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Article ; Online: Complementary and Inducible creER

Poulos, Michael G / Ramalingam, Pradeep / Winiarski, Agatha / Gutkin, Michael C / Katsnelson, Lizabeth / Carter, Cody / Pibouin-Fragner, Laurence / Eichmann, Anne / Thomas, Jean-Leon / Miquerol, Lucile / Butler, Jason M

Stem cell reviews and reports

2024

Abstract: In the adult bone marrow (BM), endothelial cells (ECs) are an integral component of the hematopoietic stem cell (HSC)-supportive niche, which modulates HSC activity by producing secreted and membrane-bound paracrine signals. Within the BM, distinct ... ...

Abstract	In the adult bone marrow (BM), endothelial cells (ECs) are an integral component of the hematopoietic stem cell (HSC)-supportive niche, which modulates HSC activity by producing secreted and membrane-bound paracrine signals. Within the BM, distinct vascular arteriole, transitional, and sinusoidal EC subtypes display unique paracrine expression profiles and create anatomically-discrete microenvironments. However, the relative contributions of vascular endothelial subtypes in supporting hematopoiesis is unclear. Moreover, constitutive expression and off-target activity of currently available endothelial-specific and endothelial-subtype-specific murine cre lines potentially confound data analysis and interpretation. To address this, we describe two tamoxifen-inducible cre-expressing lines, Vegfr3-creER
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2495577-2
ISSN	2629-3277 ; 1558-6804 ; 1550-8943
ISSN (online)	2629-3277 ; 1558-6804
ISSN	1550-8943
DOI	10.1007/s12015-024-10703-9
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Article ; Online: Major pulmonary resection after neoadjuvant chemotherapy or chemoradiation in potentially resectable stage III non-small cell lung carcinoma.

Peer, Michael / Azzam, Sharbel / Cyjon, Arnold / Katsnelson, Rivka / Hayat, Henri / Bar, Ilan / Merimsky, Ofer

Scientific reports

2021 Volume 11, Issue 1, Page(s) 20232

Abstract: The aim of this study was to identify predictors of postoperative outcome and survival of locally advanced non-small cell lung carcinoma (NSCLC) resections after neoadjuvant chemotherapy or chemoradiation. Medical records of all patients with clinical ... ...

Abstract	The aim of this study was to identify predictors of postoperative outcome and survival of locally advanced non-small cell lung carcinoma (NSCLC) resections after neoadjuvant chemotherapy or chemoradiation. Medical records of all patients with clinical stage III potentially resectable NSCLC initially treated by neoadjuvant chemotherapy or chemoradiation followed by major pulmonary resections were retrieved from the databases of four Israeli Medical Centers between 1999 to 2019. The 124 suitable patients included, 86 males (69.4%) and 38 females (30.6%), with an average age of 64.2 years (range 37-82) and an average hospital stay of 12.6 days (range 5-123). Complete resection was achieved in 92.7% of the patients, while complete pathologic response was achieved in 35.5%. The overall readmission rate was 16.1%. The overall 5-year survival rate was 47.9%. One patient (0.8%) had local recurrence. Postoperative complications were reported in 49.2% of the patients, mainly atrial fibrillation (15.9%) and pneumonia (13.7%), empyema (10.3%), and early bronchopleural fistula (7.3%). The early in-hospital mortality rate was 6.5%, and the 6-month mortality rate was 5.6%. Pre-neoadjuvant bulky mediastinal disease (lymph nodes > 20 mm) (p = 0.034), persistent postoperative N2 disease (p = 0.016), R1 resection (p = 0.027), preoperative N2 multistation disease (p = 0.053) and postoperative stage IIIA (p = 0.001) emerged as negative predictive factors for survival. Our findings demonstrate that neoadjuvant chemotherapy or chemoradiation in locally advanced potentially resectable NSCLC, followed by major pulmonary resection, is a beneficial approach in selected cases.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Carcinoma, Non-Small-Cell Lung/surgery ; Chemoradiotherapy ; Drug Therapy ; Female ; Humans ; Israel ; Length of Stay ; Lung Neoplasms/drug therapy ; Lung Neoplasms/radiotherapy ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Neoadjuvant Therapy/methods ; Patient Readmission/statistics & numerical data ; Pneumonectomy/methods ; Retrospective Studies ; Risk Factors ; Survival Analysis ; Treatment Outcome
Language	English
Publishing date	2021-10-12
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-99271-3
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Article ; Online: Prevalence and predictors for being unscreened for diabetic retinopathy: a population-based study over a decade.

