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  1. Article ; Online: Writing Excellent Review Articles.

    Chan, Warren C W

    ACS nano

    2023  Volume 17, Issue 3, Page(s) 1723–1724

    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Editorial
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c00497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Principles of Nanoparticle Delivery to Solid Tumors.

    Chan, Warren C W

    BME frontiers

    2023  Volume 4, Page(s) 16

    Abstract: ... organs compete for nanoparticles in circulation, (c) nanoparticles must enter solid tumors to target ...

    Abstract The effective treatment of patients with cancer hinges on the delivery of therapeutics to a tumor site. Nanoparticles provide an essential transport system. We present 5 principles to consider when designing nanoparticles for cancer targeting: (a) Nanoparticles acquire biological identity in vivo, (b) organs compete for nanoparticles in circulation, (c) nanoparticles must enter solid tumors to target tumor components, (d) nanoparticles must navigate the tumor microenvironment for cellular or organelle targeting, and (e) size, shape, surface chemistry, and other physicochemical properties of nanoparticles influence their transport process to the target. This review article describes these principles and their application for engineering nanoparticle delivery systems to carry therapeutics to tumors or other disease targets.
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2765-8031
    ISSN (online) 2765-8031
    DOI 10.34133/bmef.0016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Bio-applications of nanoparticles

    Chan, Warren C. W.

    (Advances in experimental medicine and biology ; 620)

    2007  

    Author's details ed. by Warren C. W. Chan
    Series title Advances in experimental medicine and biology ; 620
    Collection
    Keywords Nanostructures ; Diagnostic Imaging / methods ; Nanostructures / toxicity ; Nanotechnology
    Language English
    Size XX, 207 S. : Ill., graph. Darst.
    Publisher Springer u.a.
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT015450692
    ISBN 978-0-387-76712-3 ; 0-387-76712-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -620- not available for loan Zeitschriften-Lesesaal

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  4. Article ; Online: Nano Research for COVID-19.

    Chan, Warren C W

    ACS nano

    2020  Volume 14, Issue 4, Page(s) 3719–3720

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Nanotechnology/trends ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-31
    Publishing country United States
    Document type Editorial
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.0c02540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Nanotechnology for modern medicine: next step towards clinical translation.

    Sindhwani, Shrey / Chan, Warren C W

    Journal of internal medicine

    2021  Volume 290, Issue 3, Page(s) 486–498

    Abstract: The field of nanotechnology has been a significant research focus in the last thirty years. This emphasis is due to the unique optical, electrical, magnetic, chemical and biological properties of materials approximately ten thousand times smaller than ... ...

    Abstract The field of nanotechnology has been a significant research focus in the last thirty years. This emphasis is due to the unique optical, electrical, magnetic, chemical and biological properties of materials approximately ten thousand times smaller than the diameter of a hair strand. Researchers have developed methods to synthesize and characterize large libraries of nanomaterials and have demonstrated their preclinical utility. We have entered a new phase of nanomedicine development, where the focus is to translate these technologies to benefit patients. This review article provides an overview of nanomedicine's unique properties, the current state of the field, and discusses the challenge of clinical translation. Finally, we discuss the need to build and strengthen partnerships between engineers and clinicians to create a feedback loop between the bench and bedside. This partnership will guide fundamental studies on the nanoparticle-biological interactions, address clinical challenges and change the development and evaluation of new drug delivery systems, sensors, imaging agents and therapeutic systems.
    MeSH term(s) Humans ; Nanomedicine/trends ; Nanotechnology
    Language English
    Publishing date 2021-03-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.44: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Nano Research for COVID-19

    Chan, Warren C. W.

    ACS Nano

    2020  Volume 14, Issue 4, Page(s) 3719–3720

    Keywords General Engineering ; General Physics and Astronomy ; General Materials Science ; covid19
    Language English
    Publisher American Chemical Society (ACS)
    Publishing country us
    Document type Article ; Online
    ISSN 1936-0851
    DOI 10.1021/acsnano.0c02540
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: The Impact of Patient Characteristics on Diagnostic Test Performance.

