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  1. Article ; Online: The blocking effect of zinc on complement factor H

    Kerboua, Kheir Eddine / Lasla, Saadia / Kerboua, Maria-Hadjer / Djennouhat, Kamel

    Journal of immunoassay & immunochemistry

    2023  Volume 44, Issue 3, Page(s) 309–312

    MeSH term(s) Humans ; Complement Factor H/genetics ; Zinc/pharmacology ; Mutation ; Atypical Hemolytic Uremic Syndrome
    Chemical Substances Complement Factor H (80295-65-4) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050610-7
    ISSN 1532-4230 ; 1532-1819
    ISSN (online) 1532-4230
    ISSN 1532-1819
    DOI 10.1080/15321819.2023.2173529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: NLR: A Cost-effective Nomogram to Guide Therapeutic Interventions in COVID-19.

    Kerboua, Kheir Eddine

    Immunological investigations

    2020  Volume 50, Issue 1, Page(s) 92–100

    Abstract: COVID-19 exhibits a non-yet elucidated heterogeneity dominated by mild form of the illness. Nevertheless, mortality is frequent among patients with a delayed innate immune response that suddenly exacerbates during the second week after admission leading ... ...

    Abstract COVID-19 exhibits a non-yet elucidated heterogeneity dominated by mild form of the illness. Nevertheless, mortality is frequent among patients with a delayed innate immune response that suddenly exacerbates during the second week after admission leading to a lethal over inflammation. Therefore, this rapid and unpredictable deterioration requires timely prediction of COVID-19 refractoriness and critical illness. The two biomarkers readily available in routine laboratories, blood lymphocytes and neutrophil counts, are expected to provide an accurate clinical tool to incline reasonable medication and care because lymphopenia marks immune exhaustion while neutrophilia demonstrates the immunological exuberation. Meanwhile, combining the two parameters as a Neutrophil-to-lymphocyte ratio (NLR) helps to constitute a powerful predictive and prognostic nomogram. This scoring tool allows clinicians to stratify COVID-19 severities on admission and guide early interventions to accelerate recovery and shorten the course of disease in order to alleviate the shortage of medical resources and reduce mortality.
    MeSH term(s) Biomarkers/blood ; COVID-19/drug therapy ; COVID-19/mortality ; COVID-19/pathology ; Cost-Benefit Analysis ; Critical Illness ; Humans ; Lymphocyte Count ; Lymphocytes/cytology ; Lymphocytes/immunology ; Lymphopenia/immunology ; Neutrophils/cytology ; Neutrophils/immunology ; Nomograms ; SARS-CoV-2 ; Severity of Illness Index
    Chemical Substances Biomarkers
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 632565-8
    ISSN 1532-4311 ; 0882-0139
    ISSN (online) 1532-4311
    ISSN 0882-0139
    DOI 10.1080/08820139.2020.1773850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The evaluation of some serum immunochemical markers in early onset pre-eclamptic women from Algeria.

    Kerboua, Kheir Eddine / Laasla, Saadia

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2022  Volume 88, Issue 3, Page(s) e13587

    Abstract: Problem: Progress in understanding the underlying mechanism responsible for the syndrome pre-eclampsia should reconfigure antenatal clinical care and minimize human and financial costs, yet at present there is no accurate theory that permits development ...

    Abstract Problem: Progress in understanding the underlying mechanism responsible for the syndrome pre-eclampsia should reconfigure antenatal clinical care and minimize human and financial costs, yet at present there is no accurate theory that permits development of reliable predictive tests and prophylactic intervention to mitigate disease. To contribute to this ongoing effort, we aimed to assess various circulating markers pertaining to different theories.
    Method of study: Serum samples from thirty-four women with established early onset preeclampsia (ePE) were assessed in terms of oxidative stress (malondialdehyde- MDA), angiogenic status (PlGF & sFLT-1), complement system (The alternative pathway- AP
    Results: Our work shows that PlGF is the only serum marker who does exhibit a continued decrease from NPW to GH to ePE (r
    Conclusion: Our data confirm that the angiogenic factor PlGF may be highly relevant in biological mechanisms underlying the development of ePE.
    MeSH term(s) Algeria ; Biomarkers ; Female ; Humans ; Placenta Growth Factor ; Pre-Eclampsia/diagnosis ; Pregnancy ; Pregnancy Trimester, Second ; Vascular Endothelial Growth Factor Receptor-1
    Chemical Substances Biomarkers ; Placenta Growth Factor (144589-93-5) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1)
    Language English
    Publishing date 2022-07-07
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.13587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1653: Show issues Location:
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  4. Article ; Online: NLR

