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  1. Article ; Online: Synthesis and Characterization of Versatile O-Glycan Precursors for Cellular O-Glycomics.

    Zhang, Qing / Li, Zhonghua / Chernova, Tatiana / Saikam, Varma / Cummings, Richard / Song, Xuezheng / Ju, Tongzhong / Smith, David F / Wang, Peng G

    ACS synthetic biology

    2019  Volume 8, Issue 11, Page(s) 2507–2513

    Abstract: Protein O-glycosylation is a universal post-translational modification and plays essential roles ... in many biological processes. Recently we reported a technology termed cellular O-glycome reporter/amplification (CORA ... to amplify and profile mucin-type O-glycans of living cells growing in the presence of peracetylated Benzyl-α ...

    Abstract Protein O-glycosylation is a universal post-translational modification and plays essential roles in many biological processes. Recently we reported a technology termed cellular O-glycome reporter/amplification (CORA) to amplify and profile mucin-type O-glycans of living cells growing in the presence of peracetylated Benzyl-α-GalNAc (Ac
    MeSH term(s) A549 Cells ; Acetylgalactosamine/analogs & derivatives ; Acetylgalactosamine/chemical synthesis ; Acetylgalactosamine/radiation effects ; Benzyl Compounds/chemical synthesis ; Benzyl Compounds/radiation effects ; Fluorescent Dyes/metabolism ; Galactose/metabolism ; Galactosyltransferases/metabolism ; Glycomics/methods ; Glycosylation ; Humans ; Microwaves ; Polysaccharides/chemical synthesis ; Protein Processing, Post-Translational ; Substrate Specificity
    Chemical Substances Benzyl Compounds ; Fluorescent Dyes ; Polysaccharides ; benzyl-alpha-N-acetylgalactosamine (3554-93-6) ; C1GALT1 protein, human (EC 2.4.1.-) ; Galactosyltransferases (EC 2.4.1.-) ; Acetylgalactosamine (KM15WK8O5T) ; Galactose (X2RN3Q8DNE)
    Language English
    Publishing date 2019-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2161-5063
    ISSN (online) 2161-5063
    DOI 10.1021/acssynbio.9b00168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cellular O-Glycome Reporter/Amplification (CORA): Analytical and Preparative Tools to Study Mucin-Type O-Glycans of Living Cells.

    Kudelka, Matthew R / Li, Zhonghua / Chernova, Tatiana A / Smith, David F / Song, Xuezheng / Cummings, Richard D / Ju, Tongzhong

    Current protocols

    2021  Volume 1, Issue 6, Page(s) e142

    Abstract: Mucin-type O-glycosylation (O-glycans, O-glycome) is among the most biologically important ... post-translational modification in glycoproteins but O-glycan structural diversity and expression are poorly understood due ... to the inadequacy of current analytical methods. We recently developed a new tool termed cellular O-glycome reporter ...

    Abstract Mucin-type O-glycosylation (O-glycans, O-glycome) is among the most biologically important post-translational modification in glycoproteins but O-glycan structural diversity and expression are poorly understood due to the inadequacy of current analytical methods. We recently developed a new tool termed cellular O-glycome reporter/amplification (CORA), which uses O-glycan precursors, benzyl-α-GalNAc (Bn-α-GalNAc) or azido-Bn-α-GalNAc (N
    MeSH term(s) Glycomics ; Glycoproteins ; Glycosylation ; Mucins ; Polysaccharides
    Chemical Substances Glycoproteins ; Mucins ; Polysaccharides
    Language English
    Publishing date 2021-06-07
    Document type Journal Article
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Amplification and Preparation of Cellular O-Glycomes for Functional Glycomics.

