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  1. Article: Berlin, 17.01.2018 – Stellungnahme der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e. V. zum Projekt S16-06 des IQWiG Nicht-invasive Pränataldiagnostik zur Bestimmung des Risikos autosomaler Trisomien 13,18 und 21 bei Risikoschwangerschaften

    Germer, Ute / Kagan, Karl Oliver / Gembruch, Ulrich

    Geburtshilfe und Frauenheilkunde

    2018  Volume 78, Issue 08, Page(s) 755–756

    Language German
    Publishing date 2018-08-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80111-2
    ISSN 1438-8804 ; 0016-5751 ; 1615-3359
    ISSN (online) 1438-8804
    ISSN 0016-5751 ; 1615-3359
    DOI 10.1055/a-0638-4737
    Database Thieme publisher's database

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  2. Article: Strukturnaia stabilizatsiia lipidov i zritel'nogo pigmenta rodopsina v fotoretseptornoĭ membrane vitaminom E.

    Tiurin, V A / Korol'kov, S N / Berman, A L / Kagan, V E

    Biulleten' eksperimental'noi biologii i meditsiny

    1987  Volume 104, Issue 10, Page(s) 391–394

    Abstract: Interaction of alpha-tocopherol with free fatty acids in bovine retinal photoreceptor membranes was studied using ESR spin-probe technique and measurements of rhodopsin thermal denaturation rates. Exogenous alpha-tocopherol incorporated into ... ...

    Title translation Structural stabilization of lipids and visual pigment rhodopsin in the photoreceptor membrane by vitamin E.
    Abstract Interaction of alpha-tocopherol with free fatty acids in bovine retinal photoreceptor membranes was studied using ESR spin-probe technique and measurements of rhodopsin thermal denaturation rates. Exogenous alpha-tocopherol incorporated into photoreceptor membranes prevented thermal destabilization of rhodopsin caused by free fatty acids. The efficiency of the stabilizing action of alpha-tocopherol directly depended both on the chain length and the degree of fatty acid unsaturation.
    MeSH term(s) Animals ; Cattle ; Drug Interactions ; Electron Spin Resonance Spectroscopy ; Fatty Acids, Nonesterified/metabolism ; Male ; Membrane Fluidity/drug effects ; Membrane Lipids/metabolism ; Phospholipids/metabolism ; Photoreceptor Cells/drug effects ; Photoreceptor Cells/metabolism ; Retinal Pigments/metabolism ; Rhodopsin/metabolism ; Spin Labels ; Vitamin E/pharmacology
    Chemical Substances Fatty Acids, Nonesterified ; Membrane Lipids ; Phospholipids ; Retinal Pigments ; Spin Labels ; Vitamin E (1406-18-4) ; Rhodopsin (9009-81-8)
    Language Russian
    Publishing date 1987-10
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 127365-6
    ISSN 0365-9615 ; 0006-4041
    ISSN 0365-9615 ; 0006-4041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Aktivatsiia éndogennogo perekisnogo okisleniia lipidov v mozge pri okislitel'nom stresse, vyzvannom vvedeniem zheleza, i ee predotvrashchenie vitaminom E.

    Kaĭnova, G M / Markovska, D / Staneva, D / Kagan, V E

    Biulleten' eksperimental'noi biologii i meditsiny

    1990  Volume 109, Issue 1, Page(s) 35–37

    Abstract: Looking for an appropriate model of accelerated aging in vivo we investigated the content of endogenous products of lipid peroxidation (LP) in the rat brain after single or 4 day-lasting intramuscular injection of complex-bind iron (ferum Hausman, 50 mg/ ... ...

