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  1. Article ; Online: Valerie Horsley: getting under the skin. Interview by Ben Short.

    Horsley, Valerie

    The Journal of cell biology

    2009  Volume 184, Issue 4, Page(s) 466–467

    MeSH term(s) Awards and Prizes ; Biomedical Research ; Cell Biology/history ; History, 20th Century ; Medical Laboratory Personnel ; Portraits as Topic ; Skin/cytology ; Stem Cells/cytology ; Transcription, Genetic ; United States
    Language English
    Publishing date 2009-02-23
    Publishing country United States
    Document type Biography ; Historical Article ; Interview
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.1844pi
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cut out that YAPping: Mechanisms to reduce scar formation.

    Horsley, Valerie

    Cell stem cell

    2022  Volume 29, Issue 2, Page(s) 179–181

    Abstract: Tissue repair in adult mammals lacks the regenerative ability of many tissues in other adult organisms like axolotl and newts. In this issue of Cell Stem Cell, Mascharak et al. use multi-omics approaches to identify an essential role for the ... ...

    Abstract Tissue repair in adult mammals lacks the regenerative ability of many tissues in other adult organisms like axolotl and newts. In this issue of Cell Stem Cell, Mascharak et al. use multi-omics approaches to identify an essential role for the transcription factor Trps1 in Yap-inhibited fibroblasts' tissue regenerative responses in murine skin.
    MeSH term(s) Animals ; Cicatrix/pathology ; Fibroblasts/pathology ; Mammals ; Mice ; Skin/pathology ; Transcription Factors ; Wound Healing/physiology
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2022-02-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2022.01.005
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    Zs.A 6589: Show issues Location:
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  3. Article ; Online: Adipocyte plasticity in tissue regeneration, repair, and disease.

    Horsley, Valerie

    Current opinion in genetics & development

    2022  Volume 76, Page(s) 101968

    Abstract: Mammalian tissue repair forms a scar that fills the injured area with a fibrotic lesion, limiting tissue function. Adipocytes, lipid-filled cells, well-known for energy storage and endocrine functions, can reside adjacent to or within many tissues, and ... ...

    Abstract Mammalian tissue repair forms a scar that fills the injured area with a fibrotic lesion, limiting tissue function. Adipocytes, lipid-filled cells, well-known for energy storage and endocrine functions, can reside adjacent to or within many tissues, and are emerging as critical regulators of tissue repair. In this review, the plasticity and function of adipocytes to tissue repair and fibrosis in four tissues: skin, heart, skeletal muscle, and mammary gland, will be discussed. The dynamic nature of adipocytes as they release bioactive products, lipids, and adipokines, and their ability to form contractile fibroblasts, is emerging as an essential regulator of wound healing and tumorigenesis in multiple tissues. Thus, modulation of adipocytes may provide therapeutic avenues for regenerative medicine and cancer.
    MeSH term(s) Adipocytes ; Adipokines/genetics ; Animals ; Fibrosis ; Humans ; Lipids ; Mammals ; Regenerative Medicine ; Wound Healing/genetics
    Chemical Substances Adipokines ; Lipids
    Language English
    Publishing date 2022-08-18
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2022.101968
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  4. Article ; Online: Skin in the Game: Stem Cells in Repair, Cancer, and Homeostasis.

    Horsley, Valerie

    Cell

    2020  Volume 181, Issue 3, Page(s) 492–494

    Abstract: The 2020 Canada Gairdner International Award has been awarded to Elaine Fuchs for her discovery of the role of adult skin stem cells in homeostasis, wound repair, inflammation, and cancer. These insights have established a foundation for basic knowledge ... ...

    Abstract The 2020 Canada Gairdner International Award has been awarded to Elaine Fuchs for her discovery of the role of adult skin stem cells in homeostasis, wound repair, inflammation, and cancer. These insights have established a foundation for basic knowledge on how adult stem cells form, maintain, and repair tissues and have provided the groundwork for additional exploration and discovery of pathways in other stem cell systems.
    MeSH term(s) Adult Stem Cells/metabolism ; Adult Stem Cells/physiology ; Animals ; Awards and Prizes ; Canada ; Epidermal Cells/metabolism ; Female ; History, 20th Century ; History, 21st Century ; Homeostasis/physiology ; Humans ; Neoplasms/metabolism ; Skin/metabolism ; Wound Healing/physiology
    Language English
    Publishing date 2020-03-31
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.03.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lifting Each Other Up: Epidermal Stem Cells in Tissue Homeostasis.

    Horsley, Valerie

    Developmental cell

    2019  Volume 51, Issue 3, Page(s) 296–298

    Abstract: Multiple stem cells maintain and repair tissues, yet how they communicate is not well understood. In this issue of Developmental Cell, Veniaminova et al. (2019) report that each sebaceous gland is maintained by local stem cells and that Notch signaling ... ...

