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  1. Article: NEWER DRUGS IN THE TREATMENT OF HYPERTENSION.

    MIZGALA, H F

    Canadian Medical Association journal

    2003  Volume 92, Page(s) 918–922

    Abstract: The treatment of essential hypertension still consists of the judicious combination of two or more agents. The chemical nature, pharmacology, side effects and relative merits of two groups of drugs are reviewed: (1) agents interfering with the synthesis, ...

    Abstract The treatment of essential hypertension still consists of the judicious combination of two or more agents. The chemical nature, pharmacology, side effects and relative merits of two groups of drugs are reviewed: (1) agents interfering with the synthesis, storage and release of endogenous catecholamines and (2) oral diuretic agents. Rauwolfia compounds, bretylium tosylate, guanethidine, alpha-methyldopa and pargyline hydrochloride comprise the first group; thiazide derivatives, phthalimidine compounds and spironolactones constitute the second. Guanethidine is the most potent and most extensively used agent in the second group. While not yet fully assessed, alpha-methyldopa and pargyline hydrochloride are useful in selected cases. The intrinsic hypotensive properties of oral diuretics, their low incidence of side effects and their ability to potentiate the more potent agents make them useful adjuncts in the long-term treatment of hypertension. Attention is drawn to the potential diabetogenic and hyperuricemic effects of the thiazides and phthalimidine compounds.
    MeSH term(s) Antihypertensive Agents ; Bretylium Compounds ; Chlorothiazide ; Chlorthalidone ; Diuretics ; Drug Therapy ; Essential Hypertension ; Guanethidine ; Hydralazine ; Hypertension ; Methyldopa ; Pargyline ; Rauwolfia ; Spironolactone ; Toxicology
    Chemical Substances Antihypertensive Agents ; Bretylium Compounds ; Diuretics ; Hydralazine (26NAK24LS8) ; Spironolactone (27O7W4T232) ; Methyldopa (56LH93261Y) ; Chlorothiazide (77W477J15H) ; Pargyline (9MV14S8G3E) ; Chlorthalidone (Q0MQD1073Q) ; Guanethidine (ZTI6C33Q2Q)
    Language English
    Publishing date 2003-01-17
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Atrial natriuretic factor: a new diagnostic marker for right ventricular infarction?

    Mizgala, H F

    Journal of the American College of Cardiology

    1990  Volume 15, Issue 3, Page(s) 554–556

    MeSH term(s) Atrial Natriuretic Factor/blood ; Biomarkers/blood ; Blood Pressure ; Humans ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis ; Myocardial Infarction/physiopathology
    Chemical Substances Biomarkers ; Atrial Natriuretic Factor (85637-73-6)
    Language English
    Publishing date 1990-03-01
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/0735-1097(90)90624-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Residents' workloads: whose responsibility?

    Mizgala, H F

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    1989  Volume 140, Issue 12, Page(s) 1439–1440

    MeSH term(s) Canada ; Fatigue ; Humans ; Internship and Residency/legislation & jurisprudence ; New York City ; Quality of Health Care ; Stress, Psychological
    Language English
    Publishing date 1989-06-15
    Publishing country Canada
    Document type Editorial
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0820-3946 ; 0008-4409
    ISSN (online) 1488-2329
    ISSN 0820-3946 ; 0008-4409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Coronary events and coronary care: MONICA project.

    Mizgala, H F / Schulzer, M

    Lancet (London, England)

    2000  Volume 356, Issue 9227, Page(s) 430–431

    MeSH term(s) Coronary Disease/epidemiology ; Coronary Disease/therapy ; Data Interpretation, Statistical ; Global Health ; Humans ; Risk Factors ; World Health Organization
    Language English
    Publishing date 2000-07-29
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/s0140-6736(05)73577-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Coronary events and coronary care: MONICA project.

