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  1. Article ; Online: NK cell dysfunction in patients with COVID-19.

    Bi, Jiacheng

    Cellular & molecular immunology

    2022  Volume 19, Issue 2, Page(s) 127–129

    MeSH term(s) COVID-19/blood ; COVID-19/immunology ; COVID-19/therapy ; COVID-19/virology ; Cell- and Tissue-Based Therapy/methods ; Coronavirus Nucleocapsid Proteins/metabolism ; Cytokines/blood ; Humans ; Immune Checkpoint Proteins/blood ; Immunotherapy/methods ; Killer Cells, Natural/immunology ; Killer Cells, Natural/pathology ; Phosphoproteins/metabolism ; SARS-CoV-2/metabolism ; Severity of Illness Index
    Chemical Substances Coronavirus Nucleocapsid Proteins ; Cytokines ; Immune Checkpoint Proteins ; Phosphoproteins ; nucleocapsid phosphoprotein, SARS-CoV-2
    Language English
    Publishing date 2022-01-13
    Publishing country China
    Document type Journal Article
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-021-00825-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6681: Show issues Location:
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  2. Article ; Online: CD226: a potent driver of antitumor immunity that needs to be maintained.

    Bi, Jiacheng

    Cellular & molecular immunology

    2021  Volume 19, Issue 9, Page(s) 969–970

    MeSH term(s) Killer Cells, Natural ; Receptors, Virus
    Chemical Substances Receptors, Virus
    Language English
    Publishing date 2021-01-08
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-020-00633-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Expression Regulation and Function of T-Bet in NK Cells.

    Huang, Chen / Bi, Jiacheng

    Frontiers in immunology

    2021  Volume 12, Page(s) 761920

    Abstract: Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in immune surveillance. The development, maturation and effector functions of NK cells are orchestrated by the T-box transcription factor T-bet, whose expression is ... ...

    Abstract Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in immune surveillance. The development, maturation and effector functions of NK cells are orchestrated by the T-box transcription factor T-bet, whose expression is induced by cytokines such as IFN-γ, IL-12, IL-15 and IL-21 through the respective cytokine receptors and downstream JAK/STATs or PI3K-AKT-mTORC1 signaling pathways. In this review, we aim to discuss the expression and regulation of T-bet in NK cells, the role of T-bet in mouse NK cell development, maturation, and function, as well as the role of T-bet in acute, chronic infection, inflammation, autoimmune diseases and tumors.
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Humans ; Infections/immunology ; Inflammation/immunology ; Killer Cells, Natural/immunology ; Neoplasms/immunology ; T-Box Domain Proteins/immunology
    Chemical Substances T-Box Domain Proteins ; T-box transcription factor TBX21
    Language English
    Publishing date 2021-10-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.761920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular Regulation of NK Cell Maturation.

    Bi, Jiacheng / Wang, Xuefu

    Frontiers in immunology

    2020  Volume 11, Page(s) 1945

    Abstract: Natural killer (NK) cells are innate lymphocytes specialized in immune surveillance against tumors and infections. To reach their optimal functional status, NK cells must undergo a process of maturation from immature to mature NK cells. Genetically ... ...

    Abstract Natural killer (NK) cells are innate lymphocytes specialized in immune surveillance against tumors and infections. To reach their optimal functional status, NK cells must undergo a process of maturation from immature to mature NK cells. Genetically modified mice, as well as
    MeSH term(s) Cell Differentiation ; Communicable Diseases/genetics ; Communicable Diseases/immunology ; Communicable Diseases/metabolism ; Cytokines/genetics ; Cytokines/metabolism ; Gene Expression Regulation ; Host-Pathogen Interactions ; Humans ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Phenotype ; Signal Transduction ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Cytokines ; Transcription Factors
    Keywords covid19
    Language English
    Publishing date 2020-08-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Increased expression of adenosine A3 receptor in tumor-infiltrating natural killer cells.

