Article ; Online: Brief Report: In cART-Treated HIV-Infected Patients, Immunologic Failure Is Associated With a High Myeloid-Derived Suppressor Cell Frequency.
Journal of acquired immune deficiency syndromes (1999)
2024 Volume 95, Issue 2, Page(s) 185–189
Abstract: Background: During HIV infection, effective combined antiretroviral therapy suppresses viral replication and restores the number of circulating CD4+ T cells. However, 15%-30% of treated patients show a discordant response to combined antiretroviral ... ...
Abstract | Background: During HIV infection, effective combined antiretroviral therapy suppresses viral replication and restores the number of circulating CD4+ T cells. However, 15%-30% of treated patients show a discordant response to combined antiretroviral therapy. Myeloid-derived suppressor cells (MDSC) are expanded in HIV+ patients; to better understand the role of MDSC on CD4 T-cell recovery, we evaluated the frequency of MDSC in HIV+ patients under combined antiretroviral therapy and its association with immunologic response. Methods: We enrolled 60 HIV+ patients, including complete responders (R, n = 44), virologic nonresponders (VNR, n = 5), and immunologic nonresponders (INR, n = 11). The frequency of circulating MDSC and the percentage of activated and naïve CD4 T cells were evaluated by flow cytometry. Plasmatic cytokine levels were analyzed by automated ELISA. Results: As previously observed, polymorphonuclear MDSC (PMN-MDSC) frequency was higher in HIV+ patients compared with healthy donors. Furthermore, PMN-MDSC percentage was higher in INR than R patients, and a significant association between MDSC frequency and immunologic failure was confirmed by a receiver operator characteristic analysis. Accordingly, an inverse correlation was found between the percentages of PMN-MDSC and naïve CD4 T cells. A positive correlation was observed between PMN-MDSC frequency and the percentage of human leucocyte antigen locus DR + CD4 T cells and the plasmatic level of IL-1β and IL-8. Conclusion: Our results show that a high frequency of PMN-MDSC persists in INR, possibly because of immune activation, contributing to CD4 T-cell recovery failure. These findings further highlight the detrimental role of MDSC during HIV infection, suggesting these cells as a possible new therapeutic target. |
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MeSH term(s) | Humans ; Myeloid-Derived Suppressor Cells ; HIV Infections ; CD4-Positive T-Lymphocytes ; Cytokines ; Enzyme-Linked Immunosorbent Assay |
Chemical Substances | Cytokines |
Language | English |
Publishing date | 2024-01-10 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 645053-2 |
ISSN | 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135 |
ISSN (online) | 1944-7884 ; 1077-9450 |
ISSN | 0897-5965 ; 0894-9255 ; 1525-4135 |
DOI | 10.1097/QAI.0000000000003335 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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