    Title translation Activation of endogenous lipid peroxidation in the brain in oxidation stress caused by administration of iron and its prevention by vitamin E.
    Abstract Looking for an appropriate model of accelerated aging in vivo we investigated the content of endogenous products of lipid peroxidation (LP) in the rat brain after single or 4 day-lasting intramuscular injection of complex-bind iron (ferum Hausman, 50 mg/kg body weight) like promoter of LP. We found that the single administration of this iron complex fails to induce endogenous LP; after 4 day-application of iron we observed significant increase in content of primary (lipid peroxides) and final (fluorescent) products of LP. Iron-promoted activation of endogenous LP could be abolished by animal pretreatment with the natural antioxidant alpha-tocopherol. The calcium antagonist nifedipine didn't affect the content of endogenous LP products neither alone nor in combination with alpha-tocopherol.
    MeSH term(s) Administration, Oral ; Aging ; Animals ; Brain/drug effects ; Brain/metabolism ; Fluorescence ; Injections, Intramuscular ; Iron/administration & dosage ; Iron/pharmacology ; Lipid Peroxidation/drug effects ; Male ; Nifedipine/pharmacology ; Oxidation-Reduction ; Rats ; Stress, Physiological/metabolism ; Time Factors ; Vitamin E/administration & dosage ; Vitamin E/pharmacology
    Chemical Substances Vitamin E (1406-18-4) ; Iron (E1UOL152H7) ; Nifedipine (I9ZF7L6G2L)
    Language Russian
    Publishing date 1990-01
    Publishing country Russia (Federation)
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 127365-6
    ISSN 0365-9615 ; 0006-4041
    ISSN 0365-9615 ; 0006-4041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Perekisnoe okislenie lipidov i degeneratsiia fotoretseptorov v setchatke krys pri E-avitaminoze

    Kagan, V E / Barybina, G V / Novikov, K N

    Biulleten' eksperimental'noi biologii i meditsiny

    1977  Volume 83, Issue 4, Page(s) 411–413

    Abstract: Alimentary E-avitaminosis in rats was accompanied (in vivo) by a sharply intensified formation ...

    Title translation Lipid peroxidation and degeneration of the retinal photoreceptors in rats with avitaminosis E.
    Abstract Alimentary E-avitaminosis in rats was accompanied (in vivo) by a sharply intensified formation of the lipid peroxidation products (hydroperoxides, dialkylperosides, "intermolecular links") in the retina and by degeneration of photoreceptors (chiefly of the external rod segment layer). Discussion of the experimental data obtained is based upon the views on the antioxidant alpha-tocopherol action mechanism in vivo.
    MeSH term(s) Animals ; Lipid Metabolism ; Male ; Peroxides/biosynthesis ; Photoreceptor Cells ; Rats ; Retina/metabolism ; Retina/pathology ; Retinal Degeneration/etiology ; Retinal Degeneration/pathology ; Vitamin E Deficiency/complications ; Vitamin E Deficiency/metabolism
    Chemical Substances Peroxides
    Language Russian
    Publishing date 1977-04
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 127365-6
    ISSN 0365-9615 ; 0006-4041
    ISSN 0365-9615 ; 0006-4041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Aktirovanie perekisnogo okisleniia lipidov i izmenenie soderzhaniia vitamina E v legkikh pri okislitel'nom stresse.

    Kovacheva-Ivanova, S / Bakalova, R / Kagan, V / Georgiev, G

    Biulleten' eksperimental'noi biologii i meditsiny

    1992  Volume 113, Issue 2, Page(s) 132–134

    Abstract: ... products in biological objects and a strong decrease in the content of vitamin E in the lung tissue were registered. ...

    Title translation Activation of lipid peroxidation and changes in vitamin E contents in the lungs under oxidative stress.
    Abstract The lipid peroxidation (LPO) of the lung tissue and the bronchoalveolar lavage in rats under the influence of immobilization has been investigated. The effects accompanying the development of oxidative stress in animals--an increase in the content of conjugated dienes and fluorescent LPO products in biological objects and a strong decrease in the content of vitamin E in the lung tissue were registered.
    MeSH term(s) Animals ; Immobilization ; Lipid Peroxidation ; Lung/metabolism ; Male ; Oxidation-Reduction ; Rats ; Rats, Inbred Strains ; Stress, Physiological/metabolism ; Time Factors ; Vitamin E/metabolism
    Chemical Substances Vitamin E (1406-18-4)
    Language Russian
    Publishing date 1992-02
    Publishing country Russia (Federation)
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 127365-6
    ISSN 0365-9615 ; 0006-4041
    ISSN 0365-9615 ; 0006-4041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Chemical Constituents of Dysphania botrys (L.) Mosyakin & Clemants Essential Oil: Herbicidal and Antimicrobial Activities

