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  1. Article ; Online: Correction to "Triazole Modified Tetraiodothyroacetic Acid Conjugated to Polyethylene Glycol: High Affinity Thyrointegrin α

    Rajabi, Mehdi / Godugu, Kavitha / Sudha, Thangirala / Bharali, Dhruba J / Mousa, Shaker A

    Bioconjugate chemistry

    2023  Volume 34, Issue 2, Page(s) 453

    Language English
    Publishing date 2023-01-29
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.2c00521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3400: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Antitumor/anti-angiogenesis efficacy of epigallocatechin gallate nanoformulated with antioxidant in melanoma.

    Sudha, Thangirala / Salaheldin, Taher A / Darwish, Noureldien He / Mousa, Shaker A

    Nanomedicine (London, England)

    2022  Volume 17, Issue 15, Page(s) 1039–1053

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Humans ; Antioxidants/pharmacology ; Lycopene ; Olive Oil ; Zinc Oxide ; Catechin/pharmacology ; Catechin/therapeutic use ; Tea ; Melanoma/drug therapy
    Chemical Substances epigallocatechin gallate (BQM438CTEL) ; Antioxidants ; Lycopene (SB0N2N0WV6) ; Olive Oil ; Zinc Oxide (SOI2LOH54Z) ; Catechin (8R1V1STN48) ; Tea
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm-2021-0362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6617: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Correction to "Triazole Modified Tetraiodothyroacetic Acid Conjugated to Polyethylene Glycol: High Affinity Thyrointegrin α

    Rajabi, Mehdi / Godugu, Kavitha / Sudha, Thangirala / Bharali, Dhruba J / Mousa, Shaker A

    Bioconjugate chemistry

    2021  Volume 32, Issue 4, Page(s) 859

    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.1c00085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3400: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Triazole Modified Tetraiodothyroacetic Acid Conjugated to Polyethylene Glycol, a Thyrointegrin α v β 3 Antagonist as a Radio- and Chemo-Sensitizer in Pancreatic Cancer

    Thangirala Sudha / Kavitha Godugu / Gennadi V. Glinsky / Shaker A. Mousa

    Biomedicines, Vol 10, Iss 795, p

    2022  Volume 795

    Abstract: Thyroid hormone L thyroxine stimulates pancreatic carcinoma cell proliferation via thyrointegrin αvβ3 receptors, and antagonist tetraiodothyroacetic acid (tetrac) inhibits cancer cell growth. Chemically modified bis-triazole-tetrac conjugated with ... ...

    Abstract Thyroid hormone L thyroxine stimulates pancreatic carcinoma cell proliferation via thyrointegrin αvβ3 receptors, and antagonist tetraiodothyroacetic acid (tetrac) inhibits cancer cell growth. Chemically modified bis-triazole-tetrac conjugated with polyethylene glycol (P-bi-TAT) has higher binding affinity to αvβ3 receptors compared to tetrac. We investigated the antiproliferation effect of P-bi-TAT in pancreatic cancer cells (SUIT2) and its radio- and chemo-sensitizing roles in a mouse model of pancreatic cancer. P-bi-TAT treatment increased tumor-targeted radiation-induced cell death and decreased tumor size. P-bi-TAT acted as a chemo-sensitizer and enhanced the 5-fluorouracil (5FU) effect in decreasing pancreatic tumor weight compared to 5FU monotherapy. Withdrawal of treatment continued the tumor regression; however, the 5FU group showed tumor regrowth. The mechanisms of the anti-cancer activity of P-bi-TAT on SUIT2 cells were assessed by microarray experiments, and genome-wide profiling identified significant alterations of 1348 genes’ expression. Both down-regulated and up-regulated transcripts suggest that a molecular interference at the signaling pathway-associated gene expression is the prevalent mode of P-bi-TAT anti-cancer activity. Our data indicate that non-cytotoxic P-bi-TAT is not only an anti-cancer agent but also a radio-sensitizer and chemo-sensitizer that acts on the extracellular domain of the cell surface αvβ3 receptor.
    Keywords pancreatic cancer ; radiation ; chemotherapy ; radiation resistance ; chemo-resistance ; angiogenesis ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Triazole Modified Tetraiodothyroacetic Acid Conjugated to Polyethylene Glycol, a Thyrointegrin α

    Sudha, Thangirala / Godugu, Kavitha / Glinsky, Gennadi V / Mousa, Shaker A

    Biomedicines

    2022  Volume 10, Issue 4

    Abstract: Thyroid hormone L thyroxine stimulates pancreatic carcinoma cell proliferation via thyrointegrin αvβ3 receptors, and antagonist tetraiodothyroacetic acid (tetrac) inhibits cancer cell growth. Chemically modified bis-triazole-tetrac conjugated with ... ...

