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Article: Simon Rottenberg and baseball, then and now

Sanderson, Allen R / Siegfried, John J

The journal of political economy Vol. 114, No. 3 , p. 594-605

a fiftieth anniversary retrospective

2006 Volume 114, Issue 3, Page(s) 594–605

Author's details	Allen R. Sanderson; John J. Siegfried
Keywords	Professioneller Sport ; Arbeitsmarkt ; Arbeitsmarkttheorie ; Lohntheorie
Language	English
Publisher	Univ. Press
Publishing place	Chicago, Ill.
Document type	Article
ZDB-ID	3026-0
Database	ECONomics Information System

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Article ; Online: Examining the role of information integration in the continued influence effect using an event segmentation approach.

Sanderson, Jasmyne A / Farrell, Simon / Ecker, Ullrich K H

PloS one

2022 Volume 17, Issue 7, Page(s) e0271566

Abstract: Misinformation regarding the cause of an event often continues to influence an individual's event-related reasoning, even after they have received a retraction. This is known as the continued influence effect (CIE). Dominant theoretical models of the CIE ...

Abstract	Misinformation regarding the cause of an event often continues to influence an individual's event-related reasoning, even after they have received a retraction. This is known as the continued influence effect (CIE). Dominant theoretical models of the CIE have suggested the effect arises primarily from failures to retrieve the correction. However, recent research has implicated information integration and memory updating processes in the CIE. As a behavioural test of integration, we applied an event segmentation approach to the CIE paradigm. Event segmentation theory suggests that incoming information is parsed into distinct events separated by event boundaries, which can have implications for memory. As such, when an individual encodes an event report that contains a retraction, the presence of event boundaries should impair retraction integration and memory updating, resulting in an enhanced CIE. Experiments 1 and 2 employed spatial event segmentation boundaries in an attempt to manipulate the ease with which a retraction can be integrated into a participant's mental event model. While Experiment 1 showed no impact of an event boundary, Experiment 2 yielded evidence that an event boundary resulted in a reduced CIE. To the extent that this finding reflects enhanced retrieval of the retraction relative to the misinformation, it is more in line with retrieval accounts of the CIE.
MeSH term(s)	Communication ; Humans ; Memory ; Mental Recall
Language	English
Publishing date	2022-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0271566
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of multitasking on interpreting a spearcon sequence display for monitoring multiple patients.

Neary, Alexandra / Li, Simon Y W / Salisbury, Isaac / Loeb, Robert G / Sanderson, Penelope M

Applied ergonomics

2023 Volume 112, Page(s) 104072

Abstract: Spearcons are time-compressed speech phrases. When arranged in a sequence representing vital signs of multiple patients, spearcons may be more informative than conventional auditory alarms. However, multiple resource theory suggests that certain ... ...

Abstract	Spearcons are time-compressed speech phrases. When arranged in a sequence representing vital signs of multiple patients, spearcons may be more informative than conventional auditory alarms. However, multiple resource theory suggests that certain timeshared tasks might interfere with listeners' ability to understand spearcons. We tested the relative interference with spearcon identification from the following ongoing tasks: (1) manual tracking, (2) linguistic detection of spoken target words, (3) arithmetic true-false judgments, or (4) an ignored background speech control. Participants were 80 non-clinicians. The linguistic task worsened spearcon identification more than the tracking task, p < .001, and more than ignored background speech, p = .012. The arithmetic task worsened spearcon identification more than the tracking task, p < .001. The linguistic task and arithmetic task both worsened performance, p = .674. However, no ongoing task affected participants' ability to detect which patient(s) in a sequence had abnormal vital signs. Future research could investigate whether timeshared tasks affect non-speech auditory alerts.
MeSH term(s)	Humans ; Linguistics ; Vital Signs ; Monitoring, Physiologic ; Speech ; Clinical Alarms
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2003513-5
ISSN	1872-9126 ; 0003-6870
ISSN (online)	1872-9126
ISSN	0003-6870
DOI	10.1016/j.apergo.2023.104072
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In aged primary T cells, mitochondrial stress contributes to telomere attrition measured by a novel imaging flow cytometry assay.

Sanderson, Sharon Lesley / Simon, Anna Katharina

Aging cell

2017 Volume 16, Issue 6, Page(s) 1234–1243

Abstract: The decline of the immune system with age known as immune senescence contributes to inefficient pathogen clearance and is a key risk factor for many aged-related diseases. However, reversing or halting immune aging requires more knowledge about the cell ... ...

