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  1. Article: Extensive right-sided endocarditis in double-chamber right ventricle presented with leukocytoclastic vasculitis.

    Nakhaee, Akram / Koohsari, Parisa / Rahmanian, Mehrzad / Sardari, Akram / Parkhideh, Roya / Larti, Farnoosh

    Clinical case reports

    2023  Volume 11, Issue 3, Page(s) e7108

    Abstract: Congenital heart disease is a risk factor for infective endocarditis (IE). Ventricular septal defects and ventricular outflow tract obstructions are this population's most common causes of endocarditis. We present a patient diagnosed with ... ...

    Abstract Congenital heart disease is a risk factor for infective endocarditis (IE). Ventricular septal defects and ventricular outflow tract obstructions are this population's most common causes of endocarditis. We present a patient diagnosed with leukocytoclastic vasculitis, renal, and pulmonary involvement with right-sided IE as an etiology for vasculitis.
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7108
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  2. Article: A large intracardiac hydatid cyst with concomitant cervical and hepatic involvement: A case report.

    Faramarzpour, Maryam / Jafari, Sirous / Rahmanian, Mehrzad / Sardari, Akram / Larti, Farnoosh

    Clinical case reports

    2023  Volume 11, Issue 5, Page(s) e7307

    Abstract: Key clinical message: Cardiac hydatidosis is a relatively rare complication of echinococcosis. Understanding the atypical manifestations, potential associated risk factors, and epidemiology leads to optimal and timely management.: Abstract: Cardiac ... ...

    Abstract Key clinical message: Cardiac hydatidosis is a relatively rare complication of echinococcosis. Understanding the atypical manifestations, potential associated risk factors, and epidemiology leads to optimal and timely management.
    Abstract: Cardiac hydatidosis is a relatively rare complication of echinococcosis, with a potentially life-threatening condition. Here, we reported a large interventricular septal hydatid cyst bulging in the left ventricle accompanied by a huge cervical lamp with recurrent hepatic cysts that underwent cardiac surgery to excise the cyst uneventfully.
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7307
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  3. Article ; Online: Extensive right‐sided endocarditis in double‐chamber right ventricle presented with leukocytoclastic vasculitis

    Akram Nakhaee / Parisa Koohsari / Mehrzad Rahmanian / Akram Sardari / Roya Parkhideh / Farnoosh Larti

    Clinical Case Reports, Vol 11, Iss 3, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract Congenital heart disease is a risk factor for infective endocarditis (IE). Ventricular septal defects and ventricular outflow tract obstructions are this population's most common causes of endocarditis. We present a patient diagnosed with ... ...

    Abstract Abstract Congenital heart disease is a risk factor for infective endocarditis (IE). Ventricular septal defects and ventricular outflow tract obstructions are this population's most common causes of endocarditis. We present a patient diagnosed with leukocytoclastic vasculitis, renal, and pulmonary involvement with right‐sided IE as an etiology for vasculitis.
    Keywords congenital heart disease ; double chamber right ventricle ; echocardiography ; infective endocarditis ; leukocytoclastic vasculitis ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Left ventricular strain echocardiography in advanced uremic cardiomyopathy compared to dilated cardiomyopathy.

    Mohammadi, Rizan / Larti, Farnoosh / Sattarzadeh Badkoubeh, Roya / Mehrpooya, Maryam / Sardari, Akram

    The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology

    2023  Volume 75, Issue 1, Page(s) 67

    Abstract: Background: Cardiac involvement is common in end-stage renal disease patients. The presenting study aimed to evaluate the global and segmental longitudinal strain in patients with advanced uremic cardiomyopathy (AUCM) and compare it to dilated ... ...

