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Article ; Online: N

Da Silva, Afitz / Dort, Junio / Orfi, Zakaria / Pan, Xuefang / Huang, Sjanie / Kho, Ikhui / Heckel, Emilie / Muscarnera, Giacomo / van Vliet, Patrick Piet / Sturiale, Luisa / Messina, Angela / Romeo, Donata Agata / van Karnebeek, Clara D M / Wen, Xiao-Yan / Hinek, Aleksander / Molina, Thomas / Andelfinger, Gregor / Ellezam, Benjamin / Yamanaka, Yojiro /

Olivos, Hernando J / Morales, Carlos R / Joyal, Jean-Sébastien / Lefeber, Dirk J / Garozzo, Domenico / Dumont, Nicolas A / Pshezhetsky, Alexey V

Science advances

2023 Volume 9, Issue 26, Page(s) eade6308

Abstract: Deleterious variants ... ...

Abstract	Deleterious variants in
MeSH term(s)	Animals ; Humans ; Mice ; Disease Models, Animal ; Glycoproteins ; Muscle, Skeletal ; N-Acetylneuraminic Acid ; Pyruvates ; Regeneration ; Zebrafish
Chemical Substances	Glycoproteins ; N-Acetylneuraminic Acid (GZP2782OP0) ; Pyruvates ; N-acetylneuraminate lyase (EC 4.1.3.3)
Language	English
Publishing date	2023-06-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.ade6308
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Article: Anti-N-Methyl-D-Aspartate Receptor Encephalitis (ANMDARE) in a Patient With Hashimoto's Thyroiditis.

Jain, Aakangsha / Thomas, Jamie / Chong, Hernando

Cureus

2022 Volume 14, Issue 3, Page(s) e23109

Abstract: ... mediated etiologies, anti-N-methyl-D-aspartate receptor encephalitis (ANMDARE) is the most common ...

Abstract	Although encephalitis is more commonly caused by various infections, other etiologies that may rarely cause encephalitis must garner the attention of medical practitioners. In the realm of immune-mediated etiologies, anti-N-methyl-D-aspartate receptor encephalitis (ANMDARE) is the most common. It usually presents in a typical fashion with psychiatric symptoms followed by abnormal movements such as orofacial-lingual dyskinesia, tremor, dystonia, bradykinesia, ballism, or choreoathetosis occurring at or within the first month of onset, often affecting women and having a high correlation with ovarian teratomas. Our case report describes a 59-year-old Hispanic male with Hashimoto thyroiditis who presented with rapid cognitive decline. The diagnosis was confirmed with positive detection of NMDA receptor antibodies in the patient's cerebrospinal fluid following a lumbar puncture. The patient was treated with the first-line therapy of intravenous (IV) immunoglobulins and corticosteroids with temporary relief of symptoms. Due to the rare occurrence and possible atypical presentation of ANMDARE, this case illustrates the importance of maintaining a high index of clinical suspicion when diagnosing a patient with an unknown cause of cognitive dysfunction, especially when considering various differentials based on the patient's history.
Language	English
Publishing date	2022-03-12
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.23109
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Article: The Association of N-Terminal Pro-Brain Natriuretic Peptide With Time to Clinical Worsening in Hispanic Patients With Pulmonary Arterial Hypertension.

Khatab, Yacoub / Ghafouri, Sayed Reshad / Alkhateeb, Haider / Mukherjee, Debabrata / Garcia, Hernando / Nickel, Nils Patrick

Cardiology research

2022 Volume 13, Issue 2, Page(s) 73–80

Abstract: Background: Measurement of N-terminal pro-brain natriuretic peptide (NT-proBNP) level is ...