    Abstract Thyroid hormone L thyroxine stimulates pancreatic carcinoma cell proliferation via thyrointegrin αvβ3 receptors, and antagonist tetraiodothyroacetic acid (tetrac) inhibits cancer cell growth. Chemically modified bis-triazole-tetrac conjugated with polyethylene glycol (P-bi-TAT) has higher binding affinity to αvβ3 receptors compared to tetrac. We investigated the antiproliferation effect of P-bi-TAT in pancreatic cancer cells (SUIT2) and its radio- and chemo-sensitizing roles in a mouse model of pancreatic cancer. P-bi-TAT treatment increased tumor-targeted radiation-induced cell death and decreased tumor size. P-bi-TAT acted as a chemo-sensitizer and enhanced the 5-fluorouracil (5FU) effect in decreasing pancreatic tumor weight compared to 5FU monotherapy. Withdrawal of treatment continued the tumor regression; however, the 5FU group showed tumor regrowth. The mechanisms of the anti-cancer activity of P-bi-TAT on SUIT2 cells were assessed by microarray experiments, and genome-wide profiling identified significant alterations of 1348 genes' expression. Both down-regulated and up-regulated transcripts suggest that a molecular interference at the signaling pathway-associated gene expression is the prevalent mode of P-bi-TAT anti-cancer activity. Our data indicate that non-cytotoxic P-bi-TAT is not only an anti-cancer agent but also a radio-sensitizer and chemo-sensitizer that acts on the extracellular domain of the cell surface αvβ3 receptor.
    Language English
    Publishing date 2022-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10040795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Targeting Thyrointegrin αvβ3 Using Fluorobenzyl Polyethylene Glycol Conjugated Tetraiodothyroacetic Acid (NP751) in Acute Myeloid Leukemia.

    Darwish, Noureldien H E / Glinsky, Gennadi V / Sudha, Thangirala / Mousa, Shaker A

    Frontiers in oncology

    2022  Volume 11, Page(s) 793810

    Abstract: Background: Acute myeloid leukemia (AML) is associated with poor long-term survival, even with newer therapeutic agents. Here, we show the results of our preclinical study, in which we evaluated the efficacy of a new thyrointegrin αvβ3 antagonist, named ...

    Abstract Background: Acute myeloid leukemia (AML) is associated with poor long-term survival, even with newer therapeutic agents. Here, we show the results of our preclinical study, in which we evaluated the efficacy of a new thyrointegrin αvβ3 antagonist, named fluorobenzyl polyethylene glycol conjugated tetraiodothyroacetic acid (fb-PMT).
    Methods and results: fb-PMT (NP751) is a potent αvβ3 antagonist of molecular weight of 2,478.9 Da. it represents a conjugate of tetraiodothyroacetic acid (tetrac) and monodisperse polyethylene glycol (PEG36), with a 4-fluorobenzyl group capping the other end of the PEG. fb-PMT effectively suppresses the malignant growth of human acute myeloid leukemia (AML) after successful engraftment in transgenic NSG-S xenograft mouse models of either established human AML cell line or primary AML cells. Daily treatment with fb-PMT (1-10 mg/kg body weight) subcutaneously (s.c.) for 3-4 weeks was associated with marked regression of leukemogenesis and extended survival in both models. The efficiency of the fb-PMT therapy was verified using
    Conclusion: Our preclinical findings of the potent anticancer activities of fb-PMT and its favorable safety profiles warrant its clinical investigation for the effective and safe management of AML.
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.793810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Correction: Karakus et al. Development of Triiodothyronine Polymeric Nanoparticles for Targeted Delivery in the Cardioprotection against Ischemic Insult.

    Karakus, Ozlem Ozen / Darwish, Noureldien H E / Sudha, Thangirala / Salaheldin, Taher A / Fujioka, Kazutoshi / Dickinson, Peter C Taylor / Weil, Brian / Mousa, Shaker A

    Biomedicines

    2022  Volume 10, Issue 6

    Abstract: In the published manuscript [ ... ]. ...

