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Article ; Online: Vaccinations avant et après greffe de cellules hématopoïétiques autologues chez les patients atteints de maladies auto-immunes : propositions du groupe Maladies Auto-immunes et Thérapie Cellulaire de la SFGM-TC.

Maria, Alexandre Thibault Jacques / Campidelli, Arnaud / Castilla-Llorente, Cristina / Lansiaux, Pauline / Marjanovic, Zora / Pugnet, Grégory / Torregrosa-Diaz, Jose Miguel / Terriou, Louis / Algayres, Jean-Pierre / Urbain, Fanny / Yakoub-Agha, Ibrahim / Farge, Dominique

Bulletin du cancer

2023 Volume 110, Issue 2S, Page(s) S97–S107

Abstract: The Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) organized the 12th workshop on hematopoietic stem cell transplantation clinical practices harmonization procedures on September 2021 in Lille, France. In the absence of ...

Title translation	Vaccination before and after autologous hematopoietic cell transplantation for autoimmune diseases: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (MATHEC-SFGM-TC).
Abstract	The Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) organized the 12th workshop on hematopoietic stem cell transplantation clinical practices harmonization procedures on September 2021 in Lille, France. In the absence of specific national or international recommendation, the French working group for autologous stem Cell transplantation in Auto-immune Diseases (MATHEC) proposed guidances for vaccinations of patients undergoing autologous hematopoietic stem cell transplantation for autoimmune disease, including in the context of SARS-Cov-2 pandemic.
MeSH term(s)	Humans ; Hematopoietic Stem Cell Transplantation ; Bone Marrow Transplantation ; Transplantation, Autologous ; COVID-19/prevention & control ; SARS-CoV-2 ; Autoimmune Diseases/therapy ; Societies, Medical ; Vaccination ; France
Language	French
Publishing date	2023-01-17
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2022.11.005
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Article: A Western Case of Intravascular Large B-Cell Lymphoma as Unusual Cause of Persistent Fever.

Piccaluga, Pier Paolo / Paolini, Stefania / Campidelli, Cristina / Vianelli, Nicola / Bolondi, Luigi

Case reports in hematology

2019 Volume 2019, Page(s) 1480710

Abstract: Fever of unknown origin (FUO) is a common and challenging clinical condition that can be referred, among others, to infections, drug's effects, various inflammatory disorders, and cancers. Among the latter, lymphomas can indeed cause fever, which is ... ...

Abstract	Fever of unknown origin (FUO) is a common and challenging clinical condition that can be referred, among others, to infections, drug's effects, various inflammatory disorders, and cancers. Among the latter, lymphomas can indeed cause fever, which is therefore accounted as a lymphoma-related sign in patients' staging. Intravascular large B-cell lymphoma (IVLBCL) is a very rare tumor, characterized by lymphoma cell accumulation within sinusoids and, despite a very aggressive course, the evidence of this disease is scarce. Two variants are currently recognized, respectively, occurring in either Western (mainly characterized by neurological symptoms and skin involvement) or Eastern countries (with hemophagocytic syndrome, bone marrow, spleen, and liver involvement). We describe an atypical and unprecedented IVLBCL patient, presenting with pronounced features of Eastern cases as well as skin involvement. Due to the scant amount of neoplastic cells, the diagnosis was very challenging, with FUO being the first and for a certain time unique clinical sign. Although lymphoma was suspected, the lack of evidence for neoplastic cells delayed the final diagnosis. Eventually, only autopsy revealed the extensive involvement of different organs and tissues.
Language	English
Publishing date	2019-11-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627639-2
ISSN	2090-6579 ; 2090-6560
ISSN (online)	2090-6579
ISSN	2090-6560
DOI	10.1155/2019/1480710
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Article: Baru almonds (Dipteryx alata Vog.) and baru almond paste promote metabolic modulation associated with antioxidant, anti-inflammatory, and neuroprotective effects

Campidelli, Marina Leopoldina Lamounier / Carneiro, João de Deus de Souza / Souza, Ellen Cristina de / Vilas Boas, Eduardo Valério de Barros / Bertolucci, Suzan Kelly Vilela / Aazza, Smail / de Oliveira, Raphael Ricon / Chalfun-Junior, Antonio / Reis, Gabriel Lasmar dos / Seixas, Josilene Nascimento / Nelson, David Lee / Pereira, Luciano José

Innovative food science & emerging technologies. 2022 Aug., v. 80

2022

Abstract: The metabolic, antioxidant, anti-inflammatory, and neuroprotective potential of baru almonds and baru almond paste was investigated in 32 rats fed a high-fat and a normolipidic diet for 35 days. Hyperlipidic diets supplemented with baru almonds or baru ... ...