    Abstract Background: Cardiac involvement is common in end-stage renal disease patients. The presenting study aimed to evaluate the global and segmental longitudinal strain in patients with advanced uremic cardiomyopathy (AUCM) and compare it to dilated cardiomyopathy (DCM).
    Results: The mean global longitudinal strain (GLS) was significantly lower in AUCM (P value = 0.045). Comparing segmental strain showed a lower strain in mid inferoseptal (P value = 0.048), base and mid anterolateral (P value = 0.026, 0.001 respectively), base and mid anteroseptal (P value = 0.005, 0.009 respectively), base and mid inferior (P value = 0.015, 0.034 respectively) and mid anterior (P value = 0.015) in patients with AUCM compared with DCM. In both groups, the segmental strain increased from base to apex.
    Conclusions: Segmental and GLSs in advanced uremic cardiomyopathy were significantly lower than those of dilated cardiomyopathy. In both groups, the segmental strain increased from base to apex.
    Language English
    Publishing date 2023-07-26
    Publishing country Germany
    Document type Journal Article
    ISSN 2090-911X
    ISSN (online) 2090-911X
    DOI 10.1186/s43044-023-00393-y
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  5. Article ; Online: Echocardiographic estimation of left ventricular filling pressures in heart transplant recipients.

    Rahbar, Zohreh / Tavoosi, Anahita / Bakhshandeh, Alireza / Mehrpooya, Maryam / Sardari, Akram / Larti, Farnoosh / Sattarzadeh Badkoubeh, Roya

    The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology

    2024  Volume 76, Issue 1, Page(s) 12

    Abstract: Background: Echocardiographic estimation of left ventricular filling pressure in heart transplant (HTx) recipients is challenging. The ability of echocardiography to detect elevated left ventricular end-diastolic pressure (LVEDP) in HTx patients was ... ...

    Abstract Background: Echocardiographic estimation of left ventricular filling pressure in heart transplant (HTx) recipients is challenging. The ability of echocardiography to detect elevated left ventricular end-diastolic pressure (LVEDP) in HTx patients was assessed in this study.
    Results: This descriptive cross-sectional study included 39 HTx recipients who were candidates for endomyocardial biopsy as a part of their routine post-transplantation surveillance. Doppler transthoracic echocardiography was done before the procedure, and left heart catheterization was done during the endomyocardial biopsy. Thirty-nine patients (15 female, 24 male), with a mean age of 39.6 years (range 13-70), were enrolled. A strong relation was observed between lateral E/e' and LVEDP (R = 0.64, P value < 0.001) and average E/e' and LVEDP (R = 0.6, P value < 0.001). The best cutoff value for LVEDP prediction was the average E/e' ≥ 6.8 with a sensitivity of 96.15% and specificity of 68.5% for the prediction of LVEDP more than or equal to 20 mmHg. Two predictive models comprising age, gender, and lateral E/e' or average E/e' were also proposed. A significant relationship was also found between LVEDP and left ventricular global longitudinal strain (R = - 0.31, P value < 0.01).
    Conclusions: Lateral E/e' was the best predictor of LVEDP. The cutoff of average E/e' had the best validity for the estimation of LVEDP. Despite the strong observed association, echocardiographic parameters cannot be considered a surrogate for invasive LVEDP measurements when seeking information about left ventricle filling pressure on heart transplant recipients.
    Language English
    Publishing date 2024-01-30
    Publishing country Germany
    Document type Journal Article
    ISSN 2090-911X
    ISSN (online) 2090-911X
    DOI 10.1186/s43044-024-00443-z
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  6. Article: Response to Cardiac Resynchronization Therapy in Cardiomyopathy Patients with Right Bundle Branch Block.

    Zand, Sara / Sadeghian, Hakimeh / Kazemisaid, Ali / Lotfi-Tokaldany, Masoumeh / Jalali, Arash / Sardari, Akram

    The journal of Tehran Heart Center

    2023  Volume 18, Issue 2, Page(s) 109–114

    Abstract: Background: The use of cardiac resynchronization therapy (CRT) in heart failure patients with right bundle branch block (RBBB) is under debate. We present early and late echocardiographic characteristics of a series of heart failure patients with RBBB ... ...