    Kozlowski, Hannah N / Sindhwani, Shrey / Chan, Warren C W

    Small methods

    2022  Volume 6, Issue 2, Page(s) e2101233

    Abstract: Diagnostic tests can detect diseases, monitor responses, and inform treatments. They are vital to the effective management of disease. There have been significant advances in the engineering of new diagnostic technologies. These technologies may forgo ... ...

    Abstract Diagnostic tests can detect diseases, monitor responses, and inform treatments. They are vital to the effective management of disease. There have been significant advances in the engineering of new diagnostic technologies. These technologies may forgo sample extraction, simplify readout, or automate processing. Many researchers design these diagnostics based on test performance in a limited sample subset. This approach ignores the intertwined relationship between patient characteristics and diagnostic test results. Yet, it is important to understand the clinical decision-making workflow and how the disease manifests in order to optimally design diagnostic tests. This review article explores the three aspects of incorporating patient characteristics to maximize diagnostic performance. 1) Characterize patient populations using patient demographics, disease prevalence, and other unique features. 2) Use the characteristics of the patient population to establish design requirements. 3) Determine the best use case since each case has different performance and target requirements. In this framework the clinical, technological, and unmet needs of a patient population shape the diagnostics design requirements. Following these steps will lead to maximal diagnostic performance and poise new diagnostics for real world use.
    MeSH term(s) Clinical Decision-Making ; Humans ; Molecular Diagnostic Techniques/methods ; Patient Selection ; Workflow
    Language English
    Publishing date 2022-01-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202101233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Nanoparticles Bind to Endothelial Cells in Injured Blood Vessels via a Transient Protein Corona.

    Lin, Zachary P / Ngo, Wayne / Mladjenovic, Stefan M / Wu, Jamie L Y / Chan, Warren C W

    Nano letters

    2023  Volume 23, Issue 3, Page(s) 1003–1009

    Abstract: Nanoparticles travel through blood vessels to reach disease sites, but the local environment they encounter may affect their surface chemistry and cellular interactions. Here, we found that as nanoparticles transit through injured blood vessels they may ... ...

    Abstract Nanoparticles travel through blood vessels to reach disease sites, but the local environment they encounter may affect their surface chemistry and cellular interactions. Here, we found that as nanoparticles transit through injured blood vessels they may interact with a highly localized concentration of platelet factor 4 proteins released from activated platelets. The platelet factor 4 binds to the nanoparticle surface and interacts with heparan sulfate proteoglycans on endothelial cells, and induces uptake. Understanding nanoparticle interactions with blood proteins and endothelial cells during circulation is critical to optimizing their design for diseased tissue targeting and delivery.
    MeSH term(s) Endothelial Cells/metabolism ; Platelet Factor 4/metabolism ; Protein Corona/metabolism ; Blood Platelets/metabolism ; Nanoparticles
    Chemical Substances Platelet Factor 4 (37270-94-3) ; Protein Corona
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.2c04501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sequential Reagent Release from a Layered Tablet for Multistep Diagnostic Assays.

    Li, Vanessa Y C / Udugama, Buddhisha / Kadhiresan, Pranav / Chan, Warren C W

    Analytical chemistry

    2022  

    Abstract: Diagnostic assays are commonly performed in multiple steps, where reagents are added at specific times and concentrations into a reaction chamber. The reagents require storage, preparation, and addition in the correct sequence and amount. These steps ... ...

    Abstract Diagnostic assays are commonly performed in multiple steps, where reagents are added at specific times and concentrations into a reaction chamber. The reagents require storage, preparation, and addition in the correct sequence and amount. These steps rely on trained technicians and instrumentation to perform each task. The reliance on such resources hinders the use of these diagnostic assays by lay users. We developed a tablet that can sequentially introduce prequantified lyophilized diagnostic reagents at specific time points for a multistep assay. We designed the tablet to have multiple layers using cellulose-grade polymers, such as microcrystalline cellulose and hydroxypropyl cellulose. Our formulation allows each layer to dissolve at a controlled rate to introduce reagents into the solution sequentially. The release rate is controlled by modulating the compression force or chemical formulation of the layer. Controlling the reagent release time is important because different assays have specific times when reagents need to be added. As proof of concept, we demonstrated two different assays with our tablet system. Our tablet detected nucleic acid target (
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c03315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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