Felfeli, Tina / Katsnelson, Glen / Kiss, Alex / Plumptre, Lesley / Paterson, J Michael / Ballios, Brian G / Mandelcorn, Efrem D / Glazier, Richard H / Brent, Michael H / Wong, David T

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2022 Volume 58, Issue 4, Page(s) 278–286

Abstract: Objective: To determine the population-level predictors for being unscreened for diabetic retinopathy (DR) among individuals with diabetes in a developed country.: Design: A retrospective population-based repeated-cross-sectional study.: ... ...

Abstract	Objective: To determine the population-level predictors for being unscreened for diabetic retinopathy (DR) among individuals with diabetes in a developed country. Design: A retrospective population-based repeated-cross-sectional study. Participants: All individuals with diabetes (types 1 and 2) aged ≥20 years in the universal health care system in Ontario were identified in the 2011-2013 and 2017-2019 time periods. Methods: The Mantel-Haenszel test was used for the relative risk (RR) comparison of subcategories stratified by the 2 cross-sectional time periods. Results: A total of 1 145 645 and 1 346 578 individuals with diabetes were identified in 2011-2013 and 2017-2019, respectively. The proportion of patients unscreened for DR declined very slightly from 35% (n = 405 967) in 2011-2013 to 34% (n = 455 027) in 2017-2019 of the population with diabetes (RR = 0.967; 95% CI, 0.964-0.9693; p < 0.0001). Young adults aged 20-39 years of age had the highest proportion of unscreened patients (62% and 58% in 2011-2013 and 2017-2019, respectively). Additionally, those who had a lower income quintile (RR = 1.039; 95% CI, 1.036-1.044; p < 0.0001), were recent immigrants (RR = 1.286; 95% CI, 1.280-1.293; p < 0.0001), lived in urban areas (RR = 1.149; 95% CI, 1.145-1.154; p < 0.0001), had a mental health history (RR = 1.117; 95% CI, 1.112-1.122; p < 0.0001), or lacked a connection to a primary care provider (RR = 1.656; 95% CI, 1.644-1.668; p < 0.0001) had a higher risk of being unscreened. Conclusions: This population-based study suggests that over 1 decade, 33% of individuals with diabetes are unscreened for DR, and young age, low income, immigration, residing in a large city, mental health illness, and no primary care access are the main predictors.
MeSH term(s)	Young Adult ; Humans ; Adult ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/epidemiology ; Cross-Sectional Studies ; Prevalence ; Retrospective Studies ; Mental Disorders ; Risk Factors ; Diabetes Mellitus/epidemiology
Language	English
Publishing date	2022-05-13
Publishing country	England
Document type	Journal Article
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2022.04.002
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Article ; Online: Phonon-mediated room-temperature quantum Hall transport in graphene.

Vaquero, Daniel / Clericò, Vito / Schmitz, Michael / Delgado-Notario, Juan Antonio / Martín-Ramos, Adrian / Salvador-Sánchez, Juan / Müller, Claudius S A / Rubi, Km / Watanabe, Kenji / Taniguchi, Takashi / Beschoten, Bernd / Stampfer, Christoph / Diez, Enrique / Katsnelson, Mikhail I / Zeitler, Uli / Wiedmann, Steffen / Pezzini, Sergio

Nature communications

2023 Volume 14, Issue 1, Page(s) 318

Abstract: The quantum Hall (QH) effect in two-dimensional electron systems (2DESs) is conventionally observed at liquid-helium temperatures, where lattice vibrations are strongly suppressed and bulk carrier scattering is dominated by disorder. However, due to ... ...

Abstract	The quantum Hall (QH) effect in two-dimensional electron systems (2DESs) is conventionally observed at liquid-helium temperatures, where lattice vibrations are strongly suppressed and bulk carrier scattering is dominated by disorder. However, due to large Landau level (LL) separation (~2000 K at B = 30 T), graphene can support the QH effect up to room temperature (RT), concomitant with a non-negligible population of acoustic phonons with a wave-vector commensurate to the inverse electronic magnetic length. Here, we demonstrate that graphene encapsulated in hexagonal boron nitride (hBN) realizes a novel transport regime, where dissipation in the QH phase is governed predominantly by electron-phonon scattering. Investigating thermally-activated transport at filling factor 2 up to RT in an ensemble of back-gated devices, we show that the high B-field behaviour correlates with their zero B-field transport mobility. By this means, we extend the well-accepted notion of phonon-limited resistivity in ultra-clean graphene to a hitherto unexplored high-field realm.
Language	English
Publishing date	2023-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-35986-3
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Article ; Online: Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP.

