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Article: Editorial: Current concepts and recent advances on pediatric appendicitis.

Suominen, Janne S / Gorter, Ramon R / Svensson, Jan F

2023 Volume 10, Page(s) 1111122

Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.1111122
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Article ; Online: Children's interstitial lung disease: Multidetector computed tomography patterns and correlations between imaging and histopathology.

Miraftabi, Päria / Kirjavainen, Turkka / Suominen, Janne S / Lohi, Jouko / Martelius, Laura

European journal of radiology

2023 Volume 165, Page(s) 110886

Abstract: Purpose: Childhood interstitial lung disease (chILD) is an umbrella concept covering a wide range of rare lung diseases, many of which are unique to childhood. The diagnosis is based on clinical presentation, multidetector computed tomography (MDCT), ... ...

Abstract	Purpose: Childhood interstitial lung disease (chILD) is an umbrella concept covering a wide range of rare lung diseases, many of which are unique to childhood. The diagnosis is based on clinical presentation, multidetector computed tomography (MDCT), genetic testing, lung-function testing, and lung biopsy. Because knowledge of the usefulness of MDCT pattern recognition in ChILD is at present limited, we examined the occurrence of MDCT patterns in children with histologically confirmed interstitial lung disease. Method: We searched the biopsy, MDCT, and clinical information database of a single national paediatric referral hospital for 2004-2020. Data were from affected children under age 18. MDCT images we reanalysed while blinded to the identity and referral information. Results: We included 90 patients, of whom 63 (70 %) were male. The median age at biopsy was 1.3 years (interquartile range 0.1-16.8). Biopsy findings fell into 26 histological classes covering all nine chILD classification categories. We recognized six distinct MDCT patterns: neuroendocrine cell hyperplasia of infancy (23), organizing pneumonia (5), non-specific interstitial pneumonia (4), bronchiolitis obliterans (3), pulmonary alveolar proteinosis (2), and bronchopulmonary dysplasia (n = 2). Of the total 90, in 51 (57 %) children, none of these six MDCT patterns appeared. Of those 39 children with a recognizable MDCT pattern, in 34 (87 %), that pattern predicted their final diagnosis. Conclusions: Among cases of chILD, we identified a specific predefined MDCT pattern in only 43 %. However, when such a recognizable pattern occurred, it was predictive of the final chILD diagnosis.
MeSH term(s)	Infant, Newborn ; Child ; Humans ; Male ; Infant ; Adolescent ; Female ; Multidetector Computed Tomography ; Lung Diseases, Interstitial/diagnostic imaging ; Lung/diagnostic imaging ; Lung/pathology ; Bronchiolitis Obliterans/pathology ; Pneumonia/pathology
Language	English
Publishing date	2023-05-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2023.110886
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Article ; Online: Oesophageal atresia with very low birth weight: Clinical characteristics and long-term outcome.

Koivusalo, Antti I / Suominen, Janne S / Pakarinen, Mikko P

Journal of pediatric surgery

2021 Volume 57, Issue 2, Page(s) 192–194

Abstract: Aim of the study: An assessment of the clinical data and outcome of patients with oesophageal atresia (OA) with very low birth weight (VLBW) was completed.: Method: With ethical consent, we reviewed the records of 327 successive patients with OA from ...