    Veryer, Kağan / Bozok, Fuat

    Journal of Essential Oil Bearing Plants. 2023 Mar. 04, v. 26, no. 2 p.411-419

    2023  

    Abstract: ... on S. aureus (13 mm) and this was followed by B. cereus (10 mm)> E. faecalis = P. aeruginosa (8 mm ...

    Abstract Dysphania botrys (L.) Mosyakin & Clemants, belonging to the Amaranthaceae family, is a plant species commonly found in Asian and Mediterranean regions. Furthermore, the herb has significant medical value (antiviral, antibacterial, anti-inflammatory, antifungal, and so on). In the present study, chemical compounds of essential oil of D. botrys collected from Central Anatolia (Kayseri province) of Türkiye were investigated and thirty components were identified in the oil by gas chromatography/mass spectrometry (GC/MS). β-elemene (27.56%), elemol (18.00%), selina-3,7(11)-diene (6.74%), β-eudesmol (5.87%), α-eudesmol (4.48%), (-)-isolongifolol acetate (3.56%), and β-selinene (3.12%) were determined as the main components. The Kirby-Baurer disc diffusion technique was used to evaluate the oil's antibacterial effects against six distinct bacterial strains. The results showed that the most inhibitory effect was observed on S. aureus (13 mm) and this was followed by B. cereus (10 mm)> E. faecalis = P. aeruginosa (8 mm) > A. baumannii = Y. enterocolitica (7 mm). It was established that the oil significantly inhibited the growth of the tested bacterial strains. In vitro allelopathic effects of the oil at different doses (1.0-8.0 μl/ml) were researched on Lepidium sativum and Triticum aestivum. In both tested plants, the oil at 4.0 and 8.0 μl/ml doses significantly inhibited the germination, root, and shoot elongation and decreased total chlorophyll and carotenoid contents. This is also the first study on the phytotoxic activity of D. botrys' essential oil.
    Keywords Bacillus cereus ; Dysphania botrys ; Lepidium sativum ; Triticum aestivum ; Turkey (country) ; acetates ; carotenoids ; chlorophyll ; essential oils ; gas chromatography ; germination ; mass spectrometry ; oils ; phytotoxicity ; Allelopathy ; Antibacterial activity ; Chemical composition ; Essential oil
    Language English
    Dates of publication 2023-0304
    Size p. 411-419.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ISSN 0976-5026
    DOI 10.1080/0972060X.2023.2189531
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Factors affecting adherence to physical training in the outpatient phase of rehabilitation, in patients after coronary artery bypass grafting.

    Pomeshkina, S A / Bezzubova, V A / Zvereva, T N / Kagan, E S / Barbarash, O L

    Kardiologiia

    2022  Volume 62, Issue 6, Page(s) 37–44

    Abstract: Aim      To evaluate the outpatient physical exercise (PE) compliance and the affecting factors in patients after coronary bypass (CB).Material and methods  The study included 67 men with ischemic heart disease younger than 75 years who had had CB. All ... ...

