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  1. Article ; Online: Lung function trajectories in a cohort of patients with moderate-to-severe asthma on mepolizumab, omalizumab, or dupilumab.

    Nopsopon, Tanawin / Barrett, Nora A / Phipatanakul, Wanda / Laidlaw, Tanya M / Weiss, Scott T / Akenroye, Ayobami

    Allergy

    2024  

    Abstract: Background: Lung function is an independent predictor of mortality. We evaluated the lung function trajectories of a cohort of patients with asthma receiving biologic therapy.: Methods: We identified 229 monoclonal antibody-naïve adult patients with ... ...

    Abstract Background: Lung function is an independent predictor of mortality. We evaluated the lung function trajectories of a cohort of patients with asthma receiving biologic therapy.
    Methods: We identified 229 monoclonal antibody-naïve adult patients with moderate-to-severe asthma who initiated omalizumab, mepolizumab, or dupilumab between 2010 and 2022 in a large healthcare system in Boston, MA. Generalized additive mixed models were used to estimate the lung function trajectories during the 156 weeks following biologic initiation. Response was defined as an improvement in FEV
    Results: Eighty-eight patients initiated mepolizumab, 76 omalizumab, and 65 dupilumab. Baseline eosinophil count was highest in the mepolizumab group (405 cells/mcL) and lowest for omalizumab (250 cells/mcL). Both FEV
    Conclusion: In this clinical cohort, mepolizumab, omalizumab, and dupilumab had beneficial effects on FEV
    Language English
    Publishing date 2024-01-02
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.16002
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  2. Article ; Online: Mepolizumab does not prevent all aspirin-induced reactions in patients with aspirin-exacerbated respiratory disease: A case series.

    Martin, Hannah / Barrett, Nora Amanda / Laidlaw, Tanya

    The journal of allergy and clinical immunology. In practice

    2020  Volume 9, Issue 3, Page(s) 1384–1385

    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Aspirin/adverse effects ; Asthma, Aspirin-Induced/diagnosis ; Asthma, Aspirin-Induced/drug therapy ; Humans
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Antibodies, Monoclonal, Humanized ; mepolizumab (90Z2UF0E52) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2020-09-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.09.007
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  3. Article ; Online: Performance feedback during writing instruction: A cost-effectiveness analysis.

    Barrett, Courtenay A / Truckenmiller, Adrea J / Eckert, Tanya L

    School psychology (Washington, D.C.)

    2020  Volume 35, Issue 3, Page(s) 193–200

    Abstract: Students in K-12 settings experience poor writing outcomes, with less than 30% of students writing at the proficient level. Coupled with the pressure to improve academic outcomes with limited resources, schools are in dire need of efficient, universally ... ...

    Abstract Students in K-12 settings experience poor writing outcomes, with less than 30% of students writing at the proficient level. Coupled with the pressure to improve academic outcomes with limited resources, schools are in dire need of efficient, universally provided instructional activities that promote writing skills. Performance feedback on writing fluency was designed to be a brief, low-resource universally provided instructional activity to facilitate writing development and has demonstrated moderate to large effects on formative writing measures. The current study was conducted to directly evaluate the extent to which performance feedback on writing fluency is cost-effective. This study uses the ingredients method to estimate the costs of providing performance feedback on writing fluency and calculates incremental cost-effectiveness ratios based on secondary data from a randomized controlled trial. Results suggest that performance feedback is more cost-effective than comprehensive systems reform initiatives and comparable to other universally provided interventions, and therefore should be considered a cost-effective approach to improve writing fluency for all students. Results provide school psychologists with concrete examples of how to support prevention and intervention activities aimed to improve student writing outcomes. Limitations and suggestions for future research are also discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
    MeSH term(s) Adolescent ; Child ; Cost-Benefit Analysis ; Feedback, Psychological ; Humans ; Psychology, Educational/economics ; Psychology, Educational/methods ; Remedial Teaching/economics ; Remedial Teaching/methods ; Students ; Teaching ; Writing
    Language English
    Publishing date 2020-03-05
    Publishing country United States
    Document type Journal Article
    ISSN 2578-4226
    ISSN (online) 2578-4226
    DOI 10.1037/spq0000356
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  4. Article ; Online: A nasal cell atlas reveals heterogeneity of tuft cells and their role in directing olfactory stem cell proliferation.