Abstract	The metabolic, antioxidant, anti-inflammatory, and neuroprotective potential of baru almonds and baru almond paste was investigated in 32 rats fed a high-fat and a normolipidic diet for 35 days. Hyperlipidic diets supplemented with baru almonds or baru almond paste resulted in lower levels of triacylglycerols, glutathione reductase, malondialdehyde, and acetylcholinesterase. Expression of the prostaglandin-endoperoxide synthase 2 gene (COX-2) was reduced. High-density lipoprotein cholesterol (HDL-c) levels and catalase activity increased. The diet supplemented with baru almonds caused increased ferric reducing antioxidant power and expression of manganese superoxide dismutase. It also resulted in reduced total cholesterol levels, risk of cardiovascular disease, and malondialdehyde levels. Supplementation with baru almond paste led to lower levels of low-density lipoprotein cholesterol (LDL-c) and a lower Castelli II index (ratio of LDL-c to HDL-c). It also led to higher levels of alanine aminotransferase, ferric reducing antioxidant power, and oxygen radical absorbing capacity. In conclusion, a hyperlipidic diet supplemented with baru almonds and baru almond paste promoted metabolic benefits in rats, which may suggest similar beneficial effects in humans.
Keywords	Dipteryx alata ; acetylcholinesterase ; alanine transaminase ; almonds ; antioxidant activity ; cardiovascular diseases ; catalase ; food science ; genes ; glutathione-disulfide reductase ; high density lipoprotein cholesterol ; low density lipoprotein cholesterol ; malondialdehyde ; neuroprotective effect ; prostaglandin synthase ; reactive oxygen species ; risk ; superoxide dismutase ; triacylglycerols
Language	English
Dates of publication	2022-08
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2025029-0
ISSN	1466-8564
ISSN	1466-8564
DOI	10.1016/j.ifset.2022.103068
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Determination of the phenolic, antioxidant and antimicrobial potential of leaf extracts of Pereskia grandifolia Haw

Nelma Ferreira de Paula Vicente / Heloísa Helena de Abreu Martins / Marina Leopoldina Lamounier Campidelli / Diogo Mendes da Silva / Smail Aazza / Ellen Cristina de Souza / Suzan Kelly Vilela Bertolucci / Roberta Hilsdorf Piccoli

Research, Society and Development, Vol 9, Iss

2020 Volume 10

Abstract: Pesquisas em Plantas Alimentícias Não Convencionais (PANC) quanto à presença de compostos bioativos e antimicrobianos são escassas e a ampliação do conhecimento a respeito de suas propriedades torna-se necessária. Neste estudo, quatro tipos diferentes de ...

Abstract	Pesquisas em Plantas Alimentícias Não Convencionais (PANC) quanto à presença de compostos bioativos e antimicrobianos são escassas e a ampliação do conhecimento a respeito de suas propriedades torna-se necessária. Neste estudo, quatro tipos diferentes de extratos (aquosos e hidroalcoólicos obtidos por refluxo e sonicação) de ora-pro-nóbis (Pereskia grandifolia Haw) foram investigados quanto à presença de compostos fenólicos, antioxidantes e antibacterianos. Os extratos de Pereksia grandifolia Haw obtidos por refluxo foram mais eficientes do que a sonicação, pois extraíram uma quantidade maior de compostos fenólicos, antioxidantes, flavonas e flavonóis. Em relação ao solvente, detectou-se que o hidroalcoólico permitiu uma maior quantificação de flavonóides totais (flavonas e flavonóis, flavanonas e di-hidroflavonóis) e antioxidantes (medidos pelos métodos de DPPH, molibdato e poder quelante). Quando a água foi usada como solvente extrator, maiores quantidades de compostos fenólicos totais e antioxidantes (medidos pelo DPPH e poder quelante) foram observados. Todos os extratos apresentaram atividade inibitória contra Staphylococcus aureus e Pseudomonas aeruginosa, sendo os extratos aquosos obtidos por refluxo e sonicação os que apresentaram maiores halos de inibição. Porém, quando a concentração minima bactericida foi determinada, apenas o extrato hidroalcoólico obtido por refluxo apresentou resultado efetivo nas concentrações testadas. A caracterização e quantificação dos compostos fenólicos, antioxidantes e antibacterianos de Pereskia grandifolia Haw fornecem informações importantes para aumentar o uso dessa planta, como fonte alternativa de compostos benéficos à saúde, e com potencial antimicrobiano.
Keywords	UFP ; Ora-pro-nóbis ; Bioactive compounds ; Spectrophotometry ; Pathogens. ; Special aspects of education ; LC8-6691 ; Science (General) ; Q1-390 ; Social Sciences ; H
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Study of the nutritional, sensory and microbiological properties of food pastes made with baru almonds (Dipteryx alata vog.)

