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Article: Selenium and zinc supplementation in HIV-infected patients.

Pourmoradian, Samira / Rezazadeh, Leila / Tutunchi, Helda / Ostadrahimi, Alireza

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition

2023 Volume 94, Issue 2, Page(s) 153–159

MeSH term(s)	Humans ; Dietary Supplements ; HIV ; HIV Infections/complications ; HIV Infections/drug therapy ; Selenium ; Zinc
Chemical Substances	Selenium (H6241UJ22B) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2023-02-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	120692-8
ISSN	0300-9831
ISSN	0300-9831
DOI	10.1024/0300-9831/a000778
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Article ; Online: Reply to H. Raeisi-Dehkordi et al.

Tutunchi, Helda / Ostadrahimi, Alireza

Advances in nutrition (Bethesda, Md.)

2021 Volume 12, Issue 2, Page(s) 577–578

MeSH term(s)	Diet ; Humans ; Obesity ; Oleic Acid
Chemical Substances	Oleic Acid (2UMI9U37CP)
Language	English
Publishing date	2021-03-29
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2583634-1
ISSN	2156-5376 ; 2156-5376
ISSN (online)	2156-5376
ISSN	2156-5376
DOI	10.1093/advances/nmab006
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Article ; Online: Clinical effectiveness of α-lipoic acid, myo-inositol and propolis supplementation on metabolic profiles and liver function in obese patients with NAFLD: A randomized controlled clinical trial.

Tutunchi, Helda / Arefhosseini, Sara / Ebrahimi-Mameghani, Mehrangiz

Clinical nutrition ESPEN

2023 Volume 54, Page(s) 412–420

Abstract: Background: To compare the effects of α-lipoic acid (ALA), myo-inositol (MI) and propolis supplementation on metabolic parameters and liver function in obese patients with non-alcoholic fatty liver disease (NAFLD) METHODS: Ninety-two obese patients with ...

Abstract	Background: To compare the effects of α-lipoic acid (ALA), myo-inositol (MI) and propolis supplementation on metabolic parameters and liver function in obese patients with non-alcoholic fatty liver disease (NAFLD) METHODS: Ninety-two obese patients with NAFLD were randomly allocated into one of the four groups (ALA, MI, propolis, and control groups) for 8 weeks. At pre-and post-intervention, anthropometric measures, metabolic parameters and liver function were assessed. Clinical effectiveness was assessed using Absolute Risk Reduction (ARR) and Number Needed to Treat (NNT). Results: After 8 weeks, apart from waist-to-hip ratio, all studied anthropometric measures decreased significantly in each of the groups over the trial. Although the greatest improvements in glycemic indices were observed in MI group (p < 0.05), the differences among the groups were not significant. Control group showed the greatest reduction in serum triglyceride level (p = 0.026) while the greatest improvements in serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were observed in MI group (p = 0.043, p = 0.019 and p = 0.041, respectively). Alanine aminotransferase (ALT) levels reduced significantly in all groups, particularly in propolis group (p = 0.012). The greatest reduction in serum aspartate transaminase (AST) level was observed in control group (p < 0.001), however, the difference among the groups was statistically marginal (p = 0.058). The estimated NNTs for one grade reduction in liver steatosis for MI, ALA and propolis supplementation compared with control group were 1.5, 2.2 and 3, respectively. Conclusion: Dietary recommendation for weight loss accompanied by MI and then ALA supplementation improved metabolic parameters and liver steatosis. "Registered under ClinicalTrials.gov Identifier no: IRCT20100209003320N22".
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/drug therapy ; Thioctic Acid/therapeutic use ; Propolis/therapeutic use ; Obesity ; Dietary Supplements ; Metabolome ; Treatment Outcome ; Cholesterol
Chemical Substances	Thioctic Acid (73Y7P0K73Y) ; Propolis (9009-62-5) ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2023-02-23
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2023.02.016
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Article ; Online: Clinical effectiveness of α-lipoic acid, myo-inositol and propolis supplementation on metabolic profiles and liver function in obese patients with NAFLD: A randomized controlled clinical trial

Tutunchi, Helda / Arefhosseini, Sara / Ebrahimi-Mameghani, Mehrangiz

European Society for Clinical Nutrition and Metabolism Clinical Nutrition ESPEN. 2023 Apr., v. 54 p.412-420

2023

Abstract: To compare the effects of α-lipoic acid (ALA), myo-inositol (MI) and propolis supplementation on metabolic parameters and liver function in obese patients with non-alcoholic fatty liver disease (NAFLD) Ninety-two obese patients with NAFLD were randomly ... ...