    Ualiyeva, Saltanat / Lemire, Evan / Wong, Caitlin / Perniss, Alexander / Boyd, Amelia A / Avilés, Evelyn C / Minichetti, Dante G / Maxfield, Alice / Roditi, Rachel / Matsumoto, Ichiro / Wang, Xin / Deng, Wenjiang / Barrett, Nora A / Buchheit, Kathleen M / Laidlaw, Tanya M / Boyce, Joshua A / Bankova, Lora G / Haber, Adam L

    Science immunology

    2024  Volume 9, Issue 92, Page(s) eabq4341

    Abstract: The olfactory neuroepithelium serves as a sensory organ for odors and forms part of the nasal mucosal barrier. Olfactory sensory neurons are surrounded and supported by epithelial cells. Among them, microvillous cells (MVCs) are strategically positioned ... ...

    Abstract The olfactory neuroepithelium serves as a sensory organ for odors and forms part of the nasal mucosal barrier. Olfactory sensory neurons are surrounded and supported by epithelial cells. Among them, microvillous cells (MVCs) are strategically positioned at the apical surface, but their specific functions are enigmatic, and their relationship to the other specialized epithelial cells is unclear. Here, we establish that the family of MVCs comprises tuft cells and ionocytes in both mice and humans. Integrating analysis of the respiratory and olfactory epithelia, we define the distinct receptor expression of TRPM5
    MeSH term(s) Humans ; Mice ; Animals ; Tuft Cells ; Olfactory Mucosa/metabolism ; Nasal Mucosa ; Epithelial Cells/metabolism ; Cell Proliferation ; Doublecortin-Like Kinases
    Chemical Substances DCLK1 protein, human (EC 2.7.1.11) ; Doublecortin-Like Kinases (EC 2.7.1.11)
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abq4341
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  5. Article ; Online: The Gene Expression Omnibus Database.

    Clough, Emily / Barrett, Tanya

    Methods in molecular biology (Clifton, N.J.)

    2016  Volume 1418, Page(s) 93–110

    Abstract: The Gene Expression Omnibus (GEO) database is an international public repository that archives and freely distributes high-throughput gene expression and other functional genomics data sets. Created in 2000 as a worldwide resource for gene expression ... ...

    Abstract The Gene Expression Omnibus (GEO) database is an international public repository that archives and freely distributes high-throughput gene expression and other functional genomics data sets. Created in 2000 as a worldwide resource for gene expression studies, GEO has evolved with rapidly changing technologies and now accepts high-throughput data for many other data applications, including those that examine genome methylation, chromatin structure, and genome-protein interactions. GEO supports community-derived reporting standards that specify provision of several critical study elements including raw data, processed data, and descriptive metadata. The database not only provides access to data for tens of thousands of studies, but also offers various Web-based tools and strategies that enable users to locate data relevant to their specific interests, as well as to visualize and analyze the data. This chapter includes detailed descriptions of methods to query and download GEO data and use the analysis and visualization tools. The GEO homepage is at http://www.ncbi.nlm.nih.gov/geo/.
    MeSH term(s) Computational Biology/methods ; Databases, Genetic ; Gene Expression ; Gene Expression Profiling/methods ; Genomics/methods ; Software ; Web Browser
    Language English
    Publishing date 2016-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-3578-9_5
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  6. Article ; Online: Intuitive Dualism and Afterlife Beliefs: A Cross-Cultural Study.

    Barrett, H Clark / Bolyanatz, Alexander / Broesch, Tanya / Cohen, Emma / Froerer, Peggy / Kanovsky, Martin / Schug, Mariah G / Laurence, Stephen

    Cognitive science

    2021  Volume 45, Issue 6, Page(s) e12992

    Abstract: It is widely held that intuitive dualism-an implicit default mode of thought that takes minds to be separable from bodies and capable of independent existence-is a human universal. Among the findings taken to support universal intuitive dualism is a ... ...

