that our work exhibits better performance in terms of computational complexity.
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23052706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: N-glycan biosignatures as a potential diagnostic biomarker for early-stage pancreatic cancer.

    Wen, Yan-Rong / Lin, Xia-Wen / Zhou, Yu-Wen / Xu, Lei / Zhang, Jun-Li / Chen, Cui-Ying / He, Jian

    World journal of gastrointestinal oncology

    2024  Volume 16, Issue 3, Page(s) 659–669

    Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with a 5-year survival rate of less than 10%, owing to its late-stage diagnosis. Early detection of pancreatic cancer (PC) can significantly increase survival rates.: Aim: To ... ...

    Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with a 5-year survival rate of less than 10%, owing to its late-stage diagnosis. Early detection of pancreatic cancer (PC) can significantly increase survival rates.
    Aim: To identify the serum biomarker signatures associated with early-stage PDAC by serum N-glycan analysis.
    Methods: An extensive patient cohort was used to determine a biomarker signature, including patients with PDAC that was well-defined at an early stage (stages I and II). The biomarker signature was derived from a case-control study using a case-cohort design consisting of 29 patients with stage I, 22 with stage II, 4 with stage III, 16 with stage IV PDAC, and 88 controls. We used multiparametric analysis to identify early-stage PDAC N-glycan signatures and developed an N-glycan signature-based diagnosis model called the "Glyco-model".
    Results: The biomarker signature was created to discriminate samples derived from patients with PC from those of controls, with a receiver operating characteristic area under the curve of 0.86. In addition, the biomarker signature combined with cancer antigen 19-9 could discriminate patients with PDAC from controls, with a receiver operating characteristic area under the curve of 0.919. Glyco-model demonstrated favorable diagnostic performance in all stages of PC. The diagnostic sensitivity for stage I PDAC was 89.66%.
    Conclusion: In a prospective validation study, this serum biomarker signature may offer a viable method for detecting early-stage PDAC.
    Language English
    Publishing date 2024-04-03
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573696-6
    ISSN 1948-5204
    ISSN 1948-5204
    DOI 10.4251/wjgo.v16.i3.659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Environmentally relevant concentrations of benzophenones exposure disrupt intestinal homeostasis, impair the intestinal barrier, and induce inflammation in mice.

    Lin, Yu-Jia / Li, Hong-Mei / Gao, Yan-Rong / Wu, Ping-Fan / Cheng, Bin / Yu, Chen-Long / Sheng, Yu-Xin / Xu, Hai-Ming

    Environmental pollution (Barking, Essex : 1987)

    2024  Volume 350, Page(s) 123948

    Abstract: The aim of this study is to investigate the adverse effects of benzophenones (BPs) on the intestinal tract of mice and the potential mechanism. F1-generation ICR mice were exposed to BPs (benzophenone-1, benzophenone-2, and benzophenone-3) by ... ...

    Abstract The aim of this study is to investigate the adverse effects of benzophenones (BPs) on the intestinal tract of mice and the potential mechanism. F1-generation ICR mice were exposed to BPs (benzophenone-1, benzophenone-2, and benzophenone-3) by breastfeeding from birth until weaning, and by drinking water after weaning until maturity. The offspring mice were executed on postnatal day 56, then their distal colons were sampled. AB-PAS staining, HE staining, immunofluorescence, Transmission Electron Microscope, immunohistochemistry, Western Blot and RT-qPCR were used to study the effects of BPs exposure on the colonic tissues of offspring mice. The results showed that colonic microvilli appeared significantly deficient in the high-dose group, and the expression of tight junction markers Zo-1 and Occludin was significantly down-regulated and the number of goblet cells and secretions were reduced in all dose groups, and the expression of secretory cell markers MUC2 and KI67 were decreased, as well as the expression of intestinal stem cell markers Lgr5 and Bmi1, suggesting that BPs exposure caused disruption of intestinal barrier and imbalance in the composition of the intestinal stem cell pool. Besides, the expression of cellular inflammatory factors such as macrophage marker F4/80 and tumor necrosis factor TNF-α was elevated in the colonic tissues of all dose groups, and the inflammatory infiltration was observed, which means the exposure of BPs caused inflammatory effects in the intestinal tract of F1-generation mice. In addition, the contents of Notch/Wnt signaling pathway-related genes, such as Dll-4, Notch1, Hes1, Ctnnb1and Sfrp2 were significantly decreased in each high-dose group (P < 0.05), suggesting that BPs may inhibit the regulation of Notch/Wnt signaling pathway. In conclusion, exposure to BPs was able to imbalance colonic homeostasis, disrupt the intestinal barrier, and trigger inflammation in the offspring mice, which might be realized through interfering with the Notch/Wnt signaling pathway.
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2024.123948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Enalapril increases the urinary excretion of metformin in rats by inducing multidrug and toxin excretion protein 1 in the kidney.

