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  1. Book: Advances in malignant hematology

    Saba, Hussain I. / Mufti, Ghulam J.

    2011  

    Author's details ed. by Hussain I. Saba ; Ghulam J. Mufti
    Keywords Leukemia, Myeloid / metabolism ; Leukemia, Myeloid / therapy ; Leukemia, Lymphoid ; Myelodysplastic Syndromes / therapy
    Language English
    Size XXI, 416 S. : Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Chichester u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016789591
    ISBN 978-1-4051-9626-0 ; 1-4051-9626-2
    Database Catalogue ZB MED Medicine, Health

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    2011 A 1651 order for loan Magazin

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  2. Book: An atlas of malignant haematology

    Mufti, Ghulam J.

    cytology, histology and cytogenetics

    1996  

    Title variant Malignant haematology
    Author's details Ghulam J. Mufti
    Keywords Hematologic Diseases / atlases ; Neoplasms / atlases
    Language English
    Size 424 S. : überw. Ill.
    Publisher Lippincott-Raven
    Publishing place S.l.
    Publishing country United States
    Document type Book
    HBZ-ID HT007481065
    ISBN 0-397-51400-X ; 978-0-397-51400-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    1997 A 3087 order for loan Magazin

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  3. Book: The myelodysplastic syndromes

    Mufti, Ghulam J.

    1992  

    Author's details ed. by G. J. Mufti
    Keywords Myelodysplastic Syndromes ; Myelodysplastisches Syndrom
    Subject MDS ; Präleukämie ; Präleukose ; Präleukämisches Syndrom ; Hämatopoetische Dysplasie
    Language English
    Size XII, 240 S. : Ill., graph. Darst.
    Publisher Churchill Livingstone
    Publishing place Edingburgh u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT004438026
    ISBN 0-443-04083-4 ; 978-0-443-04083-2
    Database Catalogue ZB MED Medicine, Health

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    1993 A 543 order for loan Magazin

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  4. Article ; Online: Prevalence of Thiamine Deficiency in Pregnancy and its impact on fetal outcome in an area endemic for thiamine deficiency.

    Kareem, Ozaifa / Mufti, Samiya / Nisar, Sobia / Tanvir, Masood / Muzaffer, Umar / Ali, Nahida / Sheikh, Ishfaq Ahmad / Bader, Ghulam Nabi

    PLoS neglected tropical diseases

    2023  Volume 17, Issue 5, Page(s) e0011324

    Abstract: Background: Pregnancy is a metabolically challenging state with increased nutritional demand. Thiamine is an important cofactor in various metabolic pathways and thus its deficiency could have a serious impact on both maternal and fetal outcomes. ... ...

    Abstract Background: Pregnancy is a metabolically challenging state with increased nutritional demand. Thiamine is an important cofactor in various metabolic pathways and thus its deficiency could have a serious impact on both maternal and fetal outcomes. Kashmir has thiamine deficiency in endemic proportions, with multiple reports of infantile beriberi, postpartum neuropathy, and gastric beriberi. This prompted us to assess the extent of the burden of thiamine deficiency during pregnancy.
    Methods: This cross-sectional study was conducted for a period of two years in pregnant women attending the antenatal clinic. A demographic, clinical, biochemical, and dietary assessment was done in all participants. The whole blood thiamine levels were assessed by high-performance liquid chromatography.
    Results: A total of 492 participants were included in the study with a mean age of 30.30±4.57 years and a mean BMI of 24.25±3.32 Kg/m2. The mean whole blood thiamine level of all participants was 133.29±14.32 nmol/L. Low thiamine status was present in 38.2% (n = 188) of participants. Participants with low thiamine had poor perinatal outcomes, with 3.1% (n = 6) reporting early infant death.
    Conclusion: A high prevalence of thiamine deficiency occurs in pregnant women of Kashmir. Low thiamine is associated with poor nutritional status as well as poor perinatal outcomes.
    Trial registration: CTRI/2022/07/044217.
    MeSH term(s) Infant ; Female ; Humans ; Pregnancy ; Adult ; Beriberi/complications ; Prevalence ; Cross-Sectional Studies ; Thiamine Deficiency/epidemiology ; Thiamine Deficiency/complications ; Thiamine
    Chemical Substances Thiamine (X66NSO3N35)
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reactivation of hepatitis B virus infection in patients with hematologic disorders.

