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Article ; Online: Signal transduction with a swing.

Cash, Kevin J / Plaxco, Kevin W

2021 Volume 13, Issue 5, Page(s) 392–393

MeSH term(s)	Signal Transduction
Language	English
Publishing date	2021-04-30
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2464596-5
ISSN	1755-4349 ; 1755-4330
ISSN (online)	1755-4349
ISSN	1755-4330
DOI	10.1038/s41557-021-00692-4
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Article ; Online: A near-infrared optical nanosensor for measuring aerobic respiration in microbial systems.

Saccomano, Samuel C / Cash, Kevin J

The Analyst

2021 Volume 147, Issue 1, Page(s) 120–129

Abstract: We developed a ratiometric oxygen-sensitive nanosensor and demonstrated application in monitoring metabolic oxygen consumption in microbial samples over time. Based on a near-infrared (NIR) emitting oxygen-quenched luminophore, platinum(II) ... ...

Abstract	We developed a ratiometric oxygen-sensitive nanosensor and demonstrated application in monitoring metabolic oxygen consumption in microbial samples over time. Based on a near-infrared (NIR) emitting oxygen-quenched luminophore, platinum(II) octaethylporphine ketone (PtOEPK), along with a stable dioctadecyl dicarbocyanine reference dye (DiD), this nanosensor system provides an advantageous approach for overcoming imaging issues in biological systems, such as autofluorescence and optical scattering in the visible wavelength region. The dyes are encapsulated within a polymer-based nanoparticle matrix to maintain them at a constant ratio in biological samples, precluding the need for complex synthetic approaches. With this constant ratio of the two dyes, the nanosensor response can be measured as a ratio of their two signals, accounting for nanosensor concentration artifacts in measurements. The nanosensors are reversible, which enabled us to temporally monitor systems in which dissolved oxygen concentrations both increase and decrease. These sensors were applied for the monitoring of oxygen in samples of
MeSH term(s)	Biosensing Techniques ; Nanotechnology ; Oxygen/analysis
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2021-12-20
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d1an01855h
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Zs.A 2423: Show issues

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Article ; Online: Head and neck oncology professionals' perceptions of suicide risk screening among patients.

Adjei Boakye, Eric / Sykes, Kevin J / Hamilton, Jessica L / Cash, Elizabeth D / Duffy, Nicole M / Maurer, Stacey / Williams, Amy M

Oral oncology

2024 Volume 151, Page(s) 106728

MeSH term(s)	Humans ; Suicide ; Suicide Prevention ; Head ; Neck
Language	English
Publishing date	2024-02-24
Publishing country	England
Document type	Letter
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2024.106728
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Zs.A 4869: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Triplet-Triplet Annihilation Upconversion-Based Oxygen Sensors to Overcome the Limitation of Autofluorescence.

Mendonsa, Adrian A / Soeldner, Cassandra C / Mudd, Natalie E / Saccomano, Samuel C / Cash, Kevin J

ACS sensors

2023 Volume 8, Issue 8, Page(s) 3043–3050

Abstract: Autofluorescence is one of the many challenges in bioimaging as it can mask the emission from fluorescent probes or markers, a limitation that can be overcome via upconversion. Herein, we have developed a nanosensor that uses triplet-triplet annihilation ...

Abstract	Autofluorescence is one of the many challenges in bioimaging as it can mask the emission from fluorescent probes or markers, a limitation that can be overcome via upconversion. Herein, we have developed a nanosensor that uses triplet-triplet annihilation upconversion to optically report changes in the dissolved oxygen concentration. Using a sensitizer-annihilator dye pairing of platinum(II) octaethylporphyrin and 9,10-diphenylanthracene, we monitored the oxygen consumption (as a proxy for metabolic activity) over time in a biological system─
MeSH term(s)	Saccharomyces cerevisiae ; Fluorescent Dyes ; Oxygen
Chemical Substances	Fluorescent Dyes ; Oxygen (S88TT14065)
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.3c00548
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Article ; Online: Expression of the GCG gene and secretion of active glucagon-like peptide-1 varies along the length of intestinal tract in horses.

Fitzgerald, Danielle M / Cash, Christina M / Dudley, Kevin J / Sibthorpe, Poppy E M / Sillence, Martin N / de Laat, Melody A

Equine veterinary journal

2023 Volume 56, Issue 2, Page(s) 352–360

Abstract: Background: Active glucagon-like peptide-1 (aGLP-1) has been implicated in the pathogenesis of equine insulin dysregulation (ID), but its role is unclear. Cleavage of proglucagon (coded by the GCG gene) produces aGLP-1 in enteral L cells.: Objectives!# ...

