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Article ; Online: Reflections on 30 years of publishing osteoarthritis research: Where we've been and where we're going.

Yau, Michelle S / Filbay, Stephanie R / Block, Joel A / Lohmander, L Stefan

2024 Volume 32, Issue 4, Page(s) 349–351

Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Editorial
ZDB-ID	1167809-4
ISSN	1522-9653 ; 1063-4584
ISSN (online)	1522-9653
ISSN	1063-4584
DOI	10.1016/j.joca.2024.02.008
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Article ; Online: Update on Fibrocartilaginous Disease Clinical Examination.

Butterworth, Michelle L / Block, Alan J

Clinics in podiatric medicine and surgery

2022 Volume 39, Issue 3, Page(s) 371–392

Abstract: This article provides an update on fibrocartilaginous disease clinical examination. Lesser metatarsophalangeal joint instability is a challenging entity for the foot and ankle surgeon. A correct diagnosis is crucial to instill an appropriate treatment ... ...

Abstract	This article provides an update on fibrocartilaginous disease clinical examination. Lesser metatarsophalangeal joint instability is a challenging entity for the foot and ankle surgeon. A correct diagnosis is crucial to instill an appropriate treatment plan that will result in a successful outcome and a satisfied patient. Insertional Achilles tendon disorders are common among active and inactive patients. There is also a high predilection for Achilles tendon pathology among athletes. In this article demographics and patient history, causative factors, differential diagnosis, physical examination, clinical tests, and radiographic evaluation are discussed for plantar plate disorders and insertional Achilles disorders.
MeSH term(s)	Achilles Tendon/surgery ; Ankle ; Ankle Joint/surgery ; Humans ; Metatarsophalangeal Joint/surgery ; Physical Examination
Language	English
Publishing date	2022-05-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1323674-x
ISSN	1558-2302 ; 0742-0668 ; 0891-8422
ISSN (online)	1558-2302
ISSN	0742-0668 ; 0891-8422
DOI	10.1016/j.cpm.2022.03.002
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Article ; Online: The Use of Standardized Diesel Exhaust Particles in Alzheimer's Disease Research.

Block, Michelle L / Kodavanti, Urmila P

Journal of Alzheimer's disease : JAD

2021 Volume 84, Issue 2, Page(s) 607–608

Abstract: The mechanisms underlying how urban air pollution exposure conveys Alzheimer's disease risk and affects plaque pathology is largely unknown. Because particulate matter, the particle component of urban air pollution, varies across location, pollution ... ...

Abstract	The mechanisms underlying how urban air pollution exposure conveys Alzheimer's disease risk and affects plaque pathology is largely unknown. Because particulate matter, the particle component of urban air pollution, varies across location, pollution source, and time, a single model representative of all ambient particulate matter is unfeasible for research investigating the role of ar pollution in central nervous system diseases. More specifically, the investigation of several models of particulate matter with enrichment of source-specific components are essential to employ, in order to more fully understand what characteristics of particulate matter affects Alzheimer's disease, including standardized diesel exhaust particles.
MeSH term(s)	Air Pollution/adverse effects ; Alzheimer Disease/complications ; Biomedical Research ; Humans ; Particulate Matter/adverse effects ; Particulate Matter/standards ; Vehicle Emissions/toxicity
Chemical Substances	Particulate Matter ; Vehicle Emissions
Language	English
Publishing date	2021-09-27
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-215201
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Article ; Online: Peripheral HMGB1 is linked to O

Ahmed, Chandrama / Greve, Hendrik J / Garza-Lombo, Carla / Malley, Jamie A / Johnson, James A / Oblak, Adrian L / Block, Michelle L

Alzheimer's & dementia : the journal of the Alzheimer's Association

2024

Abstract: Introduction: Ozone (O: Methods: The O: Results: O: Discussion: Astrocytes and peripheral myeloid cells are critical lung-brain axis interactors. HMGB1 loss in peripheral myeloid cells regulates the O: Highlights: Astrocytes are part of the ... ...

Abstract	Introduction: Ozone (O Methods: The O Results: O Discussion: Astrocytes and peripheral myeloid cells are critical lung-brain axis interactors. HMGB1 loss in peripheral myeloid cells regulates the O Highlights: Astrocytes are part of the lung-brain axis, regulating how air pollution affects plaque pathology. Ozone (O
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13825
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Zs.A 6316: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 540: Show issues

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Article ; Online: Neuroinflammation: modulating mighty microglia.

Block, Michelle L

Nature chemical biology

2014 Volume 10, Issue 12, Page(s) 988–989

MeSH term(s)	Animals ; Brain/drug effects ; HMGB1 Protein/immunology ; HMGB2 Protein/immunology ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Male ; Microglia/drug effects ; Neurons/drug effects ; Neuroprotective Agents/pharmacology ; Protein Processing, Post-Translational
Chemical Substances	HMGB1 Protein ; HMGB1 protein, mouse ; HMGB2 Protein ; Heterocyclic Compounds, 4 or More Rings ; Neuroprotective Agents ; inflachromene
Language	English
Publishing date	2014-12
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2202962-X
ISSN	1552-4469 ; 1552-4450
ISSN (online)	1552-4469
ISSN	1552-4450
DOI	10.1038/nchembio.1691
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Zs.A 6251: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Mentoring: An Evolving Relationship.

