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  1. Article ; Online: One-dimensional patient.

    Rovai, Daniele / Bonaguidi, Franco

    Journal of the American College of Cardiology

    2015  Volume 65, Issue 7, Page(s) 757–758

    MeSH term(s) Cardiology/methods ; Humans ; Physician-Patient Relations ; Precision Medicine/methods
    Language English
    Publishing date 2015-02-24
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2014.10.072
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1846: Show issues Location:
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    Zs.MO 196: Show issues

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  2. Article: Deep Learning for Reaction-Diffusion Glioma Growth Modeling: Towards a Fully Personalized Model?

    Martens, Corentin / Rovai, Antonin / Bonatto, Daniele / Metens, Thierry / Debeir, Olivier / Decaestecker, Christine / Goldman, Serge / Van Simaeys, Gaetan

    Cancers

    2022  Volume 14, Issue 10

    Abstract: Reaction-diffusion models have been proposed for decades to capture the growth of gliomas, the most common primary brain tumors. However, ill-posedness of the initialization at diagnosis time and parameter estimation of such models have restrained their ... ...

    Abstract Reaction-diffusion models have been proposed for decades to capture the growth of gliomas, the most common primary brain tumors. However, ill-posedness of the initialization at diagnosis time and parameter estimation of such models have restrained their clinical use as a personalized predictive tool. In this work, we investigate the ability of deep convolutional neural networks (DCNNs) to address commonly encountered pitfalls in the field. Based on 1200 synthetic tumors grown over real brain geometries derived from magnetic resonance (MR) data of six healthy subjects, we demonstrate the ability of DCNNs to reconstruct a whole tumor cell-density distribution from only two imaging contours at a single time point. With an additional imaging contour extracted at a prior time point, we also demonstrate the ability of DCNNs to accurately estimate the individual diffusivity and proliferation parameters of the model. From this knowledge, the spatio-temporal evolution of the tumor cell-density distribution at later time points can ultimately be precisely captured using the model. We finally show the applicability of our approach to MR data of a real glioblastoma patient. This approach may open the perspective of a clinical application of reaction-diffusion growth models for tumor prognosis and treatment planning.
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14102530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Symptomatic post COVID patients have impaired alveolar capillary membrane function and high VE/VCO

    Agostoni, Piergiuseppe / Mapelli, Massimo / Salvioni, Elisabetta / Mattavelli, Irene / Banfi, Cristina / Bonomi, Alice / Biondi, Maria Luisa / Rovai, Sara / Tamborini, Gloria / Muratori, Manuela / Ghulam Ali, Sarah / Ghilardi, Stefania / De Martino, Fabiana / Vignati, Carlo / Palermo, Pietro / Gugliandolo, Paola / Elia, Davide / Moscucci, Federica / Cassandro, Roberto /
    Andreini, Daniele / Mancini, Elisabetta / Harari, Sergio

    Respiratory research

    2024  Volume 25, Issue 1, Page(s) 82

    Abstract: Background: Post COVID-19 syndrome is characterized by several cardiorespiratory symptoms but the origin of patients' reported symptomatology is still unclear.: Methods: Consecutive post COVID-19 patients were included. Patients underwent full ... ...

    Abstract Background: Post COVID-19 syndrome is characterized by several cardiorespiratory symptoms but the origin of patients' reported symptomatology is still unclear.
    Methods: Consecutive post COVID-19 patients were included. Patients underwent full clinical evaluation, symptoms dedicated questionnaires, blood tests, echocardiography, thoracic computer tomography (CT), spirometry including alveolar capillary membrane diffusion (DM) and capillary volume (Vcap) assessment by combined carbon dioxide and nitric oxide lung diffusion (DLCO/DLNO) and cardiopulmonary exercise test. We measured surfactant derive protein B (immature form) as blood marker of alveolar cell function.
    Results: We evaluated 204 consecutive post COVID-19 patients (56.5 ± 14.5 years, 89 females) 171 ± 85 days after the end of acute COVID-19 infection. We measured: forced expiratory volume (FEV
    Conclusions: In patients with post COVID-19, cardiorespiratory symptoms are linked to VE/VCO
    MeSH term(s) Female ; Humans ; Post-Acute COVID-19 Syndrome ; COVID-19/complications ; Lung/diagnostic imaging ; Respiratory Function Tests ; Exercise Test/methods ; Dyspnea ; Oxygen Consumption/physiology ; Heart Failure/diagnosis
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-023-02602-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Myocardial contrast echocardiography: advantages of quantitative analysis.

