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Article ; Online: Primary Conjunctiva Tuberculosis and Review of Literature.

Aliff, I C / Fazliana, I / Tajunisah, I / Mimiwati, Z / Chandran, P A / Subrayan, V

2021 Volume 35, Issue 1, Page(s) 26–31

Abstract: The causes of chronic conjunctivitis are exhaustive, infection being the commonest. Primary tuberculosis(TB) involving the conjunctiva is rare. History of chronicity, worsening symptoms with steroids and clinical signs of subconjunctiva nodules could ... ...

Abstract	The causes of chronic conjunctivitis are exhaustive, infection being the commonest. Primary tuberculosis(TB) involving the conjunctiva is rare. History of chronicity, worsening symptoms with steroids and clinical signs of subconjunctiva nodules could point towards the diagnosis of primary conjunctiva tuberculosis especially in endemic countries. Clinicopathological diagnosis is imperative to confirm this diagnosis. We report a case of a young lady who presented with a non-resolving chronic conjunctivitis that was proven to be TB and responded well to anti-tuberculosis treatment.
Language	English
Publishing date	2021-01-06
Publishing country	Malaysia
Document type	Journal Article
ZDB-ID	1068371-9
ISSN	2521-9855 ; 0127-5720
ISSN (online)	2521-9855
ISSN	0127-5720
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Article: Visual outcome in open globe injuries.

Thevi, T / Mimiwati, Z / Reddy, S C

Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH

2012 Volume 4, Issue 2, Page(s) 263–270

Abstract: Objective: To determine the factors affecting the visual outcome in patients with open globe injuries of eye.: Materials and methods: In a prospective interventional study of consecutive patients with open globe injuries, the age, gender, place of ... ...

Abstract	Objective: To determine the factors affecting the visual outcome in patients with open globe injuries of eye. Materials and methods: In a prospective interventional study of consecutive patients with open globe injuries, the age, gender, place of injury, object causing injury and safety precautions taken were recorded. A detailed examination of the eye was done with a slit-lamp. X-rays of the orbits were taken in order to determine the presence of a foreign body. The injuries were classified as simple or complicated depending on the involvement of the pupil/iris, lens and retina. Finally, post operative best-corrected visual acuity at last follow up was noted. Results: Fifty-two patients (52 eyes) were included in the study. The mean age of patients was 27.25±12.62 years (range 9-73 years). The majority of injuries occurred in the workplace (36.5%); nail (15.4%) and glass (15.4%) were the most common objects causing injury. Of those with good initial visual acuity, 90% maintained good visual outcome. Patients with corneal lacerations of less than 5 mm had significant good visual outcome. The number of corneal lacerations and visual axis involvement did not affect the visual outcome. Those with corneoscleral lacerations had significantly poor visual outcomes compared to those with corneal or scleral lacerations alone. Conclusion: Predictors of good visual outcome are good initial visual acuity, a corneal laceration wound of less than 5mm, a deep anterior chamber, and simple lacerations. Age, gender, place of injury, object causing injury, presence of hyphema or intraocular foreign body, and the use of safety precautions did not affect the visual outcome.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Eye Injuries, Penetrating/diagnosis ; Eye Injuries, Penetrating/physiopathology ; Eye Injuries, Penetrating/surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Ophthalmologic Surgical Procedures/methods ; Prognosis ; Prospective Studies ; Tomography, X-Ray Computed ; Trauma Severity Indices ; Visual Acuity/physiology ; Young Adult
Language	English
Publishing date	2012-08-04
Publishing country	Nepal
Document type	Comparative Study ; Journal Article
ZDB-ID	2596436-7
ISSN	2091-0320 ; 2072-6805
ISSN (online)	2091-0320
ISSN	2072-6805
DOI	http://dx.doi.org/10.3126/nepjoph.v4i2.6542
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Article ; Online: Corneal Hysteresis Is Reduced in Obstructive Sleep Apnea Syndrome.

