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  1. Book ; Online: Oral Cancer

    Ogbureke, Kalu U. E.

    2012  

    Keywords Oncology
    Size 1 electronic resource (402 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021044926
    ISBN 9789535168737 ; 9535168738
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Effects of DSPP and MMP20 Silencing on Adhesion, Metastasis, Angiogenesis, and Epithelial-Mesenchymal Transition Proteins in Oral Squamous Cell Carcinoma Cells.

    Aseervatham, Jaya / Ogbureke, Kalu U E

    International journal of molecular sciences

    2020  Volume 21, Issue 13

    Abstract: ... Kallikerin- 4,-5,-8,-10, E-cadherin, N-cadherin, Vimentin, met, src, snail, and Twist by Western blot ...

    Abstract Recent reports highlight the potential tumorigenic role of Dentin Sialophosphoprotein (DSPP) and its cognate partner Matrix Metalloproteinase 20 (MMP-20) in Oral Squamous Cell Carcinomas (OSCCs). However, the function/mechanism of these roles is yet to be fully established. The present study aimed to investigate the effects of DSPP and MMP20 silencing on specific proteins involved in oral cancer cell adhesion, angiogenesis, metastasis, and epithelial-mesenchymal transition (EMT). Stable lines of DSPP/MMP20 silenced OSCC cell line (OSC2), previously established via lentiviral-mediated shRNA transduction, were analyzed for the effects of DSPP, MMP20, and combined DSPP-MMP20 silencing on MMP2, MMP9, integrins αvβ3 and αvβ6, VEGF, Kallikerin- 4,-5,-8,-10, E-cadherin, N-cadherin, Vimentin, met, src, snail, and Twist by Western blot. Results show a significant decrease (
    MeSH term(s) Cadherins/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Adhesion/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Epithelial-Mesenchymal Transition/genetics ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Extracellular Matrix Proteins/pharmacology ; Gene Expression Regulation, Neoplastic/genetics ; Head and Neck Neoplasms/pathology ; Humans ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 20/genetics ; Matrix Metalloproteinase 20/metabolism ; Matrix Metalloproteinase 9/metabolism ; Mouth Neoplasms/pathology ; Neoplasm Invasiveness ; Neoplasm Metastasis/genetics ; Neovascularization, Pathologic/genetics ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Phosphoproteins/pharmacology ; Sialoglycoproteins/genetics ; Sialoglycoproteins/metabolism ; Sialoglycoproteins/pharmacology ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/metabolism
    Chemical Substances Cadherins ; Extracellular Matrix Proteins ; Phosphoproteins ; Sialoglycoproteins ; dentin sialophosphoprotein ; Matrix Metalloproteinase 20 (EC 3.4.24.-) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
    Language English
    Publishing date 2020-07-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21134734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Metastatic renal cell carcinoma to the oral cavity as first sign of disease: A case report.

    Patel, Shalizeh / Barros, Juliana / Nwizu, Ngozi N / Ogbureke, Kalu U E

    Clinical case reports

    2020  Volume 8, Issue 8, Page(s) 1517–1521

    Abstract: Renal cell carcinoma metastasis to the oral cavity is rare. Significantly, the oral lesion in this case was the first indication of a malignant disease in the patient. This case underscores the importance of detailed history taking, interpretation of ... ...

    Abstract Renal cell carcinoma metastasis to the oral cavity is rare. Significantly, the oral lesion in this case was the first indication of a malignant disease in the patient. This case underscores the importance of detailed history taking, interpretation of clinical finding, and high index of suspicion for metastatic disease to the oral cavity.
    Language English
    Publishing date 2020-07-14
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of DSPP and MMP20 Silencing on Adhesion, Metastasis, Angiogenesis, and Epithelial-Mesenchymal Transition Proteins in Oral Squamous Cell Carcinoma Cells

    Jaya Aseervatham / Kalu U. E. Ogbureke

    International Journal of Molecular Sciences, Vol 21, Iss 4734, p

    2020  Volume 4734

    Abstract: ... Kallikerin- 4,-5,-8,-10, E-cadherin, N-cadherin, Vimentin, met, src, snail, and Twist by Western blot ... individually and in combination. On the other hand, the expression of E-cadherin was found to be significantly ...

