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  1. Article ; Online: Myelodysplastic syndromes, thy name is heterogeneity.

    Greenberg, Peter L

    British journal of haematology

    2023  Volume 201, Issue 3, Page(s) 381–382

    Abstract: Classification of the heterogeneous spectrum of myelodysplastic syndromes (MDS) requires both morphologic and molecular analysis to effectively subgroup patients. The paper by Zhang et al demonstrated the positive impact of combining the International ... ...

    Abstract Classification of the heterogeneous spectrum of myelodysplastic syndromes (MDS) requires both morphologic and molecular analysis to effectively subgroup patients. The paper by Zhang et al demonstrated the positive impact of combining the International Consensus Consortium (ICC) morphologic approach with prior clinical (IPSS-R) and mutational (IPSS-M) categorization to provide useful clinical evaluation of MDS patients. Commentary on: Zhang et al. Impact of the International Consensus Classification of Myelodysplastic Syndromes. Br J Haematol 2022 (Online ahead of print). doi: 10.1111/bjh.18628.
    MeSH term(s) Humans ; Prognosis ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/genetics ; Mutation
    Language English
    Publishing date 2023-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Metchnikoff's legacy: the dysplastic nature of innate immunity in myelodysplastic syndromes.

    Greenberg, Peter L

    Haematologica

    2022  Volume 107, Issue 3, Page(s) 568–569

    MeSH term(s) Humans ; Hyperplasia ; Immunity, Innate ; Myelodysplastic Syndromes ; Phagocytosis
    Language English
    Publishing date 2022-03-01
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2021.279419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: How I reduce and treat posttransplant relapse of MDS.

    Mina, Alain / Greenberg, Peter L / Deeg, H Joachim

    Blood

    2024  Volume 143, Issue 14, Page(s) 1344–1354

    Abstract: Abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) is the only potentially curative option for patients with high-risk myelodysplastic syndromes (MDS). Advances in conditioning regimens and supportive measures have reduced treatment- ... ...

    Abstract Abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) is the only potentially curative option for patients with high-risk myelodysplastic syndromes (MDS). Advances in conditioning regimens and supportive measures have reduced treatment-related mortality and increased the role of transplantation, leading to more patients undergoing HSCT. However, posttransplant relapse of MDS remains a leading cause of morbidity and mortality for this procedure, necessitating expert management and ongoing results analysis. In this article, we review treatment options and our institutional approaches to managing MDS relapse after HSCT, using illustrative clinical cases that exemplify different clinical manifestations and management of relapse. We address areas of controversy relating to conditioning regimen intensity, chemotherapeutic bridging, and donor selection. In addition, we discuss future directions for advancing the field, including (1) the need for prospective clinical trials separating MDS from acute myeloid leukemia and focusing on posttransplant relapse, as well as (2) the validation of measurable residual disease methodologies to guide timely interventions.
    MeSH term(s) Humans ; Myelodysplastic Syndromes/therapy ; Prospective Studies ; Transplantation, Homologous ; Transplantation Conditioning/methods ; Recurrence ; Leukemia, Myeloid, Acute/therapy ; Chronic Disease ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023023005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 364: Show issues

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  4. Book: Myelodysplastic syndromes

    Greenberg, Peter L.

    clinical and biological advances

    2006  

    Author's details ed. by Peter L. Greenberg
    Keywords Myelodysplastic Syndromes ; Myelodysplastic syndromes
    Subject code 616.41
    Language English
    Size XIII, 312 S. : Ill., graph. Darst.
    Publisher Cambridge Univ. Press
    Publishing place Cambridge u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014500747
    ISBN 978-0-521-49668-1 ; 0-521-49668-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2005 A 5404 order for loan Magazin

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  5. Article: The Relationship of

    Soto-Aceves, Martin P / Smalley, Nicole E / Schaefer, Amy L / Greenberg, E Peter

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The opportunistic ... ...

    Abstract The opportunistic pathogen
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.22.586172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The trajectory of prognostication and risk stratification for patients with myelodysplastic syndromes.

    DeZern, Amy E / Greenberg, Peter L

    Blood

    2023  Volume 142, Issue 26, Page(s) 2258–2267

    Abstract: Abstract: Risk stratification and prognostication are crucial for the appropriate management of patients with myelodysplastic syndromes (MDSs) or myelodysplastic neoplasms, for whom the expected survival can vary from a few months to >10 years. For the ... ...

    Abstract Abstract: Risk stratification and prognostication are crucial for the appropriate management of patients with myelodysplastic syndromes (MDSs) or myelodysplastic neoplasms, for whom the expected survival can vary from a few months to >10 years. For the past 5 decades, patients with MDS have been classified into higher-risk vs lower-risk disease phenotypes using sequentially developed clinical prognostic scoring systems. Factors such as morphologic dysplasia, clinical hematologic parameters, cytogenetics, and, more recently, mutational information have been captured in prognostic scoring systems that refine risk stratification and guide therapeutic management in patients with MDS. This review describes the progressive evolution and improvement of these systems which has led to the current Molecular International Prognostic Scoring System.
    MeSH term(s) Humans ; Prognosis ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/therapy ; Leukemia, Myeloid, Acute ; Phenotype ; Risk Assessment
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Review ; Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023020081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 364: Show issues

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  7. Article ; Online: The classical nature of distinctive CMML monocytes.