    Gou, Xue-Yan / Wu, Yan-Fang / Ran, Feng-Lin / Ma, Yan-Rong / Wu, Xin-An

    Biopharmaceutics & drug disposition

    2022  

    Abstract: Two-thirds of patients with type 2 diabetes mellitus (T2DM) have hypertension, and thus the combination of two or more drugs to treat these diseases is common. It has been shown that the combination of metformin and enalapril has beneficial effects, but ... ...

    Abstract Two-thirds of patients with type 2 diabetes mellitus (T2DM) have hypertension, and thus the combination of two or more drugs to treat these diseases is common. It has been shown that the combination of metformin and enalapril has beneficial effects, but few studies have evaluated the interactions between these two drugs. In this study we investigated the effects of enalapril on the pharmacokinetics and urinary excretion of metformin in rats, with a focus on transporter-mediated drug interactions. Rats were orally dosed with metformin alone (100 mg/kg) or in combination with enalapril (4 mg/kg). The concentration of metformin was measured by HPLC and the level of organic cation transporters (rOCTs) and multidrug and toxin excretion protein 1 (rMATE1), which mediate the uptake and efflux of metformin, respectively, were evaluated by immunoblotting. After single and 7-day dosing, the plasma concentration of metformin in the co-administration group was significantly lower than that in the metformin-only group, and the CL/F and urinary excretion were increased in the co-administration group. Enalapril did not affect the Kp of metformin but elevated slice-uptake of metformin. The expression of rMATE1 was increased, whereas rOCT2 expression was decreased in rat kidney. Importantly, long-term co-administration of metformin and enalapril markedly decreased the level of lactic acid and uric acid in the blood. Enalapril increases the urinary excretion of metformin through the up-regulation of rMATE1. This reveals a new mechanism of drug interactions and provides a basis for drug dosage adjustment when these drugs are co-administered. This article is protected by copyright. All rights reserved.
    Language English
    Publishing date 2022-12-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 603014-2
    ISSN 1099-081X ; 0142-2782
    ISSN (online) 1099-081X
    ISSN 0142-2782
    DOI 10.1002/bdd.2341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Effects of elevated atmospheric ammonia concentration on photosynthetic characteristics and grain yield in wheat under different nitrogen rates.

    Zhang, Peng-Fei / Liu, Peng-Zhao / Wang, Cheng-Long / Deng, Ming-Zhu / Lin, Yan-Rong / Ren, Xiao-Long / Chen, Xiao-Li

    Ying yong sheng tai xue bao = The journal of applied ecology

    2023  Volume 34, Issue 4, Page(s) 1009–1014

    Abstract: To evaluate the effects of nitrogen (N) application rates on the growth, photosynthetic traits and yield of winter wheat under elevated atmospheric ammonia ( ... ...

    Title translation 大气NH
    Abstract To evaluate the effects of nitrogen (N) application rates on the growth, photosynthetic traits and yield of winter wheat under elevated atmospheric ammonia (NH
    MeSH term(s) Triticum ; Ammonia ; Nitrogen/pharmacology ; Plant Leaves ; Fertilizers ; Photosynthesis ; Edible Grain
    Chemical Substances Ammonia (7664-41-7) ; Nitrogen (N762921K75) ; Fertilizers
    Language English
    Publishing date 2023-04-20
    Publishing country China
    Document type Journal Article
    ZDB-ID 2881809-X
    ISSN 1001-9332
    ISSN 1001-9332
    DOI 10.13287/j.1001-9332.202304.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Study on the cyclic adsorption performance of biomass composite membrane for Hg(II).

    Zhao, Bai-Yun / Yang, Xing-Lin / Liu, Xiao-Kai / Shi, Qi / Liu, Yan-Rong / Wang, Li

    Environmental technology

    2022  Volume 44, Issue 25, Page(s) 3777–3790

    Abstract: Salix psammophila wood flour /polyvinyl alcohol hydrogel composite ... ...