Marina Leopoldina Lamounier Campidelli / Maica de Paula Naves / Grayce Kelly de Andrade / João de Deus de Souza Carneiro / Ellen Cristina de Souza / Maísa Lamounier Magalhães / Priscila Castellani Coli / David Nelson Lee / Eduardo Valério de Barros Vilas Boas

Research, Society and Development, Vol 9, Iss

2020 Volume 8

Abstract: Baru almond is an oilseed native to the Cerrado biome and stands out because of its large nutrient content. The present study sought to perform a centesimal, mineral, microbiological and sensory characterization of food pastes made with different ... ...

Abstract	Baru almond is an oilseed native to the Cerrado biome and stands out because of its large nutrient content. The present study sought to perform a centesimal, mineral, microbiological and sensory characterization of food pastes made with different contents of baru almonds: P1 (35%); P2 (17.5%); and P3 (0%). Hazelnuts were used as the control to counterbalance the different percentages of almond. The highest concentrations of moisture, lipids, and calcium and the highest total energy value were observed with the food pastes consisting of 35% baru almond (P1). However, a decrease in ash, protein and carbohydrate contents occurred. Higher concentrations of potassium and zinc were found in the food pastes made with 0% baru almond (P3), indicating that hazelnuts contained a greater quantity of these minerals. As for the microbiological results, no coliforms were found for any of the pastes tested. Low levels of molds and yeasts were observed at the dilutions of 10-1 and 10-2 UFC/g and none at 10-3 UFC/g. For the taste sensorial attributes, global impression and intention to purchase, no significant differences were observed between the formulations. However, the food pastes consisting of 17.5% baru almond and 17.5% hazelnut (P2) received the highest scores for appearance and texture. It is concluded that the food pastes made with different contents of baru almond had satisfactory nutritional, sensory and microbiological characteristics for consumption.
Keywords	Cerrado ; Oilseeds ; Development of new products ; Special aspects of education ; LC8-6691 ; Science (General) ; Q1-390 ; Social Sciences ; H
Subject code	590
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Myeloid sarcoma: extramedullary manifestation of myeloid disorders.

Campidelli, Cristina / Agostinelli, Claudio / Stitson, Richard / Pileri, Stefano A

American journal of clinical pathology

2009 Volume 132, Issue 3, Page(s) 426–437

Abstract: Myeloid sarcoma (MS), also termed extramedullary acute myeloid leukemia, extramedullary myeloid tumor, and granulocytic sarcoma or chloroma, is a rare manifestation that is characterized by the occurrence of 1 or more tumor myeloid masses occurring at an ...

Abstract	Myeloid sarcoma (MS), also termed extramedullary acute myeloid leukemia, extramedullary myeloid tumor, and granulocytic sarcoma or chloroma, is a rare manifestation that is characterized by the occurrence of 1 or more tumor myeloid masses occurring at an extramedullary site. The wide spectrum of this disorder and the conditions that it overlaps diagnostically were well reflected in the 25 cases submitted to the Society for Hematopathology/European Association for Haematopathology Workshop held in Indianapolis, IN, in November 2007. This review, on the one hand, focuses on the definition and most recent achievements on the pathobiology of MS, and on the other, also in the light of the revised World Health Organization classification, summarizes the main features of a representative series of this condition aiming to provide readers a useful document for daily practice.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Child, Preschool ; Congresses as Topic ; Female ; Humans ; Infant ; Male ; Middle Aged ; Sarcoma, Myeloid/classification ; Sarcoma, Myeloid/pathology ; Sarcoma, Myeloid/physiopathology
Language	English
Publishing date	2009-09
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1309/AJCP1ZA7HYZKAZHS
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Article ; Online: HIV infection and c-MYC status in endemic Burkitt lymphoma.

