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  1. Article ; Online: 11th World biomaterials congress, 11th - 15th December 2020.

    Alakpa, Enateri V

    EBioMedicine

    2021  Volume 64, Page(s) 103232

    MeSH term(s) Biocompatible Materials ; Biomedical Technology ; Humans ; Nanomedicine/methods
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2021-01-29
    Publishing country Netherlands
    Document type Congress
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103232
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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  2. Article ; Online: Engineered living materials (May 4-7, 2021).

    Alakpa, Enateri V

    EBioMedicine

    2021  Volume 69, Page(s) 103473

    MeSH term(s) Animals ; Congresses as Topic ; Humans ; Synthetic Biology/methods ; Tissue Engineering/methods
    Language English
    Publishing date 2021-07-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article ; Online: 11th World biomaterials congress, 11th – 15th December 2020

    Enateri V. Alakpa

    EBioMedicine, Vol 64, Iss , Pp 103232- (2021)

    2021  

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Engineered living materials (May 4–7, 2021)

    Enateri V Alakpa

    EBioMedicine, Vol 69, Iss , Pp 103473- (2021)

    2021  

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Bioprinted Schwann and Mesenchymal Stem Cell Co-Cultures for Enhanced Spatial Control of Neurite Outgrowth.

    Alakpa, Enateri V / Bahrd, Anton / Wiklund, Krister / Andersson, Magnus / Novikov, Lev N / Ljungberg, Christina / Kelk, Peyman

    Gels (Basel, Switzerland)

    2023  Volume 9, Issue 3

    Abstract: Bioprinting nerve conduits supplemented with glial or stem cells is a promising approach to promote axonal regeneration in the injured nervous system. In this study, we examined the effects of different compositions of bioprinted fibrin hydrogels ... ...

    Abstract Bioprinting nerve conduits supplemented with glial or stem cells is a promising approach to promote axonal regeneration in the injured nervous system. In this study, we examined the effects of different compositions of bioprinted fibrin hydrogels supplemented with Schwann cells and mesenchymal stem cells (MSCs) on cell viability, production of neurotrophic factors, and neurite outgrowth from adult sensory neurons. To reduce cell damage during bioprinting, we analyzed and optimized the shear stress magnitude and exposure time. The results demonstrated that fibrin hydrogel made from 9 mg/mL of fibrinogen and 50IE/mL of thrombin maintained the gel's highest stability and cell viability. Gene transcription levels for neurotrophic factors were significantly higher in cultures containing Schwann cells. However, the amount of the secreted neurotrophic factors was similar in all co-cultures with the different ratios of Schwann cells and MSCs. By testing various co-culture combinations, we found that the number of Schwann cells can feasibly be reduced by half and still stimulate guided neurite outgrowth in a 3D-printed fibrin matrix. This study demonstrates that bioprinting can be used to develop nerve conduits with optimized cell compositions to guide axonal regeneration.
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels9030172
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  6. Article ; Online: Bioprinted Schwann and Mesenchymal Stem Cell Co-Cultures for Enhanced Spatial Control of Neurite Outgrowth

    Enateri V. Alakpa / Anton Bahrd / Krister Wiklund / Magnus Andersson / Lev N. Novikov / Christina Ljungberg / Peyman Kelk

    Gels, Vol 9, Iss 172, p

    2023  Volume 172

    Abstract: Bioprinting nerve conduits supplemented with glial or stem cells is a promising approach to promote axonal regeneration in the injured nervous system. In this study, we examined the effects of different compositions of bioprinted fibrin hydrogels ... ...

    Abstract Bioprinting nerve conduits supplemented with glial or stem cells is a promising approach to promote axonal regeneration in the injured nervous system. In this study, we examined the effects of different compositions of bioprinted fibrin hydrogels supplemented with Schwann cells and mesenchymal stem cells (MSCs) on cell viability, production of neurotrophic factors, and neurite outgrowth from adult sensory neurons. To reduce cell damage during bioprinting, we analyzed and optimized the shear stress magnitude and exposure time. The results demonstrated that fibrin hydrogel made from 9 mg/mL of fibrinogen and 50IE/mL of thrombin maintained the gel’s highest stability and cell viability. Gene transcription levels for neurotrophic factors were significantly higher in cultures containing Schwann cells. However, the amount of the secreted neurotrophic factors was similar in all co-cultures with the different ratios of Schwann cells and MSCs. By testing various co-culture combinations, we found that the number of Schwann cells can feasibly be reduced by half and still stimulate guided neurite outgrowth in a 3D-printed fibrin matrix. This study demonstrates that bioprinting can be used to develop nerve conduits with optimized cell compositions to guide axonal regeneration.
    Keywords 3D bioprinting ; biosynthetic conduit ; dorsal root ganglion ; mesenchymal stem cells ; nerve regeneration ; Schwann cells ; Science ; Q ; Chemistry ; QD1-999 ; Inorganic chemistry ; QD146-197 ; General. Including alchemy ; QD1-65
    Subject code 571
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A Metabolomics-Based Approach to Identify Lineage Guiding Molecules in Pericyte Cultures.

    Alakpa, Enateri V / West, Christopher C / Goldie, Laura / Harper, Mhairi M / Burgess, Karl / Ulijn, Rein V / Dalby, Matthew J

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2235, Page(s) 47–59

    Abstract: We report the use of self-assembled peptide ( ... ...

