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  1. Article ; Online: Nitric oxide achieves master regulator status.

    Lundberg, Jon O

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2023  Volume 45, Issue 8, Page(s) e2300089

    MeSH term(s) Nitric Oxide ; Energy Metabolism
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.202300089
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2024: Show issues Location:
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  2. Article: Is nitric oxide a clue to endemic goitre in highlanders?

    Lundberg, Jon O / Weitzberg, Eddie

    Thyroid research

    2023  Volume 16, Issue 1, Page(s) 41

    Abstract: Goitre is commonly caused by a lack of iodine in the diet. This condition is particularly prevalent in high-altitude areas where iodine deficiency is common. Here we speculate that inorganic nitrate, the oxidation product of nitric oxide, which is ... ...

    Abstract Goitre is commonly caused by a lack of iodine in the diet. This condition is particularly prevalent in high-altitude areas where iodine deficiency is common. Here we speculate that inorganic nitrate, the oxidation product of nitric oxide, which is generated endogenously at very high levels in highlanders, further increases the risk of goitre and thyroid dysfunction in this population by inhibiting the transport of iodide into the thyroid gland. Indeed, it is well-known that nitrate and iodide compete for such transport. While iodine scarcity is a primary cause of goitre, the excessive nitrate levels in highlanders may further hinder iodide transport, exacerbating the problem.
    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type Letter
    ZDB-ID 2454440-1
    ISSN 1756-6614
    ISSN 1756-6614
    DOI 10.1186/s13044-023-00183-3
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  3. Article ; Online: Nitric oxide signaling in health and disease.

    Lundberg, Jon O / Weitzberg, Eddie

    Cell

    2022  Volume 185, Issue 16, Page(s) 2853–2878

    Abstract: The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian cells and serves to regulate a multitude of physiological processes has continued to fascinate biologists for almost four decades. The biochemistry of NO is ... ...

    Abstract The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian cells and serves to regulate a multitude of physiological processes has continued to fascinate biologists for almost four decades. The biochemistry of NO is complex, and novel insights into the control of NO biosynthesis and mechanisms of signal transduction are continuously emerging. NO is a key regulator of cardiovascular function, metabolism, neurotransmission, immunity, and more, and aberrant NO signaling is a central feature of many major disorders including cardiovascular disease, diabetes, and cancer. Here, we discuss the basics of NO biology emphasizing recent advances in the field including novel means of increasing NO bioactivity with therapeutic and nutritional implications.
    MeSH term(s) Animals ; Cardiovascular Diseases/drug therapy ; Cardiovascular Physiological Phenomena ; Humans ; Mammals/metabolism ; Nitric Oxide/metabolism ; Nitrites/metabolism ; Nitrites/therapeutic use ; Signal Transduction
    Chemical Substances Nitrites ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.06.010
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    Zs.A 1167: Show issues Location:
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  4. Article ; Online: Nitric oxide signaling in health and disease

    Lundberg, Jon O. / Weitzberg, Eddie

    Cell. 2022 Aug., v. 185, no. 16 p.2853-2878

    2022  

    Abstract: The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian cells and serves to regulate a multitude of physiological processes has continued to fascinate biologists for almost four decades. The biochemistry of NO is ... ...

    Abstract The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian cells and serves to regulate a multitude of physiological processes has continued to fascinate biologists for almost four decades. The biochemistry of NO is complex, and novel insights into the control of NO biosynthesis and mechanisms of signal transduction are continuously emerging. NO is a key regulator of cardiovascular function, metabolism, neurotransmission, immunity, and more, and aberrant NO signaling is a central feature of many major disorders including cardiovascular disease, diabetes, and cancer. Here, we discuss the basics of NO biology emphasizing recent advances in the field including novel means of increasing NO bioactivity with therapeutic and nutritional implications.
    Keywords bioactive properties ; biosynthesis ; cardiovascular diseases ; diabetes ; immunity ; mammals ; nitric oxide ; signal transduction ; synaptic transmission ; therapeutics ; S-nitrosothiol ; nitrate ; nitrite ; cardiovascular disease ; cancer ; blood pressure
    Language English
    Dates of publication 2022-08
    Size p. 2853-2878.
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.06.010
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: The Tortoise and the Hare.