    Abstract It is widely held that intuitive dualism-an implicit default mode of thought that takes minds to be separable from bodies and capable of independent existence-is a human universal. Among the findings taken to support universal intuitive dualism is a pattern of evidence in which "psychological" traits (knowledge, desires) are judged more likely to continue after death than bodily or "biological" traits (perceptual, physiological, and bodily states). Here, we present cross-cultural evidence from six study populations, including non-Western societies with diverse belief systems, that shows that while this pattern exists, the overall pattern of responses nonetheless does not support intuitive dualism in afterlife beliefs. Most responses of most participants across all cultures tested were not dualist. While our sample is in no way intended to capture the full range of human societies and afterlife beliefs, it captures a far broader range of cultures than in any prior study, and thus puts the case for afterlife beliefs as evidence for universal intuitive dualism to a strong test. Based on these findings, we suggest that while dualist thinking is a possible mode of thought enabled by evolved human psychology, such thinking does not constitute a default mode of thought. Rather, our data support what we will call intuitive materialism-the view that the underlying intuitive systems for reasoning about minds and death produce as a default judgment that mental states cease to exist with bodily death.
    MeSH term(s) Cross-Cultural Comparison ; Culture ; Human Body ; Humans ; Problem Solving ; Religion and Psychology
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2002940-8
    ISSN 1551-6709 ; 0364-0213
    ISSN (online) 1551-6709
    ISSN 0364-0213
    DOI 10.1111/cogs.12992
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  7. Article ; Online: NCBI GEO: archive for gene expression and epigenomics data sets: 23-year update.

    Clough, Emily / Barrett, Tanya / Wilhite, Stephen E / Ledoux, Pierre / Evangelista, Carlos / Kim, Irene F / Tomashevsky, Maxim / Marshall, Kimberly A / Phillippy, Katherine H / Sherman, Patti M / Lee, Hyeseung / Zhang, Naigong / Serova, Nadezhda / Wagner, Lukas / Zalunin, Vadim / Kochergin, Andrey / Soboleva, Alexandra

    Nucleic acids research

    2023  Volume 52, Issue D1, Page(s) D138–D144

    Abstract: The Gene Expression Omnibus (GEO) is an international public repository that archives gene expression and epigenomics data sets generated by next-generation sequencing and microarray technologies. Data are typically submitted to GEO by researchers in ... ...

    Abstract The Gene Expression Omnibus (GEO) is an international public repository that archives gene expression and epigenomics data sets generated by next-generation sequencing and microarray technologies. Data are typically submitted to GEO by researchers in compliance with widespread journal and funder mandates to make generated data publicly accessible. The resource handles raw data files, processed data files and descriptive metadata for over 200 000 studies and 6.5 million samples, all of which are indexed, searchable and downloadable. Additionally, GEO offers web-based tools that facilitate analysis and visualization of differential gene expression. This article presents the current status and recent advancements in GEO, including the generation of consistently computed gene expression count matrices for thousands of RNA-seq studies, and new interactive graphical plots in GEO2R that help users identify differentially expressed genes and assess data set quality. The GEO repository is built and maintained by the National Center for Biotechnology Information (NCBI), a division of the National Library of Medicine (NLM), and is publicly accessible at https://www.ncbi.nlm.nih.gov/geo/.
    MeSH term(s) Databases, Genetic ; Epigenomics ; Gene Expression ; Gene Expression Profiling ; Oligonucleotide Array Sequence Analysis
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkad965
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    Zs.A 1067: Show issues Location:
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  8. Article ; Online: Type 2 inflammation drives an airway basal stem cell program through insulin receptor substrate signaling.

    Wang, Xin / Hallen, Nils R / Lee, Minkyu / Samuchiwal, Sachin / Ye, Qihua / Buchheit, Kathleen M / Maxfield, Alice Z / Roditi, Rachel E / Bergmark, Regan W / Bhattacharyya, Neil / Ryan, Tessa / Gakpo, Deb / Raychaudhuri, Soumya / Dwyer, Dan / Laidlaw, Tanya M / Boyce, Joshua A / Gutierrez-Arcelus, Maria / Barrett, Nora A

    The Journal of allergy and clinical immunology

    2023  Volume 151, Issue 6, Page(s) 1536–1549

    Abstract: Background: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a type 2 (T2) inflammatory disease associated with an increased number of airway basal cells (BCs). Recent studies have identified transcriptionally distinct BCs, but the molecular ... ...

    Abstract Background: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a type 2 (T2) inflammatory disease associated with an increased number of airway basal cells (BCs). Recent studies have identified transcriptionally distinct BCs, but the molecular pathways that support or inhibit human BC proliferation and differentiation are largely unknown.
    Objective: We sought to determine the role of T2 cytokines in regulating airway BCs.
    Methods: Single-cell and bulk RNA sequencing of sinus and lung airway epithelial cells was analyzed. Human sinus BCs were stimulated with IL-4 and IL-13 in the presence and absence of inhibitors of IL-4R signaling. Confocal analysis of human sinus tissue and murine airway was performed. Murine BC subsets were sorted for RNA sequencing and functional assays. Fate labeling was performed in a murine model of tracheal injury and regeneration.
    Results: Two subsets of BCs were found in human and murine respiratory mucosa distinguished by the expression of basal cell adhesion molecule (BCAM). BCAM expression identifies airway stem cells among P63
    Conclusions: These findings establish BCAM as a marker of airway stem cells among the BC pool and demonstrate that airway epithelial remodeling in T2 inflammation extends beyond goblet cell metaplasia to the support of a BC stem state poised to perpetuate inflammation.
    MeSH term(s) Humans ; Animals ; Mice ; Receptor, Insulin/metabolism ; Interleukin-13/metabolism ; Interleukin-4/metabolism ; Inflammation/metabolism ; Sinusitis/metabolism ; Epithelial Cells/metabolism ; Signal Transduction ; Chronic Disease ; Nasal Polyps/metabolism ; Rhinitis/metabolism
    Chemical Substances Receptor, Insulin (EC 2.7.10.1) ; Interleukin-13 ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.01.030
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  9. Article ; Online: ASHP and ASHP Foundation Pharmacy Forecast 2024: Strategic Planning Guidance for Pharmacy Departments in Hospitals and Health Systems.

    DiPiro, Joseph T / Hoffman, James M / Schweitzer, Pamela / Chisholm-Burns, Marie A / Nesbit, Todd W / Fabian, Tanya J / Cunningham, Francesca E / Barrett, Alexis / Fine, Michael J / Tichy, Eric / Hernandez, Inmaculada / Scott, Christopher M / Norman, Christy / Nelson, Scott D / Kumah-Crystal, Yaa

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2023  Volume 81, Issue 2, Page(s) 5–36

    Abstract: Purpose: The 2024 ASHP Pharmacy Forecast identifies and contextualizes emerging issues and trends that will influence healthcare, health systems, and the pharmacy profession and provides recommendations to inform long-term strategic planning that should ...

    Abstract Purpose: The 2024 ASHP Pharmacy Forecast identifies and contextualizes emerging issues and trends that will influence healthcare, health systems, and the pharmacy profession and provides recommendations to inform long-term strategic planning that should prompt action by pharmacists and health-system leaders.
    Methods: Drawing on the “wisdom of crowds” concept, a survey was constructed with 6 general themes, each with 6 to 9 focused statements and a seventh theme on preparedness (58 survey items in total). The size of and representation within the survey panel were intended to capture opinions from a wide range of pharmacy leaders. The survey instructed panelists to consider the likelihood of the events/scenarios described in the statements occurring in the next 5 years as being likely, somewhat likely, somewhat unlikely, or very unlikely. Then, survey panelists assessed the preparedness (from very unprepared to very prepared) for 12 of the statements.
    Results: The 6 survey themes identified were Urgent Public Health Priorities, Responding to the Mental Health Crisis, Achieving Care Equity, New Disease Paradigms and Treatment Innovations, Workforce: Focus on Culture for the Future, and Artificial Intelligence: Can Ethics and Regulators Catch Up? The survey was completed by 250 respondents, yielding an 88% response rate. Analysis of survey results was provided by chapter authors along with strategic recommendations to guide actions for each theme.
    Conclusion: The focus of the Pharmacy Forecast is on large-scale, long-term trends that will influence healthcare and the pharmacy profession over months and years and not on day-to-day situational dynamics. The report provides insight to stimulate thinking and discussion and provides a starting point to proactively position leaders, their teams, and departments for potential future events and trends.
    MeSH term(s) Humans ; United States ; Strategic Planning ; Pharmacy ; Pharmaceutical Services ; Pharmacies ; Hospitals ; Pharmacy Service, Hospital ; Societies, Pharmaceutical ; Pharmacists ; Surveys and Questionnaires
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxad231
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  10. Article ; Online: Non-Adherence to Antihypertensive Guidelines in Patients with Asymptomatic Carotid Stenosis.

