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Article: Editorial: Subclassification of AUS/FLUS category for thyroid nodules: trials and evidence-based clinical management.

Bayraktaroğlu, Taner / Barut, Figen / Çakmak, Güldeniz Karadeniz

2023 Volume 14, Page(s) 1209776

MeSH term(s)	Humans ; Thyroid Nodule/diagnosis ; Thyroid Nodule/therapy
Language	English
Publishing date	2023-06-13
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1209776
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Article ; Online: Parent Views on Telemedicine in Pediatric Rheumatology: A Survey Study.

Kayaalp, Gülşah Kavrul / Akgün, Özlem / Demirkan, Fatma Gül / Tanatar, Ayşe / Çakmak, Figen / Ayaz, Nuray Aktay

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

2023 Volume 29, Issue 10, Page(s) 1548–1556

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Child ; Humans ; Rheumatology ; COVID-19/epidemiology ; Cross-Sectional Studies ; Pandemics ; Parents ; Telemedicine
Language	English
Publishing date	2023-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2035659-6
ISSN	1556-3669 ; 1530-5627
ISSN (online)	1556-3669
ISSN	1530-5627
DOI	10.1089/tmj.2022.0433
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Article ; Online: The assessment of fatigue and sleep quality among children and adolescents with familial Mediterranean fever: A case-control and correlation study.

İncesu, Çağla / Kayaalp, Gülşah Kavrul / Demirkan, Fatma Gül / Köker, Oya / Çakmak, Figen / Akgün, Özlem / Ayaz, Nuray Aktay / Ömeroğlu, Rukiye Nurten

European journal of pediatrics

2024 Volume 183, Issue 5, Page(s) 2223–2229

Abstract: To evaluate the sleep quality and fatigue levels in children with familial Mediterranean fever (FMF) in comparison to healthy children. The Pediatric Quality of Life Multidimensional Fatigue Scale (PedsQL-MFS) and the Pittsburgh Sleep Quality Index (PSQI) ...

Abstract	To evaluate the sleep quality and fatigue levels in children with familial Mediterranean fever (FMF) in comparison to healthy children. The Pediatric Quality of Life Multidimensional Fatigue Scale (PedsQL-MFS) and the Pittsburgh Sleep Quality Index (PSQI) were the instruments utilized to assess fatigue and sleep quality in children with FMF and controls, respectively. Spearman's rank coefficient was decisive in determining the association between patient-reported outcome measures and disease-related features. Two hundred twenty-five (59.3% female) patients and 182 (51.6% female) healthy counterparts were enrolled in the study. In PSQI, where high scores indicate sleep disturbance, the median score was significantly higher in the patient group (5; 3-6) than the control group (3; 2-4) (p < 0.001). PEDsQL-MFS demonstrated significantly lower fatigue levels in the control group than patients (p = 0.01). The level of fatigue in the patient group was found to increase in correlation with sleep problems (r: - 0.750, p < 0.001). Additionally, a high correlation was present between the PSQI/PedsQL-MFS scores and the number of attacks in the last year (r: - 0.645, p < 0.001/r: 0.721, p < 0.001, respectively). There was no difference in terms of fatigue and sleep disorders between mutations (homozygous, heterozygous, or compound heterozygous) in the MEFV gene (p > 0.05). Conclusion: High disease activity has a significant negative impact on the sleep quality and fatigue levels of patients with FMF. This study emphasizes the importance of assessing fatigue and sleep quality with objective outcome tools periodically in FMF patients throughout the disease course. What is Known: • Fatigue is a common matter that often accompanies rheumatic diseases and causes disability. • Chronic rheumatic diseases often experience poor sleep quality. What is New: • In high correlation with the disease severity of familial Mediterranean fever, sleep quality decreases and fatigue level increases significantly. • In familial Mediterranean fever patients, a negative correlation is present between age and the general fatigue and sleep/rest related fatigue scores (low scores indicating greater fatigue) and sleep quality is poorer in the adolescent age group.
MeSH term(s)	Humans ; Familial Mediterranean Fever/complications ; Female ; Male ; Fatigue/etiology ; Child ; Case-Control Studies ; Adolescent ; Quality of Life ; Sleep Quality ; Sleep Wake Disorders/etiology ; Sleep Wake Disorders/diagnosis ; Surveys and Questionnaires ; Patient Reported Outcome Measures
Language	English
Publishing date	2024-02-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-024-05442-5
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Article ; Online: A Conceptual Framework of Raw Food Diet and Living Foods in Consumption Culture

Tolga Fahri Çakmak / Figen Sevinç

Journal of Tourismology, Vol 4, Iss 2, Pp 83-

2018 Volume 92

Abstract: The changes that come along with globalization in life styles are now evident in the tourism industry as well, and a varietyof different diets have become available in the services provided by the industry. Further, eating and drinking habits,which ... ...