    Abstract Aim      To evaluate the outpatient physical exercise (PE) compliance and the affecting factors in patients after coronary bypass (CB).Material and methods  The study included 67 men with ischemic heart disease younger than 75 years who had had CB. All patients were randomized to 2 groups: group 1 exercised on a bicycle ergometer at the rehabilitation center, under the monitoring of medical staff; patients of group 2 performed home-based exercise (HBE) by dosed walking. In the preoperative period, at one month after CB, and after 3 months of exercise, the following was evaluated: clinical condition of patients in different groups, plasma concentrations of lipids, body weight index, waist circumference, echocardiography and bicycle ergometry data, and questionnaire data (SF-36, Bek's Depression Inventory). At 3 months of follow-up, the outpatient exercise compliance and the affecting factors were also evaluated.Results The study demonstrated the effectiveness of the proposed alternative 3-month program of home-based PE. Both the patients exercising on a bicycle and those performing HBE had increased exercise tolerance (ET) and improved blood lipid concentrations. The number of obese patients decreased. Also, depression severity decreased, quality of life (physical and psychological components) improved, and compliance with drug therapy increased in both groups. Analysis of the training attendance in the recommended period showed that patients who had undergone CB were insufficiently adherent to physical rehabilitation programs, regardless of the program type (home-based or monitored). The highest PE adherence was observed in men with the following characteristics: married, working urban residents, with a previous history of cardiovascular diseases, who had regularly taken medications in the preoperative period, and who also had higher quality of life.Conclusion      The proposed outpatient 3-month physical rehabilitation programs increase the effectiveness of CB, which is evident as improved adherence to modifying cardiovascular risk factors, increased ET, optimization of the psychological status and quality of life, and improved compliance with drug therapy. However, despite the proposed alternative, home-based 3-month physical rehabilitation programs aimed at increasing the treatment compliance, the level of ET remained low. This requires further improvement of methods for monitoring and motivation of patients to physical rehabilitation and psychological support that would start already at the preoperative stage.
    MeSH term(s) Cardiac Rehabilitation/methods ; Coronary Artery Bypass/adverse effects ; Coronary Artery Bypass/rehabilitation ; Exercise Therapy/methods ; Humans ; Male ; Outpatients ; Quality of Life
    Language English
    Publishing date 2022-06-30
    Publishing country Russia (Federation)
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 131029-x
    ISSN 0022-9040
    ISSN 0022-9040
    DOI 10.18087/cardio.2022.6.n1756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Detection of HOCl-driven degradation of the pericardium scaffolds by label-free multiphoton fluorescence lifetime imaging.

    Yakimov, B P / Vlasova, I I / Efremov, Y M / Maksimov, E G / Shirshin, E A / Kagan, V E / Timashev, P S

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 10329

    Abstract: Artificial biomaterials can significantly increase the rate of tissue regeneration. However, implantation of scaffolds leads not only to accelerated tissue healing but also to an immune response of the organism, which results in the degradation of the ... ...

    Abstract Artificial biomaterials can significantly increase the rate of tissue regeneration. However, implantation of scaffolds leads not only to accelerated tissue healing but also to an immune response of the organism, which results in the degradation of the biomaterial. The synergy of the immune response and scaffold degradation processes largely determines the efficiency of tissue regeneration. Still, methods suitable for fast, accurate and non-invasive characterization of the degradation degree of biomaterial are highly demandable. Here we show the possibility of monitoring the degradation of decellularized bovine pericardium scaffolds under conditions mimicking the immune response and oxidation processes using multiphoton tomography combined with fluorescence lifetime imaging (MPT-FLIM). We found that the fluorescence lifetimes of genipin-induced cross-links in collagen and oxidation products of collagen are prominent markers of oxidative degradation of scaffolds. This was verified in model experiments, where the oxidation was induced with hypochlorous acid or by exposure to activated neutrophils. The fluorescence decay parameters also correlated with the changes of micromechanical properties of the scaffolds as assessed using atomic force microscopy (AFM). Our results suggest that FLIM can be used for quantitative assessments of the properties and degradation of the scaffolds essential for the wound healing processes in vivo.
    MeSH term(s) Animals ; Biocompatible Materials/pharmacology ; Cattle ; Collagen/metabolism ; Optical Imaging ; Pericardium/metabolism ; Tissue Scaffolds
    Chemical Substances Biocompatible Materials ; Collagen (9007-34-5)
    Language English
    Publishing date 2022-06-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-14138-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Parametric transition from deflagration to detonation in stellar medium.