    Lundberg, Jon O / Schiffer, Tomas / Weitzberg, Eddie / Larsen, Filip J

    Trends in endocrinology and metabolism: TEM

    2023  Volume 34, Issue 6, Page(s) 317–318

    Abstract: Distance running requires a high absolute oxygen consumption, while for a breath-hold diver the opposite is preferable. We compared physiological exercise parameters and mitochondrial function in a competitive triathlete with those seen in an ... ...

    Abstract Distance running requires a high absolute oxygen consumption, while for a breath-hold diver the opposite is preferable. We compared physiological exercise parameters and mitochondrial function in a competitive triathlete with those seen in an accomplished breath-hold diver and notice some remarkable differences, possibly explaining why both have become successful.
    MeSH term(s) Animals ; Humans ; Diving/physiology ; Turtles ; Hares ; Breath Holding ; Oxygen Consumption/physiology
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2023.03.003
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  6. Article ; Online: Longitudinal variability in mortality predicts COVID-19 deaths.

    Lundberg, Jon O / Zeberg, Hugo

    European journal of epidemiology

    2021  Volume 36, Issue 6, Page(s) 599–603

    Abstract: Within Europe, death rates due to COVID-19 vary greatly, with some countries being severely hit while others to date are almost unaffected. This has created a heated debate in particular regarding how effective the different measures applied by the ... ...

    Abstract Within Europe, death rates due to COVID-19 vary greatly, with some countries being severely hit while others to date are almost unaffected. This has created a heated debate in particular regarding how effective the different measures applied by the governments are in limiting the spread of the disease and ultimately deaths. It would be of considerable interest to pinpoint the factors that determine a country's susceptibility to a pandemic such as COVID-19. Here we present data demonstrating that mortality due to COVID-19 in a given country could have been predicted to some extent even before the pandemic hit Europe, simply by looking at longitudinal variability of death rates in the years preceding the current outbreak. The variability in death rates during the winter influenza seasons of 2015-2019 correlates to excess mortality in 2020 during the COVID-19 outbreak (Spearman's ρ = 0.68, 95 % CI = 0.40-0.84, p < 0.001). In contrast, there was no correlation with age, population density, latitude, GNP, governmental health spending, number of intensive care beds, degree of urbanization, or rates of influenza vaccination. These data suggest an intrinsic susceptibility in certain countries to excess mortality associated with viral respiratory diseases including COVID-19.
    MeSH term(s) Aged ; COVID-19/mortality ; Europe/epidemiology ; Humans ; Longitudinal Studies ; Middle Aged ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-07-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/s10654-021-00777-x
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  7. Article ; Online: Two-dimensional molybdenum disulfide nanosheets evoke nitric oxide-dependent antibacterial effects.

    Peng, Guotao / González, Viviana / Vázquez, Ester / Lundberg, Jon O / Fadeel, Bengt

    Nanoscale

    2023  Volume 15, Issue 43, Page(s) 17409–17421

    Abstract: Nanomaterials are currently being explored as novel antimicrobial agents. In this study, we first investigated the ability of two-dimensional (2D) molybdenum disulfide ( ... ...

    Abstract Nanomaterials are currently being explored as novel antimicrobial agents. In this study, we first investigated the ability of two-dimensional (2D) molybdenum disulfide (MoS
    MeSH term(s) Humans ; Molybdenum/pharmacology ; Molybdenum/chemistry ; Nitric Oxide ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Disulfides/pharmacology ; Disulfides/chemistry
    Chemical Substances molybdenum disulfide (ZC8B4P503V) ; Molybdenum (81AH48963U) ; Nitric Oxide (31C4KY9ESH) ; Anti-Bacterial Agents ; Disulfides
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr03120a
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  8. Article ; Online: Dietary nitrate and mitochondrial efficiency in humans.