    Kerboua, Kheir Eddine

    Immunological Investigations

    A Cost-effective Nomogram to Guide Therapeutic Interventions in COVID-19

    2020  , Page(s) 1–9

    Keywords Immunology ; General Medicine ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 632565-8
    ISSN 1532-4311 ; 0882-0139
    ISSN (online) 1532-4311
    ISSN 0882-0139
    DOI 10.1080/08820139.2020.1773850
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 988: Show issues Location:
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  5. Article: The perplexing question of trained immunity versus adaptive memory in COVID-19

    Kerboua, Kheir Eddine

    J. med. virol

    Abstract: The wide spectrum of symptoms observed in COVID-19 appears to defy explanation. Apart from geographic limitation to people with prior exposure to other coronaviruses and air pollutants, inflammatory comordidities and older ages are also among the main ... ...

    Abstract The wide spectrum of symptoms observed in COVID-19 appears to defy explanation. Apart from geographic limitation to people with prior exposure to other coronaviruses and air pollutants, inflammatory comordidities and older ages are also among the main factors of susceptibility to severe illness. The unusual epidemiological data pointed out in children and African territories have revealed new insights in host-pathogen interplay with more focus on epigenetic regulation of cognitive compartments belonging to innate immunity. Should trained immunity be proven to be involved in timely immune responsiveness against SARS-CoV-2 and that adaptive memory could be detrimental, both treatment regimens and vaccine design will tremendously change accordingly with more focus on upper respiratory tissue innate immunity to subdue this threat underway. This article is protected by copyright. All rights reserved.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32470151
    Database COVID19

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  6. Article: NLR: A Cost-effective Nomogram to Guide Therapeutic Interventions in COVID-19

    Kerboua, Kheir Eddine

    Immunol Invest

    Abstract: COVID-19 exhibits a non-yet elucidated heterogeneity dominated by mild form of the illness. Nevertheless, mortality is frequent among patients with a delayed innate immune response that suddenly exacerbates during the second week after admission leading ... ...

    Abstract COVID-19 exhibits a non-yet elucidated heterogeneity dominated by mild form of the illness. Nevertheless, mortality is frequent among patients with a delayed innate immune response that suddenly exacerbates during the second week after admission leading to a lethal over inflammation. Therefore, this rapid and unpredictable deterioration requires timely prediction of COVID-19 refractoriness and critical illness. The two biomarkers readily available in routine laboratories, blood lymphocytes and neutrophil counts, are expected to provide an accurate clinical tool to incline reasonable medication and care because lymphopenia marks immune exhaustion while neutrophilia demonstrates the immunological exuberation. Meanwhile, combining the two parameters as a Neutrophil-to-lymphocyte ratio (NLR) helps to constitute a powerful predictive and prognostic nomogram. This scoring tool allows clinicians to stratify COVID-19 severities on admission and guide early interventions to accelerate recovery and shorten the course of disease in order to alleviate the shortage of medical resources and reduce mortality.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #459477
    Database COVID19

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  7. Article ; Online: Semi-solid phase assay for the alternative complement pathway activity assessment (AP

    Kerboua, Kheir Eddine / Djenouhat, Kamal

    Journal of immunoassay & immunochemistry

    2019  Volume 41, Issue 2, Page(s) 144–151

    Abstract: Since the introduction of the most expensive drug in the world (Eculizumab) in the therapeutic arsenal of many diseases involving the alternative complement pathway (ACP) in their pathophysiology, the unmet need to perform simple ACP assays affordable ... ...

    Abstract Since the introduction of the most expensive drug in the world (Eculizumab) in the therapeutic arsenal of many diseases involving the alternative complement pathway (ACP) in their pathophysiology, the unmet need to perform simple ACP assays affordable for all countries has become one of the major challenges of the contemporary medicine. The assay currently used is AH
    MeSH term(s) Animals ; Antibodies, Monoclonal, Humanized/therapeutic use ; Chickens ; Complement Inactivating Agents/therapeutic use ; Complement Pathway, Alternative ; Complement System Proteins/analysis ; Humans ; Kidney Diseases/blood ; Kidney Diseases/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; Complement Inactivating Agents ; Complement System Proteins (9007-36-7) ; eculizumab (A3ULP0F556)
    Language English
    Publishing date 2019-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050610-7
    ISSN 1532-4230 ; 1532-1819
    ISSN (online) 1532-4230
    ISSN 1532-1819
    DOI 10.1080/15321819.2019.1696819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1606: Show issues Location:
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  8. Article ; Online: Complementology's foundation: The 100-year anniversary of the Nobel Prize to Jules Bordet.