Abstract	Aim of the study: An assessment of the clinical data and outcome of patients with oesophageal atresia (OA) with very low birth weight (VLBW) was completed. Method: With ethical consent, we reviewed the records of 327 successive patients with OA from 1980 to 2020. Main outcome measures survival and oesophageal repair were compared between patients with VLBW(≤1500 g) and with BW>1500 g. Results: Thirty-four (10%) patients had VLBW. Gross types of OA in VLBW were similar as in other patients: A (15%/7%), B (3%/3%), C (78%/82%), D (3%/4%), E (0%/7%), F (0%/1%) (p = 0.16-0.99). In VLBW the incidence of congenital heart disease (CHD) (47%) and trisomy 13/18 and Cri du Chat (15%) were higher than in BW>1500 g (23% and 1%), (p = 0.001 both). In VLBW one-month mortality was 35% vs 4% in patients with BW>1500 g (p < 0.001), overall mortality 56% and 8% (p < 0.001), respectively. Cause of one-month mortality in VLBW (12 patients) were CHD w/wo chromosomal abnormality (n = 7), cerebral hemorrhage (n = 2), gastric perforation (n = 1), anastomotic leakage (n = 1) and pulmonary hemorrhage (n = 1). Of VLBW patients 79% and of other patients 99% underwent oesophageal repair (p < 0.001). Repair in VLBW patients included early (n = 18) or delayed (n = 5) end-to-end anastomosis and reconstruction (n = 4). Anastomotic complications occurred in 24% of patients with VLBW and in 17% with BW>1500 g, (p = 0.31). From 1980-2000 to 2001-2020 survival in VLBW changed from 11% to 81% (p = 0.002). During 2001 - 2020 all VLBW patients underwent repair. Conclusion: OA with VLBW had high incidence of life-threatening associated anomalies and decreased survival. Recently survival and rate of oesophageal repair have improved significantly.
MeSH term(s)	Anastomosis, Surgical ; Anastomotic Leak ; Birth Weight ; Esophageal Atresia/epidemiology ; Esophageal Atresia/surgery ; Esophagoplasty ; Humans ; Infant, Newborn ; Infant, Very Low Birth Weight ; Retrospective Studies
Language	English
Publishing date	2021-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2021.10.047
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Article ; Online: Utility of Pentraxin-3 as a biomarker for diagnosis of acute appendicitis: a systematic review and meta-analysis.

Anand, Sachit / Pakkasjärvi, Niklas / Bajpai, Minu / Krishnan, Nellai / Goswami, Chandramouli / Suominen, Janne S / Yadav, Devendra Kumar / Goel, Prabudh

Pediatric surgery international

2022 Volume 38, Issue 8, Page(s) 1105–1112

Abstract: Purpose: To systematically summarize all relevant data and to define the current evidence on the utility of Pentraxin-3 (PTX3) as a biomarker for acute appendicitis (AA) in children.: Methods: This review was conducted in accordance with the PRISMA ... ...

Abstract	Purpose: To systematically summarize all relevant data and to define the current evidence on the utility of Pentraxin-3 (PTX3) as a biomarker for acute appendicitis (AA) in children. Methods: This review was conducted in accordance with the PRISMA guidelines. PubMed, Embase, Scopus, and Web of Science databases were systematically searched for studies comparing the levels of PTX3 in patients with AA vs healthy controls or non-specific abdominal pain (NSAP). Mean differences were calculated for all outcomes and the inverse variance method was used for weighted mean difference. The methodological quality of the included studies was assessed using the Downs and Black scale. Results: Five comparative studies were included. Significantly elevated levels of PTX3 in cases with AA vs healthy controls (WMD: 9.56, 95% CI 7.24-11.88, p < 0.00001), and patients with AA vs NSAP (WMD: 8.05, 95% CI 6.81-9.29, p < 0.00001) were demonstrated. Similarly, in separate meta-analyses, the levels of PTX3 were significantly elevated in children with AA vs healthy controls (WMD: 11.18, 95% CI 10.03-12.34, p < 0.00001), and children with AA vs NSAP (WMD: 8.35, 95% CI 6.88-9.82, p < 0.00001). Conclusions: PTX3-levels are elevated in AA, but differentiation between perforated and non-perforated appendicitis demands other methods.
MeSH term(s)	Abdominal Pain ; Acute Disease ; Appendicitis/diagnosis ; Biomarkers ; Child ; Humans
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-06-15
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	632773-4
ISSN	1437-9813 ; 0179-0358
ISSN (online)	1437-9813
ISSN	0179-0358
DOI	10.1007/s00383-022-05149-4
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Article ; Online: Alcohol intoxication and lack of helmet use are common in electric scooter-related traumatic brain injuries: a consecutive patient series from a tertiary university hospital.

Suominen, Eetu N / Sajanti, Antti J / Silver, Eero A / Koivunen, Veerakaisa / Bondfolk, Anton S / Koskimäki, Janne / Saarinen, Antti J

Acta neurochirurgica

2022 Volume 164, Issue 3, Page(s) 643–653

Abstract: Purpose: Clinicians have increasingly encountered traumatic brain injuries (TBI) related to electric scooter (ES) accidents. In this study, we aim to identify the modifiable risk factors for ES-related TBIs.: Methods: A retrospective cohort of ... ...

