LIVIVO - Search results -

Search results

Result 1 - 10 of total 55

Search options

Article: Complex dynamics of hair bundle of auditory nervous system (II): forced oscillations related to two cases of steady state.

Cao, Ben / Gu, Huaguang / Wang, Runxia

2021 Volume 16, Issue 5, Page(s) 1163–1188

Abstract: The forced oscillations of hair bundle of inner hair cells of auditory nervous system evoked by external force from steady state are related to the fast adaption of hair cells, which are very important for auditory amplification. In the present paper, ... ...

Abstract	The forced oscillations of hair bundle of inner hair cells of auditory nervous system evoked by external force from steady state are related to the fast adaption of hair cells, which are very important for auditory amplification. In the present paper, comprehensive and deep understandings to nonlinear dynamics of forced oscillations are acquired in four aspects. Firstly, the complex dynamics underlying the twitch (fast recoil of displacement
Language	English
Publishing date	2021-11-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2276890-7
ISSN	1871-4099 ; 1871-4080
ISSN (online)	1871-4099
ISSN	1871-4080
DOI	10.1007/s11571-021-09745-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- Full text online
- Order with fees

Article ; Online: Cyclin-dependent kinase 5 controls vasculogenic mimicry formation in non-small cell lung cancer via the FAK-AKT signaling pathway.

Zhou, Xiaoshu / Gu, Runxia / Han, Xiaoming / Wu, Gang / Liu, Junli

Biochemical and biophysical research communications

2021 Volume 546, Page(s) 201

Language	English
Publishing date	2021-02-18
Publishing country	United States
Document type	Published Erratum
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2021.01.064
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 116: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Pediatric-inspired regimen for adolescent and adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia: a prospective study from China.

Gong, Xiaoyuan / Fang, Qiuyun / Gu, Runxia / Qiu, Shaowei / Liu, Kaiqi / Lin, Dong / Zhou, Chunlin / Zhang, Guangji / Gong, Benfa / Liu, Yuntao / Li, Yan / Liu, Bingcheng / Wang, Ying / Wei, Hui / Mi, Yingchang / Wang, Jianxiang

Haematologica

2024

Abstract: Several international centers have used and reported pediatric-inspired regimens for adolescent and adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph- ALL). However, there is a lack of prospective data on the Chinese ... ...

Abstract	Several international centers have used and reported pediatric-inspired regimens for adolescent and adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph- ALL). However, there is a lack of prospective data on the Chinese population. Herein, we performed a prospective study with a pediatric-inspired regimen (IH-2014 regimen) in treating adolescent and adult Ph- ALL patients in our center. From 2014 to 2021, a total of 415 patients aged between 14 and 65 years (median age, 27) were included in this study. After a median follow-up of 40.8 months, the 5-year overall survival, disease-free survival, and event-free survival rates were 53.8%, 51.1% and 45.0%, respectively. The regimen was generally well tolerated and safe, and the overall chemotherapy-related mortality was 3.6%. Age ≥ 40 years and persistent detectable minimal residual disease (MRD) post-induction were independent prognostic factors. Traditional risk factors for adult patients combined with MRD post-induction exhibit predictive significance for survival and relapse, which is helpful in the selection of subsequent treatment. Patients with high risk factors who can achieve deep MRD response after induction do not derive benefit from allogeneic hematopoietic stem cell transplantation.
Language	English
Publishing date	2024-01-18
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2023.284228
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.76: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Coherence resonance for neuronal bursting with spike undershoot.

Cao, Ben / Wang, Runxia / Gu, Huaguang / Li, Yuye

Cognitive neurodynamics

2020 Volume 15, Issue 1, Page(s) 77–90

Abstract: Although the bursting patterns with spike undershoot are involved with the achievement of physiological or cognitive functions of brain with synaptic noise, noise induced-coherence resonance (CR) from resting state or subthreshold oscillations instead of ...