    Wang, Bo / Mufti, Ghulam / Agarwal, Kosh

    Haematologica

    2019  Volume 104, Issue 3, Page(s) 435–443

    Abstract: Hepatitis B reactivation is the reappearance or rise of hepatitis B virus (HBV) DNA in patients with past or chronic HBV infection, usually occurring in the context of immunosuppression. HBV reactivation has been most commonly reported in patients with ... ...

    Abstract Hepatitis B reactivation is the reappearance or rise of hepatitis B virus (HBV) DNA in patients with past or chronic HBV infection, usually occurring in the context of immunosuppression. HBV reactivation has been most commonly reported in patients with hematologic disorders, with potentially serious and life-threatening consequences. In this review, we discuss the basis and presentation of HBV reactivation, and risk factors in terms of the host, the virus and the immunosuppression regimen, including newer agents used to manage hematologic malignancies. We overview the management of HBV reactivation, highlighting an up-dated recommendation on the use of newer nucleoside and nucleotide analogs, such as tenofovir and entecavir, for antiviral prophylaxis.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers ; Combined Modality Therapy/adverse effects ; Disease Management ; Disease Susceptibility ; Hematologic Diseases/complications ; Hematologic Diseases/diagnosis ; Hematologic Diseases/therapy ; Hepatitis B/diagnosis ; Hepatitis B/drug therapy ; Hepatitis B/etiology ; Hepatitis B virus/physiology ; Hepatitis B, Chronic ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Risk Factors ; Symptom Assessment ; Virus Activation/immunology
    Chemical Substances Biomarkers ; Immunosuppressive Agents
    Language English
    Publishing date 2019-02-07
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2018.210252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes.

    Gaymes, Terry J / Shall, Sydney / Macpherson, Lee J / Twine, Natalie A / Lea, Nicholas C / Farzaneh, Farzin / Mufti, Ghulam J

    Haematologica

    2021  Volume 106, Issue 8, Page(s) 2294

    Language English
    Publishing date 2021-08-01
    Publishing country Italy
    Document type Journal Article ; Published Erratum
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2020.262857
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Case for Upfront HLA-Matched Unrelated Donor Hematopoietic Stem Cell Transplantation as a Curative Option for Adult Acquired Severe Aplastic Anemia.

    Marsh, Judith C W / Risitano, Antonio M / Mufti, Ghulam J

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2019  Volume 25, Issue 9, Page(s) e277–e284

    Abstract: The improved success of HLA-matched unrelated donor (MUD) hematopoietic stem cell transplantation (HSCT) for severe aplastic anemia (SAA) in recent decades has had an impact on the indications for and timing of this treatment modality. In the absence of ... ...

    Abstract The improved success of HLA-matched unrelated donor (MUD) hematopoietic stem cell transplantation (HSCT) for severe aplastic anemia (SAA) in recent decades has had an impact on the indications for and timing of this treatment modality. In the absence of a matched sibling donor (MSD), historically MUD HSCT was reserved as an option after failure to respond to at least 2 courses of immunosuppressive therapy (IST) in adults with SAA, but with improved outcomes over time, it is now considered following failure to respond to 1 course of IST. Recent national and international studies and guidelines now recommend upfront MUD HSCT as an option for children for whom an MUD is readily available, because outcomes are similar to those for MSD HSCT. Fludarabine-based conditioning and the use of in vivo T cell depletion with antithymocyte globulin or alemtuzumab has been associated with a reported overall survival (OS) of >85% in adult patients undergoing MUD HSCT. However, the recent introduction of eltrombopag for patients with SAA has transformed the treatment landscape, and there is currently much interest in its use with IST as upfront treatment, which showed a high response rate in an early-phase study. The risks of HSCT, especially graft-versus-host disease (GVHD), need to be carefully balanced against the concerns of IST, namely relapse and later clonal evolution to myelodysplastic syndrome (MDS)/acute myelogenous leukemia (AML). In the absence of a current prospective randomized trial comparing these 2 approaches, in this review we examine the evidence supporting consideration of early MUD HSCT in adults with SAA who would have been considered for MSD HSCT but who lack a MSD and for whom an MUD is readily available, especially using an irradiation-free conditioning regimen, with a low risk of GVHD, as another treatment option. This option may be offered to patients to provide them with an informed choice, with the aim of curing disease rather than achieving freedom from disease, relapse-free survival, or OS. Furthermore, understanding the immune signature for the response to IST and the immunologic responses to somatic mutations and clonal progression to MDS/AML may help define the future indications for upfront HSCT and a more precise medical approach to therapy.
    MeSH term(s) Adult ; Anemia, Aplastic/mortality ; Anemia, Aplastic/therapy ; Graft vs Host Disease/mortality ; Graft vs Host Disease/therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Transplantation Conditioning ; Unrelated Donors
    Language English
    Publishing date 2019-05-24
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2019.05.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5082: Show issues Location:
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    Zs.MO 462: Show issues

