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  1. Article ; Online: Neurodiversity and Early Autism.

    Bernard, Sarah / Grosjean, Bernadette / Caravallah, Laura

    JAMA pediatrics

    2022  Volume 176, Issue 12, Page(s) 1272–1273

    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2022.4144
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  2. Article ; Online: Welcome signs of the road ahead for autistic doctors and patients.

    McCowan, Sue / Shaw, Sebastian C K / Doherty, Mary / Grosjean, Bernadette / Blank, Paula / Kinnear, Malcolm

    The British journal of psychiatry : the journal of mental science

    2022  Volume 221, Issue 3, Page(s) 582–583

    MeSH term(s) Autistic Disorder/diagnosis ; Humans ; Physicians
    Language English
    Publishing date 2022-08-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 218103-4
    ISSN 1472-1465 ; 0007-1250
    ISSN (online) 1472-1465
    ISSN 0007-1250
    DOI 10.1192/bjp.2022.85
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  3. Article ; Online: A full CIRCLE: inclusion of autistic doctors in the Royal College Of Psychiatrists' values and

    McCowan, Sue / Shaw, Sebastian C K / Doherty, Mary / Grosjean, Bernadette / Blank, Paula / Kinnear, Malcolm

    The British journal of psychiatry : the journal of mental science

    2022  Volume 221, Issue 1, Page(s) 371–373

    Abstract: Autistic psychiatrists bring strengths and values to the workforce and ask to be acknowledged and supported as part of the Royal College of Psychiatrists' CIRCLE values ... ...

    Abstract Autistic psychiatrists bring strengths and values to the workforce and ask to be acknowledged and supported as part of the Royal College of Psychiatrists' CIRCLE values and
    MeSH term(s) Autistic Disorder/therapy ; Humans ; Physicians ; Psychiatry ; Workforce
    Language English
    Publishing date 2022-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 218103-4
    ISSN 1472-1465 ; 0007-1250
    ISSN (online) 1472-1465
    ISSN 0007-1250
    DOI 10.1192/bjp.2022.14
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  4. Article ; Online: The neurodiversity concept viewed through an autistic lens.

    Shaw, Sebastian C K / McCowan, Sue / Doherty, Mary / Grosjean, Bernadette / Kinnear, Malcolm

    The lancet. Psychiatry

    2021  Volume 8, Issue 8, Page(s) 654–655

    Language English
    Publishing date 2021-06-01
    Publishing country England
    Document type Letter ; Comment
    ISSN 2215-0374
    ISSN (online) 2215-0374
    DOI 10.1016/S2215-0366(21)00247-9
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  5. Article ; Online: Autistic role modelling in medical education.

    Shaw, Sebastian C K / Grosjean, Bernadette / McCowan, Sue / Kinnear, Malcolm / Doherty, Mary

    Education for primary care : an official publication of the Association of Course Organisers, National Association of GP Tutors, World Organisation of Family Doctors

    2021  Volume 33, Issue 2, Page(s) 128–129

    MeSH term(s) Autistic Disorder ; Education, Medical ; Humans
    Language English
    Publishing date 2021-12-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2074818-8
    ISSN 1475-990X ; 1473-9879
    ISSN (online) 1475-990X
    ISSN 1473-9879
    DOI 10.1080/14739879.2021.1996277
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  6. Article ; Online: Effect of dog-related parameters on the flexion test outcome

    Diane Grosjean / Evelien De Bakker / Amélie Mugnier / Franck Forterre / Jimmy Saunders / Bernadette Van Ryssen / Yves Camiel Alice Samoy

    Frontiers in Veterinary Science, Vol

    A large cohort retrospective study on physiological and orthopedic pathological-related factors

    2022  Volume 9

    Abstract: ObjectivesThis retrospective study evaluates the dog-related factors of variation influencing the outcome of the flexion test (FT), when performed to localize pain to a joint area, on a large group of canine orthopedic patients.Materials and methodsThe ... ...

