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  1. Article: Antimicrobial susceptibilities and mechanisms of resistance of commensal and invasive

    Xiao, Li / Totten, Arthur H / Crabb, Donna M / Atkinson, Thomas Prescott / Waites, Ken B

    Frontiers in microbiology

    2022  Volume 13, Page(s) 914464

    Abstract: Mycoplasma ... ...

    Abstract Mycoplasma salivarium
    Language English
    Publishing date 2022-08-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.914464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Omadacycline Is Highly Active

    Waites, Ken B / Crabb, Donna M / Atkinson, T Prescott / Geisler, William M / Xiao, Li

    Microbiology spectrum

    2022  Volume 10, Issue 6, Page(s) e0365422

    Abstract: ... Here, we ... ...

    Abstract Here, we performed
    MeSH term(s) Humans ; Tetracycline/pharmacology ; Mycoplasma genitalium ; Mycoplasma Infections/drug therapy ; Drug Resistance, Bacterial ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Macrolides/pharmacology ; Quinolones/pharmacology ; Quinolones/therapeutic use ; Minocycline/pharmacology ; Minocycline/therapeutic use ; Mitomycin/pharmacology ; Mitomycin/therapeutic use ; Protein Synthesis Inhibitors/pharmacology
    Chemical Substances omadacycline (090IP5RV8F) ; Tetracycline (F8VB5M810T) ; Anti-Bacterial Agents ; Macrolides ; Quinolones ; Minocycline (FYY3R43WGO) ; Mitomycin (50SG953SK6) ; Protein Synthesis Inhibitors
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03654-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Latest Advances in Laboratory Detection of Mycoplasma genitalium.

    Waites, Ken B / Crabb, Donna M / Ratliff, Amy E / Geisler, William M / Atkinson, T Prescott / Xiao, Li

    Journal of clinical microbiology

    2023  Volume 61, Issue 3, Page(s) e0079021

    Abstract: Mycoplasma genitalium is an important sexually transmitted pathogen affecting both men and women. Its extremely slow ... ...

    Abstract Mycoplasma genitalium is an important sexually transmitted pathogen affecting both men and women. Its extremely slow growth
    MeSH term(s) Male ; Humans ; Female ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Mycoplasma genitalium/genetics ; Laboratories ; Drug Resistance, Bacterial ; Mycoplasma Infections/microbiology ; Macrolides ; Urethritis/microbiology
    Chemical Substances Anti-Bacterial Agents ; Macrolides
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.00790-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1188: Show issues Location:
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  4. Article: What's new in diagnostic testing and treatment approaches for Mycoplasma pneumoniae infections in children?

    Waites, Ken B

    Advances in experimental medicine and biology

    2011  Volume 719, Page(s) 47–57

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Child ; Diagnostic Tests, Routine ; Humans ; Mycoplasma Infections/diagnosis ; Mycoplasma Infections/drug therapy ; Mycoplasma Infections/microbiology ; Mycoplasma pneumoniae/isolation & purification ; Mycoplasma pneumoniae/pathogenicity
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2011
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-1-4614-0204-6_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Septic polyarthritis with

    Totten, Arthur H / Xiao, Li / Crabb, Donna M / Ratliff, Amy E / Waites, Ken B / Hwangpo, Tracy / Atkinson, T Prescott

    Access microbiology

    2021  Volume 3, Issue 4, Page(s) 221

    Abstract: Mycoplasma ... ...

    Abstract Mycoplasma salivarium
    Language English
    Publishing date 2021-04-09
    Publishing country England
    Document type Case Reports
    ISSN 2516-8290
    ISSN (online) 2516-8290
    DOI 10.1099/acmi.0.000221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: In Vitro

    Waites, Ken B / Crabb, Donna M / Xiao, Li / Duffy, Lynn B / Leal, Sixto M

    Antimicrobial agents and chemotherapy

    2020  Volume 64, Issue 8

    Abstract: ... We ... ...

    Abstract We performed
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents ; Humans ; Microbial Sensitivity Tests ; Mycoplasma Infections/drug therapy ; Mycoplasma hominis ; Tetracyclines/pharmacology ; Ureaplasma ; Ureaplasma Infections/drug therapy ; Ureaplasma urealyticum
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Tetracyclines ; eravacycline (07896928ZC)
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.00698-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
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    Einzelsignatur: Show issues

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  7. Article ; Online: B-assembler: a circular bacterial genome assembler.

    Huang, Fengyuan / Xiao, Li / Gao, Min / Vallely, Ethan J / Dybvig, Kevin / Atkinson, T Prescott / Waites, Ken B / Chong, Zechen

    BMC genomics

    2022  Volume 23, Issue Suppl 4, Page(s) 361

    Abstract: ... We developed B-assembler, which is capable of assembling bacterial genomes when there are only long reads or ... a combination of short and long reads. B-assembler takes advantage of the structural resolving power of long ... Conclusions: B-assembler provides a better solution to bacterial genome assembly, which will facilitate ...