Nadarajah, Suchitra / Samsudin, Amir / Ramli, Norlina / Tan, Chong Tin / Mimiwati, Zahari

Optometry and vision science : official publication of the American Academy of Optometry

2017 Volume 94, Issue 10, Page(s) 981–985

Abstract: Significance: To our knowledge, this is the first time a study looking at the association between corneal hysteresis (CH) and obstructive sleep apnea syndrome (OSAS) severity has been reported. We provide evidence that CH is lower in OSAS and speculate ... ...

Abstract	Significance: To our knowledge, this is the first time a study looking at the association between corneal hysteresis (CH) and obstructive sleep apnea syndrome (OSAS) severity has been reported. We provide evidence that CH is lower in OSAS and speculate on the possible causes. Purpose: The present study aims to look at the association between CH and severity of OSAS, and whether CH could be another link between OSAS and the development of glaucoma. Methods: This was a cross-sectional, observational study at the University Malaya Medical Centre, Kuala Lumpur. Patients undergoing polysomnography for assessment of OSAS were recruited. We measured central corneal thickness (CCT) using optical biometry, and CH using ocular response analysis. Intraocular pressure (IOP) and Humphrey visual field (HVF) indices were also measured. The Apnea Hypopnea Index (AHI) divided patients into normal, mild, moderate, and severe OSAS categories. The normal and mild categories (47.9%) were then collectively called group 1, and the moderate and severe categories (52.1%) were called group 2. T tests, Pearson correlation tests, and general linear model analysis were performed, with P <.05 considered statistically significant. Results: One eye each from 117 patients (75 men, 42 women) was included. Patients in group 2 had lower CH (9.8 ± 1.4 vs. 10.3 ± 1.1 mm Hg, P = .029), with unchanged estimated marginal means after correcting for age, sex, CCT, and IOP (P = .026). There were no statistically significant differences in IOP, CCT, or HVF indices between the two groups (all P > .05). CH correlated negatively with AHI (r = -0.229, P = .013) and positively with lowest oxygen saturation (r = 0.213, P = .022). Conclusions: CH is lower in moderate/severe OSAS than in normal/mild cases. This may be another link between OSAS and the development of glaucoma; further studies are indicated to determine the significance of this connection.
MeSH term(s)	Adult ; Aged ; Biomechanical Phenomena ; Cornea/diagnostic imaging ; Cornea/physiopathology ; Corneal Diseases/diagnosis ; Corneal Diseases/etiology ; Corneal Diseases/physiopathology ; Cross-Sectional Studies ; Female ; Humans ; Intraocular Pressure ; Male ; Middle Aged ; Polysomnography ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/physiopathology ; Tonometry, Ocular
Language	English
Publishing date	2017-10
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	1001706-9
ISSN	1538-9235 ; 1040-5488
ISSN (online)	1538-9235
ISSN	1040-5488
DOI	10.1097/OPX.0000000000001117
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Article ; Online: Low nocturnal ocular perfusion pressure as a risk factor for normal tension glaucoma.

Ramli, N / Nurull, B S / Hairi, Noran N / Mimiwati, Z

Preventive medicine

2013 Volume 57 Suppl, Page(s) S47–9

Abstract: Objectives: In the absence of raised intraocular pressure (IOP), haemodynamic parameters have been implicated in the development of normal tension glaucoma (NTG). The purpose of this study is to compare 24-hour IOP and haemodynamic parameters in NTG ... ...