    Schiffer, Tomas A / Larsen, Filip / Lundberg, Jon O / Weitzberg, Eddie

    The American journal of clinical nutrition

    2020  Volume 111, Issue 2, Page(s) 486

    MeSH term(s) Animals ; Dietary Supplements ; Humans ; Mice ; Mitochondria ; Muscle, Skeletal ; Nitrates ; Nitrites
    Chemical Substances Nitrates ; Nitrites
    Language English
    Publishing date 2020-01-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.1093/ajcn/nqz316
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    Ue I Zs.208: Show issues Location:
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  9. Article ; Online: Renal handling of nitrate in women and men with elevated blood pressure.

    Sundqvist, Michaela L / Lundberg, Jon O / Weitzberg, Eddie / Carlström, Mattias

    Acta physiologica (Oxford, England)

    2021  Volume 232, Issue 1, Page(s) e13637

    Abstract: Aim: The inorganic anions nitrate and nitrite are oxidation products of nitric oxide (NO) that have often been used as an index of NO generation. More than just being surrogate markers of NO, nitrate/nitrite can recycle to bioactive NO again. Nitrate is ...

    Abstract Aim: The inorganic anions nitrate and nitrite are oxidation products of nitric oxide (NO) that have often been used as an index of NO generation. More than just being surrogate markers of NO, nitrate/nitrite can recycle to bioactive NO again. Nitrate is predominantly eliminated via the kidneys; however, there is less knowledge regarding tubular handling. The aim of this study, as part of a large randomized controlled trial, was to explore potential sex differences in renal nitrate handling during low and high dietary nitrate intake. We hypothesized that renal clearance and excretion of nitrate are higher in men compared to women.
    Methods: In prehypertensive and hypertensive individuals (n = 231), nitrate and nitrite were measured in plasma and urine at low dietary nitrate intake (baseline) and after 5 weeks supplementation with nitrate (300 mg potassium nitrate/day) or placebo (300 mg potassium chloride/day). Twenty-four hours ambulatory blood pressure recordings and urine collections were conducted.
    Results: At baseline, plasma nitrate and nitrite, as well as the downstream marker of NO signalling cyclic guanosine monophosphate, were similar in women and men. Approximately 80% of filtered nitrate was spared by the kidneys. Urinary nitrate concentration, amount of nitrate excreted, renal nitrate clearance (C
    Conclusion: Our findings demonstrate substantial nitrate sparing capacity of the kidneys, which is higher in women compared to men. This suggests higher tubular nitrate reabsorption in women but the underlying mechanism(s) warrants further investigation.
    MeSH term(s) Blood Pressure Monitoring, Ambulatory ; Female ; Humans ; Hypertension ; Kidney/physiology ; Male ; Nitrates ; Nitric Oxide/chemistry
    Chemical Substances Nitrates ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2021-03-07
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13637
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  10. Article ; Online: Longitudinal variability in mortality predicts Covid-19 deaths

    Lundberg, Jon O. / Zeberg, Hugo

    medRxiv

    Abstract: Within Europe, death rates due to covid-19 vary greatly, with some countries being hardly hit while others to date are almost unaffected. It would be of interest to pinpoint the factors that determine a country9s susceptibility to a pandemic such as ... ...

    Abstract Within Europe, death rates due to covid-19 vary greatly, with some countries being hardly hit while others to date are almost unaffected. It would be of interest to pinpoint the factors that determine a country9s susceptibility to a pandemic such as covid-19. Here we present data demonstrating that mortality due to covid-19 in a given country could have been largely predicted even before the pandemic hit Europe, simply by looking at longitudinal variability of all-cause mortality rates in the years preceding the current outbreak. The variability in death rates during the influenza seasons of 2015-2019 correlate to excess mortality caused by covid-19 in 2020 (R2=0.48, p<0.0001). In contrast, we found no correlation between such excess mortality and age, population density, degree of urbanization, latitude, GNP, governmental health spendings or rates of influenza vaccinations. These data may be of some relevance when discussing the effectiveness of acute measures in order to limit the spread of the disease and ultimately deaths. They suggest that in some European countries there is an intrinsic susceptibility to fatal respiratory viral disease including covid-19; a susceptibility that was evident long before the arrival of the current pandemic.
    Keywords covid19
    Language English
    Publishing date 2020-12-30
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.12.25.20248853
    Database COVID19

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