Abstract	Although the bursting patterns with spike undershoot are involved with the achievement of physiological or cognitive functions of brain with synaptic noise, noise induced-coherence resonance (CR) from resting state or subthreshold oscillations instead of bursting has been widely identified to play positive roles in information process. Instead, in the present paper, CR characterized by the increase firstly and then decease of peak value of power spectrum of spike trains is evoked from a bursting pattern with spike undershoot, which means that the minimal membrane potential within burst is lower than that of the subthreshold oscillations between bursts, while CR cannot be evoked from the bursting pattern without spike undershoot. With bifurcations and fast-slow variable dissection method, the bursting patterns with and without spike undershoot are classified into "Sub-Hopf/Fold" bursting and "Fold/Homoclinic" bursting, respectively. For the bursting with spike undershoot, the trajectory of the subthreshold oscillations is very close to that of the spikes within burst. Therefore, noise can induce more spikes from the subthreshold oscillations and modulate the bursting regularity, which leads to the appearance of CR. For the bursting pattern without spike undershoot, the trajectory of the quiescent state is not close to that of the spikes within burst, and noise cannot induce spikes from the quiescent state between bursts, which is cause for non-CR. The result provides a novel case of CR phenomenon and extends the scopes of CR concept, presents that noise can enhance rather than suppress information of the bursting patterns with spike undershoot, which are helpful for understanding the dynamics and the potential physiological or cognitive functions of the nerve fiber or brain neurons with such bursting patterns.
Language	English
Publishing date	2020-05-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2276890-7
ISSN	1871-4099 ; 1871-4080
ISSN (online)	1871-4099
ISSN	1871-4080
DOI	10.1007/s11571-020-09595-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Universal Anti-CD7 CAR-T Cells Targeting T-ALL and Functional Analysis of CD7 Antigen on T/CAR-T Cells.

Xie, Leling / Gu, Runxia / Yang, Xue / Qiu, Shaowei / Xu, Yingxi / Mou, Junli / Wang, Ying / Xing, Haiyan / Tang, Kejing / Tian, Zheng / Rao, Qing / Wang, Min / Wang, Jianxiang

Human gene therapy

2023 Volume 34, Issue 23-24, Page(s) 1257–1272

Abstract: Chimeric antigen receptor T (CAR-T) cell therapy initiates new methods and turns the scale of clinical treatment on relapsed/refractory acute T lymphoblastic leukemia (T-ALL). In this study, we generated the second-generation CD7-targeting CAR-T cells ... ...

Abstract	Chimeric antigen receptor T (CAR-T) cell therapy initiates new methods and turns the scale of clinical treatment on relapsed/refractory acute T lymphoblastic leukemia (T-ALL). In this study, we generated the second-generation CD7-targeting CAR-T cells with a new antigen-binding single-chain variable fragment sequence and made it universal via CRISPR-based knockout of
MeSH term(s)	Humans ; Animals ; Mice ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Antigens, CD7/genetics ; Immunotherapy, Adoptive/methods ; CD4-Positive T-Lymphocytes ; Gene Expression ; Antigens, CD19
Chemical Substances	Antigens, CD7 ; Antigens, CD19
Language	English
Publishing date	2023-11-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028152-6
ISSN	1557-7422 ; 1043-0342
ISSN (online)	1557-7422
ISSN	1043-0342
DOI	10.1089/hum.2023.029
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2988: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Myeloid dysregulation and therapeutic intervention in COVID-19.

Gu, Runxia / Mao, Tianyang / Lu, Qiao / Tianjiao Su, Tina / Wang, Jun

Seminars in immunology

2021 Volume 55, Page(s) 101524

Abstract: The dysregulation of myeloid cell responses is increasingly demonstrated to be a major mechanism of pathogenesis for COVID-19. The pathological cellular and cytokine signatures associated with this disease point to a critical role of a hyperactivated ... ...

Abstract	The dysregulation of myeloid cell responses is increasingly demonstrated to be a major mechanism of pathogenesis for COVID-19. The pathological cellular and cytokine signatures associated with this disease point to a critical role of a hyperactivated innate immune response in driving pathology. Unique immunopathological features of COVID-19 include myeloid-cell dominant inflammation and cytokine release syndrome (CRS) alongside lymphopenia and acute respiratory distress syndrome (ARDS), all of which correlate with severe disease. Studies suggest a range of causes mediating myeloid hyperactivation, such as aberrant innate sensing, asynchronized immune cellular responses, as well as direct viral protein/host interactions. These include the recent identification of new myeloid cell receptors that bind SARS-CoV-2, which drive myeloid cell hyperinflammatory responses independently of lung epithelial cell infection via the canonical receptor, angiotensin-converting enzyme 2 (ACE2). The spectrum and nature of myeloid cell dysregulation in COVID-19 also differs from, at least to some extent, what is observed in other infectious diseases involving myeloid cell activation. While much of the therapeutic effort has focused on preventative measures with vaccines or neutralizing antibodies that block viral infection, recent clinical trials have also targeted myeloid cells and the associated cytokines as a means to resolve CRS and severe disease, with promising but thus far modest effects. In this review, we critically examine potential mechanisms driving myeloid cell dysregulation, leading to immunopathology and severe disease, and discuss potential therapeutic strategies targeting myeloid cells as a new paradigm for COVID-19 treatment.
MeSH term(s)	Humans ; Immunity, Innate ; Myeloid Cells ; SARS-CoV-2 ; COVID-19 Drug Treatment
Language	English
Publishing date	2021-11-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1018141-6
ISSN	1096-3618 ; 1044-5323
ISSN (online)	1096-3618
ISSN	1044-5323
DOI	10.1016/j.smim.2021.101524
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2843: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Early-salvage therapy with venetoclax-based regimens for induction failure and poor early response acute lymphoblastic leukaemia: A retrospective case series of 13 patients.