    Abstract Background: The use of cardiac resynchronization therapy (CRT) in heart failure patients with right bundle branch block (RBBB) is under debate. We present early and late echocardiographic characteristics of a series of heart failure patients with RBBB who underwent CRT.
    Methods: In this retrospective descriptive study, 18 patients with RBBB in the surface electrocardiogram underwent CRT between 2005 and 2015. All the patients had the New York Heart Association functional class III/IV, a left ventricular ejection fraction (LVEF) ≤35%, and a QRS duration ≥120 milliseconds. The median follow-up duration was 19 months. The echocardiographic response was based on a ≥5% increase in LVEF.
    Results: Within 48 hours after CRT implantation, LVEF increased from 24.58%±7.08% before to 28.46±8.91% after CRT (P=0.005) and to 30.00±9.44% at follow-up (P=0.008). Among the 18 patients, 12 (66.7%) were responders within 48 hours after CRT. The following baseline echocardiographic parameters were higher in the responders than in those without an increased LVEF, although the difference did not reach statistical significance: septal-to-lateral wall delay (48.33±33.53 vs 43.33±38.82 ms), anteroseptal-to-posterior wall delay (41.7±1.75 vs 38.33±18.35 ms), and interventricular mechanical delay (48.50±21.13 vs 31.17±19.93 ms). The mean QRS duration was higher in the responders than in the non-responders (183.58±40.69 vs 169.00±27.36 ms). Death was reported in 3 out of the 18 patients (16.7%) at follow-up. The 3 deceased patients had a higher baseline interventricular mechanical delay than those who survived.
    Conclusion: Our results indicated that patients with RBBB might benefit from CRT. Further, patients with higher intra and interventricular dyssynchrony and a wider QRS may show better responses.
    Language English
    Publishing date 2023-08-21
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2476998-8
    ISSN 2008-2371 ; 1735-5370 ; 1735-8620
    ISSN (online) 2008-2371
    ISSN 1735-5370 ; 1735-8620
    DOI 10.18502/jthc.v18i2.13320
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  7. Article ; Online: Design and development of a self-assembling protein nanoparticle displaying PfHAP2 antigenic determinants recognized by natural acquired antibodies.

    Zahedi, Farhad / Abouie Mehrizi, Akram / Sardari, Soroush / Alemzadeh, Iran

    PloS one

    2022  Volume 17, Issue 9, Page(s) e0274275

    Abstract: Backgrounds: In order to move towards the elimination and eradication of malaria in the world, the development of vaccines is inevitable. Many modern vaccines are based on recombinant technology; however, they may not provide a fully protective, long- ... ...

    Abstract Backgrounds: In order to move towards the elimination and eradication of malaria in the world, the development of vaccines is inevitable. Many modern vaccines are based on recombinant technology; however, they may not provide a fully protective, long-lasting immune response. One of the strategies to improve recombinant vaccines is designing the nanovaccines such as self-assembling protein nanoparticles (SAPNs). Hence, the presentation of epitopes in a repeat array and correct conformation should be considered. P. falciparum generative cell-specific 1 (PfGCS1) is a main transmission-blocking vaccine candidate with two highly conserved fragments, HAP2-GCS1 and cd loop, inducing partial malaria transmission inhibitory antibodies. Therefore, to design an effective malaria vaccine, we used cd loop and HAP2-GCS1 fragments at the amino and carboxy terminuses of the SAPN-forming amino acid sequence, respectively.
    Methodology/principal findings: The SAPN monomer (PfGCS1-SAPN) sequence was designed, and the three-dimensional (3D) structure was predicted. The result of this prediction ensured the presence of antigens on the SAPN surface. Then the accuracy of the predicted 3D structure and its stability were confirmed by 100 ns molecular dynamics (MD) simulation. The designed SAPN substructure sequence was synthesized, cloned, and expressed in Escherichia coli. With a gradual decrease in urea concentration in dialysis solutions, the purified proteins progressed to the final desired structure of the SAPN, which then was confirmed by Dynamic Light Scattering (DLS) and Field Emission Scanning Electron Microscopy (FESEM) tests. According to the Enzyme-Linked Immunosorbent Assay (ELISA), antigenic determinants were presented on the SAPN surface and interacted with antibodies in the serum of malaria patients.
    Conclusions/significance: Our results show that the SAPN formed by PfGCS1-SAPN has produced the correct shape and size, and the antigenic determinants are presented on the surface of the SAPN, which indicates that the designed SAPN has great potential to be used in the future as a malaria vaccine.
    MeSH term(s) Antibodies ; Epitopes ; Humans ; Malaria/prevention & control ; Malaria Vaccines ; Malaria, Falciparum/prevention & control ; Nanoparticles/chemistry ; Proteins
    Chemical Substances Antibodies ; Epitopes ; Malaria Vaccines ; Proteins
    Language English
    Publishing date 2022-09-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0274275
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  8. Article ; Online: Re-emphasis on the role of echocardiography in diagnosis of aortic root surgery complications.