Abstract	Background: Measurement of N-terminal pro-brain natriuretic peptide (NT-proBNP) level is an important parameter in the risk assessment of patients with pulmonary arterial hypertension (PAH). Data about the prognostic value of NT-proBNP in the Hispanic PAH population are lacking. Historically, clinical trials in PAH have only included a minority of Hispanic patients. It has been reported that baseline NT-proBNP levels differ between different ethnicities. Furthermore, NT-proBNP levels can be impacted by declining renal function, making its interpretation difficult regarding clinical decision making. Methods: In a retrospective single-center cohort analysis, Hispanic patients with PAH had a baseline outpatient NT-proBNP level drawn during a period of clinical stability and were followed for 1 year to monitor for time to clinical worsening (TTCW). The association of baseline NT-proBNP and TTCW was assessed in patients with normal and abnormal renal function. Results: A total of 26 patients (22%) met the clinical endpoint of clinical worsening. Twenty-seven patients (24%) had chronic kidney disease (CKD). At baseline NT-proBNP levels showed a significant inverse correlation with 6-min walk test (6MWD, r = -0.382, P = 0.02), and a significant positive correlation with renal function (r = 0.273, P = 0.05). NT-proBNP levels did not correlate with age (r = 0.19, P = 0.11) or body mass index (BMI) (r = -0.292, P = 0.061). NT-proBNP levels of > 1,415 ng/L were significantly associated with shorter TTCW (P < 0.01) in all patients and in patients with CKD (P = 0.03). A stepwise increase in NT-proBNP levels by 100 ng/L was associated with a higher risk of meeting the clinical endpoint of TTCW in patients with normal renal function (hazard ratio (HR) = 1.8, P < 0.01) and CKD (HR = 1.5, P < 0.01). Conclusions: In Hispanic patients with PAH, NT-proBNP is a valuable tool to predict 1-year TTCW, independent of renal function.
Language	English
Publishing date	2022-04-05
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2598593-0
ISSN	1923-2837 ; 1923-2829
ISSN (online)	1923-2837
ISSN	1923-2829
DOI	10.14740/cr1362
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Article ; Online: Brachemys (Atelestodes) minotaurus sp.n., a new coastal Malachiidae (Coleoptera) from Crete.

Hernando, Carles / Ribera, Ignacio

Zootaxa

2019 Volume 4712, Issue 4, Page(s) zootaxa.4712.4.7

Abstract: ... minotaurus n.sp. (Coleoptera, Malachiidae). The species is included in the subgenus Atelestodes Abeille de ...

Abstract	A new species of the costal genus Brachemys Abeille de Perrin, 1890 is described from Crete, B. minotaurus n.sp. (Coleoptera, Malachiidae). The species is included in the subgenus Atelestodes Abeille de Perrin, 1890 due to the lack of modified protarsi, although the subgeneric classification of Brachemys may need to be revised. Specimens of the new species were found running on bare rock in the supralittoral zone, bearing a striking resemblance to ants.
MeSH term(s)	Animal Distribution ; Animal Structures ; Animals ; Ants ; Coleoptera ; Greece
Language	English
Publishing date	2019-12-23
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.4712.4.7
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Article ; Online: Manejo de la inmunosupresión en pacientes trasplantados de riñón con COVID19. Estudio multicéntrico nacional derivado del registro COVID de la S.E.N.

López-Oliva, María O / Pérez-Flores, Isabel / Molina, María / José Aladrén, Mª / Trujillo, Hernando / Redondo-Pachón, Dolores / López, Verónica / Facundo, Carme / Villanego, Florentino / Rodríguez, Marisa / Carmen Ruiz, Mª / Antón, Paula / Rivas-Oural, Alba / Cabello, Sheila / Portolés, José / de la Vara, Lourdes / Tabernero, Guadalupe / Valero, Rosalía / Galeano, Cristina /

Moral, Esperanza / Ventura, Ana / Coca, Armando / Muñoz, Miguel Ángel / Hernández-Gallego, Román / Shabaka, Amir / Ledesma, Gabriel / Martínez, Patricia / Ángeles Rodríguez, Mª / Tamajón, Lourdes Pérez / Cruzado, Leónidas / Emilio Sánchez, J / Jiménez, Carlos

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia

2022

Abstract: ... 2.1±1.2 and 1.8±1 mg/dl respectively (p<0.001).56.9% of the patients (N=350) were monitored for anti ... HLA antibodies. 94% (N=329) had no anti-HLA changes, while 6% (N=21) had positive anti-HLA antibodies ... Among the patients with donor-specific antibodies post-COVID19 (N=9), 7 patients (3.1%) had one immunosuppressant ...