Abstract	Background: Active glucagon-like peptide-1 (aGLP-1) has been implicated in the pathogenesis of equine insulin dysregulation (ID), but its role is unclear. Cleavage of proglucagon (coded by the GCG gene) produces aGLP-1 in enteral L cells. Objectives: The aim in vivo was to examine the sequence of the exons of GCG in horses with and without ID, where aGLP-1 was higher in the group with ID. The aims in vitro were to identify and quantify the expression of GCG in the equine intestine (as a marker of L cells) and determine intestinal secretion of aGLP-1. Study design: Genomic studies were case-control studies. Expression and secretion studies in vitro were cross-sectional. Methods: The GCG gene sequence of the exons was determined using a hybridisation capture protocol. Expression and quantification of GCG in samples of stomach duodenum, jejunum, ileum, caecum and ascending and descending colon was achieved with droplet digital PCR. For secretory studies tissue explants were incubated with 12 mM glucose and aGLP-1 secretion was measured with an ELISA. Results: Although the median [IQR] post-prandial aGLP-1 concentrations were higher (p = 0.03) in animals with ID (10.2 [8.79-15.5]), compared with healthy animals (8.47 [6.12-11.7]), there was 100% pairwise identity of the exons of the GCG sequence for the cohort. The mRNA concentrations of GCG and secretion of aGLP-1 differed (p < 0.001) throughout the intestine. Main limitations: Only the exons of the GCG gene were sequenced and breeds were not compared. The horses used for the study in vitro were not assessed for ID and different horses were used for the small, and large, intestinal studies. Conclusions: Differences in post-prandial aGLP-1 concentration were not due to a variant in the exons of the GCG gene sequence in this cohort. Both the large and small intestine are sites of GLP-1 secretion.
MeSH term(s)	Humans ; Animals ; Horses/genetics ; Glucagon-Like Peptide 1/genetics ; Insulin/metabolism ; Intestine, Small/metabolism ; Proglucagon/genetics ; Proglucagon/analysis ; Proglucagon/metabolism ; Polymerase Chain Reaction/veterinary
Chemical Substances	Glucagon-Like Peptide 1 (89750-14-1) ; Insulin ; Proglucagon (55963-74-1)
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	41606-x
ISSN	2042-3306 ; 0425-1644
ISSN (online)	2042-3306
ISSN	0425-1644
DOI	10.1111/evj.14020
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Zs.A 3105: Show issues

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Article ; Online: An ionophore-based persistent luminescent 'Glow Sensor' for sodium detection.

Ferris, Mark S / Behr, Madeline R / Cash, Kevin J

RSC advances

2019 Volume 9, Issue 56, Page(s) 32821–32825

Abstract: Optical sensors have numerous positive attributes such as low invasiveness, miniaturizability, biocompatibility, and ease of signal transduction. Recently, there has been a strong research focus on using phosphorescent readout mechanisms, specifically ... ...

Abstract	Optical sensors have numerous positive attributes such as low invasiveness, miniaturizability, biocompatibility, and ease of signal transduction. Recently, there has been a strong research focus on using phosphorescent readout mechanisms, specifically from long-lifetime phosphorescent or 'persistent luminescence' particles, for
Language	English
Publishing date	2019-10-15
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra05313a
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Article ; Online: Triplet-Triplet Annihilation Upconversion Based Nanosensors for Fluorescence Detection of Potassium.

Jewell, Megan P / Greer, Meredith D / Dailey, Alexandra L / Cash, Kevin J

ACS sensors

2020 Volume 5, Issue 2, Page(s) 474–480

Abstract: Typical ionophore-based nanosensors use Nile blue derived indicators called chromoionophores, which must contend with strong background absorption, autofluorescence, and scattering in biological samples that limit their usefulness. Here, we demonstrate ... ...

Abstract	Typical ionophore-based nanosensors use Nile blue derived indicators called chromoionophores, which must contend with strong background absorption, autofluorescence, and scattering in biological samples that limit their usefulness. Here, we demonstrate potassium-selective nanosensors that utilize triplet-triplet annihilation upconversion to minimize potential optical interference in biological media and a pH-sensitive quencher molecule to modulate the upconversion intensity in response to changes in analyte concentration. A triplet-triplet annihilation dye pair (platinum(II) octaethylporphyrin and 9,10-diphenylanthracene) was integrated into nanosensors containing an analyte binding ligand (ionophore), charge-balancing additive, and a pH indicator quencher. The nanosensor response to potassium was shown to be reversible and stable for 3 days. In addition, the nanosensors are selective against sodium, calcium, and magnesium (selectivity coefficients in log
MeSH term(s)	Humans ; Nanotechnology/methods ; Potassium/chemistry ; Spectrometry, Fluorescence/methods
Chemical Substances	Potassium (RWP5GA015D)
Language	English
Publishing date	2020-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.9b02252
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Article ; Online: Global distribution of Leptospira serovar isolations and detections from animal host species: A systematic review and online database.