    Abstract We report the use of self-assembled peptide (F
    MeSH term(s) Animals ; Biocompatible Materials/metabolism ; Capillaries/cytology ; Cell Differentiation/drug effects ; Cell Differentiation/physiology ; Cells, Cultured ; Endothelial Cells/cytology ; Humans ; Hydrogels/chemistry ; Metabolomics/methods ; Microvessels/cytology ; Multipotent Stem Cells/drug effects ; Peptides/chemistry ; Pericytes/cytology ; Pericytes/metabolism ; Pericytes/transplantation ; Phenotype
    Chemical Substances Biocompatible Materials ; Hydrogels ; Peptides
    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1056-5_5
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  8. Article: Biomimetic oyster shell-replicated topography alters the behaviour of human skeletal stem cells.

    Waddell, Shona J / de Andrés, María C / Tsimbouri, Penelope M / Alakpa, Enateri V / Cusack, Maggie / Dalby, Matthew J / Oreffo, Richard Oc

    Journal of tissue engineering

    2018  Volume 9, Page(s) 2041731418794007

    Abstract: The regenerative potential of skeletal stem cells provides an attractive prospect to generate bone tissue needed for musculoskeletal reparation. A central issue remains efficacious, controlled cell differentiation strategies to aid progression of cell ... ...

    Abstract The regenerative potential of skeletal stem cells provides an attractive prospect to generate bone tissue needed for musculoskeletal reparation. A central issue remains efficacious, controlled cell differentiation strategies to aid progression of cell therapies to the clinic. The nacre surface from
    Language English
    Publishing date 2018-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2573915-3
    ISSN 2041-7314
    ISSN 2041-7314
    DOI 10.1177/2041731418794007
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  9. Article ; Online: Improving cartilage phenotype from differentiated pericytes in tunable peptide hydrogels.

    Alakpa, Enateri V / Jayawarna, Vineetha / Burgess, Karl E V / West, Christopher C / Péault, Bruno / Ulijn, Rein V / Dalby, Matthew J

    Scientific reports

    2017  Volume 7, Issue 1, Page(s) 6895

    Abstract: Differentiation of stem cells to chondrocytes in vitro usually results in a heterogeneous phenotype. This is evident in the often detected over expression of type X collagen which, in hyaline cartilage structure is not characteristic of the mid-zone but ... ...

    Abstract Differentiation of stem cells to chondrocytes in vitro usually results in a heterogeneous phenotype. This is evident in the often detected over expression of type X collagen which, in hyaline cartilage structure is not characteristic of the mid-zone but of the deep-zone ossifying tissue. Methods to better match cartilage developed in vitro to characteristic in vivo features are therefore highly desirable in regenerative medicine. This study compares phenotype characteristics between pericytes, obtained from human adipose tissue, differentiated using diphenylalanine/serine (F
    MeSH term(s) Adipose Tissue/cytology ; Adipose Tissue/metabolism ; Biomarkers ; Cell Differentiation ; Cells, Cultured ; Chondrocytes/cytology ; Chondrocytes/metabolism ; Chondrogenesis ; Collagen Type II/metabolism ; Dipeptides ; Humans ; Hydrogels/chemistry ; Metabolomics ; Peptides/chemistry ; Pericytes/cytology ; Pericytes/metabolism ; Phenotype ; Phenylalanine/analogs & derivatives ; Phenylalanine/chemistry ; Tissue Engineering/methods
    Chemical Substances Biomarkers ; Collagen Type II ; Dipeptides ; Hydrogels ; Peptides ; phenylalanylphenylalanine (2577-40-4) ; Phenylalanine (47E5O17Y3R)
    Language English
    Publishing date 2017-07-31
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-07255-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Nacre Topography Produces Higher Crystallinity in Bone than Chemically Induced Osteogenesis.

    Alakpa, Enateri V / Burgess, Karl E V / Chung, Peter / Riehle, Mathis O / Gadegaard, Nikolaj / Dalby, Matthew John / Cusack, Maggie

    ACS nano

    2017  Volume 11, Issue 7, Page(s) 6717–6727

    Abstract: It is counterintuitive that invertebrate shells can induce bone formation, yet nacre, or mother of pearl, from marine shells is both osteoinductive and osteointegrative. Nacre is composed of aragonite (calcium carbonate) and induces production of ... ...

    Abstract It is counterintuitive that invertebrate shells can induce bone formation, yet nacre, or mother of pearl, from marine shells is both osteoinductive and osteointegrative. Nacre is composed of aragonite (calcium carbonate) and induces production of vertebrate bone (calcium phosphate). Exploited by the Mayans for dental implants, this remarkable phenomenon has been confirmed in vitro and in vivo, yet the characteristic of nacre that induces bone formation remains unknown. By isolating nacre topography from its inherent chemistry in the production of polycaprolactone (PCL) nacre replica, we show that, for mesenchymal stem cells, nacre topography is osteoinductive. Gene expression of specific bone marker proteins, osteopontin, osteocalcin, osteonectin, and osterix, is increased 10-, 2-, 1.7-, and 1.8-fold, respectively, when compared to planar PCL. Furthermore, we demonstrate that bone tissue that forms in response to the physical topographical features of nacre has a higher crystallinity than bone formed in response to chemical cues with a full width half-maximum for PO
    MeSH term(s) Animals ; Biocompatible Materials/chemistry ; Cell Differentiation ; Humans ; Mesenchymal Stem Cells/cytology ; Nacre/chemistry ; Osteoblasts/cytology ; Osteogenesis ; Pinctada/chemistry ; Polyesters/chemistry ; Surface Properties
    Chemical Substances Biocompatible Materials ; Nacre ; Polyesters ; polycaprolactone (24980-41-4)
    Language English
    Publishing date 2017-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.7b01044
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