    Abstract In the published manuscript [...].
    Language English
    Publishing date 2022-06-13
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10061395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Editorial Expression of Concern: Response of human pancreatic cancer cell xenografts to tetraiodothyroacetic acid nanoparticles.

    Yalcin, Murat / Lin, Hung-Yun / Sudha, Thangirala / Bharali, Dhruba J / Meng, Ran / Tang, Heng-Yuan / Davis, Faith B / Stain, Steven C / Davis, Paul J / Mousa, Shaker A

    Discover. Oncology

    2023  Volume 14, Issue 1, Page(s) 75

    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Expression of Concern
    ISSN 2730-6011
    ISSN (online) 2730-6011
    DOI 10.1007/s12672-023-00668-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Nano Diaminopropane tetrac and integrin αvβ3 expression in different cancer types: Anti-cancer efficacy and Safety.

    Godugu, Kavitha / Sudha, Thangirala / Davis, Paul J / Mousa, Shaker A

    Cancer treatment and research communications

    2021  Volume 28, Page(s) 100395

    Abstract: Integrins are a family of heterodimeric plasma membrane glycoproteins, which regulate tumor growth, angiogenesis, migration, and metastasis. Integrin αvβ3 has been recognized as a putative target for the treatment of several cancers. Thus, the ... ...

    Abstract Integrins are a family of heterodimeric plasma membrane glycoproteins, which regulate tumor growth, angiogenesis, migration, and metastasis. Integrin αvβ3 has been recognized as a putative target for the treatment of several cancers. Thus, the characterization of αvβ3 distribution in different human tumors is of substantial interest in tumor targeting and its suppression. In this study we evaluated the expression of integrin αvβ3 in different cancer types to define the expression pattern in cancer model. Furthermore, we investigated the effect of novel αvβ3 antagonist Diaminopropane Tetraiodothyroacetic acid conjugated to poly (lactic-co-glycolic acid) polymer and its nanoformulated form (NDAT), on different cancer cell lines both in vitro and in xenografts. In vitro, NDAT downregulated αv and β3 monomer expression. In vivo in tumor xenografts, similarly, NDAT downregulated αv and β3. Distinct reduction in tumor weight and viability was observed in glioblastoma xenografts treated with NDAT. Furthermore, NDAT was safe and tolerable in mice treated with high doses. In conclusion, NDAT is an effective and safe inhibitor of integrin αvβ3 expression in various cancer types, which indicates its impact on the targetability and suppression of αvβ3-associated tumor functions.
    MeSH term(s) Animals ; Antineoplastic Agents/administration & dosage ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Integrin alphaVbeta3/antagonists & inhibitors ; Integrin alphaVbeta3/genetics ; Male ; Mice, Nude ; Nanoparticles/administration & dosage ; Neoplasms/drug therapy ; Neoplasms/genetics ; Polylactic Acid-Polyglycolic Acid Copolymer/administration & dosage ; Thyroxine/administration & dosage ; Thyroxine/analogs & derivatives ; Treatment Outcome ; Mice
    Chemical Substances Antineoplastic Agents ; Integrin alphaVbeta3 ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; tetraiodothyroacetic acid (PA7UX1FFYQ) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2021-05-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2468-2942
    ISSN (online) 2468-2942
    DOI 10.1016/j.ctarc.2021.100395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Anticancer Effects of the

    Tosoc, John Paul Sese / Nuñeza, Olga Macas / Sudha, Thangirala / Darwish, Noureldien H E / Mousa, Shaker A

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 19

    Abstract: Corchorus ... ...

    Abstract Corchorus olitorius
    MeSH term(s) Angiogenesis Inhibitors/chemistry ; Angiogenesis Inhibitors/pharmacology ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chick Embryo ; Chlorogenic Acid/pharmacology ; Chromatography, Liquid ; Corchorus/chemistry ; Humans ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Quercetin/analogs & derivatives ; Quercetin/pharmacology ; Tandem Mass Spectrometry
    Chemical Substances Angiogenesis Inhibitors ; Antineoplastic Agents ; Plant Extracts ; isoquercitrin (0YX10VRV6J) ; Chlorogenic Acid (318ADP12RI) ; Quercetin (9IKM0I5T1E)
    Language English
    Publishing date 2021-10-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26196033
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    Zs.MO 81: Show issues

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