Wei, Shuning / Gu, Runxia / Song, Yang / Yan, Zhangsong / Hu, Yimin / Lin, Dong / Liu, Kaiqi / Zhou, Chunlin / Zhang, Guangji / Wang, Ying / Wang, Jianxiang / Mi, Yingchang

British journal of haematology

2022 Volume 199, Issue 5, Page(s) 772–776

MeSH term(s)	Humans ; Salvage Therapy ; Retrospective Studies ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Remission Induction
Chemical Substances	venetoclax (N54AIC43PW) ; Bridged Bicyclo Compounds, Heterocyclic
Language	English
Publishing date	2022-09-26
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.18487
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.182: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Molecular landscape and targeted therapy of acute myeloid leukemia.

Gu, Runxia / Yang, Xue / Wei, Hui

Biomarker research

2018 Volume 6, Page(s) 32

Abstract: For decades, genetic aberrations including chromosome and molecular abnormalities are important diagnostic and prognostic factors in acute myeloid leukemia (AML). ATRA and imatinib have been successfully used in AML and chronic myelogenous leukemia, ... ...

Abstract	For decades, genetic aberrations including chromosome and molecular abnormalities are important diagnostic and prognostic factors in acute myeloid leukemia (AML). ATRA and imatinib have been successfully used in AML and chronic myelogenous leukemia, which proved that targeted therapy by identifying molecular lesions could improve leukemia outcomes. Recent advances in next generation sequencing have revealed molecular landscape of AML, presenting us with many molecular abnormalities. The individual prognostic information derived from a specific mutation could be modified by other molecular lesions. Therefore, the genomic complexity in AML poses a huge challenge to successful translation into more accurate risk stratification and targeted therapy. Herein, a summary of these mutations and targeted therapies are described. We focus on the prognostic information of recent identified molecular lesions and emerging targeted therapy.
Language	English
Publishing date	2018-11-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2699926-2
ISSN	2050-7771
ISSN	2050-7771
DOI	10.1186/s40364-018-0146-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Construction of CD19 targeted dual- and enhanced dual-antibodies and their efficiency in the treatment of B cell malignancy.

Chen, Manling / Liu, Xiaoyu / Peng, Nan / Zhang, Ting / Mou, Junli / He, Huizhen / Wang, Ying / Xu, Yingxi / Xing, Haiyan / Tang, Kejing / Tian, Zheng / Rao, Qing / Gu, Runxia / Qiu, Shaowei / Wang, Min / Wang, Jianxiang

Experimental hematology & oncology

2023 Volume 12, Issue 1, Page(s) 64

Abstract: Background: T cell-redirecting bispecific antibodies establish a connection between endogenous T cells and tumor cells, activating T cells function to eliminate tumor cells without ex vivo genetic alteration or manipulation. Here, we developed a novel ... ...

Abstract	Background: T cell-redirecting bispecific antibodies establish a connection between endogenous T cells and tumor cells, activating T cells function to eliminate tumor cells without ex vivo genetic alteration or manipulation. Here, we developed a novel dual-specific antibody (DuAb) and an enhanced DuAb (EDuAb) with different stimulation signal to activate T cells, and evaluated their impact on the treatment of acute lymphoblastic leukemia (ALL). Methods: The expression plasmids of the DuAb and EDuAb containing CD80 molecule were constructed by cloning heavy chain and light chain variable fragments from anti-human CD19 (HI19a) and CD3 (HIT3a) monoclonal antibody hybridomas, respectively. The activation and the anti-tumor efficacy of human T cells mediated by DuAb and EDuAb were evaluated in vitro. B-cell ALL xenograft NSG mouse model was established to investigate the therapeutic effect in vivo. Results: EDuAb promoted the optimal expansion of primary human T cells with low expression of inhibitory markers in vitro than DuAb did. Both DuAb and EDuAb showed a similar capability in inducing healthy donor T cells to specifically eliminate B-ALL cell lines and primary blasts from patients. The similar ability was also observed in the patient-derived T cells. In vivo study showed that both DuAb and EDuAb significantly alleviated tumor burden and extended survival of B-ALL xenograft NSG mice. The median survival of PBS, DuAb and EDuAb treatment groups were 27, 38 and 45 days, respectively. The phenotype of T cells and cytokine release in peripheral blood (PB) of B-ALL xenograft NSG mice on day 24 were analyzed as well. The results showed that the proportion of CD8 Conclusions: Both DuAb and EDuAb showed great potential as novel treatments for B-ALL in clinical applications. However, compared to DuAb, EDuAb showed a significant advantage in promoting the proliferation and survival of T cells. Furthermore, EDuAb showed a better promising effect on eliminating tumor cells and extending survival in vivo, which provides new insights for the development of new multi-specific antibodies.
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2669066-4
ISSN	2162-3619
ISSN	2162-3619
DOI	10.1186/s40164-023-00423-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A novel subclonal rearrangement of the STRN3::PDGFRB gene in de novo acute myeloid leukemia with NPM1 mutation and its leukemogenic effects.