    Bi, Jiacheng / Zheng, Chaoyue / Zheng, Xiaohu

    Cellular & molecular immunology

    2021  Volume 18, Issue 2, Page(s) 496–497

    MeSH term(s) Carcinoma, Hepatocellular/immunology ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Case-Control Studies ; Humans ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Liver Neoplasms/immunology ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Receptor, Adenosine A3/metabolism
    Chemical Substances ADORA3 protein, human ; Receptor, Adenosine A3
    Language English
    Publishing date 2021-01-08
    Publishing country China
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-020-00632-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6681: Show issues Location:
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  6. Article ; Online: Suppression of protein quality control system by TRIM30a sensitises tumour cells to NK cell-mediated immune surveillance.

    Afolabi, Lukman O / Bi, Jiacheng / Chen, Liang / Yang, Xiaolu / Wan, Xiaochun

    Immunology

    2023  Volume 171, Issue 1, Page(s) 60–76

    Abstract: Tumorigenesis entails circumventing cell-intrinsic regulatory mechanisms while avoiding extrinsic immune surveillance and other host defence systems. Nevertheless, how tumour cells' ability to eliminate misfolded proteins affects immune surveillance ... ...

    Abstract Tumorigenesis entails circumventing cell-intrinsic regulatory mechanisms while avoiding extrinsic immune surveillance and other host defence systems. Nevertheless, how tumour cells' ability to eliminate misfolded proteins affects immune surveillance remains poorly understood. In this study, we find that overexpression of murine tripartite motif-containing protein 30a (TRIM30a) sensitises tumour cells to natural killer (NK) cells-mediated cytolysis. TRIM30a has no effect on tumour cell proliferation or apoptosis in vitro. However, TRIM30a-overexpressing tumour cells grow substantially slower than control tumour cells in immune-competent mice but not in NK cell-depleted mice. [Correction added on 04 October 2023, after first online publication: 'NK-depleted' has been changed to 'NK cell-depleted' in the preceding sentence.] Mechanistically, TRIM30a overexpression impedes the clearance of misfolded proteins and increases the production of reactive oxygen species induced by proteotoxic stress, implying that TRIM30a impairs protein quality control (PQC) systems in tumour cells. Furthermore, TRIM30a reduces expression of genes encoding proteasome subunits and antioxidant proteins. Our study demonstrates that TRIM30a is a potential tumour suppressor and immune modulator that promotes tumour cytolysis by NK cells, and suggests that an enhanced PQC and antioxidant capacity is an integral part of the immune escape mechanism during tumorigenesis.
    MeSH term(s) Animals ; Mice ; Antioxidants/metabolism ; Carcinogenesis/metabolism ; Killer Cells, Natural ; Neoplasms ; Reactive Oxygen Species/metabolism
    Chemical Substances Antioxidants ; Reactive Oxygen Species ; Trim30a protein, mouse
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/imm.13694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.181: Show issues Location:
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  7. Article ; Online: Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8

    Bi, Jiacheng / Jin, Xiaomeng / Zheng, Chaoyue / Huang, Chen / Zhong, Chao / Zheng, Xiaohu / Tian, Zhigang / Sun, Haoyu

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 12, Page(s) e2207499

    Abstract: Natural killer (NK) cells not only are innate effector lymphocytes that directly participate in tumor surveillance but are also essential helpers in the antitumor ... ...

    Abstract Natural killer (NK) cells not only are innate effector lymphocytes that directly participate in tumor surveillance but are also essential helpers in the antitumor CD8
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Killer Cells, Natural ; Neoplasms/therapy ; Neoplasms/pathology ; Proteins ; Immunotherapy
    Chemical Substances Proteins
    Language English
    Publishing date 2023-02-19
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202207499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: NK Cell Dysfunction and Checkpoint Immunotherapy.

    Bi, Jiacheng / Tian, Zhigang

    Frontiers in immunology

    2019  Volume 10, Page(s) 1999

    Abstract: NK cells play important roles in the innate immune responses against tumors. The effector function of NK cells relies on the integration of activating and inhibitory signals. Emerging checkpoint receptors and molecules are being revealed to mediate NK ... ...