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  8. Article ; Online: Clinical efficacy of rituximab in the treatment of pemphigus vulgaris: A 10-year follow-up.

    Laftah, Zainab / Craythorne, Emma / Mufti, Ghulam J / du Vivier, Anthony

    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

    2019  Volume 48, Issue 9, Page(s) 861–862

    MeSH term(s) Follow-Up Studies ; Humans ; Immunologic Factors/therapeutic use ; Pemphigus/drug therapy ; Rituximab/therapeutic use ; Treatment Outcome
    Chemical Substances Immunologic Factors ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2019-09-03
    Publishing country Denmark
    Document type Letter
    ZDB-ID 1021270-x
    ISSN 1600-0714 ; 0904-2512
    ISSN (online) 1600-0714
    ISSN 0904-2512
    DOI 10.1111/jop.12948
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article ; Online: Guidelines for the diagnosis and management of adult aplastic anaemia: A British Society for Haematology Guideline.

    Kulasekararaj, Austin / Cavenagh, Jamie / Dokal, Inderjeet / Foukaneli, Theodora / Gandhi, Shreyans / Garg, Mamta / Griffin, Morag / Hillmen, Peter / Ireland, Robin / Killick, Sally / Mansour, Sahar / Mufti, Ghulam / Potter, Victoria / Snowden, John / Stanworth, Simon / Zuha, Roslin / Marsh, Judith

    British journal of haematology

    2024  Volume 204, Issue 3, Page(s) 784–804

    Abstract: Pancytopenia with hypocellular bone marrow is the hallmark of aplastic anaemia (AA) and the diagnosis is confirmed after careful evaluation, following exclusion of alternate diagnosis including hypoplastic myelodysplastic syndromes. Emerging use of ... ...

    Abstract Pancytopenia with hypocellular bone marrow is the hallmark of aplastic anaemia (AA) and the diagnosis is confirmed after careful evaluation, following exclusion of alternate diagnosis including hypoplastic myelodysplastic syndromes. Emerging use of molecular cyto-genomics is helpful in delineating immune mediated AA from inherited bone marrow failures (IBMF). Camitta criteria is used to assess disease severity, which along with age and availability of human leucocyte antigen compatible donor are determinants for therapeutic decisions. Supportive care with blood and platelet transfusion support, along with anti-microbial prophylaxis and prompt management of opportunistic infections remain key throughout the disease course. The standard first-line treatment for newly diagnosed acquired severe/very severe AA patients is horse anti-thymocyte globulin and ciclosporin-based immunosuppressive therapy (IST) with eltrombopag or allogeneic haemopoietic stem cell transplant (HSCT) from a matched sibling donor. Unrelated donor HSCT in adults should be considered after lack of response to IST, and up front for young adults with severe infections and a readily available matched unrelated donor. Management of IBMF, AA in pregnancy and in elderly require special attention. In view of the rarity of AA and complexity of management, appropriate discussion in multidisciplinary meetings and involvement of expert centres is strongly recommended to improve patient outcomes.
    MeSH term(s) Young Adult ; Humans ; Aged ; Anemia, Aplastic/therapy ; Immunosuppressive Agents/therapeutic use ; Cyclosporine/therapeutic use ; Hematopoietic Stem Cell Transplantation ; Bone Marrow Failure Disorders/drug therapy ; Unrelated Donors ; Pancytopenia/drug therapy ; Hematology
    Chemical Substances Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D)
    Language English
    Publishing date 2024-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: David Galton, myelodysplasia and little me!

    Mufti, Ghulam

    Leukemia & lymphoma

    2007  Volume 48, Issue 12, Page(s) 2286–2287

    MeSH term(s) Humans ; Myelodysplastic Syndromes/classification ; Myelodysplastic Syndromes/therapy
    Language English
    Publishing date 2007-10-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428190701705784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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