Title translation	Management of immunosuppressive therapy in kidney transplant recipients with COVID19. A multicentre national study derived form the S.E.N. COVID registry.
Abstract	Introduction: SARS CoV2 infection has had a major impact on renal transplant patients with a high mortality in the first months of the pandemic. Intentional reduction of immunosuppressive therapy has been postulated as one of the cornerstone in the management of the infection in the absence of targeted antiviral treatment. This has been modified according to the patient`s clinical situation and its effect on renal function or anti-HLA antibodies in the medium term has not been evaluated. Objectives: Evaluate the management of immunosuppressive therapy made during SARS-CoV2 infection, as well as renal function and anti-HLA antibodies in kidney transplant patients 6 months after COVID19 diagnosis. Material and methods: Retrospective, national multicentre, retrospective study (30 centres) of kidney transplant recipients with COVID19 from 01/02/20 to 31/12/20. Clinical variables were collected from medical records and included in an anonymised database. SPSS statistical software was used for data analysis. Results: 615 renal transplant recipients with COVID19 were included (62.6% male), with a mean age of 57.5 years.The predominant immunosuppressive treatment prior to COVID19 was triple therapy with prednisone, tacrolimus and mycophenolic acid (54.6%) followed by m-TOR inhibitor regimens (18.6%). After diagnosis of infection, mycophenolic acid was discontinued in 73.8% of patients, m-TOR inhibitor in 41.4%, tacrolimus in 10.5% and cyclosporin A in 10%. In turn, 26.9% received dexamethasone and 50.9% were started on or had their baseline prednisone dose increased.Mean creatinine before diagnosis of COVID19, at diagnosis and at 6 months was: 1.7±0.8, 2.1±1.2 and 1.8±1 mg/dl respectively (p<0.001).56.9% of the patients (N=350) were monitored for anti-HLA antibodies. 94% (N=329) had no anti-HLA changes, while 6% (N=21) had positive anti-HLA antibodies. Among the patients with donor-specific antibodies post-COVID19 (N=9), 7 patients (3.1%) had one immunosuppressant discontinued (5 patients had mycophenolic acid and 2 had tacrolimus), 1 patient had both immunosuppressants discontinued (3.4%) and 1 patient had no change in immunosuppression (1.1%), these differences were not significant. Conclusions: The management of immunosuppressive therapy after diagnosis of COVID19 was primarily based on discontinuation of mycophenolic acid with very discrete reductions or discontinuations of calcineurin inhibitors. This immunosuppression management did not influence renal function or changes in anti-HLA antibodies 6 months after diagnosis.
Language	Spanish
Publishing date	2022-04-30
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	632512-9
ISSN	1989-2284 ; 0211-6995
ISSN (online)	1989-2284
ISSN	0211-6995
DOI	10.1016/j.nefro.2022.03.008
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Article ; Online: Differential phosphorylation and n-terminal configuration of capsid subunits in parvovirus assembly and viral trafficking.

Gil-Ranedo, Jon / Hernando, Eva / Valle, Noelia / Riolobos, Laura / Maroto, Beatriz / Almendral, José M

Virology

2018 Volume 518, Page(s) 184–194

Abstract: The T1 parvovirus Minute Virus of Mice (MVM) was used to study the roles that phosphorylation and N ...