    Abstract NK cells play important roles in the innate immune responses against tumors. The effector function of NK cells relies on the integration of activating and inhibitory signals. Emerging checkpoint receptors and molecules are being revealed to mediate NK cell dysfunction in the tumor microenvironment. Inhibition of some NK cell surface checkpoint receptors has displayed the potential to reverse NK cell dysfunction in tumors, and to boost anti-tumor immunity, both in clinical trials (anti-KIR and anti-NKG2A), and in preclinical studies (e.g., anti-TIGIT, and anti-CD96). To fully exploit the potential of NK-based checkpoint immunotherapy, more understanding of the regional features of NK cells in the tumor microenvironment is required. This will provide valuable information regarding the dynamic nature of NK cell immune response against tumors, as well as novel checkpoints or pathways to be targeted. In this Review, we discuss recent advances in the understanding of NK cell dysfunction in tumors, as well as emerging strategies of NK-based checkpoint immunotherapy for tumors.
    MeSH term(s) Animals ; Humans ; Immunotherapy ; Killer Cells, Natural/immunology ; Neoplasms/immunology ; Neoplasms/therapy
    Language English
    Publishing date 2019-08-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.01999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: TIPE2

    Bi, Jiacheng / Huang, Chen / Jin, Xiaomeng / Zheng, Chaoyue / Huang, Yingying / Zheng, Xiaohu / Tian, Zhigang / Sun, Haoyu

    Journal for immunotherapy of cancer

    2023  Volume 11, Issue 2

    Abstract: Background: To enhance the efficacy of adoptive NK cell therapy against solid tumors, NK cells must be modified to resist exhaustion in the tumor microenvironment (TME). However, the molecular checkpoint underlying NK cell exhaustion in the TME remains ... ...

    Abstract Background: To enhance the efficacy of adoptive NK cell therapy against solid tumors, NK cells must be modified to resist exhaustion in the tumor microenvironment (TME). However, the molecular checkpoint underlying NK cell exhaustion in the TME remains elusive.
    Methods: We analyzed the correlation between
    Results: By single-cell transcriptomic analysis and by using gene reporter mice, we found that
    Conclusions: This study highlighted TIPE2 targeting as a promising approach for enhancing adoptive NK cell therapy against solid tumors.
    MeSH term(s) Animals ; Humans ; Mice ; Immunotherapy, Adoptive ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Killer Cells, Natural/metabolism ; Neoplasms/metabolism ; Tumor Microenvironment
    Chemical Substances Intracellular Signaling Peptides and Proteins ; TIPE2 protein, mouse ; TNFAIP8L2 protein, human
    Language English
    Publishing date 2023-01-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2022-006002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Review immune response of targeting CD39 in cancer.

    Liu, Yao / Li, Zhongliang / Zhao, Xiaoguang / Xiao, Jing / Bi, Jiacheng / Li, Xian-Yang / Chen, Guokai / Lu, Ligong

    Biomarker research

    2023  Volume 11, Issue 1, Page(s) 63

    Abstract: The ATP-adenosine pathway has emerged as a promising target for cancer therapy, but challenges remain in achieving effective tumor control. Early research focused on blocking the adenosine generating enzyme CD73 and the adenosine receptors A2AR or A2BR ... ...

    Abstract The ATP-adenosine pathway has emerged as a promising target for cancer therapy, but challenges remain in achieving effective tumor control. Early research focused on blocking the adenosine generating enzyme CD73 and the adenosine receptors A2AR or A2BR in cancer. However, recent studies have shown that targeting CD39, the rate-limiting ecto-enzyme of the ATP-adenosine pathway, can provide more profound anti-tumor efficacy by reducing immune-suppressive adenosine accumulation and increasing pro-inflammatory ATP levels. In addition, combining CD39 blocking antibody with PD-1 immune checkpoint therapy may have synergistic anti-tumor effects and improve patient survival. This review will discuss the immune components that respond to CD39 targeting in the tumor microenvironment. Targeting CD39 in cancer has been shown to not only decrease adenosine levels in the tumor microenvironment (TME), but also increase ATP levels. Additionally, targeting CD39 can limit the function of Treg cells, which are known to express high levels of CD39. With phase I clinical trials of CD39 targeting currently underway, further understanding and rational design of this approach for cancer therapy are expected.
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699926-2
    ISSN 2050-7771
    ISSN 2050-7771
    DOI 10.1186/s40364-023-00500-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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