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  1. Article ; Online: Identifying the Right Target for New Drugs in Acute Kidney Injury: A Long Way Off?

    Doi, Kent

    Kidney international reports

    2023  Volume 8, Issue 7, Page(s) 1287–1289

    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Editorial
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.05.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; E-Book: Acute Kidney Injury and Regenerative Medicine

    Terada, Yoshio / Wada, Takashi / Doi, Kent

    2020  

    Abstract: This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also ... ...

    Author's details edited by Yoshio Terada, Takashi Wada, Kent Doi
    Abstract This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis. Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.
    Keywords Nephrology ; Regenerative medicine ; Tissue engineering ; Regenerative Medicine/Tissue Engineering
    Subject code 780
    Language English
    Size 1 online resource (IX, 396 p. 39 illus., 33 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-1108-X ; 981-15-1107-1 ; 978-981-15-1108-0 ; 978-981-15-1107-3
    DOI 10.1007/978-981-15-1108-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Authors' reply to the comment from Uchida et al.

    Osawa, Itsuki / Doi, Kent

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 327

    MeSH term(s) Humans ; Polymyxin B ; Hemadsorption ; Sepsis ; Patients
    Chemical Substances Polymyxin B (J2VZ07J96K)
    Language English
    Publishing date 2023-08-25
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04606-3
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    Zs.A 5517: Show issues Location:
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  4. Article ; Online: The authors reply.

    Ohbe, Hiroyuki / Sasabuchi, Yusuke / Doi, Kent / Matsui, Hiroki / Yasunaga, Hideo

    Critical care medicine

    2024  Volume 52, Issue 2, Page(s) e108–e109

    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006122
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  5. Article ; Online: The need for disruptive innovation in acute kidney injury.

    Doi, Kent

    Clinical and experimental nephrology

    2020  Volume 24, Issue 11, Page(s) 979–988

    Abstract: Acute kidney injury (AKI) is a threatening medical condition associated with poor outcomes at different settings. The development of standardized diagnostic criteria and new biomarkers addressed significant clinical impacts of AKI and the need for an ... ...

    Abstract Acute kidney injury (AKI) is a threatening medical condition associated with poor outcomes at different settings. The development of standardized diagnostic criteria and new biomarkers addressed significant clinical impacts of AKI and the need for an early AKI detection, respectively. There have been some breakthroughs in understanding the pathogenesis of AKI through basic research; however, treatments against AKI aside from renal replacement therapy (RRT) have not shown adequate successful results. Biomarkers that could identify good responders to certain treatment are expected to facilitate translation of basic research findings. Most patients with severe AKI treated with RRT died due to multiple-organ failure, not renal dysfunction. Hence, it is essential to identify other organ dysfunctions induced by AKI as organ crosstalk. Also, a multidisciplinary approach of critical care nephrology is needed to evaluate a complex organ crosstalk in AKI. For disruptive innovation for AKI, we further explore these new aspects of AKI, which previously were considered outside the scope of nephrology.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/physiopathology ; Acute Kidney Injury/therapy ; Animals ; Biomarkers/blood ; Biomarkers/urine ; Biomedical Research ; Creatinine/blood ; Critical Care ; Disease Models, Animal ; Fatty Acid-Binding Proteins/urine ; Humans ; Inventions ; Lipocalin-2/urine ; Renal Replacement Therapy ; Urine
    Chemical Substances Biomarkers ; FABP1 protein, human ; Fatty Acid-Binding Proteins ; LCN2 protein, human ; Lipocalin-2 ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2020-06-24
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-020-01920-w
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  6. Article ; Online: Sympathetic Nerve Activation in Acute Kidney Injury and Cardiorenal Syndrome.

    Doi, Kent / Matsuura, Ryo

    Nephron

    2023  Volume 147, Issue 12, Page(s) 717–720

    Abstract: The interactions between the kidney and heart are well studied and frequently lumped together as cardiorenal syndrome. It is believed that the sympathetic nervous system is involved in the mechanism of kidney injury caused by heart failure, but direct ... ...