    Li, Zhonghua / Zhang, Qing / Ashline, David / Zhu, Yuyang / Lasanajak, Yi / Chernova, Tatiana / Reinhold, Vernon / Cummings, Richard D / Wang, Peng G / Ju, Tongzhong / Smith, David F / Song, Xuezheng

    Analytical chemistry

    2020  Volume 92, Issue 15, Page(s) 10390–10401

    Abstract: Mucin-type O-glycans play key roles in many cellular processes, and they are often altered ... in human diseases. A major challenge in studying the role of O-glycans through functional O-glycomics is the absence ... of a complete repertoire of the glycans that comprise the human O-glycome. Here we describe a cellular O-glycome ...

    Abstract Mucin-type O-glycans play key roles in many cellular processes, and they are often altered in human diseases. A major challenge in studying the role of O-glycans through functional O-glycomics is the absence of a complete repertoire of the glycans that comprise the human O-glycome. Here we describe a cellular O-glycome preparation strategy, Preparative Cellular O-Glycome Reporter/Amplification (pCORA), that introduces 4-N
    MeSH term(s) Animals ; Cell Line, Tumor ; Glycomics/methods ; Humans ; Mice ; Polysaccharides/chemistry ; Polysaccharides/metabolism
    Chemical Substances Polysaccharides
    Language English
    Publishing date 2020-07-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.0c00632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4033: Show issues Location:
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  4. Article ; Online: Li-Nb-O Coating/Substitution Enhances the Electrochemical Performance of the LiNi

    Xin, Fengxia / Zhou, Hui / Chen, Xiaobo / Zuba, Mateusz / Chernova, Natasha / Zhou, Guangwen / Whittingham, M Stanley

    ACS applied materials & interfaces

    2019  Volume 11, Issue 38, Page(s) 34889–34894

    Abstract: ... reactivity and structural instability. Through a wet chemistry method, a Li-Nb-O coated and substituted NMC ... 811 was obtained in a single step treatment. This Li-Nb-O treatment not only supplied a protective ...

    Abstract High-nickel layered oxides, such as NMC 811, are very attractive high energy density cathode materials. However, the high nickel content creates a number of challenges, including high surface reactivity and structural instability. Through a wet chemistry method, a Li-Nb-O coated and substituted NMC 811 was obtained in a single step treatment. This Li-Nb-O treatment not only supplied a protective surface coating but also optimized the electrochemical behavior by Nb
    Language English
    Publishing date 2019-09-10
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.9b09696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Amplification and Preparation of Cellular O-Glycomes for Functional Glycomics

    Li, Zhonghua / Zhang, Qing / Ashline, David / Zhu, Yuyang / Lasanajak, Yi / Chernova, Tatiana / Reinhold, Vernon / Cummings, Richard D / Wang, Peng G / Ju, Tongzhong / Smith, David F / Song, Xuezheng

    Analytical chemistry. 2020 June 15, v. 92, no. 15

    2020  

    Abstract: Mucin-type O-glycans play key roles in many cellular processes, and they are often altered ... in human diseases. A major challenge in studying the role of O-glycans through functional O-glycomics is the absence ... of a complete repertoire of the glycans that comprise the human O-glycome. Here we describe a cellular O-glycome ...

    Abstract Mucin-type O-glycans play key roles in many cellular processes, and they are often altered in human diseases. A major challenge in studying the role of O-glycans through functional O-glycomics is the absence of a complete repertoire of the glycans that comprise the human O-glycome. Here we describe a cellular O-glycome preparation strategy, Preparative Cellular O-Glycome Reporter/Amplification (pCORA), that introduces 4-N₃-Bn-GalNAc(Ac)₃ as a novel precursor in large-scale cell cultures to generate usable amounts of O-glycans as a potential O-glycome factory. Cultured human non-small cell lung cancer (NSCLC) A549 cells take up the precursor, which is extended by cellular glycosyltransferases to produce 4-N₃-Bn-α-O-glycans that are secreted into the culture medium. The O-glycan derivatives can be clicked with a fluorescent bifunctional tag that allows multidimensional HPLC purification and production of a tagged glycan library, representing the O-glycome of the corresponding cells. We obtained ∼5% conversion of precursor to O-glycans and purified a tagged O-glycan library of over 100 O-glycan derivatives, many of which were present in >100 nmol amounts and were sequenced by sequential MS fragmentation (MSⁿ). These O-glycans were successfully printed onto epoxy glass slides as an O-glycome shotgun microarray. We used this novel array to explore binding activity of serum IgM in healthy persons and NSCLC patients at different cancer stages. This novel strategy provides access to complex O-glycans in significant quantities and may offer a new route to discovery of potential diagnostic disease biomarkers.
    Keywords analytical chemistry ; biomarkers ; blood serum ; culture media ; epoxides ; fluorescence ; glass ; glycomics ; glycosyltransferases ; humans ; lung neoplasms ; microarray technology ; polysaccharides
    Language English
    Dates of publication 2020-0615
    Size p. 10390-10401.
    Publishing place American Chemical Society
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.0c00632
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    In stock of ZB MED Bonn / Germany