Abstract	The T1 parvovirus Minute Virus of Mice (MVM) was used to study the roles that phosphorylation and N-terminal domains (Nt) configuration of capsid subunits may play in icosahedral nuclear viruses assembly. In synchronous MVM infection, capsid subunits newly assembled as two types of cytoplasmic trimeric intermediates (3VP2, and 1VP1:2VP2) harbored a VP1 phosphorylation level fivefold higher than that of VP2, and hidden Nt. Upon nuclear translocation at S phase, VP1-Nt became exposed in the heterotrimer and subsequent subviral assembly intermediates. Empty capsid subunits showed a phosphorylation level restored to VP1:VP2 stoichiometry, and the Nt concealed in their interior. However ssDNA-filled virus maturing at S/G2 lacked VP1 phosphorylation and one major VP2 phosphopeptide, and exposed VP2-Nt. Endosomal VP2-Nt cleavage resulted in VP3 subunits devoid of any phospholabel, implying that incoming viral particles specifically harbor a low phosphorylation status. Phosphorylation provides a mechanistic coupling of parvovirus nuclear assembly to the cell cycle.
MeSH term(s)	Animals ; Antibodies, Viral ; Capsid Proteins/genetics ; Capsid Proteins/metabolism ; Cell Line ; Gene Expression Regulation, Viral/physiology ; Humans ; Mice ; Minute Virus of Mice/genetics ; Minute Virus of Mice/physiology ; Phosphorylation ; Protein Domains ; Protein Subunits ; Rabbits ; Virus Assembly/physiology
Chemical Substances	Antibodies, Viral ; Capsid Proteins ; Protein Subunits
Language	English
Publishing date	2018
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2018.02.018
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Article ; Online: Is XPR1 mediating phosphate efflux?

Hernando, Nati

Pflugers Archiv : European journal of physiology

2024 Volume 476, Issue 5, Page(s) 717–719

MeSH term(s)	Phosphates/metabolism ; Humans ; Animals ; Receptors, G-Protein-Coupled/metabolism
Chemical Substances	Phosphates ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2024-03-21
Publishing country	Germany
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	6380-0
ISSN	1432-2013 ; 0031-6768
ISSN (online)	1432-2013
ISSN	0031-6768
DOI	10.1007/s00424-024-02946-9
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Article ; Online: Beneficial effects of n-3 polyunsaturated fatty acids administration in a partial lesion model of Parkinson's disease: The role of glia and NRf2 regulation.

Hernando, Sara / Requejo, Catalina / Herran, Enara / Ruiz-Ortega, Jose Angel / Morera-Herreras, Teresa / Lafuente, Jose Vicente / Ugedo, Luisa / Gainza, Eusebio / Pedraz, Jose Luis / Igartua, Manoli / Hernandez, Rosa Maria

Neurobiology of disease

2018 Volume 121, Page(s) 252–262

Abstract: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been widely associated to beneficial effect ... administration. Animal groups under n-3 PUFA treatments exhibited a trend to improve in amphetamine-induced ...

Abstract	Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been widely associated to beneficial effect over different neurodegenerative diseases. In the present study, we tested the potential therapeutic effect of docohexanoic acid (DHA) and its hydroxylated derivate, DHAH, in a partial lesion model of Parkinson's disease (PD). One month before and four months after the striatal lesion with 6-OHDA was made, the animals were daily treated with DHA (50 mg/kg), DHAH (50 mg/kg), vehicle or saline, by intragastric administration. Animal groups under n-3 PUFA treatments exhibited a trend to improve in amphetamine-induced rotations and cylinder test. The beneficial effect seen in behavioral studies were confirmed with TH immunostaining. TH
MeSH term(s)	Amphetamine/administration & dosage ; Animals ; Antioxidants/administration & dosage ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Dopamine/metabolism ; Dopamine Agents/administration & dosage ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Fatty Acids, Omega-3/administration & dosage ; Male ; Motor Activity/drug effects ; NF-E2-Related Factor 2/metabolism ; Neuroglia/drug effects ; Neuroglia/metabolism ; Oxidative Stress/drug effects ; Oxidopamine/administration & dosage ; Parkinson Disease/metabolism ; Parkinson Disease/prevention & control ; Rats, Sprague-Dawley ; Tyrosine 3-Monooxygenase/metabolism
Chemical Substances	Antioxidants ; Dopamine Agents ; Fatty Acids, Omega-3 ; NF-E2-Related Factor 2 ; Nfe2l2 protein, rat ; Oxidopamine (8HW4YBZ748) ; Amphetamine (CK833KGX7E) ; Tyrosine 3-Monooxygenase (EC 1.14.16.2) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2018-10-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1211786-9
ISSN	1095-953X ; 0969-9961
ISSN (online)	1095-953X
ISSN	0969-9961
DOI	10.1016/j.nbd.2018.10.001
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Article: Liposomes equipped with poly(N-isopropyl acryl amide)-containing coatings as potential drug carriers