    Abstract Multiple stem cells maintain and repair tissues, yet how they communicate is not well understood. In this issue of Developmental Cell, Veniaminova et al. (2019) report that each sebaceous gland is maintained by local stem cells and that Notch signaling regulates multiple aspects of their function, revealing tissue homeostasis mechanisms.
    MeSH term(s) Cell Differentiation ; Homeostasis ; Lifting ; Receptors, Notch ; Sebaceous Glands ; Stem Cells
    Chemical Substances Receptors, Notch
    Language English
    Publishing date 2019-10-31
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2019.10.013
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    Zs.MG 76: Show issues

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  6. Article ; Online: Reindeer light the way to scarless wound healing.

    Caves, Elizabeth / Horsley, Valerie

    Cell

    2022  Volume 185, Issue 25, Page(s) 4675–4677

    Abstract: Wound healing in adult mammalian tissues generally involves scarring instead of tissue regeneration. A study in this issue of Cell reveals that after injury, reindeer antler skin regenerates by priming regenerative genes in wound fibroblasts instead of ... ...

    Abstract Wound healing in adult mammalian tissues generally involves scarring instead of tissue regeneration. A study in this issue of Cell reveals that after injury, reindeer antler skin regenerates by priming regenerative genes in wound fibroblasts instead of forming a scar through an inflammatory gene program.
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.11.013
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  7. Article ; Online: Research Techniques Made Simple: Scientific Communication using Twitter.

    Daneshjou, Roxana / Shmuylovich, Leonid / Grada, Ayman / Horsley, Valerie

    The Journal of investigative dermatology

    2021  Volume 141, Issue 7, Page(s) 1615–1621.e1

    Abstract: The scientific process depends on social interactions: communication and dissemination of research findings, evaluation and discussion of scientific work, and collaboration with other scientists. Social media, and specifically, Twitter has accelerated ... ...

    Abstract The scientific process depends on social interactions: communication and dissemination of research findings, evaluation and discussion of scientific work, and collaboration with other scientists. Social media, and specifically, Twitter has accelerated the ability to accomplish these goals. We discuss the ways that Twitter is used by scientists and provide guidance on navigating the academic Twitter community.
    MeSH term(s) Biomedical Research/methods ; Communication ; Dermatology/methods ; Humans ; Information Dissemination ; Research Personnel ; Social Media
    Language English
    Publishing date 2021-06-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2021.03.026
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  8. Article ; Online: Thin Skinned: Aged Adipocyte Atrophy Impacts Innate Immunity.

    Wasko, Renee R / Horsley, Valerie

    Trends in immunology

    2019  Volume 40, Issue 3, Page(s) 175–177

    Abstract: In a recent study, Zhang et al. (Immunity 2019;50:121-136) report that adipocyte atrophy in aged skin increases susceptibility to bacterial infection. Enhanced TGF-β signaling in aged adipocyte progenitor cells induces a fibrotic cell fate that lacks ... ...

    Abstract In a recent study, Zhang et al. (Immunity 2019;50:121-136) report that adipocyte atrophy in aged skin increases susceptibility to bacterial infection. Enhanced TGF-β signaling in aged adipocyte progenitor cells induces a fibrotic cell fate that lacks antimicrobial peptides produced by mature adipocytes, highlighting the importance of stromal cells as innate immune effectors.
    MeSH term(s) Adipocytes/metabolism ; Adipocytes/pathology ; Adipogenesis ; Adipose Tissue, White/pathology ; Aging/physiology ; Animals ; Antimicrobial Cationic Peptides/metabolism ; Disease Resistance ; Fibrosis ; Humans ; Immunity, Innate ; Mice ; Skin Physiological Phenomena ; Staphylococcal Infections/immunology ; Staphylococcus aureus/physiology
    Chemical Substances Antimicrobial Cationic Peptides ; ropocamptide (3DD771JO2H)
    Language English
    Publishing date 2019-01-31
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2019.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Split decisions: oesophageal progenitor cell behaviour.

    Horsley, Valerie

    The EMBO journal

    2012  Volume 31, Issue 18, Page(s) 3653–3654

    Language English
    Publishing date 2012-08-10
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.1038/emboj.2012.230
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  10. Article ; Online: T

    Horsley, Valerie / Naik, Shruti

    Developmental cell

    2017  Volume 41, Issue 5, Page(s) 455–456

    Abstract: Regulatory T cells ( ... ...

    Abstract Regulatory T cells (T
    MeSH term(s) Cell Differentiation ; Hair Follicle/cytology ; Humans ; Signal Transduction ; Skin ; Stem Cell Niche ; Stem Cells/cytology
    Language English
    Publishing date 2017-06-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2017.05.020
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