    Z 4' 52/94: Show issues
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  6. Article: Li–Nb–O Coating/Substitution Enhances the Electrochemical Performance of the LiNi₀.₈Mn₀.₁Co₀.₁O₂ (NMC 811) Cathode

    Xin, Fengxia / Zhou, Hui / Chen, Xiaobo / Zuba, Mateusz / Chernova, Natasha / Zhou, Guangwen / Whittingham, M. Stanley

    ACS applied materials & interfaces. 2019 Aug. 30, v. 11, no. 38

    2019  

    Abstract: ... reactivity and structural instability. Through a wet chemistry method, a Li–Nb–O coated and substituted NMC ... 811 was obtained in a single step treatment. This Li–Nb–O treatment not only supplied a protective ...

    Abstract High-nickel layered oxides, such as NMC 811, are very attractive high energy density cathode materials. However, the high nickel content creates a number of challenges, including high surface reactivity and structural instability. Through a wet chemistry method, a Li–Nb–O coated and substituted NMC 811 was obtained in a single step treatment. This Li–Nb–O treatment not only supplied a protective surface coating but also optimized the electrochemical behavior by Nb⁵⁺ incorporation into the bulk structure. As a result, the 1st capacity loss was significantly reduced (13.7 vs 25.1 mA h/g), contributing at least a 5% increase to the energy density of the full cell. In addition, both the rate (158 vs 135 mA h/g at 2C) and capacity retention (89.6 vs 81.6% after 60 cycles) performance were enhanced.
    Keywords cathodes ; coatings ; electrochemistry ; energy density ; nickel ; oxides
    Language English
    Dates of publication 2019-0830
    Size p. 34889-34894.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1944-8252
    DOI 10.1021/acsami.9b09696
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Composition-structure relationships in the Li-ion battery electrode material LiNi(0.5)Mn(1.5)O(4).

    Cabana, Jordi / Casas-Cabanas, Montserrat / Omenya, Fredrick O / Chernova, Natasha A / Zeng, Dongli / Whittingham, M Stanley / Grey, Clare P

    Chemistry of materials : a publication of the American Chemical Society

    2012  Volume 24, Issue 15, Page(s) 2952–2964

    Abstract: ... ordering of LiNi(0.5)Mn(1.5)O(4) was undertaken by characterizing samples synthesized at different ...

    Abstract A study of the correlations between the stoichiometry, secondary phases and transition metal ordering of LiNi(0.5)Mn(1.5)O(4) was undertaken by characterizing samples synthesized at different temperatures. Insight into the composition of the samples was obtained by electron microscopy, neutron diffraction and X-ray absorption spectroscopy. In turn, analysis of cationic ordering was performed by combining neutron diffraction with Li MAS NMR spectroscopy. Under the conditions chosen for the synthesis, all samples systematically showed an excess of Mn, which was compensated by the formation of a secondary rock salt phase and not via the creation of oxygen vacancies. Local deviations from the ideal 3:1 Mn:Ni ordering were found, even for samples that show the superlattice ordering by diffraction, with different disordered schemes also being possible. The magnetic behavior of the samples was correlated with the deviations from this ideal ordering arrangement. The in-depth crystal-chemical knowledge generated was employed to evaluate the influence of these parameters on the electrochemical behavior of the materials.
    Language English
    Publishing date 2012-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1500399-1
    ISSN 1520-5002 ; 0897-4756
    ISSN (online) 1520-5002
    ISSN 0897-4756
    DOI 10.1021/cm301148d
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  8. Article: O klassifikatsii pnevmokonioza.

