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  1. Article ; Online: Lessons in Transcellular Membrane Transport Re-Learned.

    Hann, Michael M

    Journal of pharmaceutical sciences

    2020  Volume 110, Issue 1, Page(s) 548–551

    Abstract: A brief note on the studies we have conducted on total and free drug concentration of thousands of drug discovery compounds in HeLa cells as measured by an approach inspired by the work of Professor Per Arturrsson. We conclude that the familiar QSAR ... ...

    Abstract A brief note on the studies we have conducted on total and free drug concentration of thousands of drug discovery compounds in HeLa cells as measured by an approach inspired by the work of Professor Per Arturrsson. We conclude that the familiar QSAR equations of Corwin Hansch which were modelled as a bell shape by using logP and -logP
    MeSH term(s) Biological Transport ; Cell Membrane Permeability ; HeLa Cells ; Humans ; Permeability ; Quantitative Structure-Activity Relationship
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2020.10.056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Crystal structure and ligandability of the 14-3-3/pyrin interface.

    Lau, Roxanne / Hann, Michael M / Ottmann, Christian

    Biochemical and biophysical research communications

    2023  Volume 651, Page(s) 1–7

    Abstract: Overactivation of Pyrin is the cause of the inflammatory diseases Mediterranean Fever and Pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND). Binding of 14-3-3 proteins reduces the pro-inflammatory activity of Pyrin, hence small ... ...

    Abstract Overactivation of Pyrin is the cause of the inflammatory diseases Mediterranean Fever and Pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND). Binding of 14-3-3 proteins reduces the pro-inflammatory activity of Pyrin, hence small molecules that stabilize the Pyrin/14-3-3 complex could convey an anti-inflammatory effect. We have solved the atomic resolution crystal structures of phosphorylated peptides derived from PyrinpS208 and PyrinpS242 - the two principle 14-3-3 binding sites in Pyrin - in complex with 14-3-3 and analyzed the ligandability of these protein-peptide interfaces by crystal-based fragment soaking. The complex between 14-3-3 and PyrinpS242 appears to be much more amenable for small-molecule binding than that of 14-3-3/PyrinpS208. Consequently, only for the 14-3-3/PyrinpS242 complex could we find an interface-binding fragment, validating protein crystallography and fragment soaking as a method to evaluate the ligandability of protein surfaces.
    MeSH term(s) Pyrin ; Binding Sites ; 14-3-3 Proteins ; Crystallography, X-Ray ; Protein Binding
    Chemical Substances Pyrin ; 14-3-3 Proteins
    Language English
    Publishing date 2023-02-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.02.013
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    Zs.A 116: Show issues Location:
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  3. Article ; Online: The Bullet Related Injury Clinic-Healing the Deep Wounds of Gun Violence.

    Hayes, Jane M / Hann, Indigo / Punch, L J

    JAMA surgery

    2021  Volume 157, Issue 2, Page(s) 167–168

    MeSH term(s) African Americans/statistics & numerical data ; Culturally Competent Care ; Emergency Service, Hospital ; Female ; Gun Violence ; Humans ; Male ; Missouri/epidemiology ; Organizational Innovation ; United States/epidemiology ; Wounds, Gunshot/ethnology ; Wounds, Gunshot/therapy
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2021.4889
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  4. Article ; Online: Safer Patients Empowered to Engage and Communicate about Health (SPEECH) in primary care: a feasibility study and process evaluation of an intervention for older people with multiple long-term conditions (multimorbidity).

    Goulding, Rebecca / Birtwell, Kelly / Hann, Mark / Peters, Sarah / van Marwijk, Harm / Bower, Peter

    BMC primary care

    2024  Volume 25, Issue 1, Page(s) 12

    Abstract: Background: Older people with multiple long-term conditions (multimorbidity) (MLTC-M) experience ... practices invited patients aged 65+ with MLTC-M who had an appointment scheduled during the study period ...

    Abstract Background: Older people with multiple long-term conditions (multimorbidity) (MLTC-M) experience difficulties accessing and interacting with health and care services. Breakdowns in communication between patients and staff can threaten patient safety. To improve communication and reduce risks to patient safety in primary care, we developed an intervention: Safer Patients Empowered to Engage and Communicate about Health (SPEECH). SPEECH comprises a booklet for patients and an associated guide for staff. The booklet is designed to provide patients with information about staff and services, skills to prepare and explain, and confidence to speak up and ask.
    Methods: A single-arm mixed methods feasibility study with embedded process evaluation. General practices in the North West of England were recruited. Participating practices invited patients aged 65+ with MLTC-M who had an appointment scheduled during the study period. Patients were asked to complete questionnaires at baseline and follow-up (four to eight weeks after being sent the patient booklet), including the Consultation and Relational Empathy measure, Empowerment Scale, Multimorbidity Treatment Burden Questionnaire, and Primary Care Patient Measure of Safety. Staff completed questionnaires at the end of the study period. A sub-sample of patients and staff were interviewed about the study processes and intervention. Patients and the public were involved in all aspects of the study, from generation of the initial idea to interpretation of findings.
    Results: Our target of four general practices were recruited within 50 days of the study information being sent out. A fifth practice was recruited later to boost patient recruitment. We received expressions of interest from 55 patients (approx. 12% of those invited). Our target of 40 patient participants completed baseline questionnaires and were sent the SPEECH booklet. Of these, 38 (95%) completed follow-up. Patients found the intervention and study processes acceptable, and staff found the intervention acceptable and feasible to deliver.
    Conclusions: Our findings suggest the intervention is acceptable, and it would be feasible to deliver a trial to assess effectiveness. Prior to further evaluation, study processes and the intervention will be updated to incorporate suggestions from participants.
    Trial registration: The study was registered on the ISRCTN registry (ISRCTN13196605: https://doi.org/10.1186/ISRCTN13196605 ).
    MeSH term(s) Humans ; Aged ; Multimorbidity ; Feasibility Studies ; Patient Safety ; Speech ; Primary Health Care
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2731-4553
    ISSN (online) 2731-4553
    DOI 10.1186/s12875-023-02221-3
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  5. Article ; Online: Letter to the Editor: Machine perfusion and acute rejection: Not as simple as it seems-The influence of retransplantation.