    Abstract Recent reports highlight the potential tumorigenic role of Dentin Sialophosphoprotein (DSPP) and its cognate partner Matrix Metalloproteinase 20 (MMP-20) in Oral Squamous Cell Carcinomas (OSCCs). However, the function/mechanism of these roles is yet to be fully established. The present study aimed to investigate the effects of DSPP and MMP20 silencing on specific proteins involved in oral cancer cell adhesion, angiogenesis, metastasis, and epithelial-mesenchymal transition (EMT). Stable lines of DSPP/MMP20 silenced OSCC cell line (OSC2), previously established via lentiviral-mediated shRNA transduction, were analyzed for the effects of DSPP, MMP20, and combined DSPP–MMP20 silencing on MMP2, MMP9, integrins αvβ3 and αvβ6, VEGF, Kallikerin- 4,-5,-8,-10, E-cadherin, N-cadherin, Vimentin, met, src, snail, and Twist by Western blot. Results show a significant decrease ( p < 0.05) in the expression of MMP2, MMP9, integrin αvβ3, αvβ6, VEGF, Kallikerins -4, -5, -8, -10, N-cadherin, vimentin met, src, snail and twist following DSPP and MMP20 silencing, individually and in combination. On the other hand, the expression of E-cadherin was found to be significantly increased ( p < 0.05). These results suggest that the tumorigenic effect of DSPP and MMP20 on OSC2 cells is mediated via the upregulation of the genes involved in invasion, metastasis, angiogenesis, and epithelial-mesenchymal transition (EMT).
    Keywords DSPP ; MMP-20 ; lentivirus ; EMT ; invasion and metastasis ; Kallikerins ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article: Oral and maxillofacial pathology: Case of the month.

    Ogbureke, Kalu U E / Clark, Ashley N / Nwizu, Ngozi N / McGehee, John

    Texas dental journal

    2019  Volume 134, Issue 4, Page(s) 226–8, 232–4, 252–3

    MeSH term(s) Child ; Diagnosis, Differential ; Female ; Gingival Hyperplasia/diagnosis ; Gingival Hyperplasia/pathology ; Gingival Hyperplasia/surgery ; Humans ; Mandible ; Orthodontic Appliances
    Language English
    Publishing date 2019-02-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 412554-x
    ISSN 0040-4284
    ISSN 0040-4284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Metastatic renal cell carcinoma to the oral cavity as first sign of disease

    Shalizeh Patel / Juliana Barros / Ngozi N. Nwizu / Kalu U. E. Ogbureke

    Clinical Case Reports, Vol 8, Iss 8, Pp 1517-

    A case report

    2020  Volume 1521

    Abstract: Abstract Renal cell carcinoma metastasis to the oral cavity is rare. Significantly, the oral lesion in this case was the first indication of a malignant disease in the patient. This case underscores the importance of detailed history taking, ... ...

    Abstract Abstract Renal cell carcinoma metastasis to the oral cavity is rare. Significantly, the oral lesion in this case was the first indication of a malignant disease in the patient. This case underscores the importance of detailed history taking, interpretation of clinical finding, and high index of suspicion for metastatic disease to the oral cavity.
    Keywords Guillain‐Barre syndrome ; metastasis ; oral cavity ; renal cell carcinoma ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Peripheral Giant Cell Granuloma.