Abstract	The changes that come along with globalization in life styles are now evident in the tourism industry as well, and a varietyof different diets have become available in the services provided by the industry. Further, eating and drinking habits,which differ according to the cultural features of their geography, are rapidly integrated into the existing consumptiondrivenconcept. In this sense, this study discusses the raw food diet, which has been popular around the world, within aconceptual framework, provides an insight into different practices regarding live foods as well as the perception of theraw food diet in consumption culture.
Keywords	Living food ; Live food ; Raw food ; Consumption ; Consumption culture ; Geography (General) ; G1-922
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	Istanbul University
Document type	Article ; Online
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Article ; Online: Vaccination coverage of children with rheumatic diseases compared with healthy controls: a retrospective case-control study.

Akgün, Özlem / Demirkan, Fatma Gül / Kavrul Kayaalp, Gülşah / Erdemir, Merve / Akay, Nergis / Çakmak, Figen / Önel, Mustafa / Keskindemirci, Gonca / Eker Ömeroğlu, Rukiye / Gökçay, Emine Gülbin / Aktay Ayaz, Nuray

Postgraduate medicine

2024 Volume 135, Issue 8, Page(s) 824–830

Abstract: Objective: To reveal the vaccination status of patients with pediatric rheumatic disease (PedRD) and to compare this with healthy controls.: Methods: The electronic health records of the Ministry of Health regarding the vaccination status of children ...

Abstract	Objective: To reveal the vaccination status of patients with pediatric rheumatic disease (PedRD) and to compare this with healthy controls. Methods: The electronic health records of the Ministry of Health regarding the vaccination status of children with PedRD followed in a tertiary hospital were analyzed cross-sectionally and compared with their healthy controls. The missing vaccines were reported according to individual, age-appropriate schedule and causes of skipped vaccines in both groups were investigated with an online survey. Results: The vaccination rate of patients in the last examination was 71.4% (90/126) and 95.7% (110/115) in healthy controls ( Conclusion: Vaccination coverage of PedRD patients has been shown to lag behind the routine vaccination schedule (71.4%). In addition to new recommendations, electronic health system records for vaccination may be appropriate for the follow-up of these patients, and the addition of reminder alerts may be useful to reduce the rate of missed vaccinations.
MeSH term(s)	Humans ; Child ; Infant ; Vaccination Coverage ; Diphtheria-Tetanus-Pertussis Vaccine ; Retrospective Studies ; Case-Control Studies ; Vaccination
Chemical Substances	Diphtheria-Tetanus-Pertussis Vaccine
Language	English
Publishing date	2024-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	410138-8
ISSN	1941-9260 ; 0032-5481
ISSN (online)	1941-9260
ISSN	0032-5481
DOI	10.1080/00325481.2023.2287988
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Article ; Online: Performance of Recent PRINTO Criteria Versus Current ILAR Criteria for Systemic Juvenile Idiopathic Arthritis: A Single-Center Experience.

Koker, Oya / Demirkan, Fatma Gul / Cakmak, Figen / Aktay Ayaz, Nuray

Modern rheumatology

2021

Abstract: Objectives: The purpose of this study is to evaluate the performances of recently proposed Pediatric Rheumatology International Trials Organization (PRINTO) criteria versus current International League of Associations for Rheumatology (ILAR) criteria, ... ...