Block, Michelle / Florczak, Kristine L

Nursing science quarterly

2017 Volume 30, Issue 2, Page(s) 100–104

Abstract: The column concerns itself with mentoring as an evolving relationship between mentor and mentee. The collegiate mentoring model, the transformational transcendence model, and the humanbecoming mentoring model are considered in light of a dialogue with ... ...

Abstract	The column concerns itself with mentoring as an evolving relationship between mentor and mentee. The collegiate mentoring model, the transformational transcendence model, and the humanbecoming mentoring model are considered in light of a dialogue with mentors at a Midwest university and conclusions are drawn.
MeSH term(s)	Faculty ; Humans ; Interprofessional Relations ; Mentoring/methods ; Mentors/psychology
Language	English
Publishing date	2017-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	645072-6
ISSN	1552-7409 ; 0894-3184
ISSN (online)	1552-7409
ISSN	0894-3184
DOI	10.1177/0894318417693312
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Zs.A 2449: Show issues

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Article ; Online: Impact of a Multidisciplinary Post-COVID-19 Clinic on Hospital Admissions and ED Visits.

Levan, Sophia / Mourad, Michelle / Block, Brian / Shah, Rupal / Santhosh, Lekshmi

Chest

2023 Volume 164, Issue 1, Page(s) 199–202

MeSH term(s)	Humans ; COVID-19 ; Hospitalization ; Patient Admission ; Ambulatory Care Facilities ; Hospitals ; Emergency Service, Hospital ; Retrospective Studies
Language	English
Publishing date	2023-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2022.12.031
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Article ; Online: Rheumatology Clinic Staff Needs: Barriers and Strategies to Addressing High Blood Pressure and Smoking Risk.

Tong, Michelle / Gilmore-Bykovskyi, Andrea / Block, Laura / Ramly, Edmond / White, Douglas W / Messina, Monica L / Bartels, Christie M

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

2022 Volume 28, Issue 7, Page(s) 354–361

Abstract: Objective: Patients with rheumatologic conditions are at elevated risk of cardiovascular disease (CVD) due to inflammatory and traditional risk factors, such as high blood pressure (BP) and smoking. However, rheumatology clinics rarely address ... ...

Abstract	Objective: Patients with rheumatologic conditions are at elevated risk of cardiovascular disease (CVD) due to inflammatory and traditional risk factors, such as high blood pressure (BP) and smoking. However, rheumatology clinics rarely address traditional risk factors, although they are routinely assessed and modifiable in primary care. The present study sought to (1) characterize rheumatology clinic staff's work process for addressing high BP and smoking and (2) identify barriers and strategies for effective management of these risk factors. Methods: We conducted 7 focus groups with medical assistants, nurses, and scheduling staff from 4 adult rheumatology clinics across 2 health systems (BP focus groups, n = 23; smoking, n = 20). Transcripts were analyzed using thematic analysis to elucidate barriers and strategies. Results: We found 3 clinic work processes for the management of high BP and smoking risk: (1) risk identification, (2) follow-up within the clinic, and (3) follow-up with primary care and community resources. Within these processes, we identified barriers and strategies grouped into themes: (1) time, (2) clinic workflows, (3) technology and resources, (4) staff's attitudes and knowledge, and (5) staff's perceptions of patients. The most pervasive barriers were (1) no structured system for follow-up and (2) staff confidence and skill in initiating conversations about health-related behavior change. Conclusions: Our study identified generalizable gaps in rheumatology staff's work processes and competencies for addressing high BP and smoking in patients. Future efforts to support staff needs should target (1) systems for follow-up within and outside the clinic and (2) conversation support tools.
MeSH term(s)	Adult ; Ambulatory Care Facilities ; Communication ; Humans ; Hypertension/epidemiology ; Hypertension/therapy ; Rheumatology ; Smoking/adverse effects ; Smoking/epidemiology
Language	English
Publishing date	2022-06-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1283266-2
ISSN	1536-7355 ; 1076-1608
ISSN (online)	1536-7355
ISSN	1076-1608
DOI	10.1097/RHU.0000000000001868
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Article ; Online: Chemicals in Cigarette Flavor Capsules From Guatemala and Mexico.

Mus, Sophia / Barrientos, Inti / Vidaña-Pérez, Desirée / Monzon, José / Barnoya, Joaquin / Page, Michelle K / Block, Ashleigh C / Goniewicz, Maciej L / O'Connor, Richard J / Thrasher, James F

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

2023 Volume 26, Issue 5, Page(s) 545–551

Abstract: Background: The global market share for cigarettes with flavor capsules has grown exponentially over the last decade, particularly in Latin America. When smoking, consumers crush a liquid capsule in the filter that flavors the smoke. Little is known ... ...