    Abstract ObjectivesThis retrospective study evaluates the dog-related factors of variation influencing the outcome of the flexion test (FT), when performed to localize pain to a joint area, on a large group of canine orthopedic patients.Materials and methodsThe selection criteria for this retrospective study were dogs undergoing a FT in a referral orthopedic clinic between 2009 and 2020 with a complete medical record. The canine FT, described in a previously published protocol, was performed on dogs presented with an orthopedic problem. In summary, a dog's joint, identified as suspected of an orthopedic problem according to the clinical examination, was flexed for 1 min before walking 15 m on a hard and even surface. The FT was considered positive if the lameness increased after the application of the FT and negative when it remained unchanged. Statistical analysis was performed to determine which of the following criteria could influence the outcome of the flexion test: age, gender, neutered status, weight category, tested joint and initial lameness score.ResultsOver 1,161 patients' files were collected and analyzed for this research. The FT showed 82.8% (95%IC: 80.5–84.9) of true positives and 17.2% of false negatives. None of the patient's intrinsic characteristics influenced the outcome of the test (age, gender, neutered status, and weight category). The orthopedic parameters, such as the initial lameness score and the tested joint, showed to have a statistically significant influence on the outcome of the test.Clinical relevanceThe FT is an easy-to-perform technique presenting reliable results on most joints. This test presents an interest when performed in addition to a complete orthopedic examination to localize pain to a joint area. Only the orthopedic pathological-related parameters such as the lameness score and the tested joint seem to influence the outcome of the FT. The FT is not influenced by the physiological-related characteristic of the patient (age, weight category, sex, and neutered status).
    Keywords dog ; orthopedic examination ; joint assessment ; flexion test ; pathological factors ; Veterinary medicine ; SF600-1100
    Subject code 630
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: From synapse to psychotherapy: the fascinating evolution of neuroscience.

    Grosjean, Bernadette

    American journal of psychotherapy

    2005  Volume 59, Issue 3, Page(s) 181–197

    Abstract: This paper reviews neuroscientific advances across the therapeutic disciplines and outlines new potential insights into understanding the biology of the psychotherapeutic processes. In a quest to understand the modus operandi of psychotherapy, the author ...

    Abstract This paper reviews neuroscientific advances across the therapeutic disciplines and outlines new potential insights into understanding the biology of the psychotherapeutic processes. In a quest to understand the modus operandi of psychotherapy, the author reviews the evolution of the biology of psychotherapy. The mechanisms involved in learning processes, such as memory and priming, attachment, and long-term consequences of early life trauma, demonstrate how brain structures can be affected by environmental changes. Finally, the author proposes that verbal and non-verbal aspects of the psychotherapeutic process mediate their therapeutic effects through biological changes as they work on primitive emotional reflexes and stimulate mentalization processes.
    MeSH term(s) Emotions/physiology ; Humans ; Interpersonal Relations ; Life Change Events ; Memory/physiology ; Neurosciences/methods ; Object Attachment ; Psychotherapy/methods ; Synapses/physiology
    Language English
    Publishing date 2005
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2950-6
    ISSN 0002-9564
    ISSN 0002-9564
    DOI 10.1176/appi.psychotherapy.2005.59.3.181
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  8. Article: Lameness Localization in Dogs: An Exploratory Study of the Translation of the Equine Flexion Test to Canine Orthopaedics

    Grosjean, Diane / De Bakker, Evelien / Mugnier, Amélie / Verschooten, Francis / Rytz, Ulrich / Forterre, Franck / Samoy, Yves / Van Ryssen, Bernadette

    VCOT Open

    2022  Volume 05, Issue 02, Page(s) e116–e122

    Abstract: Objectives: The aim of this study was to describe the method and feasibility of the flexion test (FT) as a diagnostic tool to localize lameness on dogs.: Study Design: Canine FT was designed and based on the FT routinely used on horses. In dogs, the ... ...

    Abstract Objectives: The aim of this study was to describe the method and feasibility of the flexion test (FT) as a diagnostic tool to localize lameness on dogs.
    Study Design: Canine FT was designed and based on the FT routinely used on horses. In dogs, the test consisted in a flexion of a joint to its full range of motion for 1 minute. Eventual increased lameness was then evaluated. The gait was evaluated using a visual analogue scale. An increase in the lameness score compared with the baseline score was considered as a positive result. The method was described for every major joint of the appendicular skeleton and was evaluated in sound and lame dogs. To evaluate the feasibility, the FT was applied for 3 minutes in eight healthy dogs on all joints. On 27 clinically lame dogs, flexion was applied for 1 minute on the joints with a suspected pathology and on their contralateral side used as a control.
    Results: The FT was feasible and well tolerated by the sound dogs on all joints and no positive results were recorded. On clinically lame dogs, lameness increased in 81.5% of dogs. These cases were afterwards diagnosed with an orthopaedic-related disorder and then defined as true positives. False negative results occurred in 18.5% of the lameness cases.
    Conclusion: The FT is safe and easy to perform. It did not produce any false positive results. False negatives might occur in a minor number of cases, implying that a negative result does not exclude a joint pathology.
    Keywords lameness evaluation ; orthopaedic examination ; joint pain ; diagnostic tool ; locomotor system
    Language English
    Publishing date 2022-07-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2934191-7
    ISSN 2625-2325 ; 2625-2325
    ISSN (online) 2625-2325
    ISSN 2625-2325
    DOI 10.1055/s-0042-1750036
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  9. Article: NMDA neurotransmission as a critical mediator of borderline personality disorder.