Karmakar, Mausita / Katsnelson, Michael A / Dubyak, George R / Pearlman, Eric

Nature communications

2016 Volume 7, Page(s) 10555

Abstract: Although extracellular ATP is abundant at sites of inflammation, its role in activating inflammasome signalling in neutrophils is not well characterized. In the current study, we demonstrate that human and murine neutrophils express functional cell- ... ...

Abstract	Although extracellular ATP is abundant at sites of inflammation, its role in activating inflammasome signalling in neutrophils is not well characterized. In the current study, we demonstrate that human and murine neutrophils express functional cell-surface P2X7R, which leads to ATP-induced loss of intracellular K(+), NLRP3 inflammasome activation and IL-1β secretion. ATP-induced P2X7R activation caused a sustained increase in intracellular [Ca(2+)], which is indicative of P2X7R channel opening. Although there are multiple polymorphic variants of P2X7R, we found that neutrophils from multiple donors express P2X7R, but with differential efficacies in ATP-induced increase in cytosolic [Ca(2+)]. Neutrophils were also the predominant P2X7R-expressing cells during Streptococcus pneumoniae corneal infection, and P2X7R was required for bacterial clearance. Given the ubiquitous presence of neutrophils and extracellular ATP in multiple inflammatory conditions, ATP-induced P2X7R activation and IL-1β secretion by neutrophils likely has a significant, wide ranging clinical impact.
MeSH term(s)	Adenosine Triphosphate/immunology ; Animals ; Blotting, Western ; Calcium/metabolism ; Carrier Proteins/genetics ; Carrier Proteins/immunology ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Eye Infections, Bacterial/immunology ; Flow Cytometry ; Humans ; Inflammasomes/immunology ; Interleukin-1beta/secretion ; Keratitis/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microscopy, Fluorescence ; NLR Family, Pyrin Domain-Containing 3 Protein ; Neutrophils/drug effects ; Neutrophils/immunology ; Neutrophils/metabolism ; Potassium/metabolism ; Purinergic P2X Receptor Antagonists/pharmacology ; Receptors, Purinergic P2X7/immunology ; Spectrophotometry, Atomic ; Streptococcal Infections/immunology
Chemical Substances	Carrier Proteins ; IL1B protein, human ; IL1B protein, mouse ; Inflammasomes ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human ; Nlrp3 protein, mouse ; Purinergic P2X Receptor Antagonists ; Receptors, Purinergic P2X7 ; Adenosine Triphosphate (8L70Q75FXE) ; Potassium (RWP5GA015D) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2016-02-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2041-1723
ISSN (online)	2041-1723
DOI	10.1038/ncomms10555
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Article ; Online: K+ efflux agonists induce NLRP3 inflammasome activation independently of Ca2+ signaling.

Katsnelson, Michael A / Rucker, L Graham / Russo, Hana M / Dubyak, George R

Journal of immunology (Baltimore, Md. : 1950)

2015 Volume 194, Issue 8, Page(s) 3937–3952

Abstract: Perturbation of intracellular ion homeostasis is a major cellular stress signal for activation of NLRP3 inflammasome signaling that results in caspase-1-mediated production of IL-1β and pyroptosis. However, the relative contributions of decreased ... ...