    Nakhaee, Akram / Parkhideh, Roya / Rahmanian, Mehrzad / Pouraliakbar, Hamidreza / Sardari, Akram / Larti, Farnoosh / Badkoubeh, Roya Sattarzadeh

    Echocardiography (Mount Kisco, N.Y.)

    2022  Volume 39, Issue 10, Page(s) 1344–1347

    Abstract: Background: Aortic pseudoaneurysm is an infrequent complication of ascending aorta surgery.: Cases: This is a report of two cases that underwent the Bentall procedure that presented with large pseudoaneurysms.: Conclusion: Use of multimodality ... ...

    Abstract Background: Aortic pseudoaneurysm is an infrequent complication of ascending aorta surgery.
    Cases: This is a report of two cases that underwent the Bentall procedure that presented with large pseudoaneurysms.
    Conclusion: Use of multimodality imaging after Bentall surgery has been advocated for the detection of surgical complications. Although 3D CT angiography has the highest diagnostic accuracy, familiarity with transthoracic echocardiographic finding in these patients will lead to earlier diagnosis.
    MeSH term(s) Humans ; Aortic Aneurysm/surgery ; Aortic Valve/surgery ; Aorta/diagnostic imaging ; Aorta/surgery ; Echocardiography ; Aneurysm, False/etiology ; Aneurysm, False/complications ; Postoperative Complications/diagnostic imaging
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 843645-9
    ISSN 1540-8175 ; 0742-2822
    ISSN (online) 1540-8175
    ISSN 0742-2822
    DOI 10.1111/echo.15430
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  9. Article ; Online: Successful transvenous lead extraction of abandoned lead implanted through persistent left superior vena cava.

    Samimi, Sahar / Eslami, Masoud / Sardari, Akram / Heidari-Bakavoli, Ali Reza / Mazaherian, Mahdieh / Mollazadeh, Reza

    Future cardiology

    2022  Volume 18, Issue 3, Page(s) 185–190

    Abstract: Persistent left superior vena cava, the most common thoracic venous anomaly, may complicate transvenous lead extraction (TLE). We report a successful case of TLE in a patient with persistent left superior vena cava, despite a long dwelling time and ... ...

    Abstract Persistent left superior vena cava, the most common thoracic venous anomaly, may complicate transvenous lead extraction (TLE). We report a successful case of TLE in a patient with persistent left superior vena cava, despite a long dwelling time and several pocket revisions due to pocket infection. The lead was removed via a hand-powered mechanical extraction sheath, and postoperative complications did not occur. Complicated TLE cases may have a better outcome if performed in a high-volume center with experienced specialists.
    MeSH term(s) Defibrillators, Implantable ; Device Removal ; Humans ; Persistent Left Superior Vena Cava ; Treatment Outcome ; Vena Cava, Superior/abnormalities ; Vena Cava, Superior/surgery
    Language English
    Publishing date 2022-01-14
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2274267-0
    ISSN 1744-8298 ; 1479-6678
    ISSN (online) 1744-8298
    ISSN 1479-6678
    DOI 10.2217/fca-2021-0098
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    Zs.A 6836: Show issues Location:
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  10. Article ; Online: Myocarditis detected after COVID-19 recovery.

    Sardari, Akram / Tabarsi, Payam / Borhany, Hamed / Mohiaddin, Raad / Houshmand, Golnaz

    European heart journal cardiovascular Imaging

    2020  Volume 22, Issue 1, Page(s) 131–132

    MeSH term(s) Adult ; Biomarkers/blood ; COVID-19/complications ; Echocardiography ; Electrocardiography ; Humans ; Male ; Myocarditis/diagnostic imaging ; Myocarditis/drug therapy ; Myocarditis/virology ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Tomography, X-Ray Computed
    Chemical Substances Biomarkers
    Keywords covid19
    Language English
    Publishing date 2020-05-28
    Publishing country England
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeaa166
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