    Krasniuk, E P / Tkach, S I / Shkondin, A N / Doroshenko, A N / Lubianova, I P / Basanets, A V / Prilipskaia, N I / Dynnik, V I / Brykalin, V P / Chernova, S D

    Likars'ka sprava

    2001  , Issue 5-6, Page(s) 30–36

    Abstract: The article presents a modern classification of pneumoconiosis taking account of the international classification and experience gained by specialists in this country. ...

    Title translation Classification of pneumoconiosis.
    Abstract The article presents a modern classification of pneumoconiosis taking account of the international classification and experience gained by specialists in this country.
    MeSH term(s) Humans ; Pneumoconiosis/classification ; Pneumoconiosis/diagnostic imaging ; Pneumoconiosis/pathology ; Radiography ; Ukraine
    Language Russian
    Publishing date 2001-09
    Publishing country Ukraine
    Document type Journal Article
    ZDB-ID 40876-1
    ISSN 1019-5297 ; 0049-6804
    ISSN 1019-5297 ; 0049-6804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1161: Show issues Location:
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  9. Article ; Online: Posterior Septal Artery Flap for Endoscopic Repair of Large Nasal Septal Perforation: How I Do It.

    Rusetsky, Yury / Mokoyan, Zhanna / Elumeeva, Anna / Chernova, Olga

    The Laryngoscope

    2024  

    Abstract: Endoscopic repair of large nasal septal perforation (SP) remains a rather challenging procedure. The presented modification of vascularized flap, which is supplied with branches of posterior septal artery, has proven to be convenient and effective in ... ...

    Abstract Endoscopic repair of large nasal septal perforation (SP) remains a rather challenging procedure. The presented modification of vascularized flap, which is supplied with branches of posterior septal artery, has proven to be convenient and effective in closure of SPs larger than 2 cm. Laryngoscope, 2024.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31348
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    Ul II Zs.82: Show issues Location:
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  10. Article ; Online: Lithium cobalt(II) pyrophosphate, Li(1.86)CoP(2)O(7), from synchrotron X-ray powder data.

    Zhou, Hui / Upreti, Shailesh / Chernova, Natasha A / Whittingham, M Stanley

    Acta crystallographica. Section E, Structure reports online

    2011  Volume 67, Issue Pt 10, Page(s) i58–i59

    Abstract: ... the composition Li(1.865)CoP(2)O(7), which is also verified by the ICP measurement. Two Co sites exist ... further inter-connected through P(2)O(7) groups, forming a three-dimensional framework, which exhibits ...

    Abstract Structure refinement of high-resolution X-ray powder diffraction data of the title compound gave the composition Li(1.865)CoP(2)O(7), which is also verified by the ICP measurement. Two Co sites exist in the structure: one is a CoO(5) square pyramid and the other is a CoO(6) octa-hedron. They share edges and are further inter-connected through P(2)O(7) groups, forming a three-dimensional framework, which exhibits different kinds of inter-secting tunnels containing Li cations and could be of great inter-est in Li ion battery chemistry. The structure also exhibits cation disorder with 13.5% Co residing at the lithium (Li1) site. Co seems to have an average oxidation state of 2.135, as obtained from the strutural stochiometry that closely supports the magnetic susceptibility findings.
    Language English
    Publishing date 2011-09-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 1600-5368 ; 1600-5368
    ISSN (online) 1600-5368
    ISSN 1600-5368
    DOI 10.1107/S1600536811038451
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