Abstract	To compare the effects of α-lipoic acid (ALA), myo-inositol (MI) and propolis supplementation on metabolic parameters and liver function in obese patients with non-alcoholic fatty liver disease (NAFLD) Ninety-two obese patients with NAFLD were randomly allocated into one of the four groups (ALA, MI, propolis, and control groups) for 8 weeks. At pre-and post-intervention, anthropometric measures, metabolic parameters and liver function were assessed. Clinical effectiveness was assessed using Absolute Risk Reduction (ARR) and Number Needed to Treat (NNT). After 8 weeks, apart from waist-to-hip ratio, all studied anthropometric measures decreased significantly in each of the groups over the trial. Although the greatest improvements in glycemic indices were observed in MI group (p < 0.05), the differences among the groups were not significant. Control group showed the greatest reduction in serum triglyceride level (p = 0.026) while the greatest improvements in serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were observed in MI group (p = 0.043, p = 0.019 and p = 0.041, respectively). Alanine aminotransferase (ALT) levels reduced significantly in all groups, particularly in propolis group (p = 0.012). The greatest reduction in serum aspartate transaminase (AST) level was observed in control group (p < 0.001), however, the difference among the groups was statistically marginal (p = 0.058). The estimated NNTs for one grade reduction in liver steatosis for MI, ALA and propolis supplementation compared with control group were 1.5, 2.2 and 3, respectively. Dietary recommendation for weight loss accompanied by MI and then ALA supplementation improved metabolic parameters and liver steatosis. “Registered under ClinicalTrials.gov Identifier no: IRCT20100209003320N22”
Keywords	alanine transaminase ; aspartate transaminase ; blood serum ; clinical nutrition ; clinical trials ; fatty liver ; high density lipoprotein cholesterol ; liver function ; low density lipoprotein cholesterol ; myo-inositol ; propolis ; risk reduction ; triacylglycerols ; waist-to-hip ratio ; weight loss ; α-lipoic acid ; Clinical trial ; Lipid profile ; Myo-iniositol ; Non-alcoholic fatty liver disease (NAFLD) ; Insulin resistance
Language	English
Dates of publication	2023-04
Size	p. 412-420.
Publishing place	Elsevier Ltd
Document type	Article ; Online
ISSN	2405-4577
DOI	10.1016/j.clnesp.2023.02.016
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of Hydroxycitric Acid Supplementation on Body Composition, Obesity Indices, Appetite, Leptin, and Adiponectin of Women with NAFLD on a Calorie-Restricted Diet.

Tutunchi, Helda / Arefhosseini, Sara / Nomi-Golzar, Solmaz / Ebrahimi-Mameghani, Mehrangiz

International journal of clinical practice

2023 Volume 2023, Page(s) 6492478

Abstract: Background: This trial assessed the effects of a calorie-restricted diet (CRD) with hydroxycitric acid (HCA) supplementation on appetite-regulating hormones, obesity indices, body composition, and appetite in women with nonalcoholic fatty liver disease ( ...