    Abstract Salix psammophila wood flour /polyvinyl alcohol hydrogel composite membrane
    MeSH term(s) Spectroscopy, Fourier Transform Infrared ; Adsorption ; Biomass ; Mercury/chemistry ; Temperature ; Kinetics ; Water Pollutants, Chemical/chemistry ; Hydrogen-Ion Concentration
    Chemical Substances Mercury (FXS1BY2PGL) ; Water Pollutants, Chemical
    Language English
    Publishing date 2022-05-09
    Publishing country England
    Document type Journal Article
    ISSN 1479-487X
    ISSN (online) 1479-487X
    DOI 10.1080/09593330.2022.2071644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A modified QuEChERS-based UPLC-MS/MS method for rapid determination of multiple antibiotics and sedative residues in freshwater fish.

    Yang, Yan / Li, Xin / Lin, Jian / Bao, Rong

    Food chemistry: X

    2024  Volume 22, Page(s) 101268

    Abstract: Antibiotics and sedatives are used in freshwater fish culture and transportation, and residue in freshwater fish pose potential risks to human health. Therefore, a throughput method was developed to detect antibiotic and sedative residues in fish, ... ...

    Abstract Antibiotics and sedatives are used in freshwater fish culture and transportation, and residue in freshwater fish pose potential risks to human health. Therefore, a throughput method was developed to detect antibiotic and sedative residues in fish, simultaneously quantifying 68 antibiotics and 9 sedatives in freshwater fish using a modified QuEChERS extraction method and UPLC-MS/MS. Matrix-matched calibrations demonstrated good correlation coefficients (R
    Language English
    Publishing date 2024-03-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-1575
    ISSN (online) 2590-1575
    DOI 10.1016/j.fochx.2024.101268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Interaction between Organic Solvents and Three Types of Kerogen Investigated via X-ray Diffraction

    Liang, Tian / Zhan, Zhao-Wen / Zou, Yan-Rong / Lin, Xiao-Hui / Peng, Ping’an

    Energy & fuels. 2022 Jan. 21, v. 36, no. 3

    2022  

    Abstract: In this work, for the first time, a new swelling method was applied to study the chemical structure of kerogen. Structural changes during the swelling process were detected via X-ray diffraction (XRD). Three types of kerogen samples and three organic ... ...

    Abstract In this work, for the first time, a new swelling method was applied to study the chemical structure of kerogen. Structural changes during the swelling process were detected via X-ray diffraction (XRD). Three types of kerogen samples and three organic solvents were selected for this study. It was found that kerogens have a selective absorption of aromatic hydrocarbons compared with saturated hydrocarbons. Type I kerogen demonstrated the strongest ability to sorb hydrocarbons; it can sorb more than half of its own weight at normal temperature and pressure (25 °C and 1.013 × 10⁵ Pa). However, under the same conditions, type III kerogen can sorb around 40% of its own weight. XRD detection revealed that the microcrystalline structure of kerogen was not affected by liquid organic matter during the swelling process. Three kinds of organic solvent are mainly sorbed in the γ band (amorphous carbon) comprising aliphatic carbon, and the γ band swells under the swelling action, causing the value of dᵧ to increase. This study explored the ability of kerogen to sorb hydrocarbon compounds and discovered the chemical structural units that occur in kerogen during solvent swelling. It is of great significance for the study of the hydrocarbon generation and expulsion in oil shale under geological conditions and the structure of kerogen.
    Keywords X-ray diffraction ; absorption ; carbon ; chemical structure ; energy ; liquids ; oil shale ; organic matter ; solvents ; temperature
    Language English
    Dates of publication 2022-0121
    Size p. 1350-1357.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 1483539-3
    ISSN 1520-5029 ; 0887-0624
    ISSN (online) 1520-5029
    ISSN 0887-0624
    DOI 10.1021/acs.energyfuels.1c03589
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Research Advance of Chinese Medicine in Treating Atherosclerosis: Focus on Lipoprotein-Associated Phospholipase A2.

    Wang, Lu-Ming / Zhang, Wen-Lan / Lyu, Nuan / Suo, Yan-Rong / Yang, Lin / Yu, Bin / Jiang, Xi-Juan

    Chinese journal of integrative medicine

    2023  Volume 30, Issue 3, Page(s) 277–288

    Abstract: As a serious cardiovascular disease, atherosclerosis (AS) causes chronic inflammation and oxidative stress in the body and poses a threat to human health. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a member of the phospholipase A2 (PLA2) family, ...