Abstract	Purpose: Clinicians have increasingly encountered traumatic brain injuries (TBI) related to electric scooter (ES) accidents. In this study, we aim to identify the modifiable risk factors for ES-related TBIs. Methods: A retrospective cohort of consecutive patients treated for ES-related traumatic brain injuries in a tertiary university hospital between May 2019 and September 2021 was identified and employed for the study. The characteristics of the accidents along with the clinical and imaging findings of the injuries were collected from the patient charts. Results: During the study period, 104 TBIs related to ES accidents were identified. There was a high occurrence of accidents late at night and on Saturdays. In four cases, the patient's helmet use was mentioned (3.8%). Seventy-four patients (71%) were intoxicated. At the scene of the accident, seventy-seven (74%) of the patients had a Glasgow Coma Scale score of 13-15, three patients (3%) had a score of 9-12, and two patients (2%) had a score of 3-8. The majority (83%) of TBIs were diagnosed as concussions. Eighteen patients had evidence of intracranial injuries in the imagining. Two patients required neurosurgical procedures. The estimated population standardized incidence increased from 7.0/100,000 (95% CI 3.5-11/100,000) in 2019 to 27/100,000 (95% CI 20-34/100,000) in 2021. Conclusions: Alcohol intoxication and the lack of a helmet were common in TBIs caused by ES accidents. Most of the accidents occurred late at night. Targeting these modifiable factors could decrease the incidence of ES-related TBIs.
MeSH term(s)	Accidents, Traffic ; Alcoholic Intoxication/epidemiology ; Brain Injuries, Traumatic/diagnostic imaging ; Brain Injuries, Traumatic/epidemiology ; Brain Injuries, Traumatic/etiology ; Head Protective Devices ; Hospitals, University ; Humans ; Retrospective Studies
Language	English
Publishing date	2022-01-14
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-021-05098-2
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Article ; Online: A randomized, controlled multicenter feasibility pilot trial on imaging confirmed uncomplicated acute appendicitis: Appendectomy vs. symptomatic treatment in pediatric patients (the APPSYPP) trial study protocol.

Puputti, Jenny / Suominen, Janne S / Luoto, Topi / Hiltunen, Pauliina / Ripatti, Liisi / Nikoskelainen, Marianna / Nuutinen, Susanna / Sinikumpu, Juha-Jaakko / Tahkola, Esko / Porela-Tiihonen, Susanna / Hurme, Saija / Salminen, Paulina / Pakarinen, Mikko P

Contemporary clinical trials

2022 Volume 123, Page(s) 106970

MeSH term(s)	Adult ; Humans ; Child ; Adolescent ; Appendectomy/adverse effects ; Appendectomy/methods ; Appendicitis/diagnostic imaging ; Appendicitis/surgery ; Pilot Projects ; Feasibility Studies ; Acute Disease ; Anti-Bacterial Agents/therapeutic use ; Treatment Outcome ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-10-22
Publishing country	United States
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2182176-8
ISSN	1559-2030 ; 1551-7144
ISSN (online)	1559-2030
ISSN	1551-7144
DOI	10.1016/j.cct.2022.106970
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Article ; Online: Large‐scale long‐term passive‐acoustic monitoring reveals spatio‐temporal activity patterns of boreal bats

Ecography. 2023 June, v. 2023, no. 6 p.e06617-

2023

Abstract: The distribution ranges and spatio‐temporal patterns in the occurrence and activity of boreal bats are yet largely unknown due to their cryptic lifestyle and lack of suitable and efficient study methods. We approached the issue by establishing a ... ...

Abstract	The distribution ranges and spatio‐temporal patterns in the occurrence and activity of boreal bats are yet largely unknown due to their cryptic lifestyle and lack of suitable and efficient study methods. We approached the issue by establishing a permanent passive‐acoustic sampling setup spanning the area of Finland to gain an understanding on how latitude affects bat species composition and activity patterns in northern Europe. The recorded bat calls were semi‐automatically identified for three target taxa; Myotis spp., Eptesicus nilssonii or Pipistrellus nathusii and the seasonal activity patterns were modeled for each taxa across the seven sampling years (2015–2021). We found an increase in activity since 2015 for E. nilssonii and Myotis spp. For E. nilssonii and Myotis spp. we found significant latitude ‐dependent seasonal activity patterns, where seasonal variation in patterns appeared stronger in the north. Over the years, activity of P. nathusii increased during activity peak in June and late season but decreased in mid season. We found the passive‐acoustic monitoring network to be an effective and cost‐efficient method for gathering bat activity data to analyze spatio‐temporal patterns. Long‐term data on the composition and dynamics of bat communities facilitates better estimates of abundances and population trend directions for conservation purposes and predicting the effects of climate change.
Keywords	Eptesicus ; Myotis ; Pipistrellus nathusii ; climate change ; cost effectiveness ; latitude ; lifestyle ; seasonal variation ; species diversity ; Finland ; Northern European region
Language	English
Dates of publication	2023-06
Publishing place	Blackwell Publishing Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1112659-0
ISSN	0906-7590
ISSN	0906-7590
DOI	10.1111/ecog.06617
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Article ; Online: Gender Identity and Sex Role of Patients Operated on for Bladder Exstrophy-Epispadias.