    Greenberg, Peter L

    Blood

    2017  Volume 129, Issue 13, Page(s) 1745–1746

    MeSH term(s) Flow Cytometry ; Humans ; Leukemia, Myelomonocytic, Chronic ; Monocytes
    Language English
    Publishing date 2017-03-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-02-767590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Recent Clinical and Molecular Advances for the Classification of Myelodysplastic Neoplasms.

    DeZern, Amy E / Greenberg, Peter L

    Journal of the National Comprehensive Cancer Network : JNCCN

    2022  Volume 20, Issue 12, Page(s) 1280–1283

    Abstract: Several major updates have recently occurred for the NCCN Guidelines for Myelodysplastic Syndromes (MDS) based on a number of prominent articles that have particular clinical and biologic impact for the field. These changes, which have been included in ... ...

    Abstract Several major updates have recently occurred for the NCCN Guidelines for Myelodysplastic Syndromes (MDS) based on a number of prominent articles that have particular clinical and biologic impact for the field. These changes, which have been included in the current iteration of the NCCN Guidelines (Version 1.2023), include the WHO 2022 classification of MDS as well as the ICC suggestions for same. In addition, the molecular underpinning of MDS has been greatly updated with the generation of the Molecular International Prognostic Scoring System (IPSS-M) and an improved understanding to the prognostic implications of mutated TP53 subtypes, which are additive to the revised IPSS (IPSS-R) for stratification and management of patients with MDS. This report emphasizes the major components of the relevant changes to serve as a guide for therapeutic decision-making for patients with MDS.
    MeSH term(s) Humans ; Neoplasms ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/therapy ; Prognosis
    Language English
    Publishing date 2022-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2250759-0
    ISSN 1540-1413 ; 1540-1405
    ISSN (online) 1540-1413
    ISSN 1540-1405
    DOI 10.6004/jnccn.2022.7088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A

    Suo, Zehui / Cummings, Dale A / Puri, Aaron W / Schaefer, Amy L / Greenberg, E Peter

    mBio

    2023  Volume 14, Issue 4, Page(s) e0101023

    Abstract: Members of the ... ...

    Abstract Members of the genus
    MeSH term(s) Quorum Sensing/genetics ; Acyl-Butyrolactones/metabolism ; Mesorhizobium/genetics ; Mesorhizobium/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Trans-Activators/genetics ; Coenzyme A
    Chemical Substances Acyl-Butyrolactones ; Bacterial Proteins ; Trans-Activators ; Coenzyme A (SAA04E81UX)
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.01010-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Subclinical optic neuritis in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease.

    Nguyen, Linda / Wang, Cynthia X / Conger, Darrel L / Sguigna, Peter V / Singh, Sumit / Greenberg, Benjamin M

    Multiple sclerosis and related disorders

    2023  Volume 76, Page(s) 104802

    Abstract: Background and objectives: The clinical spectrum of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is heterogenous and has evolved over time since the commercial availability of the anti-MOG antibody assay. Subclinical ... ...

    Abstract Background and objectives: The clinical spectrum of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is heterogenous and has evolved over time since the commercial availability of the anti-MOG antibody assay. Subclinical disease activity has been previously reported in the visual pathway, but prevalence data remains limited. We investigated subclinical optic neuritis (ON) based on changes on retinal nerve fiber layer (RNFL) thickness on optic coherence tomography (OCT) in pediatric patients who tested positive for the anti-MOG antibody.
    Methods: In this retrospective, single-center cohort study, we examined children with MOGAD with at least one complete assessment of the anterior visual pathway. Subclinical ON was defined by structural visual system disease in the absence of a subjective complaint of vision loss, pain (particularly with eye movement), or color desaturation.
    Results: Records were reviewed from 85 children with MOGAD, 67 of whom (78.8%) had complete records for review. Eleven children (16.4%) had subclinical ON on OCT. Ten had significant reductions in RNFL, of which one had two distinct episodes of decreased RNFL, and one had significant elevations in RNFL. Of the eleven children with subclinical ON, six (54.5%) had a relapsing disease course. We also highlighted the clinical course of three children with subclinical ON detected on longitudinal OCT, including two who had subclinical ON outside of clinical relapses.
    Conclusion: Children with MOGAD can have subclinical ON events that can manifest as significant reductions or elevations in RNFL on OCT. OCT should be used routinely in the management and monitoring of MOGAD patients.
    MeSH term(s) Humans ; Myelin-Oligodendrocyte Glycoprotein ; Cohort Studies ; Retrospective Studies ; Tomography, Optical Coherence ; Optic Neuritis/diagnostic imaging ; Retina ; Vision Disorders ; Autoantibodies
    Chemical Substances Myelin-Oligodendrocyte Glycoprotein ; Autoantibodies
    Language English
    Publishing date 2023-06-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2023.104802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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