    Mizgala, H F / Schulzer, M

    Lancet (London, England)

    2000  Volume 356, Issue 9227, Page(s) 431–432

    MeSH term(s) Coronary Disease/epidemiology ; Coronary Disease/therapy ; Data Interpretation, Statistical ; Humans ; Risk Factors
    Language English
    Publishing date 2000-07-29
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/s0140-6736(05)73579-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Contemporary treatment of acute myocardial infarction and unstable angina: cost effectiveness.

    Mizgala, H F

    The Canadian journal of cardiology

    1989  Volume 5, Issue 3, Page(s) 127–128

    MeSH term(s) Angina Pectoris/therapy ; Angina, Unstable/economics ; Angina, Unstable/therapy ; Clinical Trials as Topic ; Cost-Benefit Analysis ; Humans ; Myocardial Infarction/economics ; Myocardial Infarction/therapy ; Prognosis ; United States
    Language English
    Publishing date 1989-04
    Publishing country England
    Document type Clinical Trial ; Editorial
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The calcium channel blockers: pharmacology and clinical applications.

    Mizgala, H F

    Canadian Anaesthetists' Society journal

    1983  Volume 30, Issue 3 Pt 2, Page(s) S5–10

    Abstract: The calcium channel blockers provide an exciting and effective new therapeutic tool in the management of ischaemic cardiac syndromes and may prove popular and effective in the treatment of a variety of other disorders. They have provided a new approach ... ...

    Abstract The calcium channel blockers provide an exciting and effective new therapeutic tool in the management of ischaemic cardiac syndromes and may prove popular and effective in the treatment of a variety of other disorders. They have provided a new approach to treatment and have added new insights into the pathogenesis of ischaemic cardiac syndromes. Their introduction into clinical practice has been swift and many of our concepts regarding their pharmacologic activities in man remain based on theoretic considerations. Their expanding clinical use and further comparative studies will undoubtedly provide further information in regard to indications, adverse effects, drug interaction and long-term safety. Particular caution is advised when they are combined with certain antiarrhythmic agents, digitalis and particularly beta adrenergic blocking agents. Little is known about their interaction with various general anaesthetic agents and for this reason particular vigilance is required as more patients receiving these agents are admitted for surgical procedures.
    MeSH term(s) Calcium Channel Blockers/pharmacokinetics ; Calcium Channel Blockers/pharmacology ; Calcium Channel Blockers/therapeutic use ; Humans
    Chemical Substances Calcium Channel Blockers
    Language English
    Publishing date 1983-05
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 82022-2
    ISSN 0008-2856
    ISSN 0008-2856
    DOI 10.1007/bf03009971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: L'angine instable.

    Mizgala, H F

    L'union medicale du Canada

    1979  Volume 108, Issue 10, Page(s) 1251–1252

    Title translation Unstable angina.
    MeSH term(s) Angina Pectoris/diagnosis ; Humans ; Myocardial Infarction/diagnosis
    Language French
    Publishing date 1979-10
    Publishing country Canada
    Document type Editorial
    ZDB-ID 390006-x
    ISSN 0041-6959 ; 0701-2543
    ISSN 0041-6959 ; 0701-2543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Letter: Surgical vs. medical therapy in unstable angian.

    Mizgala, H F

    The American journal of cardiology

    1975  Volume 36, Issue 1, Page(s) 119–120

    MeSH term(s) Angina Pectoris/surgery ; Angina Pectoris/therapy ; Follow-Up Studies ; Humans ; Length of Stay ; Long-Term Care
    Language English
    Publishing date 1975-07
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/0002-9149(75)90878-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Effect of diltiazem overdose.

    Jakubowski, A T / Mizgala, H F

    The American journal of cardiology

    1987  Volume 60, Issue 10, Page(s) 932–933

    MeSH term(s) Adult ; Bradycardia/chemically induced ; Bradycardia/therapy ; Diltiazem/poisoning ; Humans ; Male ; Suicide, Attempted
    Chemical Substances Diltiazem (EE92BBP03H)
    Language English
    Publishing date 1987-10-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/0002-9149(87)91058-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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