    Grosjean, Bernadette / Tsai, Guochuan E

    Journal of psychiatry & neuroscience : JPN

    2007  Volume 32, Issue 2, Page(s) 103–115

    Abstract: Studies of the neurobehavioural components of borderline personality disorder (BPD) have shown that symptoms and behaviours of BPD are partly associated with disruptions in basic neurocognitive processes, in particular, in the executive neurocognition ... ...

    Abstract Studies of the neurobehavioural components of borderline personality disorder (BPD) have shown that symptoms and behaviours of BPD are partly associated with disruptions in basic neurocognitive processes, in particular, in the executive neurocognition and memory systems. A growing body of data indicates that the glutamatergic system, in particular, the N-methyl-D-aspartate (NMDA) subtype receptor, plays a major role in neuronal plasticity, cognition and memory and may underlie the pathophysiology of multiple psychiatric disorders. In this paper, we review the literature regarding BPD and its cognitive deficits and the current data on glutamatergic and NMDA neurotransmission. We propose that multiple cognitive dysfunctions and symptoms presented by BPD patients, like dissociation, psychosis and impaired nociception, may result from the dysregulation of the NMDA neurotransmission. This impairment may be the result of a combination of biological vulnerability and environmental influences mediated by the NMDA neurotransmission.
    MeSH term(s) Borderline Personality Disorder/diagnosis ; Borderline Personality Disorder/physiopathology ; Borderline Personality Disorder/psychology ; Borderline Personality Disorder/therapy ; Brain/physiopathology ; Cognition Disorders/physiopathology ; Humans ; Life Change Events ; Memory Disorders/physiopathology ; N-Methylaspartate/agonists ; N-Methylaspartate/physiology ; Neuronal Plasticity/physiology ; Psychotherapy ; Receptors, N-Methyl-D-Aspartate/agonists ; Receptors, N-Methyl-D-Aspartate/physiology ; Risk Factors ; Social Environment ; Synaptic Transmission/physiology
    Chemical Substances Receptors, N-Methyl-D-Aspartate ; N-Methylaspartate (6384-92-5)
    Language English
    Publishing date 2007-03
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1077443-9
    ISSN 1180-4882
    ISSN 1180-4882
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  10. Article: A polypyrrole protein microarray for antibody-antigen interaction studies using a label-free detection process.

    Grosjean, Ludivine / Cherif, Boutheina / Mercey, Emilie / Roget, André / Levy, Yves / Marche, Patrice Noel / Villiers, Marie-Bernadette / Livache, Thierry

    Analytical biochemistry

    2005  Volume 347, Issue 2, Page(s) 193–200

    Abstract: Protein microarray is a promising technology that should combine rapidity and easy use with high throughput and versatility. This article describes a method in which an electrocopolymerization process is employed to graft biological molecules on to a ... ...

    Abstract Protein microarray is a promising technology that should combine rapidity and easy use with high throughput and versatility. This article describes a method in which an electrocopolymerization process is employed to graft biological molecules on to a chip so that surface plasmon resonance imaging may be used to detect molecular interactions. Copolymerization of pyrrole-modified protein and pyrrole is an efficient grafting process which immobilizes molecules at defined positions on a gold surface. Surface plasmon resonance imaging is an optical technique that allows real-time simultaneous detection of molecular interactions on a large number of spots without labeling. This method was successfully used to analyze antibody-antigen interactions. This illustrates its high specificity and good sensitivity and demonstrates its suitability for biological studies.
    MeSH term(s) Animals ; Antigen-Antibody Reactions ; Chemistry Techniques, Analytical ; Chorionic Gonadotropin/immunology ; Humans ; In Vitro Techniques ; Muramidase/immunology ; Polymers ; Protein Array Analysis/instrumentation ; Protein Array Analysis/methods ; Pyrroles ; Surface Plasmon Resonance ; Surface Properties
    Chemical Substances Chorionic Gonadotropin ; Polymers ; Pyrroles ; polypyrrole (30604-81-0) ; Muramidase (EC 3.2.1.17)
    Language English
    Publishing date 2005-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1110-1
    ISSN 1096-0309 ; 0003-2697
    ISSN (online) 1096-0309
    ISSN 0003-2697
    DOI 10.1016/j.ab.2005.09.033
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