Wang, Zhe / Liu, Ting / Liu, Wenbing / Gao, Xin / Wan, Li / Qiu, Shaowei / Song, Yang / Gu, Runxia / Tian, Zheng / Wang, Min / Wang, Jianxiang / Mi, Yingchang / Wei, Shuning

Cancer gene therapy

2023 Volume 30, Issue 11, Page(s) 1471–1484

Abstract: Chromosome translocations in the 5q31-33 region are associated with a range of hematologic malignancies, some of which involve the platelet-derived growth factor receptor beta (PDGFRB) gene. We report a case of acute myeloid leukemia (AML) with a ... ...

Abstract	Chromosome translocations in the 5q31-33 region are associated with a range of hematologic malignancies, some of which involve the platelet-derived growth factor receptor beta (PDGFRB) gene. We report a case of acute myeloid leukemia (AML) with a mutation in the NPM1 gene (NPM1-mut AML) and a subclonal gene rearrangement involving the PDGFRB gene. We identified a novel fusion gene, STRN3::PDGFRB, resulting from t(5;14) (q32;q12) chromosomal rearrangement. Sequential FISH confirmed that ~15% of leukemic cells carried the PDGFRB gene rearrangement, which suggests that STRN3::PDGFRB is a previously unreported fusion gene in a subclone. Reverse transcription PCR (RT-PCR) and Sanger sequencing confirmed that the fusion gene consisted of STRN3 exon 7 fused to PDGFRB exon 11, resulting in a chimeric protein containing the coiled-coil domain of striatin-3 and the transmembrane and intracellular tyrosine kinase domains of the PDGFRB. The new protein exhibited distinct cytoplasmic localization and had leukemogenic effects, as demonstrated by its ability to transform Ba/F3 cells to growth factor independence and cause a fatal myelodysplastic/myeloproliferative neoplasm (MDS/MPN)-like disease in mice, which then transformant to T-cell lymphoblastic lymphoma in secondary recipients. Ba/F3 cells expressing STRN3::PDGFRB or ETV6::PDGFRB were sensitive to tyrosine kinase inhibitors (TKIs) and selinexor, but in vitro experiments showed that the combination of imatinib and selinexor had a marked synergistic effect, although only the imatinib alone group could prolong the survival of T-cell blast transformation recipient mice. Our findings demonstrate the leukemogenic effects of the novel fusion gene and provide insights into the clone evolution of AML, which can be influenced by therapy selection. Furthermore, our results provide insight into the potential therapeutic options for patients with this type of mutation, as well as the need for careful consideration of treatment selection to prevent undesirable side effects.
MeSH term(s)	Humans ; Animals ; Mice ; Imatinib Mesylate/therapeutic use ; Receptor, Platelet-Derived Growth Factor beta/genetics ; Oncogene Proteins, Fusion/genetics ; Translocation, Genetic ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/drug therapy ; Nuclear Proteins/genetics ; Autoantigens ; Calmodulin-Binding Proteins/genetics ; Hydrazines ; Triazoles
Chemical Substances	Imatinib Mesylate (8A1O1M485B) ; selinexor (31TZ62FO8F) ; Receptor, Platelet-Derived Growth Factor beta (EC 2.7.10.1) ; Oncogene Proteins, Fusion ; Nuclear Proteins ; STRN3 protein, human ; Autoantigens ; Calmodulin-Binding Proteins ; PDGFRB protein, human (EC 2.7.10.1) ; Hydrazines ; Triazoles
Language	English
Publishing date	2023-08-07
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212513-1
ISSN	1476-5500 ; 0929-1903
ISSN (online)	1476-5500
ISSN	0929-1903
DOI	10.1038/s41417-023-00651-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4125: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito