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  1. Article: Personalized Approach to Olfactory Neuroblastoma Care.

    Lerner, David K / Palmer, James N

    Journal of personalized medicine

    2024  Volume 14, Issue 4

    Abstract: Olfactory neuroblastoma (ONB) is an uncommon neuroendocrine malignancy arising from the olfactory neuroepithelium. ONB frequently presents with nonspecific sinonasal complaints, including nasal obstruction and epistaxis, and diagnosis can be obtained ... ...

    Abstract Olfactory neuroblastoma (ONB) is an uncommon neuroendocrine malignancy arising from the olfactory neuroepithelium. ONB frequently presents with nonspecific sinonasal complaints, including nasal obstruction and epistaxis, and diagnosis can be obtained through a combination of physical examination, nasal endoscopy, and computed tomography and magnetic resonance imaging. Endoscopic resection with negative margins, with or without craniotomy, as necessary, is the standard of care for definitive treatment of ONB. Regional metastasis to the neck is often detected at presentation or may occur in a delayed fashion and should be addressed through elective neck dissection or radiation. Adjuvant radiotherapy should be considered, particularly in the case of high grade or tumor stage, as well as positive surgical margins. Systemic therapy is an area of active investigation in both the neoadjuvant and adjuvant setting, with many advocating in favor of induction chemotherapy for significant orbital or intracranial involvement prior to surgical resection. Various targeted immunotherapies are currently being studied for the treatment of recurrent or metastatic ONB. Prolonged locoregional and distant surveillance are indicated following definitive treatment, given the tendency for delayed recurrence and metastasis.
    Language English
    Publishing date 2024-04-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14040423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characterisation of anhydro-sialic acid transporters from mucosa-associated bacteria.

    Wu, Yunhan / Bell, Andrew / Thomas, Gavin H / Bolam, David N / Sargent, Frank / Juge, Nathalie / Palmer, Tracy / Severi, Emmanuele

    Microbiology (Reading, England)

    2024  Volume 170, Issue 3

    Abstract: ... Sia for growth and/or cell surface modification. While N-acetyl-neuraminic acid (Neu5Ac)-specific ...

    Abstract Sialic acid (Sia) transporters are critical to the capacity of host-associated bacteria to utilise Sia for growth and/or cell surface modification. While N-acetyl-neuraminic acid (Neu5Ac)-specific transporters have been studied extensively, little is known on transporters dedicated to anhydro-Sia forms such as 2,7-anhydro-Neu5Ac (2,7-AN) or 2,3-dehydro-2-deoxy-Neu5Ac (Neu5Ac2en). Here, we used a Sia-transport-null strain of
    MeSH term(s) N-Acetylneuraminic Acid/chemistry ; N-Acetylneuraminic Acid/analogs & derivatives ; Symporters/genetics ; Symporters/metabolism ; Bacteria/metabolism ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Organic Anion Transporters
    Chemical Substances 2-deoxy-2,3-dehydro-N-acetylneuraminic acid (24967-27-9) ; sialic acid transport proteins ; N-Acetylneuraminic Acid (GZP2782OP0) ; Symporters ; Membrane Transport Proteins ; Organic Anion Transporters
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/mic.0.001448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Metagenomic Characterisation of the Gut Microbiome and Effect of Complementary Feeding on

    Parkin, Kimberley / Palmer, Debra J / Verhasselt, Valerie / Amenyogbe, Nelly / Cooper, Matthew N / Christophersen, Claus T / Prescott, Susan L / Silva, Desiree / Martino, David

    Microorganisms

    2024  Volume 12, Issue 1

    Abstract: Complementary feeding induces dramatic ecological shifts in the infant gut microbiota toward more diverse compositions and functional metabolic capacities, with potential implications for immune and metabolic health. The aim of this study was to examine ... ...

    Abstract Complementary feeding induces dramatic ecological shifts in the infant gut microbiota toward more diverse compositions and functional metabolic capacities, with potential implications for immune and metabolic health. The aim of this study was to examine whether the age at which solid foods are introduced differentially affects the microbiota in predominantly breastfed infants compared with predominantly formula-fed infants. We performed whole-genome shotgun metagenomic sequencing of infant stool samples from a cohort of six-month-old Australian infants enrolled in a nested study within the ORIGINS Project longitudinal birth cohort. Infants born preterm or those who had been administered antibiotics since birth were excluded. The taxonomic composition was highly variable among individuals at this age. Predominantly formula-fed infants exhibited a higher microbiome diversity than predominantly breastfed infants. Among the predominantly breastfed infants, the introduction of solid foods prior to five months of age was associated with higher alpha diversity than solid food introduction after six months of age, primarily due to the loss of
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12010228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Characterization of neuropathology in ovine CLN5 and CLN6 neuronal ceroid lipofuscinoses (Batten disease).

    Mitchell, Nadia L / Russell, Katharina N / Barrell, Graham K / Tammen, Imke / Palmer, David N

    Developmental neurobiology

    2023  Volume 83, Issue 5-6, Page(s) 127–142

    Abstract: Sheep with naturally occurring CLN5 and CLN6 forms of neuronal ceroid lipofuscinoses (Batten disease) share the key clinical features of the human disease and represent an ideal model system in which the clinical efficacy of gene therapies is developed ... ...

    Abstract Sheep with naturally occurring CLN5 and CLN6 forms of neuronal ceroid lipofuscinoses (Batten disease) share the key clinical features of the human disease and represent an ideal model system in which the clinical efficacy of gene therapies is developed and test. However, it was first important to characterize the neuropathological changes that occur with disease progression in affected sheep. This study compared neurodegeneration, neuroinflammation, and lysosomal storage accumulation in CLN5 affected Borderdale, CLN6 affected South Hampshire, and Merino sheep brains from birth to end-stage disease at ≤24 months of age. Despite very different gene products, mutations, and subcellular localizations, the pathogenic cascade was remarkably similar for all three disease models. Glial activation was present at birth in affected sheep and preceded neuronal loss, with both spreading from the visual and parieto-occipital cortices most prominently associated with clinical symptoms to the entire cortical mantle by end-stage disease. In contrast, the subcortical regions were less involved, yet lysosomal storage followed a near-linear increase across the diseased sheep brain with age. Correlation of these neuropathological changes with published clinical data identified three potential therapeutic windows in affected sheep-presymptomatic (3 months), early symptomatic (6 months), and a later symptomatic disease stage (9 months of age)-beyond which the extensive depletion of neurons was likely to diminish any chance of therapeutic benefit. This comprehensive natural history of the neuropathological changes in ovine CLN5 and CLN6 disease will be integral in determining what impact treatment has at each of these disease stages.
    MeSH term(s) Humans ; Sheep ; Animals ; Neuronal Ceroid-Lipofuscinoses/genetics ; Neuronal Ceroid-Lipofuscinoses/pathology ; Neuronal Ceroid-Lipofuscinoses/veterinary ; Brain/pathology ; Neurons/pathology ; Cerebral Cortex/pathology ; Mutation ; Lysosomal Membrane Proteins/genetics ; Membrane Proteins
    Chemical Substances CLN5 protein, human ; Lysosomal Membrane Proteins ; CLN6 protein, human ; Membrane Proteins
    Language English
    Publishing date 2023-05-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2256184-5
    ISSN 1932-846X ; 1097-4695 ; 1932-8451 ; 0022-3034
    ISSN (online) 1932-846X ; 1097-4695
    ISSN 1932-8451 ; 0022-3034
    DOI 10.1002/dneu.22918
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 853: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A vicious cycle: employment challenges associated with diabetes foot ulcers in an economically marginalized Southwest US sample.

    Palmer, Kelly N B / Crocker, Rebecca M / Marrero, David G / Tan, Tze-Woei

    Frontiers in clinical diabetes and healthcare

    2023  Volume 4, Page(s) 1027578

    Abstract: Aim: To describe patients' reported employment challenges associated with diabetic foot ulcers (DFUs).: Methods: Fifteen patients from under-resourced communities in Southern Arizona, with a history of DFUs and/or amputations, were recruited from a ... ...

    Abstract Aim: To describe patients' reported employment challenges associated with diabetic foot ulcers (DFUs).
    Methods: Fifteen patients from under-resourced communities in Southern Arizona, with a history of DFUs and/or amputations, were recruited from a tertiary referral center from June 2020 to February 2021. Participants consented to an audio-recorded semi-structured phone interview. Interviews were transcribed and thematically analyzed using the Dedoose data analysis platform.
    Results: Participants shared a common theme around the cyclic challenges of DFU prevention/management and employment. Those employed in manual labor-intensive jobs or jobs requiring them to be on their feet for long durations of time believed working conditions contributed to the development of their DFUs. Patients reported work incapacity due to declines in mobility and the need to offload for DFU management. Many expressed frustration and emotional distress related to these challenges noting that DFUs resulted in lower remuneration as medical expenses increased. Consequently, loss of income and/or medical insurance often hindered participants' ability to manage DFUs and subsequent complications.
    Conclusion: These data illuminate the vicious cycle of DFU and employment challenges that must be addressed through patient-centered prevention strategies. Healthcare providers should consider a person's contextual factors such as employment type to tailor treatment approaches. Employers should establish inclusive policies that support patients with DFUs returning to work through flexible working hours and adapted work tasks as needed. Policymakers can also mitigate employment challenges by implementing social programs that provide resources for employees who are unable to return to work in their former capacity.
    Language English
    Publishing date 2023-04-14
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-6616
    ISSN (online) 2673-6616
    DOI 10.3389/fcdhc.2023.1027578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Long-term safety and dose escalation of intracerebroventricular CLN5 gene therapy in sheep supports clinical translation for CLN5 Batten disease.

    Mitchell, Nadia L / Murray, Samantha J / Wellby, Martin P / Barrell, Graham K / Russell, Katharina N / Deane, Ashley R / Wynyard, John R / Palmer, Madeleine J / Pulickan, Anila / Prendergast, Phillipa M / Casy, Widler / Gray, Steven J / Palmer, David N

    Frontiers in genetics

    2023  Volume 14, Page(s) 1212228

    Abstract: CLN5 neuronal ceroid lipofuscinosis (NCL, Batten disease) is a rare, inherited fatal neurodegenerative disorder caused by mutations in ... ...

    Abstract CLN5 neuronal ceroid lipofuscinosis (NCL, Batten disease) is a rare, inherited fatal neurodegenerative disorder caused by mutations in the
    Language English
    Publishing date 2023-08-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1212228
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  7. Article: The relevance of the storage of subunit c of ATP synthase in different forms and models of Batten disease (NCLs).

    Palmer, David N

    Biochimica et biophysica acta

    2015  Volume 1852, Issue 10 Pt B, Page(s) 2287–2291

    Abstract: The discoveries of specific protein storage in the NCLs, particularly of subunit c of ATP synthase in most, and the sphingolipid activator proteins, SAPs or saposins A and D in CLN1, CLN10 and an unassigned form are reviewed. The subunit c stored in the ... ...