Campidelli, Cristina / Gazzola, Anna / Vitone, Francesca / Pileri, Stefano A / Tumwine, Lynnette

Human pathology

2008 Volume 39, Issue 9, Page(s) 1408–1409

MeSH term(s)	Burkitt Lymphoma/complications ; Burkitt Lymphoma/genetics ; Burkitt Lymphoma/pathology ; Genes, myc/genetics ; HIV Infections/complications ; Humans
Language	English
Publishing date	2008-09
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2008.06.002
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Article ; Online: Clinical, phenotypic and genetic similarities and disparities between post-transplant and classical Hodgkin lymphomas with respect to therapeutic targets.

Adams, Heiner / Campidelli, Cristina / Dirnhofer, Stephan / Pileri, Stefano A / Tzankov, Alexandar

Expert opinion on therapeutic targets

2009 Volume 13, Issue 10, Page(s) 1137–1145

Abstract: Objective: Post-transplant Hodgkin lymphoma (ptHL) is a rare but serious complication. We explored the clinical, phenotypic and genetic similarities and disparities between ptHL and classical Hodgkin lymphoma (cHL) in immunocompetent patients and sought ...

Abstract	Objective: Post-transplant Hodgkin lymphoma (ptHL) is a rare but serious complication. We explored the clinical, phenotypic and genetic similarities and disparities between ptHL and classical Hodgkin lymphoma (cHL) in immunocompetent patients and sought proteins/pathways in ptHL that might have potential as therapeutic targets. Research design and methods: Eight ptHL cases in solid organ recipients (mean patient age 36 years; mean duration between organ transplant and onset of ptHL 80 months) were phenotypically and genotypically analyzed and the results were compared with known phenotypic and molecular characteristics of cHL. Results: All ptHL expressed CD15, CD30 and LMP-1 of EBV; the B-cell markers BOB-1, Oct2, CD79a and CD20 were more commonly expressed in ptHL versus cHL (100%, 86%, 50% and 38% in ptHL compared to 6%, 14%, 10% and 33% in cHL, respectively); all ptHL expressed phosphoinositide 3-kinase (PI3K) versus 81% of cHL; 2/6 (33%) ptHL displayed gains at 9p24 that were similar to cHL (32%). The JAK2 downstream pSTAT3 slightly predominated in ptHL versus cHL (60% versus 50%). Clonal immunoglobulin gene rearrangements were found in 2/4 cases. Conclusions: ptHL and cHL are closely related, but not identical, neoplasms, with the primary differences being the strict association with EBV infection, persistent phenotypic B-cell signature and high expression of PI3K as well as the slightly CD4-depleted but TIA-1/Granzyme B-enriched cellular background composition in ptHL.
MeSH term(s)	Adolescent ; Adult ; Antigens, CD/genetics ; Antineoplastic Agents/pharmacology ; Female ; Gene Expression Regulation, Neoplastic/physiology ; Hodgkin Disease/chemically induced ; Hodgkin Disease/drug therapy ; Hodgkin Disease/genetics ; Humans ; Immunosuppression/adverse effects ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation ; Male ; Middle Aged ; Young Adult
Chemical Substances	Antigens, CD ; Antineoplastic Agents ; Immunosuppressive Agents
Language	English
Publishing date	2009-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2055208-7
ISSN	1744-7631 ; 1472-8222
ISSN (online)	1744-7631
ISSN	1472-8222
DOI	10.1517/14728220903196779
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Article: Autoimmune pancreatitis associated with high levels of chromogranin a, serotonin and 5-hydroxyindoleacetic Acid.

Nobili, Elisabetta / Pezzilli, Raffaele / Santini, Donatella / Campidelli, Cristina / Calculli, Lucia / Casadei, Riccardo / Biasco, Guido

Case reports in gastroenterology

2008 Volume 2, Issue 1, Page(s) 11–17

Abstract: We report a case of a male patient with autoimmune pancreatitis in whom biochemical examination revealed high plasma chromogranin A concentrations, histological demonstration of a small lymphocytic infiltrate and rapid decrease in size of the pancreatic ... ...