    Abstract The interactions between the kidney and heart are well studied and frequently lumped together as cardiorenal syndrome. It is believed that the sympathetic nervous system is involved in the mechanism of kidney injury caused by heart failure, but direct evidence is still lacking. In chronic renal fibrosis, sympathetic nerve activation was demonstrated to be harmful by unilateral ureteral obstruction and post-ischemia reperfusion injury models. On the other hand, sympathetic nerve activation seemed protective in acute kidney injury models such as ischemia reperfusion injury and lipopolysaccharide injection. Our recent investigation showed that post-ischemic renal fibrosis was attenuated when preexisting heart failure was induced by transverse aortic constriction surgery and renal denervation canceled this protection. These findings suggest sympathetic nerve activation in cardiorenal syndrome may be protective on chronic renal fibrosis development caused by ischemic an insult.
    MeSH term(s) Rats ; Animals ; Humans ; Cardio-Renal Syndrome ; Rats, Sprague-Dawley ; Acute Kidney Injury ; Kidney/pathology ; Sympathetic Nervous System/physiology ; Ischemia ; Reperfusion Injury/pathology ; Heart Failure/complications ; Fibrosis
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000534217
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  7. Article ; Online: How to sharpen a novel sword from AKI basic research.

    Doi, Kent

    Kidney international

    2019  Volume 95, Issue 1, Page(s) 19–20

    Abstract: No specific drug against acute kidney injury is clinically available and novel findings in basic research urgently need to be translated to the clinical in order to improve the outcome of patients. Chen and colleagues demonstrated the protective role of ... ...

    Abstract No specific drug against acute kidney injury is clinically available and novel findings in basic research urgently need to be translated to the clinical in order to improve the outcome of patients. Chen and colleagues demonstrated the protective role of tenascin-C on acute kidney injury by using animal models and in vitro and ex vivo experiments. We need to find a better way to overcome the barrier for translation of this new target.
    MeSH term(s) Acute Kidney Injury ; Animals ; Humans ; Ligands ; Tenascin
    Chemical Substances Ligands ; Tenascin
    Language English
    Publishing date 2019-01-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2018.09.017
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  8. Article: Does a slight change in serum creatinine matter in coronavirus disease 2019 (COVID-19) patients?

    Komaru, Yohei / Doi, Kent

    Kidney research and clinical practice

    2021  Volume 40, Issue 2, Page(s) 177–179

    Language English
    Publishing date 2021-06-09
    Publishing country Korea (South)
    Document type Editorial
    ZDB-ID 2656420-8
    ISSN 2211-9132
    ISSN 2211-9132
    DOI 10.23876/j.krcp.21.108
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  9. Article ; Online: Acute kidney injury and distant organ dysfunction-network system analysis.

    Matsuura, Ryo / Doi, Kent / Rabb, Hamid

    Kidney international

    2023  Volume 103, Issue 6, Page(s) 1041–1055

    Abstract: Acute kidney injury (AKI) occurs in about half of critically ill patients and is associated with high in-hospital mortality, increased long-term mortality postdischarge, and subsequent progression to chronic kidney disease. Numerous clinical studies have ...

    Abstract Acute kidney injury (AKI) occurs in about half of critically ill patients and is associated with high in-hospital mortality, increased long-term mortality postdischarge, and subsequent progression to chronic kidney disease. Numerous clinical studies have shown that AKI is often complicated by dysfunction of distant organs, which is a cause of the high mortality incidence associated with AKI. Experimental studies have elucidated many mechanisms of AKI-induced distant organ injury, which include inflammatory cytokines, oxidative stress, and immune responses. This review provides an update on evidence of organ crosstalk and potential therapeutics for AKI-induced organ injuries, and presents the new concept of a systemic organ network that balances homeostasis and involves multi-organ crosstalk beyond that of the kidney with a single distant organ.
    MeSH term(s) Humans ; Multiple Organ Failure/etiology ; Aftercare ; Patient Discharge ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Acute Kidney Injury/epidemiology ; Kidney ; Critical Illness
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.03.025
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  10. Article ; Online: Reddish-purple effluent fluid induced by hydroxocobalamin in continuous renal replacement therapy.

    Yamamoto, Miyuki / Watanabe, Yasuyuki / Doi, Kent

    Acute medicine & surgery

    2022  Volume 9, Issue 1, Page(s) e773

    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2751184-4
    ISSN 2052-8817 ; 2052-8817
    ISSN (online) 2052-8817
    ISSN 2052-8817
    DOI 10.1002/ams2.773
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