    Rovai, Daniele

    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology

    2004  Volume 5, Issue 1, Page(s) 2–4

    MeSH term(s) Cardiomyopathies/diagnostic imaging ; Contrast Media ; Echocardiography/methods ; Humans ; Sensitivity and Specificity ; Tomography, Emission-Computed, Single-Photon/methods
    Chemical Substances Contrast Media
    Language English
    Publishing date 2004-07-28
    Publishing country England
    Document type Comparative Study ; Editorial ; Comment
    ZDB-ID 2021408-X
    ISSN 1532-2114 ; 1525-2167
    ISSN (online) 1532-2114
    ISSN 1525-2167
    DOI 10.1016/j.euje.2003.10.003
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    Zs.A 5614: Show issues Location:
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  5. Article ; Online: Myocardium at risk: reasons and methods for measuring the extent.

    Gimelli, Alessia / Rovai, Daniele

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2012  Volume 20, Issue 1, Page(s) 23–26

    MeSH term(s) Female ; Heart/diagnostic imaging ; Humans ; Male ; Myocardial Perfusion Imaging/methods ; Myocardium/pathology ; Tomography, Emission-Computed, Single-Photon/methods
    Language English
    Publishing date 2012-11-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-012-9659-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 4121: Show issues Location:
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  6. Book: Come si visita il cardiopatico

    Rovai, Daniele

    2005  

    Author's details Daniele Rovai
    MeSH term(s) Heart Diseases/diagnosis ; Medical History Taking ; Physical Examination
    Language Italian
    Size ix, 101 p. :, ill.
    Publisher Editrice Kurtis
    Publishing place Milano
    Document type Book
    ISBN 9788885030862 ; 8885030866
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Article ; Online: Rhabdomyolysis in an HIV-infected patient following coronary angiography: case report and literature review.

    Sbrana, Francesco / Coceani, Michele / Iapoce, Riccardo / Petersen, Christina / Rovai, Daniele

    International journal of STD & AIDS

    2014  Volume 25, Issue 6, Page(s) 452–454

    Abstract: Rhabdomyolysis is a rare, but possible, complication of combination antiretroviral therapy (cART). We report a unique case of an HIV-positive patient on cART who came to our attention for suspected ischaemic heart disease. Coronary angiography was ... ...

    Abstract Rhabdomyolysis is a rare, but possible, complication of combination antiretroviral therapy (cART). We report a unique case of an HIV-positive patient on cART who came to our attention for suspected ischaemic heart disease. Coronary angiography was carried out and complicated in the following days by rhabdomyolysis. We discuss the possible links between rhabdomyolysis, iodinated contrast media and HAART.
    MeSH term(s) Anti-Retroviral Agents/adverse effects ; Anti-Retroviral Agents/therapeutic use ; Contrast Media/adverse effects ; Coronary Angiography/adverse effects ; Coronary Artery Bypass ; Drug Therapy, Combination ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Protease Inhibitors/administration & dosage ; Humans ; Iopamidol/adverse effects ; Iopamidol/analogs & derivatives ; Ischemia/diagnostic imaging ; Ischemia/surgery ; Male ; Middle Aged ; Reverse Transcriptase Inhibitors/administration & dosage ; Rhabdomyolysis/blood ; Rhabdomyolysis/chemically induced ; Rhabdomyolysis/diagnosis ; Treatment Outcome
    Chemical Substances Anti-Retroviral Agents ; Contrast Media ; HIV Protease Inhibitors ; Reverse Transcriptase Inhibitors ; iomeprol (17E17JBP8L) ; Iopamidol (JR13W81H44)
    Language English
    Publishing date 2014-05
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1018089-8
    ISSN 1758-1052 ; 0956-4624
    ISSN (online) 1758-1052
    ISSN 0956-4624
    DOI 10.1177/0956462413512809
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    Zs.A 2829: Show issues Location:
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  8. Article ; Online: Myocardial bridging: a review with emphasis on electrocardiographic findings.

    Rovai, Daniele / Di Bella, Gianluca / Pingitore, Alessandro / Coceani, Michele

    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc

    2014  Volume 20, Issue 2, Page(s) 103–107

    Abstract: Background: Myocardial bridging (MB) occurs when a segment of an epicardial coronary artery takes an intra- myocardial course, thus leading to systolic compression. Most myocardial bridges involve the left anterior descending artery and are observed in ... ...