Abstract	We report a case of a male patient with autoimmune pancreatitis in whom biochemical examination revealed high plasma chromogranin A concentrations, histological demonstration of a small lymphocytic infiltrate and rapid decrease in size of the pancreatic mass following short-lasting therapy with methylprednisolone. To our knowledge, this is the first patient with autoimmune pancreatitis who had a simultaneous increase of serum chromogranin A levels, circulating and urinary serotonin concentrations and urine 5-hydroxyindoleacetic acid concentrations. This is one of the few cases of mass forming pancreatitis with small lymphocytic infiltrate found in a Caucasian patient and rapid decrease in size of the pancreatic mass following short-lasting therapy with methylprednisolone.
Language	English
Publishing date	2008-01-24
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2440540-1
ISSN	1662-0631
ISSN	1662-0631
DOI	10.1159/000113218
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Article ; Online: B-cell non-Hodgkin lymphomas in Uganda: an immunohistochemical appraisal on tissue microarray.

Tumwine, Lynnette K / Campidelli, Cristina / Righi, Simona / Neda, Sophia / Byarugaba, Wilson / Pileri, Stefano A

Human pathology

2008 Volume 39, Issue 6, Page(s) 817–823

Abstract: The most common non-Hodgkin lymphomas in Uganda are neoplasms of B-cell derivation. The field of B-cell lymphoma immunophenotype has rapidly progressed because of the increasing availability of markers applicable to routine sections. Although the latter ... ...

Abstract	The most common non-Hodgkin lymphomas in Uganda are neoplasms of B-cell derivation. The field of B-cell lymphoma immunophenotype has rapidly progressed because of the increasing availability of markers applicable to routine sections. Although the latter have allowed the identification of distinctive lymphoma entities in the developed countries, such approach has not yet been used in Uganda. One hundred twenty-nine formalin-fixed, paraffin-embedded tissue samples from the Department of Pathology of Makerere University were used for tissue micro-array (TMA) construction. Four-micrometer-thick sections were cut from TMAs and stained with hematoxylin and eosin and Giemsa. They were also used for immunohistochemistry and in situ hybridization. According to morphology and immunohistochemistry, lymphoid neoplasms were classified as Burkitt's lymphoma (BL) (95 cases), diffuse large B-cell lymphoma (19 cases), mantle cell lymphoma (4 cases), and B-cell lymphoblastic lymphoma (1 case). In BL, a homogeneous phenotype (CD10(+), Bcl-6(+), Bcl-2(-), MUM1/IRF4-, and Ki-67 approximately 100%) and a stable Epstein-Barr virus integration were found. A distinctive and unusual feature was the frequent plasma cellular differentiation, along with the positivity for CD30 and CD138 (recorded in 35 and 43 cases, respectively). According to our findings, most non-Hodgkin B-cell tumors in Uganda are endemic BLs followed by diffuse large B-cell lymphomas. The rest consist of rare but clinically important entities such as mantle cell lymphoma and B-cell lymphoblastic lymphoma. The availability of TMAs and immunohistochemistry has enabled us to precisely categorize tumors that have so far been diagnosed in Uganda as "high-grade/aggressive" lymphomas on the basis of cell morphology alone.
MeSH term(s)	Adolescent ; Adult ; Biomarkers, Tumor/metabolism ; Child ; Child, Preschool ; Cross-Sectional Studies ; DNA, Neoplasm/analysis ; Female ; Herpesviridae Infections/complications ; Herpesviridae Infections/virology ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/isolation & purification ; Humans ; Immunohistochemistry ; Immunophenotyping ; In Situ Hybridization ; Ki-1 Antigen/metabolism ; Lymphoma, B-Cell/diagnosis ; Lymphoma, B-Cell/metabolism ; Lymphoma, B-Cell/virology ; Male ; Middle Aged ; Plasma Cells/metabolism ; Plasma Cells/pathology ; RNA, Viral/analysis ; Syndecan-1/metabolism ; Tissue Array Analysis/methods ; Uganda
Chemical Substances	Biomarkers, Tumor ; DNA, Neoplasm ; Ki-1 Antigen ; RNA, Viral ; Syndecan-1
Language	English
Publishing date	2008-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2007.10.025
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