Abstract	The decline of the immune system with age known as immune senescence contributes to inefficient pathogen clearance and is a key risk factor for many aged-related diseases. However, reversing or halting immune aging requires more knowledge about the cell biology of senescence in immune cells. Telomere shortening, low autophagy and mitochondrial dysfunction have been shown to underpin cell senescence. While autophagy has been found to control mitochondrial damage, no link has been made to telomere attrition. In contrast, mitochondrial stress can contribute to telomere attrition and vice versa. Whereas this link has been investigated in fibroblasts or cell lines, it is unclear whether this link exists in primary cells such as human lymphocytes and whether autophagy contributes to it. As traditional methods for measuring telomere length are low throughput or unsuitable for the analysis of cell subtypes within a mixed population of primary cells, we have developed a novel sensitive flow-FISH assay using the imaging flow cytometer. Using this assay, we show a correlation between age and increased mitochondrial reactive oxygen species in CD8
MeSH term(s)	Flow Cytometry/methods ; Humans ; Mitochondria/metabolism ; T-Lymphocyte Subsets/metabolism ; Telomere/metabolism
Language	English
Publishing date	2017-08-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2113083-8
ISSN	1474-9726 ; 1474-9718
ISSN (online)	1474-9726
ISSN	1474-9718
DOI	10.1111/acel.12640
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reputational Risk Associated with Big Data Research and Development

Cara Stitzlein / Simon Fielke / François Waldner / Todd Sanderson

Sustainability, Vol 13, Iss 9280, p

An Interdisciplinary Perspective

2021 Volume 9280

Abstract: Many private and public actors are incentivized by the promises of big data technologies: digital tools underpinned by capabilities like artificial intelligence and machine learning. While many shared value propositions exist regarding what these ... ...

Abstract	Many private and public actors are incentivized by the promises of big data technologies: digital tools underpinned by capabilities like artificial intelligence and machine learning. While many shared value propositions exist regarding what these technologies afford, public-facing concerns related to individual privacy, algorithm fairness, and the access to insights requires attention if the widespread use and subsequent value of these technologies are to be fully realized. Drawing from perspectives of data science, social science and technology acceptance, we present an interdisciplinary analysis that links these concerns with traditional research and development (R&D) activities. We suggest a reframing of the public R&D ‘brand’ that responds to legitimate concerns related to data collection, development, and the implementation of big data technologies. We offer as a case study Australian agriculture, which is currently undergoing such digitalization, and where concerns have been raised by landholders and the research community. With seemingly limitless possibilities, an updated account of responsible R&D in an increasingly digitalized world may accelerate the ways in which we might realize the benefits of big data and mitigate harmful social and environmental costs.
Keywords	digital transformation ; research and development ; reputational risk ; interdisciplinary science ; big data ; innovation systems ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High pretreatment disease burden as a risk factor for infectious complications following CD19 chimeric antigen receptor T-cell therapy for large B-cell lymphoma.

O'Reilly, Maeve A / Neill, Lorna / Collin, Simon M / Stone, Neil / Springell, Deborah / Mensah, Jeremy / Cheok, Kathleen P L / Jalowiec, Katarzyna / Benjamin, Reuben / Kuhnl, Andrea / Roddie, Claire / Sanderson, Robin

HemaSphere

2024 Volume 8, Issue 1, Page(s) e29

Abstract: Infection has emerged as the chief cause of non-relapse mortality (NRM) post CD19-targeting chimeric antigen receptor T-cell therapy (CAR-T) therapy. Even though up to 50% of patients may remain infection-free, many suffer multiple severe, life- ... ...

Abstract	Infection has emerged as the chief cause of non-relapse mortality (NRM) post CD19-targeting chimeric antigen receptor T-cell therapy (CAR-T) therapy. Even though up to 50% of patients may remain infection-free, many suffer multiple severe, life-threatening, or fatal infectious events. The primary aim of this study was to explore severe and life-threatening infections post licensed CAR-T therapy in large B-cell lymphoma, with a focus on the role of disease burden and disease sites in assessing individual risk. We sought to understand the cohort of patients who experience ≥2 infections and those at the highest risk of infectious NRM. Our analysis identifies a higher disease burden after bridging therapy as associated with infection events. Those developing ≥2 infections emerged as a uniquely high-risk cohort, particularly if the second (or beyond) infection occurred during an episode of immune effector cell-associated neurotoxicity syndrome (ICANS) or while on steroids and/or anakinra for ICANS. Herein, we also describe the first reported cases of "CAR-T cold sepsis," a phenomenon characterized by the lack of an appreciable systemic inflammatory response at the time of detection of infection. We propose a risk-based strategy to encourage heightened clinician awareness of cold sepsis, with a view to reducing NRM.
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article
ISSN	2572-9241
ISSN (online)	2572-9241
DOI	10.1002/hem3.29
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Craving inclusion: a systematic review on the experiences and needs of people with disability eating out.

Hemsley, Bronwyn / Almond, Barbara / Given, Fiona / Darcy, Simon / L'Espoir Decosta, Patrick / Dann, Stephen / Carnemolla, Phillippa / Freeman-Sanderson, Amy / Debono, Deborah / Balandin, Susan

Disability and rehabilitation

2023 , Page(s) 1–16

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2023-12-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1104775-6
ISSN	1464-5165 ; 0963-8288
ISSN (online)	1464-5165
ISSN	0963-8288
DOI	10.1080/09638288.2023.2295006
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Article ; Online: Improving the Diagnosis of Endometrial Hyperplasia Using Computerized Analysis and Immunohistochemical Biomarkers.