Abstract	Background: This trial assessed the effects of a calorie-restricted diet (CRD) with hydroxycitric acid (HCA) supplementation on appetite-regulating hormones, obesity indices, body composition, and appetite in women with nonalcoholic fatty liver disease (NAFLD). Methods: This study was carried out on 44 overweight/obese women with NAFLD. The patients were randomly assigned into two groups, namely, " Results: Forty patients completed the trial. At the end of the trial, although significant reductions were found in most of the studied obesity indices in the intervention group, there was only a significant decrease in waist circumference and waist-to-height ratio in the control group. Fat mass and muscle mass significantly decreased in the intervention group ( Conclusion: HCA plus weight loss diet could significantly reduce visceral adipose tissue without any significant changes in serum leptin and adiponectin levels.
MeSH term(s)	Humans ; Female ; Leptin/metabolism ; Non-alcoholic Fatty Liver Disease/prevention & control ; Adiponectin/metabolism ; Appetite ; Obesity ; Body Composition ; Dietary Supplements ; Diet ; Body Mass Index
Chemical Substances	Leptin ; Adiponectin ; hydroxycitric acid (8W94T9026R)
Language	English
Publishing date	2023-07-12
Publishing country	India
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1155/2023/6492478
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Article: The effect of DASH diet on atherogenic indices, pro-oxidant-antioxidant balance, and liver steatosis in obese adults with non-alcoholic fatty liver disease: A double-blind controlled randomized clinical trial.

Badali, Taghi / Arefhosseini, Sara / Rooholahzadegan, Farnaz / Tutunchi, Helda / Ebrahimi-Mameghani, Mehrangiz

Health promotion perspectives

2023 Volume 13, Issue 1, Page(s) 77–87

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-04-30
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2691688-5
ISSN	2228-6497
ISSN	2228-6497
DOI	10.34172/hpp.2023.10
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Article ; Online: Effects of Hydroxycitric Acid Supplementation on Body Composition, Obesity Indices, Appetite, Leptin, and Adiponectin of Women with NAFLD on a Calorie-Restricted Diet

Helda Tutunchi / Sara Arefhosseini / Solmaz Nomi-Golzar / Mehrangiz Ebrahimi-Mameghani

International Journal of Clinical Practice, Vol

2023 Volume 2023

Abstract: Background. This trial assessed the effects of a calorie-restricted diet (CRD) with hydroxycitric acid (HCA) supplementation on appetite-regulating hormones, obesity indices, body composition, and appetite in women with nonalcoholic fatty liver disease ( ... ...

Abstract	Background. This trial assessed the effects of a calorie-restricted diet (CRD) with hydroxycitric acid (HCA) supplementation on appetite-regulating hormones, obesity indices, body composition, and appetite in women with nonalcoholic fatty liver disease (NAFLD). Methods. This study was carried out on 44 overweight/obese women with NAFLD. The patients were randomly assigned into two groups, namely, “Intervention group” (receiving individual CRD plus HCA tablets per day) and “Control group” (receiving only CRD) for eight weeks. Obesity indices, body composition, appetite status, and serum levels of leptin and adiponectin were assessed before and after the intervention. Results. Forty patients completed the trial. At the end of the trial, although significant reductions were found in most of the studied obesity indices in the intervention group, there was only a significant decrease in waist circumference and waist-to-height ratio in the control group. Fat mass and muscle mass significantly decreased in the intervention group (p=0.044 and p=0.024, respectively), and the reduction in visceral fat in the intervention group was significantly greater than that in the control group (−0.49 kg vs −0.37 kg, p=0.024). Intra- and intergroup differences in serum leptin and adiponectin levels and their ratios before and after the trial were not significant. We found a negative and marginally significant correlation between percent of changes in serum adiponectin level and percent of changes in visceral adipose tissue (VAT) (r = −0.429, p=0.067) and BMI (r = −0.440, p=0.059) as well as an inverse relationship between percent of changes in leptin/adiponectin with VAT (r = −0.724, p<0.001) in the intervention group. Conclusion. HCA plus weight loss diet could significantly reduce visceral adipose tissue without any significant changes in serum leptin and adiponectin levels.
Keywords	Medicine ; R
Subject code	796 ; 630
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
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Article ; Online: Soy isoflavone intake and risk of cardiovascular disease in adults: A systematic review and dose-response meta-analysis of prospective cohort studies.

Naghshi, Sina / Tutunchi, Helda / Yousefi, Mojtaba / Naeini, Fatemeh / Mobarak, Sara / Asadi, Masoomeh / Sadeghi, Omid

Critical reviews in food science and nutrition

2023 , Page(s) 1–15

Abstract: We examined the association between soy isoflavone intake and risk of cardiovascular disease (CVD) outcomes in adults. We searched the online databases for relevant studies published up to September 2021. In total, 13 publications were included in the ... ...