Abstract	Objectives: The purpose of this study is to evaluate the performances of recently proposed Pediatric Rheumatology International Trials Organization (PRINTO) criteria versus current International League of Associations for Rheumatology (ILAR) criteria, for systemic juvenile idiopathic arthritis (sJIA). Methods: The study was performed at the Department of Pediatric Rheumatology in Istanbul Faculty of Medicine with a retrospective design, covering the date range 2010 to 2021. Patients being followed-up with a diagnosis of sJIA, Kawasaki disease (control group-1), and common autoinflammatory diseases (control group-2) were included in the study. Both the ILAR and PRINTO classification criteria were applied to each patient and compared against expert rheumatologist diagnosis. Results: Eighty-two patients with a diagnosis of sJIA compared against 189 [74 Kawasaki disease, 83 familial Mediterranean fever (FMF), 16 mevalonate kinase deficiency (MKD), 10 cryopyrin-associated periodic syndromes (CAPS), 6 tumor necrosis factor receptor-associated periodic fever syndrome (TRAPS)] patients. The PRINTO criteria demonstrated higher sensitivity (62.2% vs 80.5%, p=0.003), but comparable specificity (90.5% vs 91%) as regards the ILAR criteria. Conclusions: The revised criteria appear to enhance the ability to provide early recognition and pertinent classification of sJIA. The two criteria were not superior to each other in segregating sJIA from common autoinflammatory diseases and Kawasaki disease, namely in terms of specificity.
Language	English
Publishing date	2021-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2078157-X
ISSN	1439-7609 ; 1439-7595
ISSN (online)	1439-7609
ISSN	1439-7595
DOI	10.1093/mr/roab115
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Article: Endoscopic closure of a duodenal perforation secondary to a migrated biliary plastic stent using hemoclips.

Cakmak, Erol

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2022 Volume 114, Issue 5, Page(s) 295

Abstract: ... into the peritoneal cavity. However, there was no evidence of perforation (Fig. 1A). During ERCP, it was observed ... opposite the papilla (Fig. 1B). The plastic stent was held with rat-tooth forceps and removed with a slight ... upward movement towards the common bile duct and then a downward movement towards the lumen (Fig. 1C ...

Abstract	A 28-year-old female patient was admitted to our hospital with right upper quadrant pain and fever. The patient was diagnosed with acute cholangitis and choledocholithiasis. Stone removal was performed with Endoscopic retrograde cholangiopancreatography (ERCP) as it measured 1cm in size and a 10-Fr 10 cm straight plastic stent (Flexima™, Boston Scientific) was placed in the common bile duct. The patient was discharged after his symptoms subsided and was admitted to our hospital again two months later with abdominal pain, back pain, nausea and vomiting. On physical examination, mild tenderness was detected in the right upper quadrant. Laboratory tests showed a white blood cell (WBC) count of 6.82x109/L, hemoglobin 10.3 g/mL, alanine aminotransferase (ALT) 19 U/L, aspartate aminotransferase (AST) 18 U/L and total bilirubin (TB) 0.76 g/mL. All other laboratory parameters were normal. Abdominal computed tomography (CT) showed that the distal end of the plastic stent migrated to the lower wall of the third part of the duodenum and protruded into the peritoneal cavity. However, there was no evidence of perforation (Fig. 1A). During ERCP, it was observed that the proximal end of the plastic stent was in the bile duct and the distal end perforated the duodenal wall opposite the papilla (Fig. 1B). The plastic stent was held with rat-tooth forceps and removed with a slight upward movement towards the common bile duct and then a downward movement towards the lumen (Fig. 1C). Closure of the defect in the duodenum was performed with three hemostatic clips (Fig. 1D). Oral intake started a few days after the procedure and there were no complications. Duodenal perforation caused by migration of biliary stents is a rare complication. Abdominal CT scanning is usually preferred in these cases, and endoscopic intervention is an effective method for treatment.
MeSH term(s)	Cholangiopancreatography, Endoscopic Retrograde ; Choledocholithiasis ; Duodenal Ulcer ; Female ; Humans ; Peptic Ulcer Perforation ; Plastics ; Stents/adverse effects ; Surgical Instruments
Chemical Substances	Plastics
Language	English
Publishing date	2022-01-15
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2022.8514/2021
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Article ; Online: Hepatitis B vaccination response of treatment-naive patients with juvenile idiopathic arthritis.

Çakmak, Figen / Çakan, Mustafa / Demir, Ferhat / Sonmez, Hafize Emine / Çakmak, Sedat / Demirkan, Fatma Gul / Karadağ, Şerife Gül / Ayaz, Nuray Aktay / Sözeri, Betül

Rheumatology international

2021 Volume 42, Issue 7, Page(s) 1199–1205

Abstract: To evaluate the vaccine response of treatment-naive juvenile idiopathic arthritis (JIA) patients who were fully vaccinated against Hepatitis B Virus (HBV) and then compare their antibody status with healthy controls. In this multicenter study, initial ... ...