Abstract	Objectives: In the absence of raised intraocular pressure (IOP), haemodynamic parameters have been implicated in the development of normal tension glaucoma (NTG). The purpose of this study is to compare 24-hour IOP and haemodynamic parameters in NTG patients and non-glaucoma patients. Methods: This is a cross sectional study involving 72 NTG patients from University of Malaya Medical Centre eye clinic glaucoma registry. The non-glaucoma patients were volunteers selected from eye clinic patients. All enrolled patients underwent 24-hour IOP and blood pressure monitoring via 2-hourly IOP and blood pressure (BP) measurements. All readings were taken in the sitting position during the diurnal period and in the supine position during the nocturnal period Results: Comparison of the haemodynamic parameters, the nocturnal mean systolic BP, nocturnal mean diastolic BP and nocturnal mean arterial pressure (MAP) were significantly lower in the NTG group. The systemic ocular perfusion pressures (OPP), diastolic OPP and mean OPP taken at night were also significantly lower in the NTG group. The differences between the groups were still manifest after controlling for age and presence of hypertension. Conclusion: Our findings show that the nocturnal supine blood pressure parameters (systolic, diastolic and mean) and OPP were significantly lower in the NTG group compared to normals. This may reflect defective autoregulatory mechanisms in NTG patients.
MeSH term(s)	Blood Pressure/physiology ; Circadian Rhythm/physiology ; Cross-Sectional Studies ; Female ; Humans ; Intraocular Pressure/physiology ; Low Tension Glaucoma/etiology ; Low Tension Glaucoma/physiopathology ; Male ; Middle Aged ; Monitoring, Physiologic ; Ocular Hypotension/complications ; Ocular Hypotension/physiopathology ; Risk Factors
Language	English
Publishing date	2013
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184600-0
ISSN	1096-0260 ; 0091-7435
ISSN (online)	1096-0260
ISSN	0091-7435
DOI	10.1016/j.ypmed.2013.01.007
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Article: Intravitreal injection of recombinant tissue plasminogen activator and pneumatic displacement of submacular haemorrhage.

Fadhilah, M / Mimiwati, Z / Fong, K C S

The Medical journal of Malaysia

2010 Volume 65, Issue 4, Page(s) 271–272

Abstract: We report a case of a patient with hypertension and ischaemic heart disease on anti-platelet treatment, who developed uniocular profound visual loss from a submacular haemorrhage secondary to valsalva retinopathy. He was treated with a combination of ... ...

Abstract	We report a case of a patient with hypertension and ischaemic heart disease on anti-platelet treatment, who developed uniocular profound visual loss from a submacular haemorrhage secondary to valsalva retinopathy. He was treated with a combination of intravitreal recombinant tissue plasminogen activator (rtPA) and sulphur hexafluoride (SF6) gas followed by strict prone positioning. He demonstrated significant displacement of the haemorrhage and improvement of vision postoperatively.
MeSH term(s)	Humans ; Intravitreal Injections ; Macula Lutea ; Male ; Middle Aged ; Recombinant Proteins/administration & dosage ; Retinal Hemorrhage/therapy ; Tissue Plasminogen Activator/administration & dosage
Chemical Substances	Recombinant Proteins ; Tissue Plasminogen Activator (EC 3.4.21.68)
Language	English
Publishing date	2010-12
Publishing country	Malaysia
Document type	Case Reports ; Journal Article
ZDB-ID	604286-7
ISSN	0300-5283
ISSN	0300-5283
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Article ; Online: Ocular perfusion pressure and ophthalmic artery flow in patients with normal tension glaucoma.

Samsudin, Amir / Isaacs, Nadine / Tai, Mei-Ling Sharon / Ramli, Norlina / Mimiwati, Zahari / Choo, May May

BMC ophthalmology

2016 Volume 16, Page(s) 39

Abstract: Background: Vascular insufficiency has been reported to be a cause of normal tension glaucoma (NTG). The aim of this study was to compare ocular perfusion pressure (OPP) and ophthalmic artery flow (OAF) between patients with NTG and those without ... ...