    Gordon, Peter V / Kagan, Leonid / Sivashinsky, Gregory

    Physical review. E

    2021  Volume 103, Issue 3-1, Page(s) 33106

    Abstract: The nature of thermonuclear explosions of white-dwarf stars is a fundamental astrophysical issue, the first principle interpretation of which is still commonly regarded as an unresolved problem. There is a general consensus that stellar explosions are a ... ...

    Abstract The nature of thermonuclear explosions of white-dwarf stars is a fundamental astrophysical issue, the first principle interpretation of which is still commonly regarded as an unresolved problem. There is a general consensus that stellar explosions are a manifestation of the deflagration-to-detonation transition of an outward propagating self-accelerating thermonuclear flame subjected to instability-induced corrugations. A similar problem arises in unconfined terrestrial flames where a positive feedback mechanism leading to the pressure runaway has been identified. The present study is an application of this finding to the stellar environment. Notwithstanding a substantial modification of the equation of state the runaway effect endures. Approaching the runaway point the pretransition flame may stay perfectly subsonic, which challenges the view that to ensure the transition the flame should cross the threshold of Chapman-Jouguet deflagration.
    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.103.033106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Formation of protein adducts with Hydroperoxy-PE electrophilic cleavage products during ferroptosis.

    Amoscato, A A / Anthonymuthu, T / Kapralov, O / Sparvero, L J / Shrivastava, I H / Mikulska-Ruminska, K / Tyurin, V A / Shvedova, A A / Tyurina, Y Y / Bahar, I / Wenzel, S / Bayir, H / Kagan, V E

    Redox biology

    2023  Volume 63, Page(s) 102758

    Abstract: Ferroptosis is an iron dependent form of cell death, that is triggered by the discoordination of iron, lipids, and thiols. Its unique signature that distinguishes it from other forms of cell death is the formation and accumulation of lipid hydroperoxides, ...

    Abstract Ferroptosis is an iron dependent form of cell death, that is triggered by the discoordination of iron, lipids, and thiols. Its unique signature that distinguishes it from other forms of cell death is the formation and accumulation of lipid hydroperoxides, particularly oxidized forms of polyunsaturated phosphatidylethanolamines (PEs), which drives cell death. These readily undergo iron-catalyzed secondary free radical reactions leading to truncated products which retain the signature PE headgroup and which can readily react with nucleophilic moieties in proteins via their truncated electrophilic acyl chains. Using a redox lipidomics approach, we have identified oxidatively-truncated PE species (trPEox) in enzymatic and non-enzymatic model systems. Further, using a model peptide we demonstrate adduct formation with Cys as the preferred nucleophilic residue and PE(26:2) +2 oxygens, as one of the most reactive truncated PE-electrophiles produced. In cells stimulated to undergo ferroptosis we identified PE-truncated species with sn-2 truncations ranging from 5 to 9 carbons. Taking advantage of the free PE headgroup, we have developed a new technology using the lantibiotic duramycin, to enrich and identify the PE-lipoxidated proteins. Our results indicate that several dozens of proteins for each cell type, are PE-lipoxidated in HT-22, MLE, and H9c2 cells and M2 macrophages after they were induced to undergo ferroptosis. Pretreatment of cells with the strong nucleophile, 2-mercaptoethanol, prevented the formation of PE-lipoxidated proteins and blocked ferroptotic death. Finally, our docking simulations showed that the truncated PE species bound at least as good to several of the lantibiotic-identified proteins, as compared to the non-truncated parent molecule, stearoyl-arachidonoyl PE (SAPE), indicating that these oxidatively-truncated species favor/promote the formation of PEox-protein adducts. The identification of PEox-protein adducts during ferroptosis suggests that they are participants in the ferroptotic process preventable by 2-mercaptoethanol and may contribute to a point of no return in the ferroptotic death process.
    MeSH term(s) Humans ; Ferroptosis ; Mercaptoethanol ; Oxidation-Reduction ; Cell Death ; Iron/metabolism ; Lipid Peroxidation
    Chemical Substances Mercaptoethanol (60-24-2) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2023-05-22
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2023.102758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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