    Ogbureke, Kalu U E / Salha, Wesam / Nwizu, Ngozi N

    Texas dental journal

    2016  Volume 133, Issue 3, Page(s) 178–9, 209

    MeSH term(s) Diagnosis, Differential ; Female ; Gingival Diseases/diagnosis ; Gingival Diseases/pathology ; Gingival Diseases/surgery ; Granuloma, Giant Cell/diagnosis ; Granuloma, Giant Cell/pathology ; Granuloma, Giant Cell/surgery ; Humans ; Maxilla ; Middle Aged
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 412554-x
    ISSN 0040-4284
    ISSN 0040-4284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article: Emerging paradigm of virtual-microscopy for histopathology diagnosis: survey of US and Canadian oral pathology trainees.

    Nwizu, Ngozi N / Owosho, Adepitan / Ogbureke, Kalu U E

    BDJ open

    2017  Volume 3, Page(s) 17013

    Abstract: Objectives/aims: The application of virtual microscopy (VM) to research, pre-doctoral medical and dental educational training, and diagnostic surgical and anatomic pathology is well-documented but its application to the field of oral and maxillofacial ... ...

    Abstract Objectives/aims: The application of virtual microscopy (VM) to research, pre-doctoral medical and dental educational training, and diagnostic surgical and anatomic pathology is well-documented but its application to the field of oral and maxillofacial pathology has not been explored. This is the first study to evaluate the enthusiasm and readiness of US-/Canada-based oral and maxillofacial pathology (OMFP) residents toward employing VM use over conventional microscopy (CM) for diagnostic purposes.
    Materials and methods: All 46 current US-/Canada-based OMFP residents were invited to participate in an anonymous electronic survey via 'Survey Monkey' in 2015. The survey comprised sixteen multiple choice questions and two 'free text' questions.
    Results: 14% of respondents of the 22 (48%) respondents who completed the survey indicated a willingness to substitute CM with VM in <5 years, and 33% within 10 years. 52% reported they would never substitute CM with VM. Approximately 10 and 57% of respondents thought VM will become an acceptable sole diagnostic tool in most centers within 5 and 10 years, respectively. These findings are irrespective of the fact that overall, 90% of respondents reported being familiar with VM use.
    Discussion: VM technology is unlikely to substitute CM in diagnostic oral and maxillofacial histopathology practice among future OMFP practitioners in the foreseeable future.
    Language English
    Publishing date 2017-07-28
    Publishing country England
    Document type Journal Article
    ISSN 2056-807X
    ISSN 2056-807X
    DOI 10.1038/bdjopen.2017.13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Oral and maxillofacial pathology. Case of the month. Multiple odontogenic keratocysts in association with nevoid basal cell carcinoma syndrome (NBCCS).

    Ogbureke, Kalu U E / Alex, Bachoura

    Texas dental journal

    2013  Volume 130, Issue 11, Page(s) 1100–1, 1142–3

    MeSH term(s) Adult ; Ameloblastoma/diagnosis ; Basal Cell Nevus Syndrome/diagnosis ; Diagnosis, Differential ; Humans ; Male ; Mandibular Diseases/diagnosis ; Maxillary Diseases/diagnosis ; Odontogenic Cysts/diagnosis ; Odontogenic Tumors/diagnosis
    Language English
    Publishing date 2013-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 412554-x
    ISSN 0040-4284
    ISSN 0040-4284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1797: Show issues Location:
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  10. Article: Oral and Maxillofacial Pathology. Case of the Month. Adenomatoid Odontogenic Tumor.

    Ogbureke, Kalu U E / Scheyer, E Todd

    Texas dental journal

    2015  Volume 132, Issue 1, Page(s) 14–5, 68–9

    MeSH term(s) Adult ; Bicuspid/pathology ; Biopsy/methods ; Diagnosis, Differential ; Humans ; Male ; Mandibular Diseases/diagnosis ; Mandibular Neoplasms/diagnosis ; Odontogenic Cysts/diagnosis ; Odontogenic Tumors/diagnosis ; Periodontal Cyst/diagnosis
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 412554-x
    ISSN 0040-4284
    ISSN 0040-4284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1797: Show issues Location:
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