Abstract	Background: Vascular insufficiency has been reported to be a cause of normal tension glaucoma (NTG). The aim of this study was to compare ocular perfusion pressure (OPP) and ophthalmic artery flow (OAF) between patients with NTG and those without glaucoma. Methods: We considered one eye each from 31 NTG and 15 non-glaucoma control patients. Blood pressure and intraocular pressure (IOP) were measured in the sitting position, for calculation of OPP. Humphrey visual field (HVF) assessment was then carried out on NTG patients. All patients then underwent Transcranial Doppler ultrasound measurements of OAF parameters, including mean flow velocity (MFV), end diastolic velocity (EDV), peak systolic velocity (PSV) and resistive index (RI). We looked at differences in OPP and OAF parameters between the two groups, and their correlations in NTG patients. T-tests, χ (2), ANOVA and Pearson Correlation tests were performed, with p < 0.05 considered statistically significant. Results: There were no statistically significant differences in OPP between the NTG and control groups (60.5+/-8.7 mmHg and 62.9+/-10.2 mmHg respectively, p = 0.393), and also no statistically significant differences in MFV, EDV, PSV and RI (all p > 0.05). In the NTG group, there were positive correlations between OPP and both MFV (r = 0.416, p = 0.020) and EDV (r = 0.369, p = 0.041). There were no statistically significant correlations between HVF mean deviation and OPP or OAF parameters (all p > 0.05). Conclusion: There is no difference in OPP and OAF parameters between patients with NTG and non-glaucoma controls, suggesting that vascular insufficiency or dysregulation by themselves may not account for the pathogenesis of NTG.
MeSH term(s)	Aged ; Arterial Pressure/physiology ; Blood Flow Velocity ; Blood Pressure/physiology ; Cross-Sectional Studies ; Female ; Humans ; Intraocular Pressure/physiology ; Low Tension Glaucoma/physiopathology ; Male ; Middle Aged ; Ophthalmic Artery/physiology ; Ultrasonography, Doppler, Transcranial
Language	English
Publishing date	2016-04-14
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-016-0215-3
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Article: Post viral acute multifocal posterior placoid pigment epithiopathy in a teenage child.

Nga, Angeline D C / Ramli, N / Mimiwati, Z

The Medical journal of Malaysia

2009 Volume 64, Issue 2, Page(s) 176–178

Abstract: We report a rare case of a young boy presenting with bilateral blurring of vision following a viral like illness. Fundus examination revealed multiple pale cream-coloured lesions scattered across the posterior pole of both eyes. Fundus fluorescein ... ...

Abstract	We report a rare case of a young boy presenting with bilateral blurring of vision following a viral like illness. Fundus examination revealed multiple pale cream-coloured lesions scattered across the posterior pole of both eyes. Fundus fluorescein angiography showed characteristic features of early hypofluorescence and late hyperfluorescence, further confirming the diagnosis of acute posterior placoid pigment epitheliopathy (AMPPPE). He was treated with topical steroids for the accompanying mild anterior uveitis. He had a prompt visual recovery with no adverse sequelae.
MeSH term(s)	Acute Disease ; Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Fluorescein Angiography ; Humans ; Male ; Pigment Epithelium of Eye/pathology ; Retinal Diseases/drug therapy ; Retinal Diseases/etiology ; Virus Diseases/complications
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2009-06
Publishing country	Malaysia
Document type	Case Reports ; Journal Article
ZDB-ID	604286-7
ISSN	0300-5283
ISSN	0300-5283
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Article: The association between body mass index and age related cataract.

Noran, N H / Nooriah, S / Mimiwati, Z

The Medical journal of Malaysia

2007 Volume 62, Issue 1, Page(s) 49–52

Abstract: This study was carried out to determine the association between body mass index and age related cataract among patients attending eye clinic. We conducted a case control study. The outcome of clinical eye assessment determined the patient's status. Mean ... ...

Abstract	This study was carried out to determine the association between body mass index and age related cataract among patients attending eye clinic. We conducted a case control study. The outcome of clinical eye assessment determined the patient's status. Mean body mass index among the cases was shown to be higher (25.4 +/- 4.5) than the control group (24.4 +/- 3.9) (p < 0.01). Crude analysis showed that only obese respondents were 2.4 times more likely to develop age related cataract, however this association was not seen in the multivariate analysis after adjusting for other determinants (aOR 1.81; 95% CI 0.91 - 3.62). We conclude that there is no association between body mass index and age related cataract.
MeSH term(s)	Age Factors ; Aged ; Body Mass Index ; Case-Control Studies ; Cataract ; Female ; Humans ; Malaysia ; Male ; Middle Aged
Language	English
Publishing date	2007-03
Publishing country	Malaysia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604286-7
ISSN	0300-5283
ISSN	0300-5283
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Article: Ocular biometry in the subtypes of primary angle closure glaucoma in University Malaya Medical Centre.