    Abstract The discoveries of specific protein storage in the NCLs, particularly of subunit c of ATP synthase in most, and the sphingolipid activator proteins, SAPs or saposins A and D in CLN1, CLN10 and an unassigned form are reviewed. The subunit c stored in the relevant NCLs is the complete mature molecule including an unusual modification found only in animal species, trimethylation of its lysine-43. Because of its strongly hydrophobic and lipid-like properties subunit c is easily overlooked or incorrectly described. This is becoming more of a problem as subunit c is not detected in standard proteomic investigations. Methods are reviewed that allow its unequivocal characterisation. Subunit c storage and cellular storage body accumulation do not cause the neuropathology characteristic of these diseases. The function of the trimethyl group on lysine-43 of subunit c is considered, along with some indications of where its normal turnover may be disrupted in the NCLs.
    Language English
    Publishing date 2015-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2015.06.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.247: Show issues Location:
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  8. Article: Using simulated wildland fire to assess microbial survival at multiple depths from biocrust and bare soils.

    Palmer, Brianne / Pietrasiak, Nicole / Cobb, Polina / Lipson, David

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1123790

    Abstract: Introduction: Surface soil microbial communities are directly exposed to the heat from wildland fires. Due to this, the microbial community composition may be stratified within the soil profile with more heat tolerant microbes near the surface and less ... ...

    Abstract Introduction: Surface soil microbial communities are directly exposed to the heat from wildland fires. Due to this, the microbial community composition may be stratified within the soil profile with more heat tolerant microbes near the surface and less heat tolerant microbes, or mobile species found deeper in the soil. Biological soil crusts, biocrusts, are found on the soil surface and contain a diverse microbial community that is directly exposed to the heat from wildland fires.
    Methods: Here, we used a simulated fire mesocosm along with a culture-based approach and molecular characterization of microbial isolates to understand the stratification of biocrust and bare soil microbes after low severity (450°C) and high severity (600°C) fires. We cultured and sequenced microbial isolates from 2 to 6 cm depth from both fire types.
    Results: The isolates were stratified along the soil depth. Green algal isolates were less thermotolerant and found in the deeper depths (4-6 cm) and the control soils, while several cyanobacteria in Oscillatoriales, Synechococcales, and Nostocales were found at 2-3 cm depth for both fire temperatures. An Alphaproteobacteria isolate was common across several depths, both fire types, and both fire temperatures. Furthermore, we used RNA sequencing at three depths after the high severity fire and one control to determine what microbial community is active following a fire. The community was dominated by Gammaproteobacteria, however some Cyanobacteria ASVs were also present.
    Discussion: Here we show evidence of stratification of soil and biocrust microbes after a fire and provide evidence that these microbes are able to survive the heat from the fire by living just below the soil surface. This is a steppingstone for future work on the mechanisms of microbial survival after fire and the role of soil insulation in creating resilient communities.
    Language English
    Publishing date 2023-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1123790
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  9. Article ; Online: Utility of a LangChain and OpenAI GPT-powered chatbot based on the international consensus statement on allergy and rhinology: Rhinosinusitis.

    Workman, Alan D / Rathi, Vinay K / Lerner, David K / Palmer, James N / Adappa, Nithin D / Cohen, Noam A

    International forum of allergy & rhinology

    2023  

    Abstract: Key points: We created a LangChain/OpenAI API-powered chatbot based solely on International Consensus Statement of Allergy and Rhinology: Rhinosinusitis (ICAR-RS). The ICAR-RS chatbot is able to provide direct and actionable recommendations. Utilization ...

    Abstract Key points: We created a LangChain/OpenAI API-powered chatbot based solely on International Consensus Statement of Allergy and Rhinology: Rhinosinusitis (ICAR-RS). The ICAR-RS chatbot is able to provide direct and actionable recommendations. Utilization of consensus statements provides an opportunity for AI applications in healthcare.
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.23310
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    Zs.A 6927: Show issues Location:
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  10. Article: Efficacy of dual intracerebroventricular and intravitreal

    Murray, Samantha J / Wellby, Martin P / Barrell, Graham K / Russell, Katharina N / Deane, Ashley R / Wynyard, John R / Gray, Steven J / Palmer, David N / Mitchell, Nadia L

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1212235

    Abstract: Mutations in ... ...

    Abstract Mutations in the
    Language English
    Publishing date 2023-10-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1212235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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