Taskinen, Seppo / Suominen, Janne S / Mattila, Aino K

The Journal of urology

2016 Volume 196, Issue 2, Page(s) 531–535

Abstract: Purpose: We evaluated whether genital deformity has an impact on gender identity and sex role in patients operated on for bladder exstrophy-epispadias complex.: Materials and methods: A total of 62 adolescents and adults operated on for bladder ... ...

Abstract	Purpose: We evaluated whether genital deformity has an impact on gender identity and sex role in patients operated on for bladder exstrophy-epispadias complex. Materials and methods: A total of 62 adolescents and adults operated on for bladder exstrophy-epispadias complex were mailed questionnaires evaluating gender identity (Gender Identity/Gender Dysphoria Questionnaire for Adolescents and Adults) and sex role (Bem Sex Role Inventory). Of the patients 33 responded and the results were compared with 99 gender matched controls. Results: On the gender identity questionnaire female patients had median scores similar to those of their gender matched controls (4.93 vs 4.89, p = 0.412) but in males the score was lower compared to controls (4.87 vs 4.96, p = 0.023), indicating somewhat more conflicted gender identity. However, no patient had gender dysphoria. Female sex role index was higher in female patients vs controls (5.9 vs 5.3, p = 0.003) but was comparable between male patients and controls (5.2 vs 5.0, p = 0.459). Masculine sex role indices were comparable between female patients and controls as well as between male patients and controls. Of 32 patients 17 were considered to have androgynous sex role, as were 24 of 97 controls (p = 0.004). The exact diagnosis (bladder exstrophy or epispadias) or dissatisfaction with appearance of the genitals had no impact on gender identity or on sex role indices. Conclusions: Male patients had lower gender identity scores compared to controls and female sex role was enhanced among female patients. Androgynous sex role was more common in patients vs controls. Gender dysphoria was not noted in any patient.
MeSH term(s)	Adolescent ; Adult ; Bladder Exstrophy/psychology ; Bladder Exstrophy/surgery ; Case-Control Studies ; Epispadias/psychology ; Epispadias/surgery ; Female ; Gender Dysphoria/diagnosis ; Gender Dysphoria/etiology ; Gender Identity ; Humans ; Male ; Patient Satisfaction ; Postoperative Complications/diagnosis ; Psychological Tests ; Retrospective Studies
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2016.02.2961
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Article ; Online: Lower urinary tract symptoms (LUTS) in patients in adulthood with bladder exstrophy and epispadias.

Taskinen, Seppo / Suominen, Janne S

BJU international

2013 Volume 111, Issue 7, Page(s) 1124–1129

Abstract: Unlabelled: WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Many patients with bladder exstrophy or epispadias (BEE) have bladder augmentation or use a catheterisation programme. Of the remainder only some achieve so called '3-h urinary ... ...