    Haley, William / Shawl, Fayaz / Charles Sternbergh, W / Turan, Tanya N / Barrett, Kevin / Voeks, Jenifer / Brott, Thomas / Meschia, James F

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2021  Volume 30, Issue 8, Page(s) 105918

    Abstract: Importance: Hypertension and carotid stenosis are both risk factors for stroke, but the presence of carotid stenosis might dampen enthusiasm for tight control of hypertension because of concerns for hypoperfusion.: Objective: To determine the extent ... ...

    Abstract Importance: Hypertension and carotid stenosis are both risk factors for stroke, but the presence of carotid stenosis might dampen enthusiasm for tight control of hypertension because of concerns for hypoperfusion.
    Objective: To determine the extent to which there are opportunities to potentially improve pharmacotherapy for hypertension in patients known to have asymptomatic high-grade carotid stenosis.
    Design: We examined anti-hypertensive medication prescription and adherence to evidence-based hypertension treatment guidelines in a cross-sectional analysis of baseline data of patients enrolled in a clinical trial.
    Setting: The Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) is a multicenter prospective randomized open blinded end-point clinical trial of intensive medical management with or without revascularization by endarterectomy or stenting for asymptomatic high-grade carotid stenosis.
    Participants: 1479 participants (38.6% female; mean age 69.8 years) from 132 clinical centers enrolled in the CREST-2 trial as of April 6, 2020 who were taking ≥1 antihypertensive drug at baseline.
    Exposures: Pharmacotherapy for hypertension.
    Main outcome: Adherence to evidence-based guidelines for treating hypertension.
    Results: Of 1458 participants with complete data, 26% were on one, 31% on 2, and 43% on ≥3 antihypertensive medications at trial entry. Thirty-two percent of participants were prescribed thiazide; 74%, angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB); 38%, calcium channel blocker (CCB); 56%, a beta blocker; 11%, loop diuretic; and 27%, other. Of those prescribed a single antihypertensive medication, the proportion prescribed thiazide was 5%; ACEI or ARB, 55%, and CCB, 11%. The prevalence of guideline-adherent regimens was 34% (95% CI, 31-36%).
    Conclusions and relevance: In a diverse cohort with severe carotid disease and hypertension, non-adherence to hypertension guidelines was common. All preferred classes of antihypertensive drug were under-prescribed. Using staged iterative guideline-based care for hypertension, CREST-2 will characterize drug tolerance and stroke rates under these conditions.
    Trial registration: ClinicalTrials.gov Number NCT02089217.
    MeSH term(s) Aged ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Asymptomatic Diseases ; Blood Pressure/drug effects ; Carotid Stenosis/complications ; Carotid Stenosis/diagnosis ; Carotid Stenosis/physiopathology ; Cross-Sectional Studies ; Drug Prescriptions ; Drug Therapy, Combination ; Drug Utilization/standards ; Female ; Guideline Adherence/standards ; Humans ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/physiopathology ; Male ; Middle Aged ; North America ; Practice Guidelines as Topic/standards ; Practice Patterns, Physicians'/standards ; Randomized Controlled Trials as Topic ; Spain ; Treatment Outcome
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2021-06-18
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2021.105918
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