    Abstract As a serious cardiovascular disease, atherosclerosis (AS) causes chronic inflammation and oxidative stress in the body and poses a threat to human health. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a member of the phospholipase A2 (PLA2) family, and its elevated levels have been shown to contribute to AS. Lp-PLA2 is closely related to a variety of lipoproteins, and its role in promoting inflammatory responses and oxidative stress in AS is mainly achieved by hydrolyzing oxidized phosphatidylcholine (oxPC) to produce lysophosphatidylcholine (lysoPC). Moreover, macrophage apoptosis within plaque is promoted by localized Lp-PLA2 which also promotes plaque instability. This paper reviews those researches of Chinese medicine in treating AS via reducing Lp-PLA2 levels to guide future experimental studies and clinical applications related to AS.
    MeSH term(s) Humans ; 1-Alkyl-2-acetylglycerophosphocholine Esterase ; Medicine, Chinese Traditional ; Atherosclerosis/drug therapy ; Lipoproteins ; Plaque, Atherosclerotic ; Biomarkers
    Chemical Substances 1-Alkyl-2-acetylglycerophosphocholine Esterase (EC 3.1.1.47) ; Lipoproteins ; Biomarkers
    Language English
    Publishing date 2023-12-07
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2171254-2
    ISSN 1993-0402 ; 1672-0415
    ISSN (online) 1993-0402
    ISSN 1672-0415
    DOI 10.1007/s11655-023-3611-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hsa-miR-379 down-regulates Rac1/MLK3/JNK/AP-1/Collagen I cascade reaction by targeting connective tissue growth factor in human alveolar basal epithelial A549 cells.

    Shan, Jing / Wu, Meng-Yu / Zhang, Ying-Chi / Lin, Yu-Jia / Cheng, Bin / Gao, Yan-Rong / Liu, Zhi-Hong / Xu, Hai-Ming

    Cytokine

    2023  Volume 166, Page(s) 156191

    Abstract: Objective: This study was aimed to screen and identify miRNAs that could regulate human CTGF gene and downstream cascade reaction Rac1/MLK3/JNK/AP-1/Collagen I by bioinformatics and experimental means.: Methods: TargetScan and Tarbase were used to ... ...

    Abstract Objective: This study was aimed to screen and identify miRNAs that could regulate human CTGF gene and downstream cascade reaction Rac1/MLK3/JNK/AP-1/Collagen I by bioinformatics and experimental means.
    Methods: TargetScan and Tarbase were used to predict miRNAs that may have regulatory effects on human CTGF gene. The dual-luciferase reporter gene assay was employed to verify the results obtained in bioinformatics. Human alveolar basal epithelial A549 cells were exposed to silica (SiO
    Results: A total of 9 differentially expressed miRNAs that might regulate the human CTGF gene were predicted. Hsa-miR-379-3p and hsa-miR-411-3p were selected for the subsequent experiments. The results of the dual-luciferase reporter assay showed that hsa-miR-379-3p could bind to CTGF, but hsa-miR-411-3p could not. Compared with the control group, SiO
    Conclusion: Hsa-miR-379-3p was demonstrated for the first time that could directly target and down-regulate human CTGF gene, and further affect the expression levels of key genes and proteins in Rac1/MLK3/JNK/AP-1/Collagen I cascade reaction.
    MeSH term(s) Humans ; A549 Cells ; Collagen/metabolism ; Connective Tissue Growth Factor/genetics ; Connective Tissue Growth Factor/metabolism ; MicroRNAs/genetics ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/metabolism ; RNA, Messenger ; Silicon Dioxide/metabolism ; Transcription Factor AP-1/genetics ; Transcription Factor AP-1/metabolism
    Chemical Substances Collagen (9007-34-5) ; Connective Tissue Growth Factor (139568-91-5) ; MicroRNAs ; MIRN379 microRNA, human ; MIRN411 microRNA, human ; rac1 GTP-Binding Protein (EC 3.6.5.2) ; RAC1 protein, human ; RNA, Messenger ; Silicon Dioxide (7631-86-9) ; Transcription Factor AP-1
    Language English
    Publishing date 2023-03-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2023.156191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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