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Article ; Online: Inflammasome-Independent Roles of NLR and ALR Family Members.

Gupta, Suman / Cassel, Suzanne L / Sutterwala, Fayyaz S

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2696, Page(s) 29–45

Abstract: Pattern recognition receptors, including members of the NLR and ALR families, are essential for recognition of both pathogen- and host-derived danger signals. Several members of these families, including NLRP1, NLRP3, NLRC4, and AIM2, are capable of ... ...

Abstract	Pattern recognition receptors, including members of the NLR and ALR families, are essential for recognition of both pathogen- and host-derived danger signals. Several members of these families, including NLRP1, NLRP3, NLRC4, and AIM2, are capable of forming multiprotein complexes, called inflammasomes, that result in the activation of pro-inflammatory caspase-1. However, in addition to the formation of inflammasomes, a number of these family members exert inflammasome-independent functions. Here, we will discuss inflammasome-independent functions of NLRC4, NLRP12, and AIM2 and examine their roles in regulating innate and adaptive immune processes.
MeSH term(s)	Humans ; Inflammasomes ; Receptors, Pattern Recognition ; Immunity ; Family ; NLR Family, Pyrin Domain-Containing 3 Protein
Chemical Substances	Inflammasomes ; Receptors, Pattern Recognition ; NLR Family, Pyrin Domain-Containing 3 Protein
Language	English
Publishing date	2023-08-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3350-2_2
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Article ; Online: Confounding role of tumor necrosis factor in cryopyrin-associated periodic syndromes.

Banoth, Balaji / Sutterwala, Fayyaz S

The Journal of clinical investigation

2017 Volume 127, Issue 12, Page(s) 4235–4237

Abstract: The NLRP3 inflammasome is a critical component of the innate immune system and can be activated in response to microbial and endogenous danger signals. Activation of the NLRP3 inflammasome results in caspase-1-dependent secretion of the proinflammatory ... ...

Abstract	The NLRP3 inflammasome is a critical component of the innate immune system and can be activated in response to microbial and endogenous danger signals. Activation of the NLRP3 inflammasome results in caspase-1-dependent secretion of the proinflammatory cytokines IL-1β and IL-18. Gain-of-function missense mutations in NLRP3 result in a group of autoinflammatory diseases collectively known as the cryopyrin-associated periodic syndromes (CAPS). CAPS patients have traditionally been successfully treated with therapeutics targeting the IL-1 pathway; however, there are a number of identified CAPS patients who show only a partial response to IL-1 blockade. In this issue of the JCI, McGeough et al. demonstrated that TNF-α, in addition to IL-1β, plays an important role in promoting NLRP3 inflammasomopathies.
MeSH term(s)	Carrier Proteins ; Cryopyrin-Associated Periodic Syndromes ; Humans ; Inflammasomes ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein ; Tumor Necrosis Factor-alpha
Chemical Substances	Carrier Proteins ; Inflammasomes ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2017-11-13
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI98322
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Article ; Online: Atypical Inflammasomes.

Janowski, Ann M / Sutterwala, Fayyaz S

Methods in molecular biology (Clifton, N.J.)

2016 Volume 1417, Page(s) 45–62

Abstract: Pattern recognition receptors, including members of the NLR and PYHIN families, are essential for recognition of both pathogen- and host-derived danger signals. A number of molecules in these families are capable of forming multiprotein complexes termed ... ...

Abstract	Pattern recognition receptors, including members of the NLR and PYHIN families, are essential for recognition of both pathogen- and host-derived danger signals. A number of molecules in these families are capable of forming multiprotein complexes termed inflammasomes that result in the activation of caspase-1. In addition to NLRP1, NLRP3, NLRC4, and AIM2, which form well-described inflammasome complexes, IFI16, NLRP6, NLRP7, NLRP12, and NLRC5 have also been proposed to form inflammasomes under specific conditions. The structure and function of these atypical inflammasomes will be highlighted here.
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-3566-6_2
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Article ; Online: Monocytes Take Their Own Path to IL-1β.

Elliott, Eric I / Sutterwala, Fayyaz S

Immunity

2016 Volume 44, Issue 4, Page(s) 713–715

Abstract: Generally, two signals are required to activate the NLRP3 inflammasome. In this issue of Immunity, Hornung and colleagues (2016) describe an alternative inflammasome activation pathway in human monocytes triggering activation of the NLRP3 inflammasome in ...

Abstract	Generally, two signals are required to activate the NLRP3 inflammasome. In this issue of Immunity, Hornung and colleagues (2016) describe an alternative inflammasome activation pathway in human monocytes triggering activation of the NLRP3 inflammasome in response to a single stimulus.
MeSH term(s)	Carrier Proteins/metabolism ; Caspase 1/metabolism ; Humans ; Inflammasomes/metabolism ; Interleukin-1beta/metabolism ; Monocytes/metabolism ; Reactive Oxygen Species/metabolism
Chemical Substances	Carrier Proteins ; Inflammasomes ; Interleukin-1beta ; Reactive Oxygen Species ; Caspase 1 (EC 3.4.22.36)
Language	English
Publishing date	2016-04-14
Publishing country	United States
Document type	Comment ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2016.03.015
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article ; Online: NLRP12: The Monarch of the Gut.