Abstract	Background: The global market share for cigarettes with flavor capsules has grown exponentially over the last decade, particularly in Latin America. When smoking, consumers crush a liquid capsule in the filter that flavors the smoke. Little is known about the chemical constituents of the liquids in capsules or their potential health risks. Methods: Based on consumer data and availability in Mexico and Guatemala, 31 flavor capsule brands were purchased (19 and 12, respectively) in 2020. Since some cigarettes included multiple capsules in a stick (up to 2) or pack (up to 4), the final analytic sample included 50 capsules. We conducted qualitative and quantitative analyses using gas chromatography with mass spectrometry (GC-MS, Agilent Technologies, Inc). Results: The qualitative analysis detected 296 compounds (range = 9-67 per capsule), and all capsules contained menthol. Among the compounds detected in more than half the sample were limonene, menthone, benzaldehyde, eucalyptol, and triacetin. Traces of nicotine were found in 22% of the capsules. In the quantitative analysis, menthol concentrations were 33 times greater than the next most common compound (limonene). Benzyl alcohol and vanillin were also found in high concentrations. Comparing same-brand varieties across countries showed substantial variability in the concentration of menthol and other compounds. Conclusions: Menthol is an omnipresent constituent in capsule cigarettes, perhaps because of its anesthetizing and reinforcing addictive properties. Other compounds found are toxic, potentially carcinogenic, and may enhance addictiveness. Variance in the presence and concentrations of such compounds highlights the importance of product standards to regulate capsule content. Implications: This study evaluated the chemical content of capsule cigarettes from two Latin American countries that have two of the highest market shares for capsule cigarettes worldwide. Compared to other studies, our assessment included brand varieties from two countries to compare the differences in chemical content by country. Our results yield that menthol is found in all capsules, and that other chemicals found may prolong nicotine exposure and therefore reinforce the addictive properties of cigarettes.
MeSH term(s)	Guatemala ; Mexico ; Flavoring Agents/analysis ; Tobacco Products/analysis ; Humans ; Capsules ; Gas Chromatography-Mass Spectrometry ; Nicotine/analysis
Chemical Substances	Flavoring Agents ; Capsules ; Nicotine (6M3C89ZY6R)
Language	English
Publishing date	2023-11-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1452315-2
ISSN	1469-994X ; 1462-2203
ISSN (online)	1469-994X
ISSN	1462-2203
DOI	10.1093/ntr/ntad216
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Article ; Online: The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment.

Greve, Hendrik J / Dunbar, August L / Lombo, Carla Garza / Ahmed, Chandrama / Thang, Morrent / Messenger, Evan J / Mumaw, Christen L / Johnson, James A / Kodavanti, Urmila P / Oblak, Adrian L / Block, Michelle L

Brain : a journal of neurology

2022 Volume 146, Issue 3, Page(s) 991–1005

Abstract: The mechanisms underlying how urban air pollution affects Alzheimer's disease (AD) are largely unknown. Ozone (O3) is a reactive gas component of air pollution linked to increased AD risk, but is confined to the respiratory tract after inhalation, ... ...

Abstract	The mechanisms underlying how urban air pollution affects Alzheimer's disease (AD) are largely unknown. Ozone (O3) is a reactive gas component of air pollution linked to increased AD risk, but is confined to the respiratory tract after inhalation, implicating the peripheral immune response to air pollution in AD neuropathology. Here, we demonstrate that O3 exposure impaired the ability of microglia, the brain's parenchymal immune cells, to associate with and form a protective barrier around Aβ plaques, leading to augmented dystrophic neurites and increased Aβ plaque load. Spatial proteomic profiling analysis of peri-plaque proteins revealed a microenvironment-specific signature of dysregulated disease-associated microglia protein expression and increased pathogenic molecule levels with O3 exposure. Unexpectedly, 5xFAD mice exhibited an augmented pulmonary cell and humoral immune response to O3, supporting that ongoing neuropathology may regulate the peripheral O3 response. Circulating HMGB1 was one factor upregulated in only 5xFAD mice, and peripheral HMGB1 was separately shown to regulate brain Trem2 mRNA expression. These findings demonstrate a bidirectional lung-brain axis regulating the central and peripheral AD immune response and highlight this interaction as a potential novel therapeutic target in AD.
MeSH term(s)	Mice ; Animals ; HMGB1 Protein ; Ozone/toxicity ; Ozone/metabolism ; Proteomics ; Amyloid beta-Peptides/metabolism ; Alzheimer Disease/pathology ; Brain/pathology ; Lung/metabolism ; Lung/pathology ; Plaque, Amyloid/pathology ; Microglia/metabolism ; Mice, Transgenic ; Disease Models, Animal ; Membrane Glycoproteins/metabolism ; Receptors, Immunologic
Chemical Substances	HMGB1 Protein ; Ozone (66H7ZZK23N) ; Amyloid beta-Peptides ; Trem2 protein, mouse ; Membrane Glycoproteins ; Receptors, Immunologic
Language	English
Publishing date	2022-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awac113
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