Panneerselvam, Karthiga / Goldie, Kenneth N / Mena-Hernando, Sofia / Städler, Brigitte / Teo, Boon M

RSC advances. 2014 Sept. 19, v. 4, no. 84

2014

Abstract: ... of liposomes with mixed films containing poly(dopamine) (PDA) and different types of poly(N-isopropyl ...

Abstract	Polymer coated liposomes are promising drug delivery candidates. Herein, we report on the coating of liposomes with mixed films containing poly(dopamine) (PDA) and different types of poly(N-isopropyl acryl amide) (pNiPAAm). Their potential as drug carriers from solution in the presence of shear stress or in a substrate-mediated manner using macrophages is assessed. Although we found no difference in the cell mean fluorescence (CMF) when applying shear stress when employing fluorescently labeled liposomes, macrophages exposed to liposomes coated with a mixture of PDA and highly-branched pNiPAAm (LD/HB) exhibited significantly higher CMF after 2.5 h compared to liposomes coated with only PDA (LD) or with a mixture of PDA and aminated pNiPAAm (LD/pNH2). The coated liposomes did not affect the cell viability in the time frame tested, but the application of shear stress reduced the number of surface-adherent macrophages. LD, LD/pNH2 or LD/pHB could be immobilized to poly(l lysine) pre-coated silica substrates. All substrates were equally suited for macrophages to adhere. The CMF of the adhering macrophages was found to be independent of the coating of the surface-immobilized liposomes when using fluorescently labeled liposomes in the coatings. Taken together, we demonstrate that mixed PDA-based coatings can be used to affect the interaction of liposomes with macrophages with potential in drug delivery.
Keywords	cell viability ; coatings ; dopamine ; drug carriers ; drugs ; fluorescence ; lysine ; macrophages ; polymers ; shear stress ; silica
Language	English
Dates of publication	2014-0919
Size	p. 44769-44776.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c4ra07720b
Database	NAL-Catalogue (AGRICOLA)

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Article: Crystal structure of 2-fluoro-N-(1,3-thia-zol-2-yl)benzamide.

Moreno-Fuquen, Rodolfo / Castillo, Juan C / Becerra, Diana / Camargo, Hernando / Henao, José A

Acta crystallographica. Section E, Crystallographic communications

2015 Volume 71, Issue Pt 11, Page(s) o882–3

Abstract: ... In the crystal, pairs of N-H⋯N hydrogen bonds connect the mol-ecules into inversion dimers with R 2 (2)(8) motifs ... and weak C-H⋯O inter-actions connect the mol-ecules into C(6) [001] chains. Together, the N-H⋯N and C ...

Abstract	In the title compound, C10H7FN2OS, the mean plane of the central amide fragment (r.m.s. deviation = 0.048 Å) makes dihedral angles of 35.28 (8) and 10.14 (12)° with those of the fluoro-benzene and thia-zole rings, respectively. The thia-zole S and amide O atoms lie to the same side of the mol-ecule. In the crystal, pairs of N-H⋯N hydrogen bonds connect the mol-ecules into inversion dimers with R 2 (2)(8) motifs, and weak C-H⋯O inter-actions connect the mol-ecules into C(6) [001] chains. Together, the N-H⋯N and C-H⋯O hydrogen bonds generate (100) sheets.
Language	English
Publishing date	2015-10-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2041947-8
ISSN	2056-9890 ; 1600-5368
ISSN	2056-9890 ; 1600-5368
DOI	10.1107/S2056989015019192
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