Hagedoorn, Nienke N / Maze, Michael J / Carugati, Manuela / Cash-Goldwasser, Shama / Allan, Kathryn J / Chen, Kevin / Cossic, Brieuc / Demeter, Elena / Gallagher, Sarah / German, Richard / Galloway, Renee L / Habuš, Josipa / Rubach, Matthew P / Shiokawa, Kanae / Sulikhan, Nadezhda / Crump, John A

Tropical medicine & international health : TM & IH

2024 Volume 29, Issue 3, Page(s) 161–172

Abstract: Objectives: Leptospira, the spirochaete causing leptospirosis, can be classified into >250 antigenically distinct serovars. Although knowledge of the animal host species and geographic distribution of Leptospira serovars is critical to understand the ... ...

Abstract	Objectives: Leptospira, the spirochaete causing leptospirosis, can be classified into >250 antigenically distinct serovars. Although knowledge of the animal host species and geographic distribution of Leptospira serovars is critical to understand the human and animal epidemiology of leptospirosis, current data are fragmented. We aimed to systematically review, the literature on animal host species and geographic distribution of Leptospira serovars to examine associations between serovars with animal host species and regions and to identify geographic regions in need of study. Methods: Nine library databases were searched from inception through 9 March 2023 using keywords including Leptospira, animal, and a list of serovars. We sought reports of detection of Leptospira, from any animal, characterised by cross agglutinin absorption test, monoclonal antibody typing, serum factor analysis, or pulsed-field gel electrophoresis to identify the serovar. Results: We included 409 reports, published from 1927 through 2022, yielding data on 154 Leptospira serovars. The reports included data from 66 (26.5%) of 249 countries. Detections were from 144 animal host species including 135 (93.8%) from the class Mammalia, 5 (3.5%) from Amphibia, 3 (2.1%) from Reptilia, and 1 (0.7%) from Arachnida. Across the animal host species, Leptospira serovars that were detected in the largest number of animal species included Grippotyphosa (n = 39), Icterohaemorrhagiae (n = 29), Pomona (n = 28), Australis (n = 25), and Ballum (n = 25). Of serovars, 76 were detected in a single animal host species. We created an online database to identify animal host species for each serovar by country. Conclusions: We found that many countries have few or no Leptospira serovars detected from animal host species and that many serovars were detected from a single animal species. Our study highlights the importance of efforts to identify animal host species of leptospirosis, especially in places with a high incidence of human leptospirosis. We provide an updated resource for leptospirosis researchers.
MeSH term(s)	Animals ; Humans ; Leptospira ; Serogroup ; Antibodies, Bacterial ; Leptospirosis/epidemiology ; Leptospirosis/veterinary ; Databases, Factual
Chemical Substances	Antibodies, Bacterial
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1314080-2
ISSN	1365-3156 ; 1360-2276
ISSN (online)	1365-3156
ISSN	1360-2276
DOI	10.1111/tmi.13965
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Article ; Online: Sensors in a Flash! Oxygen Nanosensors for Microbial Metabolic Monitoring Synthesized by Flash Nanoprecipitation.

Tien, Tony / Saccomano, Samuel C / Martin, Pilar A / Armstrong, Madeleine S / Prud'homme, Robert K / Cash, Kevin J

ACS sensors

2022 Volume 7, Issue 9, Page(s) 2606–2614

Abstract: Flash nanoprecipitation (FNP) is an efficient and scalable nanoparticle synthesis method that has not previously been applied to nanosensor fabrication. Current nanosensor fabrication methods have traditionally exhibited poor replicability and ... ...

Abstract	Flash nanoprecipitation (FNP) is an efficient and scalable nanoparticle synthesis method that has not previously been applied to nanosensor fabrication. Current nanosensor fabrication methods have traditionally exhibited poor replicability and consistency resulting in high batch-to-batch variability, highlighting the need for a more tunable and efficient method such as FNP. We used FNP to fabricate nanosensors to sense oxygen based on an oxygen-sensitive dye and a reference dye, as a tool for measuring microbial metabolism. We used fluorescence spectroscopy to optimize nanosensor formulations, calibrate the nanosensors for oxygen concentration determination, and measure oxygen concentrations through oxygen-sensitive dye luminescence. FNP provides an effective platform for making sensors capable of responding to oxygen concentration in gas-bubbled solutions as well as in microbial environments. The environments we tested the sensors in are
MeSH term(s)	Luminescence ; Nanoparticles/chemistry ; Oxygen ; Spectrometry, Fluorescence
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2022-09-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.2c00859
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Article: Global distribution of

medRxiv : the preprint server for health sciences

2023

Abstract: Objectives: Leptospira: Methods: Nine library databases were searched from inception through 9 March 2023 using keywords including : Results: We included 409 reports, published from 1927 through 2022, yielding data on 154 : Conclusions: We ... ...

Abstract	Objectives: Leptospira Methods: Nine library databases were searched from inception through 9 March 2023 using keywords including Results: We included 409 reports, published from 1927 through 2022, yielding data on 154 Conclusions: We found that many countries have few or no
Language	English
Publishing date	2023-10-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.03.23296503
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