Sanderson, Peter A / Esnal-Zufiaurre, Arantza / Arends, Mark J / Herrington, C Simon / Collins, Frances / Williams, Alistair R W / Saunders, Philippa T K

Frontiers in reproductive health

2022 Volume 4, Page(s) 896170

Abstract: Endometrial hyperplasia (EH) is a precursor lesion to endometrial carcinoma (EC). Risks for EC include genetic, hormonal and metabolic factors most notably those associated with obesity: rates are rising and there is concern that cases in pre-menopausal ... ...

Abstract	Endometrial hyperplasia (EH) is a precursor lesion to endometrial carcinoma (EC). Risks for EC include genetic, hormonal and metabolic factors most notably those associated with obesity: rates are rising and there is concern that cases in pre-menopausal women may remain undetected. Making an accurate distinction between benign and pre-malignant disease is both a challenge for the pathologist and important to the gynecologist who wants to deliver the most appropriate care to meet the needs of the patient. Premalignant change may be recognized by histological changes of endometrial hyperplasia (which may occur with or without atypia) and endometrial intraepithelial neoplasia (EIN). In this study we created a tissue resource of EH samples diagnosed between 2004 and 2009 (
Language	English
Publishing date	2022-05-12
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-3153
ISSN (online)	2673-3153
DOI	10.3389/frph.2022.896170
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation.

Zhou, Dingxi / Borsa, Mariana / Puleston, Daniel J / Zellner, Susanne / Capera, Jesusa / Sanderson, Sharon / Schifferer, Martina / Hester, Svenja S / Ge, Xin / Fischer, Roman / Jostins, Luke / Behrends, Christian / Alsaleh, Ghada / Simon, Anna Katharina

Nature communications

2022 Volume 13, Issue 1, Page(s) 5174

Abstract: CD4+ T cells are pivotal cells playing roles in the orchestration of humoral and cytotoxic immune responses. It is known that CD4+ T cell proliferation relies on autophagy, but identification of the autophagosomal cargo involved is missing. Here we ... ...

Abstract	CD4+ T cells are pivotal cells playing roles in the orchestration of humoral and cytotoxic immune responses. It is known that CD4+ T cell proliferation relies on autophagy, but identification of the autophagosomal cargo involved is missing. Here we create a transgenic mouse model, to enable direct mapping of the proteinaceous content of autophagosomes in primary cells by LC3 proximity labelling. Interleukin-7 receptor-α, a cytokine receptor mostly found in naïve and memory T cells, is reproducibly detected in autophagosomes of activated CD4+ T cells. Consistently, CD4+ T cells lacking autophagy show increased interleukin-7 receptor-α surface expression, while no defect in internalisation is observed. Mechanistically, excessive surface interleukin-7 receptor-α sequestrates the common gamma chain, impairing the interleukin-2 receptor assembly and downstream signalling crucial for T cell proliferation. This study shows that key autophagy substrates can be reliably identified in this mouse model and help mechanistically unravel autophagy's contribution to healthy physiology and disease.
MeSH term(s)	Animals ; Autophagosomes/metabolism ; CD4-Positive T-Lymphocytes ; Cell Proliferation ; Interleukin-2/metabolism ; Interleukin-7/metabolism ; Lymphocyte Activation ; Mice ; Receptors, Interleukin-7/metabolism
Chemical Substances	Interleukin-2 ; Interleukin-7 ; Receptors, Interleukin-7
Language	English
Publishing date	2022-09-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-32718-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cortical cells are altered by factors including bone morphogenetic protein released from a placental barrier model under altered oxygenation.

Leinster, Veronica H L / Phillips, Thomas J / Jones, Nicola / Sanderson, Sharon / Simon, Katja / Hanley, Jon / Case, Charles Patrick

Neuronal signaling

2020 Volume 4, Issue 1, Page(s) NS20190148

Abstract: Episodes of hypoxia and hypoxia/reoxygenation during foetal development have been associated with increased risk of neurodevelopmental conditions presenting in later life. The mechanism for this is not understood; however, several authors have suggested ... ...

Abstract	Episodes of hypoxia and hypoxia/reoxygenation during foetal development have been associated with increased risk of neurodevelopmental conditions presenting in later life. The mechanism for this is not understood; however, several authors have suggested that the placenta plays an important role. Previously we found both placentas from a maternal hypoxia model and pre-eclamptic placentas from patients release factors lead to a loss of dendrite complexity in rodent neurons. Here to further explore the nature and origin of these secretions we exposed a simple
Language	English
Publishing date	2020-04-09
Publishing country	England
Document type	Journal Article
ISSN	2059-6553
ISSN (online)	2059-6553
DOI	10.1042/NS20190148
Database	MEDical Literature Analysis and Retrieval System OnLINE

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