    Abstract Background: Accurate bacteria genome de novo assembly is fundamental to understand the evolution and pathogenesis of new bacteria species. The advent and popularity of Third-Generation Sequencing (TGS) enables assembly of bacteria genomes at an unprecedented speed. However, most current TGS assemblers were specifically designed for human or other species that do not have a circular genome. Besides, the repetitive DNA fragments in many bacterial genomes plus the high error rate of long sequencing data make it still very challenging to accurately assemble their genomes even with a relatively small genome size. Therefore, there is an urgent need for the development of an optimized method to address these issues.
    Results: We developed B-assembler, which is capable of assembling bacterial genomes when there are only long reads or a combination of short and long reads. B-assembler takes advantage of the structural resolving power of long reads and the accuracy of short reads if applicable. It first selects and corrects the ultra-long reads to get an initial contig. Then, it collects the reads overlapping with the ends of the initial contig. This two-round assembling procedure along with optimized error correction enables a high-confidence and circularized genome assembly. Benchmarked on both synthetic and real sequencing data of several species of bacterium, the results show that both long-read-only and hybrid-read modes can accurately assemble circular bacterial genomes free of structural errors and have fewer small errors compared to other assemblers.
    Conclusions: B-assembler provides a better solution to bacterial genome assembly, which will facilitate downstream bacterial genome analysis.
    MeSH term(s) Bacteria/genetics ; DNA ; Genome, Bacterial ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Sequence Analysis, DNA/methods
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2022-05-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-022-08577-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A plain language summary of how lefamulin alone can be used to treat pneumonia caught outside of the hospital due to common bacterial causes, including drug-resistant bacteria.

    Paukner, Susanne / Moran, Gregory J / Sandrock, Christian / File, Thomas M / Vidal, Jorge E / Waites, Ken B / Gelone, Steven P / Yu, Kalvin

    Future microbiology

    2022  Volume 17, Page(s) 397–410

    Abstract: What is this summary about?: Bacterial pneumonia is an infection of the lung caused by bacteria that is potentially deadly, costly, and affects millions of people worldwide every year. Treatment is becoming more challenging-many current treatments no ... ...

    Abstract What is this summary about?: Bacterial pneumonia is an infection of the lung caused by bacteria that is potentially deadly, costly, and affects millions of people worldwide every year. Treatment is becoming more challenging-many current treatments no longer work well because some strains of bacteria that cause pneumonia have become resistant to current antibiotics. Many of the antibiotics that do still work have undesirable side effects. Therefore, new antibiotics that work differently are needed to treat bacterial pneumonia. Lefamulin (brand name, Xenleta
    What were the results?: After the studies were completed, the researchers looked back at what kinds of bacteria were identified from the study participants. Lefamulin worked well to kill bacteria and to improve CABP symptoms for most kinds of infecting bacteria, including bacteria resistant to many current antibiotics.
    What do the results mean?: These results suggest that lefamulin, by itself, provides a much-needed treatment option for CABP that covers most of the key bacteria causing this infection.
    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Bacteria/drug effects ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/microbiology ; Diterpenes ; Hospitals ; Humans ; Language ; Pneumonia, Bacterial/drug therapy ; Pneumonia, Bacterial/microbiology ; Polycyclic Compounds ; Thioglycolates
    Chemical Substances Anti-Bacterial Agents ; Diterpenes ; Polycyclic Compounds ; Thioglycolates ; lefamulin (21904A5386)
    Language English
    Publishing date 2022-03-14
    Publishing country England
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2021-0276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mycoplasma pneumoniae Infections in Childhood.

    Atkinson, T Prescott / Waites, Ken B

    The Pediatric infectious disease journal

    2014  Volume 33, Issue 1, Page(s) 92–94

    MeSH term(s) Adolescent ; Asthma/microbiology ; Child ; Child, Preschool ; Humans ; Infant ; Mycoplasma Infections/microbiology ; Mycoplasma pneumoniae/isolation & purification
    Language English
    Publishing date 2014-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000000171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1852: Show issues Location:
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  10. Article: Lefamulin in Patients with Community-Acquired Bacterial Pneumonia Caused by Atypical Respiratory Pathogens: Pooled Results from Two Phase 3 Trials.

    Paukner, Susanne / Mariano, David / Das, Anita F / Moran, Gregory J / Sandrock, Christian / Waites, Ken B / File, Thomas M

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 12

    Abstract: Lefamulin was the first systemic pleuromutilin antibiotic approved for intravenous and oral use in adults with community-acquired bacterial pneumonia based on two phase 3 trials (Lefamulin Evaluation Against Pneumonia [LEAP]-1 and LEAP-2). This pooled ... ...

    Abstract Lefamulin was the first systemic pleuromutilin antibiotic approved for intravenous and oral use in adults with community-acquired bacterial pneumonia based on two phase 3 trials (Lefamulin Evaluation Against Pneumonia [LEAP]-1 and LEAP-2). This pooled analysis evaluated lefamulin efficacy and safety in adults with community-acquired bacterial pneumonia caused by atypical pathogens (
    Language English
    Publishing date 2021-12-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10121489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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