    Abstract Background: Myocardial bridging (MB) occurs when a segment of an epicardial coronary artery takes an intra- myocardial course, thus leading to systolic compression. Most myocardial bridges involve the left anterior descending artery and are observed in 14-35% of patients. Different pathophysiological mechanisms can induce symptoms secondary to myocardial ischemia: systolic coronary compression, diastolic dysfunction associated with aging and coronary atherosclerosis, LV hypertrophy, vasospasm, microvascular and endothelial dysfunction, plaque development proximal to the bridge.
    Methods: We performed a literature review of MB, with a particular emphasis on electrocardiographic manifestations.
    Results: Stable angina-like chest pain is the usual presentation and MB should be suspected in patients at low risk for coronary atherosclerosis which refer this symptom or which present myocardial ischemia at instrumental examinations. ECG changes are not specific for MB and resting ECG is often normal or presents ST segment anomalies. Exercise stress test often shows non specific signs of ischemia, conduction disturbances or arrhythmias which do not allow the distinction between myocardial bridging and other causes of myocardial ischemia; angina often appears during exercise, even in the absence of ECG changes. Myocardial perfusion deficits at scintigraphy are neither obligatory nor specific. Although the clinical significance of MB is still debated, MB has been associated with acute coronary syndrome, coronary vasospasm, and even sudden cardiac death.
    Conclusion: Although MB may lead to myocardial ischemia during stress, its clinical presentation and electrocardiographic findings are not specific.
    MeSH term(s) Electrocardiography ; Humans ; Myocardial Bridging/diagnosis ; Myocardial Bridging/physiopathology
    Language English
    Publishing date 2014-12-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1325530-7
    ISSN 1542-474X ; 1082-720X
    ISSN (online) 1542-474X
    ISSN 1082-720X
    DOI 10.1111/anec.12242
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    Zs.A 4953: Show issues Location:
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  9. Article ; Online: T wave abnormalities identify patients with previous lateral wall myocardial infarction and circumflex artery disease.

    Rovai, Daniele / Gimelli, Alessia / Coceani, Michele / Sbrana, Francesco / Masini, Gabriele / Rossi, Giuseppe

    Journal of electrocardiology

    2016  Volume 49, Issue 2, Page(s) 216–222

    Abstract: Background: The diagnosis of previous lateral myocardial infarction is based on QRS morphology.: Objectives: To explore the diagnostic role of T wave abnormalities.: Methods: We studied 166 patients with known or suspected ischemic heart disease ... ...

    Abstract Background: The diagnosis of previous lateral myocardial infarction is based on QRS morphology.
    Objectives: To explore the diagnostic role of T wave abnormalities.
    Methods: We studied 166 patients with known or suspected ischemic heart disease who underwent a 12-lead electrocardiogram, myocardial perfusion scintigraphy, and coronary arteriography within 90days. We excluded patients with bundle-branch block, hypertrophy, or paced rhythm.
    Results: Only one patient had a prominent R wave in V1, no patient showed lateral Q waves of necrosis. T wave amplitude in V2-V6 ≥0.6mV, and T wave amplitude in lead 1+V6 ≤0mV detected a lateral infarction (sensitivity 33 and 44%, specificity 83 and 80%). T wave amplitude in lead 1+V6 ≤0mV was the only independent predictor of infarction or LCx occlusion (AUC 0.72 and 0.74). Serum potassium values were not associated with T wave abnormalities.
    Conclusion: T wave abnormalities identify previous lateral infarction and LCx disease.
    MeSH term(s) Aged ; Algorithms ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnosis ; Diagnosis, Computer-Assisted/methods ; Electrocardiography/methods ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/etiology ; Reproducibility of Results ; Sensitivity and Specificity
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 410286-1
    ISSN 1532-8430 ; 0022-0736
    ISSN (online) 1532-8430
    ISSN 0022-0736
    DOI 10.1016/j.jelectrocard.2015.11.008
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    Zs.A 701: Show issues Location:
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  10. Article ; Online: Calcified apical cardiomyopathy: a rare form of endomyocardial fibrosis.

    Sbrana, Francesco / Coceani, Michele / Masci, Pier Giorgio / Pasanisi, Emilio M / Rovai, Daniele

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2015  Volume 16 Suppl 2, Page(s) S79–80

    Abstract: Endomyocardial fibrosis is a rare cardiomyopathy characterized by thickening of the endocardium, which leads to a restrictive phenotype. Differential diagnosis with other forms of cardiomyopathy may not always be straightforward and various imaging ... ...

    Abstract Endomyocardial fibrosis is a rare cardiomyopathy characterized by thickening of the endocardium, which leads to a restrictive phenotype. Differential diagnosis with other forms of cardiomyopathy may not always be straightforward and various imaging modalities are frequently necessary. In the present case, we report a patient with heart failure of uncertain origin, in whom, after an in-depth instrumental evaluation, a rare variant of endomyocardial fibrosis was diagnosed.
    MeSH term(s) Calcinosis/diagnostic imaging ; Echocardiography ; Endomyocardial Fibrosis/diagnostic imaging ; Female ; Humans ; Middle Aged ; Radiography
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0b013e32836277e0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 559: Show issues

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