Abstract	Perturbation of intracellular ion homeostasis is a major cellular stress signal for activation of NLRP3 inflammasome signaling that results in caspase-1-mediated production of IL-1β and pyroptosis. However, the relative contributions of decreased cytosolic K(+) concentration versus increased cytosolic Ca(2+) concentration ([Ca(2+)]) remain disputed and incompletely defined. We investigated roles for elevated cytosolic [Ca(2+)] in NLRP3 activation and downstream inflammasome signaling responses in primary murine dendritic cells and macrophages in response to two canonical NLRP3 agonists (ATP and nigericin) that facilitate primary K(+) efflux by mechanistically distinct pathways or the lysosome-destabilizing agonist Leu-Leu-O-methyl ester. The study provides three major findings relevant to this unresolved area of NLRP3 regulation. First, increased cytosolic [Ca(2+)] was neither a necessary nor sufficient signal for the NLRP3 inflammasome cascade during activation by endogenous ATP-gated P2X7 receptor channels, the exogenous bacterial ionophore nigericin, or the lysosomotropic agent Leu-Leu-O-methyl ester. Second, agonists for three Ca(2+)-mobilizing G protein-coupled receptors (formyl peptide receptor, P2Y2 purinergic receptor, and calcium-sensing receptor) expressed in murine dendritic cells were ineffective as activators of rapidly induced NLRP3 signaling when directly compared with the K(+) efflux agonists. Third, the intracellular Ca(2+) buffer, BAPTA, and the channel blocker, 2-aminoethoxydiphenyl borate, widely used reagents for disruption of Ca(2+)-dependent signaling pathways, strongly suppressed nigericin-induced NLRP3 inflammasome signaling via mechanisms dissociated from their canonical or expected effects on Ca(2+) homeostasis. The results indicate that the ability of K(+) efflux agonists to activate NLRP3 inflammasome signaling can be dissociated from changes in cytosolic [Ca(2+)] as a necessary or sufficient signal.
MeSH term(s)	Adenosine Triphosphate/immunology ; Animals ; Boron Compounds ; Calcium Signaling/drug effects ; Calcium Signaling/immunology ; Carrier Proteins/immunology ; Chelating Agents/pharmacology ; Dipeptides/pharmacology ; Egtazic Acid/analogs & derivatives ; Egtazic Acid/pharmacology ; Immunosuppressive Agents/pharmacology ; Inflammasomes/immunology ; Interleukin-1beta/immunology ; Ionophores/pharmacology ; Mice ; Mice, Knockout ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nigericin/pharmacology ; Potassium/immunology ; Receptors, Purinergic P2X7/immunology
Chemical Substances	Boron Compounds ; Carrier Proteins ; Chelating Agents ; Dipeptides ; IL1B protein, mouse ; Immunosuppressive Agents ; Inflammasomes ; Interleukin-1beta ; Ionophores ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, mouse ; Receptors, Purinergic P2X7 ; leucyl-leucine-methyl ester (13022-42-9) ; Egtazic Acid (526U7A2651) ; Adenosine Triphosphate (8L70Q75FXE) ; 2-aminoethoxydiphenyl borate (E4ES684O93) ; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (K22DDW77C0) ; Nigericin (RRU6GY95IS) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2015-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1402658
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Article ; Online: Carotid disease and stroke.

Lovrencic-Huzjan, Arijana / Rundek, Tatjana / Katsnelson, Michael J

Stroke research and treatment

2012 Volume 2012, Page(s) 264752

Language	English
Publishing date	2012-05-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573724-7
ISSN	2042-0056 ; 2090-8105
ISSN (online)	2042-0056
ISSN	2090-8105
DOI	10.1155/2012/264752
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Article ; Online: Recommendations for management of patients with carotid stenosis.

Lovrencic-Huzjan, Arijana / Rundek, Tatjana / Katsnelson, Michael

Stroke research and treatment

2012 Volume 2012, Page(s) 175869

Abstract: Stroke is a one of the leading causes of morbidity and mortality in the world. Carotid atherosclerosis is recognized as an important factor in stroke pathophysiology and represents a key target in stroke prevention; multiple treatment modalities have ... ...

Abstract	Stroke is a one of the leading causes of morbidity and mortality in the world. Carotid atherosclerosis is recognized as an important factor in stroke pathophysiology and represents a key target in stroke prevention; multiple treatment modalities have been developed to battle this disease. Multiple randomized trials have shown the efficacy of carotid endarterectomy in secondary stroke prevention. Carotid stenting, a newer treatment option, presents a less invasive alternative to the surgical intervention on carotid arteries. Advances in medical therapy have also enabled further risk reduction in the overall incidence of stroke. Despite numerous trials and decades of clinical research, the optimal management of symptomatic and asymptomatic carotid disease remains controversial. We will attempt to highlight some of the pivotal trials already completed, discuss the current controversies and complexities in the treatment decision-making, and postulate on what likely lies ahead. This paper will highlight the complexities of decision-making optimal treatment recommendations for patients with symptomatic and asymptomatic carotid stenosis.
Language	English
Publishing date	2012-05-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573724-7
ISSN	2042-0056 ; 2042-0056
ISSN (online)	2042-0056
ISSN	2042-0056
DOI	10.1155/2012/175869
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Article ; Online: NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx.

Katsnelson, Michael A / Lozada-Soto, Kristen M / Russo, Hana M / Miller, Barbara A / Dubyak, George R

American journal of physiology. Cell physiology

2016 Volume 311, Issue 1, Page(s) C83–C100

Abstract: Nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3 (NLRP3) is a cytosolic protein that nucleates assembly of inflammasome signaling platforms, which facilitate caspase-1-mediated IL-1β release and other ... ...