Abstract	Unlabelled: WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Many patients with bladder exstrophy or epispadias (BEE) have bladder augmentation or use a catheterisation programme. Of the remainder only some achieve so called '3-h urinary continence'. In addition, some of the patients develop urinary tract infections or bladder stones related to voiding and storage problems. The present study is one of the first to evaluate lower urinary tract symptoms (LUTS) in detail in young adults treated for BEE in childhood by using a validated questionnaire. In addition the patient's own opinion about continence was ascertained. The study shows that both voiding and storage symptoms are frequent in patients with BEE and that most symptoms only become apparent by using a detailed questionnaire. Objective: To evaluate lower urinary tract symptoms (LUTS) in patients with bladder exstrophy and epispadias (BEE) who have reached adulthood. Patients and methods: A questionnaire evaluating LUTS was mailed to 52 BEE patients (aged 15-44 years), 32 (62%) returned the questionnaire (19 with bladder exstrophy and 13 with epispadias; 21 males and 11 females). Seven exstrophy patients (37%) had undergone bladder augmentation. Information on LUTS was assessed first with a preliminary question (do you have urinary incontinence?) followed by the Danish Prostatic Symptom Score (DAN-PSS) questionnaire. Results: Of the patients without bladder augmentation or clean intermittent catheterisation, five of 11 patients with exstrophy and 6 of 13 with epispadias considered themselves dry and 13 of 24 (54%) patients had >3 h dry intervals between voiding. According to DAN-PSS questionnaire only two of 11 patients with exstrophy and two of 13 with epispadias were fully continent and could void normally. In addition to storage symptoms, eight of 13 patients with epispadias and 10 of 12 with exstrophy had disturbing voiding symptoms. Moderate or severe LUTS was reported altogether by 12 of 15 (80%) males and by six of nine females. Conclusions: Continence rates in patients with BEE are very dependent on the evaluation method. Most LUTS become apparent only by using a detailed questionnaire. Moderate or severe LUTS appear to be common amongst patients with BEE.
MeSH term(s)	Adolescent ; Adult ; Bladder Exstrophy/complications ; Bladder Exstrophy/epidemiology ; Bladder Exstrophy/surgery ; Epispadias/complications ; Epispadias/epidemiology ; Epispadias/surgery ; Female ; Humans ; Lower Urinary Tract Symptoms/epidemiology ; Lower Urinary Tract Symptoms/etiology ; Lower Urinary Tract Symptoms/surgery ; Male ; Quality of Life ; Surveys and Questionnaires ; Sweden/epidemiology ; Urination
Language	English
Publishing date	2013-06
Publishing country	England
Document type	Journal Article ; Validation Studies
ZDB-ID	1462191-5
ISSN	1464-410X ; 1464-4096 ; 1358-8672
ISSN (online)	1464-410X
ISSN	1464-4096 ; 1358-8672
DOI	10.1111/j.1464-410X.2012.11756.x
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Article ; Online: Development of Late Continence in Bladder Exstrophy and Epispadias Patients.

Taskinen, Seppo / Suominen, Janne / Mäkelä, Eija

Urology

2020 Volume 144, Page(s) 194–197

Abstract: Objective: To evaluate to what extend urinary continence develops during puberty in patients with classic bladder exstrophy (CBE) and epispadias.: Methods: The operative database was reviewed for surgical procedures and urinary continence in all 65 ... ...

Abstract	Objective: To evaluate to what extend urinary continence develops during puberty in patients with classic bladder exstrophy (CBE) and epispadias. Methods: The operative database was reviewed for surgical procedures and urinary continence in all 65 CBE and epispadias patients born in 1976-2005. Excluded were 2 patients who had insufficient data for evaluation. Results: Thirty-five patients with volitional voiding were incontinent at the age of 10 years, 27 had daily incontinence, and 8 had rare incontinence. Sixteen patients (46%) became later fully continent without any major surgery (except Deflux injections in 3 patients) or CIC treatment. Among these 16 fully continent patients there were 7/8 with rare incontinence, 9/23 with daily incontinence (P = .04); 3/9 males with CBE, 10/13 males with epispadias, 3/5 females with CBE, and 0/4 females with epispadias (P = .25 between sex and P = .48 between diagnosis). Of the 15 patients remaining incontinent, 10 had daily and 5 had rare incontinence episodes. The latest control was at the median age of 19 years (interquartile range 17-21 years). Twenty-five patients (40% of the whole material) were fully continent (11/38 (29%) with CBE and 14/25 (56%) with epispadias, P = .04) and 8 (13%) had rare incontinence with volitional voiding (1/38 [3%] with CBE and 7/25 [28%] with epispadias). Conclusion: Almost half of the incontinent CBE and epispadias patients with volitional voiding achieved continence after the age of 10 without major surgery. Prognosis for pubertal development of continence was best in patients with rare incontinence and in males with epispadias.
MeSH term(s)	Adolescent ; Bladder Exstrophy/complications ; Bladder Exstrophy/physiopathology ; Bladder Exstrophy/surgery ; Child ; Epispadias/complications ; Epispadias/physiopathology ; Epispadias/surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Prognosis ; Puberty/physiology ; Remission, Spontaneous ; Severity of Illness Index ; Urinary Incontinence/diagnosis ; Urinary Incontinence/etiology ; Urinary Incontinence/physiopathology ; Urination/physiology
Language	English
Publishing date	2020-07-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2020.06.034
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