Mimiwati, Z / Fathilah, J

The Medical journal of Malaysia

2001 Volume 56, Issue 3, Page(s) 341–349

Abstract: Thirty-seven consecutive patients (41 eyes) diagnosed with primary angle closure glaucoma (PACG) attending the Glaucoma Clinic in University Malaya Medical Centre, over a period of 6 months were categorized into acute, subacute and chronic PACG from ... ...

Abstract	Thirty-seven consecutive patients (41 eyes) diagnosed with primary angle closure glaucoma (PACG) attending the Glaucoma Clinic in University Malaya Medical Centre, over a period of 6 months were categorized into acute, subacute and chronic PACG from their clinical presentation. Each case was subjected to automated refraction, A-scan biometry for anterior chamber depth, axial length and lens thickness, keratometry and corneal diameter measurement. Calculations for the relative lens position and the lens thickness: axial length index were performed. The data collected was analysed by the nonparametric test (Kruskal-Wallis), one way analysis of variance (ANOVA), chi-square test, Spearman's nonparametric correlations and regression analysis. For controls 15 eyes from 15 normal subjects matched for age, sex, refractive error and race were chosen and subjected to the same examinations. Chronic PACG was the predominant subtype (53.6% of patients and 58.5% of eyes). The ocular biometric measurements of acute PACG eyes deviated most from normals in having the shallowest anterior chamber depth, shortest axial length, smallest corneal diameter, steepest corneal radius, thickest and most anteriorly situated lens, and the greatest lens thickness: axial length index. The subacute subtype was closest to normal and chronic PACG subtype fell in between in most of the biometric characteristics. These findings were not statistically significant. All PACG eyes as a group however showed statistically significant shallower anterior chamber depth (p < 0.05), and a more anterior relative lens position (p < 0.05) compared to normals.
MeSH term(s)	Academic Medical Centers ; Aged ; Anterior Chamber/pathology ; Biometry ; Eye/pathology ; Female ; Glaucoma, Angle-Closure/classification ; Glaucoma, Angle-Closure/pathology ; Humans ; Malaysia ; Male ; Middle Aged
Language	English
Publishing date	2001-09
Publishing country	Malaysia
Document type	Journal Article
ZDB-ID	604286-7
ISSN	0300-5283
ISSN	0300-5283
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Article ; Online: Effect of haemodialysis on intraocular pressure.

Samsudin, A / Mimiwati, Z / Soong, T / Fauzi, M S Ahmad / Zabri, K

Eye (London, England)

2010 Volume 24, Issue 1, Page(s) 70–73

Abstract: Aims: To study the effect of haemodialysis on intraocular pressure (IOP) of patients at the University Malaya Medical Centre, Kuala Lumpur, and the influence of anterior chamber angles, surgery, and diabetes on the change in IOP after haemodialysis.: ... ...

Abstract	Aims: To study the effect of haemodialysis on intraocular pressure (IOP) of patients at the University Malaya Medical Centre, Kuala Lumpur, and the influence of anterior chamber angles, surgery, and diabetes on the change in IOP after haemodialysis. Methods: Prospective, single centre study on patients undergoing haemodialysis with a sample size of 98 eyes (49 patients). Ocular examination was performed before haemodialysis. Pre- and post-haemodialysis IOP measurements were taken. Plasma osmolarity changes and volume of fluid removed were noted. Patients on antiglaucoma treatment or who have had earlier laser or surgical procedures for it were excluded. Student's t-test and Pearson's coefficient test were used to determine the statistical significance. Results: Plasma osmolarity decreased significantly (-11.6+/-10.0 m Osm/l, P<0.001). In eyes with occludable angles (8% of cases), IOP decreased significantly (-3.63+/-1.92 mmHg, P<0.001). In non-occludable angle eyes (92% of cases), no significant changes (P>0.05) in all subgroups of non-operated/operated and diabetic/non-diabetic eyes were seen. Conclusions: Haemodialysis does not cause significant changes in IOP in non-glaucomatous and non-occludable angle eyes.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Anterior Chamber/pathology ; Female ; Humans ; Intraocular Pressure/physiology ; Male ; Middle Aged ; Osmolar Concentration ; Prospective Studies ; Renal Dialysis ; Young Adult
Language	English
Publishing date	2010-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/eye.2009.33
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