Sadeghi, Hengameh / Devkota, Suzanne / Sutterwala, Fayyaz S

Cell host & microbe

2018 Volume 24, Issue 3, Page(s) 326–328

Abstract: Innate pattern recognition receptors have been implicated in the obesity-associated imbalance of gut microbiota. In this issue of Cell Host & Microbe, Truax et al. (2018) report that NLRP12 prevents high-fat-diet-induced obesity by maintaining beneficial ...

Abstract	Innate pattern recognition receptors have been implicated in the obesity-associated imbalance of gut microbiota. In this issue of Cell Host & Microbe, Truax et al. (2018) report that NLRP12 prevents high-fat-diet-induced obesity by maintaining beneficial short-chain fatty acid-producing microbiota.
MeSH term(s)	Diet, High-Fat ; Gastrointestinal Microbiome ; Homeostasis ; Humans ; Immunity, Innate ; Intracellular Signaling Peptides and Proteins ; Obesity/prevention & control
Chemical Substances	Intracellular Signaling Peptides and Proteins ; NLRP12 protein, human
Language	English
Publishing date	2018-09-07
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2018.08.010
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Zs.A 6578: Show issues

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Article ; Online: Initiation and perpetuation of NLRP3 inflammasome activation and assembly.

Elliott, Eric I / Sutterwala, Fayyaz S

Immunological reviews

2015 Volume 265, Issue 1, Page(s) 35–52

Abstract: The NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome is a multiprotein complex that orchestrates innate immune responses to infection and cell stress through activation of caspase-1 and maturation of inflammatory cytokines pro- ... ...

Abstract	The NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome is a multiprotein complex that orchestrates innate immune responses to infection and cell stress through activation of caspase-1 and maturation of inflammatory cytokines pro-interleukin-1β (pro-IL-1β) and pro-IL-18. Activation of the inflammasome during infection can be protective, but unregulated NLRP3 inflammasome activation in response to non-pathogenic endogenous or exogenous stimuli can lead to unintended pathology. NLRP3 associates with mitochondria and mitochondrial molecules, and activation of the NLRP3 inflammasome in response to diverse stimuli requires cation flux, mitochondrial Ca(2+) uptake, and mitochondrial reactive oxygen species accumulation. It remains uncertain whether NLRP3 surveys mitochondrial integrity and senses mitochondrial damage, or whether mitochondria simply serve as a physical platform for inflammasome assembly. The structure of the active, caspase-1-processing NLRP3 inflammasome also requires further clarification, but recent studies describing the prion-like properties of ASC have advanced the understanding of how inflammasome assembly and caspase-1 activation occur while raising new questions regarding the propagation and resolution of NLRP3 inflammasome activation. Here, we review the mechanisms and pathways regulating NLRP3 inflammasome activation, discuss emerging concepts in NLRP3 complex organization, and expose the knowledge gaps hindering a comprehensive understanding of NLRP3 activation.
MeSH term(s)	Animals ; Calcium Signaling ; Carrier Proteins/immunology ; Carrier Proteins/metabolism ; Caspase 1/metabolism ; Humans ; Immunity, Innate ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Mitochondria/metabolism ; Multiprotein Complexes/immunology ; Multiprotein Complexes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein
Chemical Substances	Carrier Proteins ; Inflammasomes ; Multiprotein Complexes ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human ; Caspase 1 (EC 3.4.22.36)
Language	English
Publishing date	2015-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	391796-4
ISSN	1600-065X ; 0105-2896
ISSN (online)	1600-065X
ISSN	0105-2896
DOI	10.1111/imr.12286
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Se 160: Show issues

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Article ; Online: Editorial: dialing down inflammation: LRRC33 regulates Toll-like receptor signaling.

Janowski, Ann M / Sutterwala, Fayyaz S

Journal of leukocyte biology

2014 Volume 96, Issue 1, Page(s) 4–6

MeSH term(s)	Animals ; Carrier Proteins/immunology ; Dendritic Cells/immunology ; Gene Silencing/immunology ; Homeostasis/immunology ; Humans ; Latent TGF-beta Binding Proteins ; Macrophages/immunology ; Receptor Activity-Modifying Proteins ; Toll-Like Receptors/immunology
Chemical Substances	Carrier Proteins ; Latent TGF-beta Binding Proteins ; NRROS protein, human ; Receptor Activity-Modifying Proteins ; Toll-Like Receptors
Language	English
Publishing date	2014-06-28
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1189/jlb.3CE0214-119R
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Zs.A 603: Show issues

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Article ; Online: The Pseudomonas aeruginosa Type III Secretion System Exoenzyme Effector ExoU Induces Mitochondrial Damage in a Murine Bone Marrow-Derived Macrophage Infection Model.