Abstract	To evaluate the vaccine response of treatment-naive juvenile idiopathic arthritis (JIA) patients who were fully vaccinated against Hepatitis B Virus (HBV) and then compare their antibody status with healthy controls. In this multicenter study, initial visit hepatitis B surface antigen (HbsAg) and anti-hepatitis B surface antibody (anti-Hbs) titers of 262 treatment-naive JIA patients who were followed up regularly between May 2015 and October 2019 were evaluated retrospectively from patients' medical records and compared with 276 healthy peers. Both HbsAg and anti-Hbs antibody titers were tested by the ELISA technique. Anti-HBs titers ≥ 10 IU/L were considered as reactive indicating seroprotection against HBV. In the JIA group, seropositivity rate was 59.1% while 72.9% of the control group were immune against HBV (p = 0.002). The median titer for anti-Hbs was 14 (range: 0-1000) IU/L in the patient group and 43.3 (range: 0-1000) IU/L in the control group (p = 0.01). Neither JIA patients nor healthy controls were positive for HbsAg. Patients with JIA vaccinated according to the national vaccination schedule were evaluated at their first visit in pediatric rheumatology outpatient clinics for anti-Hbs presence and it was found that they have lesser seroprotectivity than their age and sex-matched routinely vaccinated, healthy peers. So, to complete missing vaccines and booster vaccine doses, assessing the immune status of the patients at the time of diagnosis against HBV should be in the check-list of physicians dealing with pediatric rheumatic diseases.
MeSH term(s)	Arthritis, Juvenile/drug therapy ; Child ; Hepatitis B/prevention & control ; Hepatitis B Antibodies ; Hepatitis B Surface Antigens ; Hepatitis B virus ; Humans ; Retrospective Studies ; Vaccination
Chemical Substances	Hepatitis B Antibodies ; Hepatitis B Surface Antigens
Language	English
Publishing date	2021-03-18
Publishing country	Germany
Document type	Journal Article ; Multicenter Study
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-021-04833-3
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Article ; Online: Evaluation of childhood malignancies presenting with musculoskeletal manifestations from two different divisions: a multicenter study.

Çağlayan, Şengül / Koç, Begüm Şirin / Baba, Özge / Bağlan, Esra / Kurucu, Burçak / Yıldırım, Deniz Gezgin / Ayhan, Aylin Canbolat / Çakan, Mustafa / Yener, Gülçin Otar / Öztürk, Kübra / Çakmak, Figen / Sönmez, Hafize Emine / Ayaz, Nuray Aktay / Kısaarslan, Ayşenur Paç / Bakkaloğlu, Sevcan / Kalyoncu, Mukaddes / Kılıç, Suar Çakı / Sözeri, Betül

The Turkish journal of pediatrics

2024 Volume 66, Issue 1, Page(s) 81–89

Abstract: Background: The aim of the study was to evaluate the approaches of pediatric rheumatologists and pediatric hematologists to patients with similar musculoskeletal (MSK) complaints and to highlight the differences that general pediatricians should ... ...