    Neil, Desley A H / Hann, Angus / Perera, M Thamara P R

    Hepatology (Baltimore, Md.)

    2023  Volume 78, Issue 4, Page(s) E68

    MeSH term(s) Reoperation ; Heart Transplantation ; Graft Rejection ; Perfusion
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000481
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    Zs.A 1660: Show issues Location:
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  6. Article ; Online: Reconstruction for complex portal vein thrombosis - Anatomical if possible.

    Durán, Manuel / Alfarah, Jameel / Hann, Angus / Perera, M T P R

    Journal of hepatology

    2023  Volume 79, Issue 3, Page(s) e129–e131

    MeSH term(s) Humans ; Portal Vein/surgery ; Venous Thrombosis/etiology ; Venous Thrombosis/surgery ; Liver Diseases
    Language English
    Publishing date 2023-03-31
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.03.019
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    Zs.A 2027: Show issues Location:
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  7. Article ; Online: Tailored extraction and ion mobility-mass spectrometry enables isotopologue analysis of tetrahydrofolate vitamers.

    Mitic, Bernd M / Mattanovich, Diethard / Hann, Stephan / Causon, Tim

    Analytical and bioanalytical chemistry

    2023  Volume 415, Issue 21, Page(s) 5151–5163

    Abstract: Climate change directs the focus in biotechnology increasingly on one-carbon metabolism for fixation of ... ...

    Abstract Climate change directs the focus in biotechnology increasingly on one-carbon metabolism for fixation of CO
    MeSH term(s) Methanol ; Carbon Dioxide ; Carbon/metabolism ; Tetrahydrofolates/metabolism ; Mass Spectrometry ; Formates
    Chemical Substances Methanol (Y4S76JWI15) ; Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0) ; Tetrahydrofolates ; formic acid (0YIW783RG1) ; Formates
    Language English
    Publishing date 2023-06-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-023-04786-5
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    In stock of ZB MED Bonn / Germany

    Z 4' 69/97: Show issues
    Archiv 3: Show issues
    Z 9.4: Show issues

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  8. Article ; Online: A native phosphoglycolate salvage pathway of the synthetic autotrophic yeast

    Baumschabl, Michael / Mitic, Bernd M / Troyer, Christina / Hann, Stephan / Ata, Özge / Mattanovich, Diethard

    microLife

    2023  Volume 5, Page(s) uqad046

    Abstract: Synthetic autotrophs can serve as chassis strains for bioproduction from ... ...

    Abstract Synthetic autotrophs can serve as chassis strains for bioproduction from CO
    Language English
    Publishing date 2023-12-11
    Publishing country England
    Document type Journal Article
    ISSN 2633-6693
    ISSN (online) 2633-6693
    DOI 10.1093/femsml/uqad046
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  9. Article ; Online: Letter to the Editor: Aberrant arteries-1 may be better than 2 for the liver, but maybe not the bile duct.

    Hann, Angus / Nutu, Anisa / Sanabria-Mateos, Rebeca / Pr Perera, M Thamara

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2023  Volume 29, Issue 7, Page(s) E16–E17

    MeSH term(s) Humans ; Liver Transplantation ; Bile Ducts/surgery ; Liver/diagnostic imaging ; Liver/surgery ; Arteries ; Bile Duct Neoplasms
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1097/LVT.0000000000000131
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    Zs.A 4702: Show issues Location:
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  10. Article ; Online: The oxygen-tolerant reductive glycine pathway assimilates methanol, formate and CO

    Mitic, Bernd M / Troyer, Christina / Lutz, Lisa / Baumschabl, Michael / Hann, Stephan / Mattanovich, Diethard

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 7754

    Abstract: The current climatic change is predominantly driven by excessive anthropogenic ... ...

    Abstract The current climatic change is predominantly driven by excessive anthropogenic CO
    MeSH term(s) Methanol/metabolism ; Carbon Dioxide/metabolism ; Glycine/metabolism ; Carbon/metabolism ; Formates/metabolism ; Oxygen/metabolism ; Pichia/metabolism
    Chemical Substances Methanol (Y4S76JWI15) ; Carbon Dioxide (142M471B3J) ; Glycine (TE7660XO1C) ; Carbon (7440-44-0) ; Formates ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43610-7
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