Hardy, Kierra S / Tuckey, Amanda N / Housley, Nicole A / Andrews, Joel / Patel, Mita / Al-Mehdi, Abu-Bakr / Barrington, Robert A / Cassel, Suzanne L / Sutterwala, Fayyaz S / Audia, Jonathon P

Infection and immunity

2022 Volume 90, Issue 3, Page(s) e0047021

Abstract: Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that causes nosocomial pneumonia, urinary tract infections, and bacteremia. A hallmark of P. aeruginosa pathogenesis is disruption of host cell function by the type III secretion system ( ... ...

Abstract	Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that causes nosocomial pneumonia, urinary tract infections, and bacteremia. A hallmark of P. aeruginosa pathogenesis is disruption of host cell function by the type III secretion system (T3SS) and its cognate exoenzyme effectors. The T3SS effector ExoU is phospholipase A
MeSH term(s)	Animals ; Caspase 1/metabolism ; Inflammasomes/metabolism ; Inflammation/metabolism ; Macrophages/metabolism ; Mice ; Phospholipases/metabolism ; Pseudomonas Infections ; Pseudomonas aeruginosa/physiology ; Type III Secretion Systems/metabolism
Chemical Substances	Inflammasomes ; Type III Secretion Systems ; Phospholipases (EC 3.1.-) ; Caspase 1 (EC 3.4.22.36)
Language	English
Publishing date	2022-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/IAI.00470-21
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Zs.A 684: Show issues

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Article ; Online: Damage control: management of cellular stress by the NLRP3 inflammasome.

Haasken, Stefanie / Sutterwala, Fayyaz S

European journal of immunology

2013 Volume 43, Issue 8, Page(s) 2003–2005

Abstract: The NLRP3 inflammasome plays a critical role in regulating inflammatory and cell death pathways in response to a diverse array of stimuli. Activation of the NLRP3 inflammasome results in activation of the cysteine protease caspase-1 and the subsequent ... ...

Abstract	The NLRP3 inflammasome plays a critical role in regulating inflammatory and cell death pathways in response to a diverse array of stimuli. Activation of the NLRP3 inflammasome results in activation of the cysteine protease caspase-1 and the subsequent processing and secretion of the proinflammatory cytokines IL-1β and IL-18. In this issue of the European Journal of Immunology, Licandro et al. [Eur. J. Immunol. 2013. 43, 2126-2137] show that the NLRP3 inflammasome contributes to oxidative DNA damage. In addition, activation of the NLRP3 inflammasome modulates a number of pathways involved in DNA damage repair, cell cycle, and apoptosis, suggesting a novel role for the NLRP3 inflammasome in DNA damage responses following cellular stress.
MeSH term(s)	Animals ; Carrier Proteins/metabolism ; DNA Damage/drug effects ; DNA Repair/genetics ; Dendritic Cells/metabolism ; Inflammasomes/immunology ; NLR Family, Pyrin Domain-Containing 3 Protein
Chemical Substances	Carrier Proteins ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, mouse
Language	English
Publishing date	2013-08-09
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.201343848
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Zs.A 489: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 85: Show issues

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Article ; Online: Obesity and cancer: inflammation bridges the two.

Kolb, Ryan / Sutterwala, Fayyaz S / Zhang, Weizhou

Current opinion in pharmacology

2016 Volume 29, Page(s) 77–89

Abstract: Obesity is a growing public health problem and affects 35% US adults. Obesity increases the risk of many cancer types and is associated with poor outcomes. Clinical management of cancer patients has been essentially the same between normal weight and ... ...

Abstract	Obesity is a growing public health problem and affects 35% US adults. Obesity increases the risk of many cancer types and is associated with poor outcomes. Clinical management of cancer patients has been essentially the same between normal weight and obese individuals. Understanding causal mechanisms by which obesity drives cancer initiation and progression is essential for the development of novel precision therapy for obese cancer patients. One caveat is that various mechanisms have been proposed for different cancer types for their progression under obesity. Since obesity is known to have global impact on inflammation, here we will summarize recent literature and discuss the potential of inflammation being the common causal mechanism to promote cancer promotion across cancer types.
MeSH term(s)	Adult ; Animals ; Body Weight ; Disease Progression ; Humans ; Inflammation/complications ; Inflammation/immunology ; Inflammation/pathology ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Obesity/complications ; Obesity/epidemiology ; Obesity/immunology ; United States/epidemiology
Language	English
Publishing date	2016-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2037057-X
ISSN	1471-4973 ; 1471-4892
ISSN (online)	1471-4973
ISSN	1471-4892
DOI	10.1016/j.coph.2016.07.005
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Zs.A 5608: Show issues

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