Abstract	Background: The aim of the study was to evaluate the approaches of pediatric rheumatologists and pediatric hematologists to patients with similar musculoskeletal (MSK) complaints and to highlight the differences that general pediatricians should consider when referring patients to these specialties. Methods: This is a cross-sectional study involving the patients who applied to pediatric rheumatology centers with MSK complaints and were diagnosed with malignancy, as well as patients who were followed up in pediatric hematology centers with a malignancy diagnosis, and had MSK complaints at the time of admission. Results: A total of 142 patients were enrolled in the study. Of these patients, 83 (58.4%) applied to pediatric rheumatology centers, and 59 (41.6%) applied to pediatric hematology centers. Acute lymphoblastic leukemia (ALL) was the most common diagnosis among the patients who applied to both centers, with 80 cases (56.3%). The median age of diagnosis was 87 (interquartile range, IQR: 48-140) months. The most common preliminary diagnosis in pediatric rheumatology centers was juvenile idiopathic arthritis (JIA), with 37 cases (44.5%). MSK involvement was mainly seen as arthralgia, and bone pain. While arthralgia (92.7%) was the most common complaint in rheumatology centers, bone pain (88.1%) was more common in hematology centers. The most frequently involved joints were the knee (62.9%), ankle (25.9%), hip (25%), and wrist (14%). The most common laboratory abnormalities were high lactate dehydrogenase (LDH), high C-reactive protein (CRP), anemia, and high erythrocyte sedimentation rate (ESR). Thrombocytopenia, neutropenia, and high LDH were statistically significantly more frequent in patients admitted to hematology centers than in patients admitted to rheumatology centers (p < 0.001, p=0.014, p=0.028, respectively). Patients who applied to rheumatology clinics were found to have statistically significantly higher CRP levels (p=0.032). Conclusions: Malignancies may present with only MSK system complaints in childhood. Therefore, malignancies should be included in the differential diagnosis of patients presenting with MSK complaints.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Cross-Sectional Studies ; Retrospective Studies ; Neoplasms/complications ; Neoplasms/diagnosis ; Arthritis, Juvenile/diagnosis ; Arthralgia
Language	English
Publishing date	2024-03-25
Publishing country	Turkey
Document type	Multicenter Study ; Journal Article
ZDB-ID	123487-0
ISSN	2791-6421 ; 0041-4301
ISSN (online)	2791-6421
ISSN	0041-4301
DOI	10.24953/turkjped.2023.446
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Article ; Online: Exploring the attitudes, concerns, and knowledge regarding COVID-19 vaccine by the parents of children with rheumatic disease: Cross-sectional online survey.

Akgün, Özlem / Kayaalp, Gülşah Kavrul / Demirkan, Fatma Gül / Çakmak, Figen / Tanatar, Ayşe / Guliyeva, Vafa / Sönmez, Hafize Emine / Ayaz, Nuray Aktay

Vaccine

2022 Volume 40, Issue 12, Page(s) 1829–1836

Abstract: Background: Vaccination programs are effective strategies in preventing infectious diseases and controlling epidemics. Vaccination against SARS-CoV-2 in children has not yet been approved globally, and it is unclear what attitude families will take when ...

Abstract	Background: Vaccination programs are effective strategies in preventing infectious diseases and controlling epidemics. Vaccination against SARS-CoV-2 in children has not yet been approved globally, and it is unclear what attitude families will take when it is approved in children. We aimed to investigate the underlying causes of vaccine acceptance, hesitation, and refusal, as well as concerns about the acceptability of the COVID-19 vaccine by parents of children with rheumatic diseases. Methods: Parents of children followed up with a diagnosis of rheumatic disease in the pediatric rheumatology outpatient clinic of a university hospital were included in the study. We applied a closed web-based online survey conducted cross-sectionally and sent to the participants via mobile smartphones. Results: For fathers, mothers, and their children, acceptance rates for a COVID-19 vaccine were 64.2%, 57.7%, and 41.8%, respectively. In the multivariate analysis, factors affecting parents' acceptance of vaccines for their children were as follows: "Receiving antirheumatic medications regularly (AOR 5.40, 95% CI 1.10-26.33, p = 0.03), the previous history of getting special recommended vaccines (AOR 4.12, 95% CI 1.12-27.85, p = 0.03), relying on vaccines for ending pandemic (AOR 8.84, 95% CI 2.80-27.85, p = 0.001), complying with the pandemic measures entirely (AOR 5.24, 95% CI 1.46-18.74, p = 0.01)". The two most common reasons for vaccine rejection were fear of the side effects of the vaccine and its possible interaction with rheumatic drugs used by children. Conclusion: According to our survey, parents were more likely to accept a COVID-19 vaccine for themselves than their children. The success of COVID-19 vaccination programs sources highly on people's willingness to accept the vaccine. It is crucial to vaccinate children for achieving herd immunity and in terms of avoiding vaccine hesitancy. Larger data examining the causes of concerns in parents of both healthy children and children with chronic diseases should be delineated.
MeSH term(s)	Attitude ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Child ; Cross-Sectional Studies ; Female ; Humans ; Pandemics/prevention & control ; Parents ; Rheumatic Diseases ; SARS-CoV-2 ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-02-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.01.061
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