    Kerboua, Kheir Eddine / Djenouhat, Kamal

    Journal of immunoassay & immunochemistry

    2019  Volume 41, Issue 1, Page(s) 106–116

    Abstract: The discovery of the complement system was associated with the creation of medical serodiagnosis in the early 20th century. Its biotechnological applications, usable even a century after its development by Jules Bordet, preceded for decades the proof of ... ...

    Abstract The discovery of the complement system was associated with the creation of medical serodiagnosis in the early 20th century. Its biotechnological applications, usable even a century after its development by Jules Bordet, preceded for decades the proof of its biochemical rather than biophysical nature. Complement science has begun to emerge, thanks to the labs of Michael Heidelberger and his student Manfred Martin Mayer. Complementology had known difficult moments like the suicide of Louis Pillemer by swallowing the reagents of his laboratory following the criticisms of his discovery by Robert A. Nelson, Jr., in March 1957, at the Walter Reed Army Institute. This alternative complement pathway continues to revolutionize medicine by its implications as the principal component of immunosurveillance and as an amplification loop for plasma proteolytic cascades. Moreover, the drug designed in pathologies related to this pathway, eculizumab, was the most expensive drug in the world at the beginning of its marketing. Complementology promises great hopes in inflammatory and degenerative diseases, regenerative medicine, transplantation, and vector nanotechnology and as a diagnostic tool primarily in transplantation and inflammatory imaging. The moral and historical responsibility requires to make known this legacy to the new generation of doctors and scientists and also the technicians of the clinical laboratory of complementology throughout the world.
    MeSH term(s) Anniversaries and Special Events ; Complement System Proteins/history ; Complement System Proteins/immunology ; History, 20th Century ; Humans ; Nobel Prize
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2019-11-20
    Publishing country England
    Document type Historical Article ; Letter
    ZDB-ID 2050610-7
    ISSN 1532-4230 ; 1532-1819
    ISSN (online) 1532-4230
    ISSN 1532-1819
    DOI 10.1080/15321819.2019.1689999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1606: Show issues Location:
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  9. Article ; Online: C3:CH50 ratio as a proposed composite marker for eculizumab monitoring in atypical hemolytic uremic syndrome: Preliminary results.

    Kerboua, Kheir Eddine / Haiba, Fatma / Batouche, Djamila

    Journal of immunoassay & immunochemistry

    2017  Volume 38, Issue 2, Page(s) 178–189

    Abstract: Treatment of atypical hemolytic uremic syndrome (aHUS) by the complement C5 inhibitor eculizumab (Soliris®) is highly effective but unfortunately, associated with an economic pressure on the health care systems even in high incomes countries. Despite ... ...

    Abstract Treatment of atypical hemolytic uremic syndrome (aHUS) by the complement C5 inhibitor eculizumab (Soliris®) is highly effective but unfortunately, associated with an economic pressure on the health care systems even in high incomes countries. Despite spacing infusions having been proposed as the unique solution to minimize this economic impact, no reliable laboratory assays are available to tailor such therapy optimization. We aimed to propose and evaluate a complement composite marker for eculizumab efficacy monitoring in aHUS. We have retrospectively analyzed complement profiles data of eight aHUS patients under eculizumab from the International Registry of HUS/Thrombotic Thrombocytopenia Purpura, and calculated a novel marker "C3:CH
    MeSH term(s) Adult ; Antibodies, Monoclonal, Humanized/therapeutic use ; Atypical Hemolytic Uremic Syndrome/blood ; Atypical Hemolytic Uremic Syndrome/drug therapy ; Biomarkers/blood ; Child ; Complement C3/analysis ; Complement Hemolytic Activity Assay ; Female ; Humans ; Male ; Retrospective Studies
    Chemical Substances Antibodies, Monoclonal, Humanized ; Biomarkers ; Complement C3 ; eculizumab (A3ULP0F556)
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050610-7
    ISSN 1532-4230 ; 1532-1819
    ISSN (online) 1532-4230
    ISSN 1532-1819
    DOI 10.1080/15321819.2016.1234485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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