Abstract	Nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3 (NLRP3) is a cytosolic protein that nucleates assembly of inflammasome signaling platforms, which facilitate caspase-1-mediated IL-1β release and other inflammatory responses in myeloid leukocytes. NLRP3 inflammasomes are assembled in response to multiple pathogen- or environmental stress-induced changes in basic cell physiology, including the destabilization of lysosome integrity and activation of K(+)-permeable channels/transporters in the plasma membrane (PM). However, the quantitative relationships between lysosome membrane permeabilization (LMP), induction of increased PM K(+) permeability, and activation of NLRP3 signaling are incompletely characterized. We used Leu-Leu-O-methyl ester (LLME), a soluble lysosomotropic agent, to quantitatively track the kinetics and extent of LMP in relation to NLRP3 inflammasome signaling responses (ASC oligomerization, caspase-1 activation, IL-1β release) and PM cation fluxes in murine bone marrow-derived dendritic cells (BMDCs). Treatment of BMDCs with submillimolar (≤1 mM) LLME induced slower and partial increases in LMP that correlated with robust NLRP3 inflammasome activation and K(+) efflux. In contrast, supramillimolar (≥2 mM) LLME elicited extremely rapid and complete collapse of lysosome integrity that was correlated with suppression of inflammasome signaling. Supramillimolar LLME also induced dominant negative effects on inflammasome activation by the canonical NLRP3 agonist nigericin; this inhibition correlated with an increase in NLRP3 ubiquitination. LMP elicited rapid BMDC death by both inflammasome-dependent pyroptosis and inflammasome-independent necrosis. LMP also triggered Ca(2+) influx, which attenuated LLME-stimulated NLRP3 inflammasome signaling but potentiated LLME-induced necrosis. Taken together, these studies reveal a previously unappreciated signaling network that defines the coupling between LMP, changes in PM cation fluxes, cell death, and NLRP3 inflammasome activation.
MeSH term(s)	Animals ; Apoptosis Regulatory Proteins/metabolism ; CARD Signaling Adaptor Proteins ; Calcium/metabolism ; Calcium Signaling/drug effects ; Caspase 1/deficiency ; Caspase 1/genetics ; Caspases/deficiency ; Caspases/genetics ; Cells, Cultured ; Dendritic Cells/drug effects ; Dendritic Cells/metabolism ; Dendritic Cells/pathology ; Dipeptides/pharmacology ; Dose-Response Relationship, Drug ; Inflammasomes/drug effects ; Inflammasomes/metabolism ; Interleukin-1beta/metabolism ; Kinetics ; Lysosomes/drug effects ; Lysosomes/metabolism ; Lysosomes/pathology ; Mice, Inbred C57BL ; Mice, Knockout ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Necrosis ; Nigericin/pharmacology ; Permeability ; Potassium/metabolism ; TRPM Cation Channels/deficiency ; TRPM Cation Channels/genetics ; Ubiquitination
Chemical Substances	Apoptosis Regulatory Proteins ; CARD Signaling Adaptor Proteins ; Dipeptides ; IL1B protein, mouse ; Inflammasomes ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, mouse ; Pycard protein, mouse ; TRPM Cation Channels ; TRPM2 protein, mouse ; leucyl-leucine-methyl ester (13022-42-9) ; Casp4 protein, mouse (EC 3.4.22.-) ; Caspases (EC 3.4.22.-) ; Caspase 1 (EC 3.4.22.36) ; Nigericin (RRU6GY95IS) ; Potassium (RWP5GA015D) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2016-05-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	392098-7
ISSN	1522-1563 ; 0363-6143
ISSN (online)	1522-1563
ISSN	0363-6143
DOI	10.1152/ajpcell.00298.2015
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Article ; Online: Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

Mausita Karmakar / Michael A. Katsnelson / George R. Dubyak / Eric Pearlman

Nature Communications, Vol 7, Iss 1, Pp 1-

2016 Volume 13

Abstract: Neutrophils are a major source of IL-1 β in a number of inflammatory settings. Here the authors show that mouse and human neutrophils express functional P2X7 receptors, which mediate ATP-triggered NLRP3 inflammasome activation and IL-1 ß secretion. ...

Abstract	Neutrophils are a major source of IL-1 β in a number of inflammatory settings. Here the authors show that mouse and human neutrophils express functional P2X7 receptors, which mediate ATP-triggered NLRP3 inflammasome activation and IL-1 ß secretion.
Keywords	Science ; Q
Language	English
Publishing date	2016-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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