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  1. Book ; Thesis: Oedemmessung am freien Myokutanlappen im Tierexperiment

    Bublitz, Rolf

    1983  

    Size 50 S.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tuebingen, Univ., Diss., 1983
    HBZ-ID HT002742352
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    83 D 4344 order for loan Magazin

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  2. Article ; Online: The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection.

    Bublitz, Arne / Brauer, Madita / Wagner, Stefanie / Hofer, Walter / Müsken, Mathias / Deschner, Felix / Lesker, Till R / Neumann-Schaal, Meina / Paul, Lena-Sophie / Nübel, Ulrich / Bartel, Jürgen / Kany, Andreas M / Zühlke, Daniela / Bernecker, Steffen / Jansen, Rolf / Sievers, Susanne / Riedel, Katharina / Herrmann, Jennifer / Müller, Rolf /
    Fuchs, Thilo M / Strowig, Till

    Cell host & microbe

    2023  Volume 31, Issue 5, Page(s) 734–750.e8

    Abstract: Clostridioides difficile infections (CDIs) remain a healthcare problem due to high rates of relapsing/recurrent CDIs (rCDIs). Breakdown of colonization resistance promoted by broad-spectrum antibiotics and the persistence of spores contribute to rCDI. ... ...

    Abstract Clostridioides difficile infections (CDIs) remain a healthcare problem due to high rates of relapsing/recurrent CDIs (rCDIs). Breakdown of colonization resistance promoted by broad-spectrum antibiotics and the persistence of spores contribute to rCDI. Here, we demonstrate antimicrobial activity of the natural product class of chlorotonils against C. difficile. In contrast to vancomycin, chlorotonil A (ChA) efficiently inhibits disease and prevents rCDI in mice. Notably, ChA affects the murine and porcine microbiota to a lesser extent than vancomycin, largely preserving microbiota composition and minimally impacting the intestinal metabolome. Correspondingly, ChA treatment does not break colonization resistance against C. difficile and is linked to faster recovery of the microbiota after CDI. Additionally, ChA accumulates in the spore and inhibits outgrowth of C. difficile spores, thus potentially contributing to lower rates of rCDI. We conclude that chlorotonils have unique antimicrobial properties targeting critical steps in the infection cycle of C. difficile.
    MeSH term(s) Animals ; Mice ; Swine ; Vancomycin/pharmacology ; Vancomycin/therapeutic use ; Clostridioides difficile ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Clostridium Infections/drug therapy ; Clostridium Infections/prevention & control
    Chemical Substances Vancomycin (6Q205EH1VU) ; chlorotonil A ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2023.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6578: Show issues Location:
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  3. Article ; Online: The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection

    Bublitz, Arne / Brauer, Madita / Wagner, Stefanie / Hofer, Walter / Müsken, Mathias / Deschner, Felix / Lesker, Till R. / Neumann-Schaal, Meina / Paul, Lena-Sophie / Nübel, Ulrich / Bartel, Jürgen / Kany, Andreas M. / Zühlke, Daniela / Bernecker, Steffen / Jansen, Rolf / Sievers, Susanne / Riedel, Katharina / Herrmann, Jennifer / Müller, Rolf /
    Fuchs, Thilo M. / Strowig, Till

    2023  

    Abstract: Clostridioides difficile infections (CDIs) remain a healthcare problem due to high rates of relapsing/recurrent CDIs (rCDIs). Breakdown of colonization resistance promoted by broad-spectrum antibiotics and the persistence of spores contribute to rCDI. ... ...

    Abstract Clostridioides difficile infections (CDIs) remain a healthcare problem due to high rates of relapsing/recurrent CDIs (rCDIs). Breakdown of colonization resistance promoted by broad-spectrum antibiotics and the persistence of spores contribute to rCDI. Here, we demonstrate antimicrobial activity of the natural product class of chlorotonils against C. difficile. In contrast to vancomycin, chlorotonil A (ChA) efficiently inhibits disease and prevents rCDI in mice. Notably, ChA affects the murine and porcine microbiota to a lesser extent than vancomycin, largely preserving microbiota composition and minimally impacting the intestinal metabolome. Correspondingly, ChA treatment does not break colonization resistance against C. difficile and is linked to faster recovery of the microbiota after CDI. Additionally, ChA accumulates in the spore and inhibits outgrowth of C. difficile spores, thus potentially contributing to lower rates of rCDI. We conclude that chlorotonils have unique antimicrobial properties targeting critical steps in the infection cycle of C. difficile.
    Keywords Text ; ddc:570
    Language English
    Publishing date 2023-04-24
    Publisher Elsevier BV
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Gesichtsverletzungen – Ursachen, Komplikationen, Erstmaßnahmen

    Stumm, Tobias / Georgi, Rainer / Bublitz, Rolf

    retten!

    2015  Volume 4, Issue 05, Page(s) 354–363

    Abstract: Die Wahrscheinlichkeit, einen Patienten mit Gesichtsverletzung behandeln zu müssen, ist groß: Nasenbluten, Kieferbruch und Co. gehören zu den häufigsten Läsionen des Alltags. Umso wichtiger ist es, genau zu wissen, was zu tun ist – auch bei selteneren ... ...

    Abstract Die Wahrscheinlichkeit, einen Patienten mit Gesichtsverletzung behandeln zu müssen, ist groß: Nasenbluten, Kieferbruch und Co. gehören zu den häufigsten Läsionen des Alltags. Umso wichtiger ist es, genau zu wissen, was zu tun ist – auch bei selteneren Ereignissen wie Fremdkörperverletzungen oder Gesichtstraumata.
    Language German
    Publishing date 2015-12-01
    Publisher © Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2193-2395 ; 2193-2387
    ISSN (online) 2193-2395
    ISSN 2193-2387
    DOI 10.1055/s-0041-101946
    Database Thieme publisher's database

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  5. Book ; Thesis: Ödemmessung am freien Myokutanlappen im Tierexperiment

    Bublitz, Rolf

    1983  

    Author's details vorgelegt von Rolf Bublitz
    Language Undetermined
    Size 50 S, graph. Ddarst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @Tübingen, Univ., Diss. : 1983
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  6. Article: Neurofibrom im Unterkieferchirurgische und pathohistologische Aspekte

    Schulze, Katharina / Bublitz, Rolf / Küper, Regina / Bosse, Alexander / Weingart, Dieter / Jundt, Gernot

    Die Quintessenz

    2006  Volume 57, Issue 6, Page(s) 599

    Language German
    Document type Article
    ZDB-ID 207532-5
    ISSN 0033-6580
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3390: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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