Abstract	We examined the association between soy isoflavone intake and risk of cardiovascular disease (CVD) outcomes in adults. We searched the online databases for relevant studies published up to September 2021. In total, 13 publications were included in the systematic review and 12 in the meta-analysis. We found that a high intake of soy isoflavones was significantly associated with a lower risk of coronary heart disease (CHD) among whole populations (Pooled RR: 0.92, 95% CI: 0.85-0.99, I
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Systematic Review
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2022.2163372
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Article: Does myo-inositol supplementation influence oxidative stress biomarkers in patients with non-alcoholic fatty liver disease?

Rostami, Somayeh / Arefhosseini, Sara / Tutunchi, Helda / Khoshbaten, Manouchehr / Ebrahimi-Mameghani, Mehrangiz

Food science & nutrition

2023 Volume 12, Issue 2, Page(s) 1279–1289

Abstract: Myo-inositol (MI) is a carbocyclic sugar polyalcohol. MI has known to exert anti-inflammatory, anti-oxidant, and anti-diabetic activities. This study aimed to investigate the effects of MI supplementation on oxidative stress biomarkers in obese patients ... ...

Abstract	Myo-inositol (MI) is a carbocyclic sugar polyalcohol. MI has known to exert anti-inflammatory, anti-oxidant, and anti-diabetic activities. This study aimed to investigate the effects of MI supplementation on oxidative stress biomarkers in obese patients with non-alcoholic fatty liver disease (NAFLD). In this double-blinded placebo-controlled randomized clinical trial, 51 newly diagnosed obese patients with NAFLD were randomly assigned to receive either MI (4 g/day) or placebo supplements accompanied by dietary recommendations for 8 weeks. Oxidative stress biomarkers, nutritional status, as well as liver enzymes and obesity indices were assessed pre- and post-intervention. A total of 48 patients completed the trial. Although anthropometric measures and obesity indices decreased significantly in both groups, the between-group differences adjusted for confounders were non-significant for these parameters, except for weight (
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.3842
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Article: Non-alcoholic fatty liver disease across endocrinopathies: Interaction with sex hormones.

Arefhosseini, Sara / Ebrahimi-Mameghani, Mehrangiz / Najafipour, Farzad / Tutunchi, Helda

Frontiers in endocrinology

2022 Volume 13, Page(s) 1032361

Abstract: Nonalcoholic fatty liver disease (NAFLD) has emerged as the most frequent chronic liver disease globally. NAFLD is strongly associated with metabolic syndrome and it has been recently suggested that to rename NAFLD as metabolic dysfunction-associated ... ...

Abstract	Nonalcoholic fatty liver disease (NAFLD) has emerged as the most frequent chronic liver disease globally. NAFLD is strongly associated with metabolic syndrome and it has been recently suggested that to rename NAFLD as metabolic dysfunction-associated fatty liver disease (MAFLD). NAFLD has been studied in different endocrine axes and accumulating body of clinical and experimental studies have suggested that NAFLD is associated with polycystic ovarian syndrome (PCOS), hypopituitarism, growth hormone deficiency (GHD), hypogonadism and other endocrine disorders. In fact, endocrine dysfunction may be considered as the major contributor for the development, progression, and severity of NAFLD. In the present comprehensive review, we discussed the epidemiological and clinical evidence on the epidemiology, pathophysiology, and management of NAFLD in endocrine disorders, with an emphasis on the effects of sex-specific hormones/conditions as well as molecular basis of NAFLD development in these endocrine diseases.
MeSH term(s)	Female ; Male ; Humans ; Non-alcoholic Fatty Liver Disease/epidemiology ; Gonadal Steroid Hormones ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/epidemiology ; Hypopituitarism ; Metabolic Syndrome
Chemical Substances	Gonadal Steroid Hormones
Language	English
Publishing date	2022-11-07
Publishing country	Switzerland
Document type	Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1032361
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